n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide has been researched along with Morphine Dependence in 2 studies
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 5.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 1.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tokuyama, S | 1 |
| Feng, Y | 1 |
| Wakabayashi, H | 1 |
| Ho, IK | 1 |
| Bilsky, EJ | 1 |
| Bernstein, RN | 1 |
| Wang, Z | 1 |
| Sadée, W | 1 |
| Porreca, F | 1 |
2 other studies available for n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide and Morphine Dependence
| Article | Year |
|---|---|
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Butorphanol; Cytosol; Enzy | 1995 |
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Dru | 1996 |