n(g),n(g')-dimethyl-l-arginine has been researched along with Subarachnoid Hemorrhage in 13 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elevated cerebrospinal fluid (CSF) concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been found in patients with subarachnoid hemorrhage (SAH)." | 7.80 | Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients. ( Hang, CH; Li, H; Liu, M; Ni, L; Wu, W; Zhang, QR; Zhang, X, 2014) |
| "Delayed cerebral ischemia (DCI) is the major cause of lethality and neuronal damage in patients who survived the primary subarachnoid hemorrhage (SAH)." | 5.48 | Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage. ( Appel, D; Böger, RH; Czorlich, P; Goetz, AE; Hannemann, J; Schwedhelm, E; Seeberger, M, 2018) |
| "Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes." | 5.42 | Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015) |
| "Elevated cerebrospinal fluid (CSF) concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been found in patients with subarachnoid hemorrhage (SAH)." | 3.80 | Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients. ( Hang, CH; Li, H; Liu, M; Ni, L; Wu, W; Zhang, QR; Zhang, X, 2014) |
| "Increased cerebrospinal fluid (CSF) levels of asymmetric dimethyl L-arginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), are associated with delayed vasospasm after subarachnoid hemorrhage (SAH); however, the source, cellular mechanisms, and pharmacological inhibition of ADMA production following SAH are unknown." | 3.73 | In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates. ( Espey, MG; Harvey-White, J; Jung, CS; Oldfield, EH; Pluta, RM; Shilad, S; Whitehead, A, 2005) |
| "Delayed cerebral ischemia (DCI) is the major cause of lethality and neuronal damage in patients who survived the primary subarachnoid hemorrhage (SAH)." | 1.48 | Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage. ( Appel, D; Böger, RH; Czorlich, P; Goetz, AE; Hannemann, J; Schwedhelm, E; Seeberger, M, 2018) |
| "Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes." | 1.42 | Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015) |
| "After aneurysmal subarachnoid hemorrhage (SAH) disturbance of this equilibrium may evoke delayed cerebral vasospasm (CVS) leading to delayed cerebral ischemia (DCI)." | 1.38 | The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage. ( Jung, CS; Lange, B; Seifert, V; Zimmermann, M, 2012) |
| "Delayed cerebral vasospasm after subarachnoid hemorrhage (SAH) may be evoked by the decreased availability of nitric oxide (NO)." | 1.34 | Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. ( Espey, MG; Harvey-White, J; Jung, CS; Oldfield, EH; Pluta, RM; Seifert, V; Zimmermann, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sabanci, PA | 1 |
| Omay, B | 1 |
| Aras, Y | 1 |
| Aydoseli, A | 1 |
| Ali, A | 1 |
| Erdem, T | 1 |
| Sencer, A | 1 |
| Kiris, T | 1 |
| Appel, D | 1 |
| Seeberger, M | 1 |
| Schwedhelm, E | 1 |
| Czorlich, P | 1 |
| Goetz, AE | 1 |
| Böger, RH | 1 |
| Hannemann, J | 1 |
| Bergström, A | 1 |
| Staalsø, JM | 1 |
| Romner, B | 1 |
| Olsen, NV | 1 |
| Lindgren, C | 1 |
| Hultin, M | 2 |
| Koskinen, LO | 2 |
| Lindvall, P | 1 |
| Borota, L | 1 |
| Naredi, S | 2 |
| Scherbakov, N | 1 |
| Doehner, W | 1 |
| Li, H | 1 |
| Wu, W | 1 |
| Liu, M | 1 |
| Zhang, X | 1 |
| Zhang, QR | 1 |
| Ni, L | 1 |
| Hang, CH | 1 |
| Zhao, D | 1 |
| Liu, Q | 1 |
| Ji, Y | 1 |
| Wang, G | 1 |
| He, X | 1 |
| Tian, W | 1 |
| Xu, H | 1 |
| Lei, T | 1 |
| Wang, Y | 1 |
| Jung, CS | 4 |
| Lange, B | 1 |
| Zimmermann, M | 2 |
| Seifert, V | 2 |
| Rodling-Wahlström, M | 1 |
| Olivecrona, M | 1 |
| Iuliano, BA | 1 |
| Harvey-White, J | 3 |
| Espey, MG | 3 |
| Oldfield, EH | 3 |
| Pluta, RM | 4 |
| Whitehead, A | 1 |
| Shilad, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.[NCT02221466] | 45 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453] | 150 participants (Actual) | Observational | 2021-08-18 | Active, not recruiting | |||
| Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265] | 32 participants (Anticipated) | Observational | 2023-05-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for n(g),n(g')-dimethyl-l-arginine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Amidohydrolases; Animals; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Humans; Muscle, | 2006 |
12 other studies available for n(g),n(g')-dimethyl-l-arginine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Effect of Visible Light on Vasospasticity of Post-Subarachnoid Hemorrhage Cerebrospinal Fluid.
Topics: Animals; Arginine; Bilirubin; Female; Humans; Light; Male; Middle Aged; Nitric Oxide; Nitric Oxide S | 2017 |
Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage.
Topics: Adult; Aged; Arginine; Biomarkers; Brain Ischemia; Cerebral Angiography; Female; Humans; Incidence; | 2018 |
Impaired endothelial function after aneurysmal subarachnoid haemorrhage correlates with arginine:asymmetric dimethylarginine ratio.
Topics: Adult; Arginine; Biomarkers; Blood Flow Velocity; Endothelium; Female; Follow-Up Studies; Humans; Hy | 2014 |
ADMA levels and arginine/ADMA ratios reflect severity of disease and extent of inflammation after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans; | 2014 |
I. Peripheral endothelial dysfunction after subarachnoid haemorrhage: what the fingertips can tell us.
Topics: Arginine; Endothelium; Female; Humans; Male; Subarachnoid Hemorrhage | 2014 |
Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients.
Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up | 2014 |
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal | 2015 |
The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Arginine; Brain Ischemia; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Retr | 2012 |
Subarachnoid haemorrhage induces an inflammatory response followed by a delayed persisting increase in asymmetric dimethylarginine.
Topics: Acute-Phase Reaction; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Humans | 2012 |
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral A | 2004 |
In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.
Topics: Animals; Antioxidants; Arginine; Bilirubin; Cell Culture Techniques; Double-Blind Method; Endothelia | 2005 |
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In | 2007 |
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In | 2007 |
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In | 2007 |
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In | 2007 |