n(g),n(g')-dimethyl-l-arginine has been researched along with Scleroderma, Systemic in 11 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to examine associations between asymmetric dimethylarginine (ADMA) - a biomarker of atherosclerosis - and assessments of macrovascular endothelial function in patients with SSc." | 4.31 | The role of asymmetric dimethylarginine in endothelial dysfunction and abnormal nitric oxide metabolism in systemic sclerosis: results from a pilot study. ( Dimitroulas, T; Doumas, M; Garyfallos, A; Karagiannis, A; Katsiki, N; Kitas, G; Loutradis, C; Malliari, A; Pagkopoulou, E; Soulaidopoulos, S, 2023) |
| " While there is no established dosing regimen, studies of oral l-arginine in secondary RP suggest that divided dosing may begin at 1-2 g/day and may be titrated up to 10 g/day." | 2.61 | The clinical effects of l-arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon. ( Curtiss, P; Franks, AG; Lo Sicco, K; Schwager, Z, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Pagkopoulou, E | 2 |
| Soulaidopoulos, S | 2 |
| Triantafyllidou, E | 1 |
| Loutradis, C | 2 |
| Malliari, A | 2 |
| Kitas, GD | 1 |
| Garyfallos, A | 3 |
| Dimitroulas, T | 4 |
| Katsiki, N | 1 |
| Karagiannis, A | 1 |
| Doumas, M | 1 |
| Kitas, G | 1 |
| Curtiss, P | 1 |
| Schwager, Z | 1 |
| Lo Sicco, K | 1 |
| Franks, AG | 1 |
| Ciurzyński, M | 1 |
| Bienias, P | 1 |
| Irzyk, K | 1 |
| Kostrubiec, M | 1 |
| Bartoszewicz, Z | 1 |
| Siwicka, M | 1 |
| Stelmaszczyk-Emmel, A | 1 |
| Górska, E | 1 |
| Demkow, U | 1 |
| Pruszczyk, P | 1 |
| Zhang, L | 1 |
| Wan, YN | 1 |
| Zhao, JH | 1 |
| Wang, YJ | 1 |
| Wang, YX | 1 |
| Yan, JW | 1 |
| Huang, XL | 1 |
| Wang, J | 1 |
| Blaise, S | 1 |
| Maas, R | 1 |
| Trocme, C | 1 |
| Kom, GD | 1 |
| Roustit, M | 1 |
| Carpentier, PH | 1 |
| Cracowski, JL | 1 |
| Giannakoulas, G | 2 |
| Papadopoulou, K | 2 |
| Karvounis, H | 2 |
| Dimitroula, H | 2 |
| Koliakos, G | 2 |
| Karamitsos, T | 1 |
| Parcharidou, D | 2 |
| Settas, L | 2 |
| Sfetsios, T | 1 |
| Styliadis, I | 1 |
| Dooley, A | 1 |
| Gao, B | 1 |
| Bradley, N | 1 |
| Abraham, DJ | 1 |
| Black, CM | 1 |
| Jacobs, M | 1 |
| Bruckdorfer, KR | 1 |
| Wipff, J | 1 |
| Avouac, J | 1 |
| Borderie, D | 1 |
| Zerkak, D | 1 |
| Lemarechal, H | 1 |
| Kahan, A | 1 |
| Boileau, C | 1 |
| Allanore, Y | 1 |
| Lischwe, MA | 1 |
| Ochs, RL | 1 |
| Reddy, R | 1 |
| Cook, RG | 1 |
| Yeoman, LC | 1 |
| Tan, EM | 1 |
| Reichlin, M | 1 |
| Busch, H | 1 |
2 reviews available for n(g),n(g')-dimethyl-l-arginine and Scleroderma, Systemic
| Article | Year |
|---|---|
The clinical effects of l-arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon.
Topics: Arginine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Raynaud Disease; Scleroderma, System | 2019 |
The association between systemic sclerosis, arginine and asymmetric dimethylarginine.
Topics: Animals; Arginine; Case-Control Studies; Humans; Nitric Oxide; Scleroderma, Systemic | 2015 |
9 other studies available for n(g),n(g')-dimethyl-l-arginine and Scleroderma, Systemic
| Article | Year |
|---|---|
Asymmetric dimethylarginine correlates with worsening peripheral microangiopathy in systemic sclerosis.
Topics: Adult; Aged; Capillaries; Cross-Sectional Studies; Female; Humans; Male; Microcirculation; Microscop | 2023 |
The role of asymmetric dimethylarginine in endothelial dysfunction and abnormal nitric oxide metabolism in systemic sclerosis: results from a pilot study.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional | 2023 |
Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis.
Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Case-Control Studies; Collagen; Echocardiography; E | 2014 |
Correlation of biomarkers of endothelium dysfunction and matrix remodeling in patients with systemic sclerosis.
Topics: Arginine; Biomarkers; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix; Female; Humans | 2009 |
Early detection of cardiac involvement in systemic sclerosis assessed by tissue-Doppler echocardiography: relationship with neurohormonal activation and endothelial dysfunction.
Topics: Adult; Aged; Analysis of Variance; Arginine; Blood Flow Velocity; Echocardiography, Doppler; Endothe | 2010 |
Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
Topics: Aged; Arginine; Biomarkers; Blood Pressure; Cross-Sectional Studies; Female; Follow-Up Studies; Hear | 2010 |
Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine.
Topics: Adult; Arginine; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Mi | 2006 |
Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin.
Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Cross-Sectional Studies; Endoglin; Female; Humans; | 2008 |
Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antigens; Arginine; Autoantibodies; Cell Nucleolus; Fluor | 1985 |