n(g),n(g')-dimethyl-l-arginine has been researched along with Pulmonary Hypertension in 40 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
| Excerpt | Relevance | Reference |
|---|---|---|
| "ADMA, SDMA, and arginine were measured (0-540 min) in 12 patients with pulmonary hypertension after a single oral dose of vardenafil." | 9.20 | Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension. ( Bondesson, U; Egeröd, H; Hedeland, M; Henrohn, D; Sandqvist, A; Wernroth, L; Wikström, G, 2015) |
| "We investigated whether infants with persistent pulmonary hypertension had elevated levels of asymmetric dimethyl arginine, an endogenous inhibitor of nitric oxide synthase, and symmetric dimethyl arginine, a regioisomer." | 9.11 | Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn. ( Krywawych, S; Petros, AJ; Pierce, CM, 2004) |
| "To study the change in asymmetric dimethylarginine (ADMA) in the circulation system of full-term infants with persistent pulmonary hypertension of the newborn (PPHN) and its association with treatment response, as well as the possibility of ADMA as a therapeutic target and a marker for treatment response." | 8.12 | Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn. ( Ding, JJ; Gu, M; Lu, Q; Zhang, WT, 2022) |
| "The objectives of this study were to evaluate the plasma levels of asymmetric dimethyl-L-arginine in children with pulmonary hypertension due to CHD before and after treatment with sildenafil and to evaluate its diagnostic and prognostic value as a biomarker in such children." | 7.88 | Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD. ( El Amrousy, D; El-Serogy, H; Farag, M; Zoair, A, 2018) |
| "To test the hypothesis that levels of the endogenous inhibitor of nitric oxide production, asymmetric dimethylarginine (ADMA), would be greater in preterm infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) than in infants with BPD alone." | 7.81 | Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension. ( Backes, CH; Chen, B; Klebanoff, MA; Nelin, LD; Peterson, E; Rogers, LK; Trittmann, JK, 2015) |
| "Dysregulated arginine metabolism was observed in advanced decompensated heart failure, particularly with pulmonary hypertension and elevated intracardiac filling pressures." | 7.78 | Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1. ( Borowski, AG; Hazen, SL; Moravec, CS; Shao, Z; Shrestha, K; Sweet, W; Tang, WH; Thakur, A; Thomas, JD; Wang, Z, 2012) |
| " Our results suggest that ADMA and oxidative stress likely reduce NO bioavailability under altitude hypoxia, which implies greater pulmonary vascular reactivity and tone, despite the more subdued effects observed under CIH." | 5.43 | Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? ( Arriaza, K; Böger, RH; Brito, J; Klose, H; Leon-Velarde, F; Lüneburg, N; Pena, E; Siques, P, 2016) |
| "ADMA, SDMA, and arginine were measured (0-540 min) in 12 patients with pulmonary hypertension after a single oral dose of vardenafil." | 5.20 | Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension. ( Bondesson, U; Egeröd, H; Hedeland, M; Henrohn, D; Sandqvist, A; Wernroth, L; Wikström, G, 2015) |
| "We investigated whether infants with persistent pulmonary hypertension had elevated levels of asymmetric dimethyl arginine, an endogenous inhibitor of nitric oxide synthase, and symmetric dimethyl arginine, a regioisomer." | 5.11 | Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn. ( Krywawych, S; Petros, AJ; Pierce, CM, 2004) |
| "To study the change in asymmetric dimethylarginine (ADMA) in the circulation system of full-term infants with persistent pulmonary hypertension of the newborn (PPHN) and its association with treatment response, as well as the possibility of ADMA as a therapeutic target and a marker for treatment response." | 4.12 | Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn. ( Ding, JJ; Gu, M; Lu, Q; Zhang, WT, 2022) |
| "The objectives of this study were to evaluate the plasma levels of asymmetric dimethyl-L-arginine in children with pulmonary hypertension due to CHD before and after treatment with sildenafil and to evaluate its diagnostic and prognostic value as a biomarker in such children." | 3.88 | Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD. ( El Amrousy, D; El-Serogy, H; Farag, M; Zoair, A, 2018) |
| "To test the hypothesis that levels of the endogenous inhibitor of nitric oxide production, asymmetric dimethylarginine (ADMA), would be greater in preterm infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) than in infants with BPD alone." | 3.81 | Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension. ( Backes, CH; Chen, B; Klebanoff, MA; Nelin, LD; Peterson, E; Rogers, LK; Trittmann, JK, 2015) |
| "The NOS (nitric oxide synthase) inhibitor ADMA (asymmetric dimethylarginine) contributes to the pathogenesis of pulmonary hypertension." | 3.80 | miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. ( Dubois, O; Duluc, L; Iannone, L; Leiper, J; Rhodes, CJ; Wharton, J; Wilkins, MR; Wojciak-Stothard, B; Zhao, L, 2014) |
| "Dysregulated arginine metabolism was observed in advanced decompensated heart failure, particularly with pulmonary hypertension and elevated intracardiac filling pressures." | 3.78 | Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1. ( Borowski, AG; Hazen, SL; Moravec, CS; Shao, Z; Shrestha, K; Sweet, W; Tang, WH; Thakur, A; Thomas, JD; Wang, Z, 2012) |
| "Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD)." | 3.76 | Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype. ( Biemond, BJ; Brandjes, DP; Duits, AJ; Landburg, PP; Muskiet, FA; Schnog, JB; Teerlink, T, 2010) |
| "Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis." | 3.73 | Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. ( Anthony, S; Hubank, M; Leiper, JM; Smith, CL; Vallance, P, 2005) |
| " Our results suggest that ADMA and oxidative stress likely reduce NO bioavailability under altitude hypoxia, which implies greater pulmonary vascular reactivity and tone, despite the more subdued effects observed under CIH." | 1.43 | Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? ( Arriaza, K; Böger, RH; Brito, J; Klose, H; Leon-Velarde, F; Lüneburg, N; Pena, E; Siques, P, 2016) |
| "The development of pulmonary hypertension is a common accompaniment of congenital heart disease (CHD) with increased pulmonary blood flow." | 1.38 | Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. ( Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J, 2012) |
| "We recruited 41 patients with Eisenmenger syndrome (13 with Down syndrome), 55 with idiopathic PAH, and 47 healthy control subjects." | 1.35 | Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. ( Ali, O; Bauersachs, J; Bédard, E; Diller, GP; Gatzoulis, MA; Gibbs, JS; Hobbs, AJ; Howard, LS; Okonko, DO; Thum, T; van Eijl, S; Wharton, J; Wilkins, MR; Wort, SJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (32.50) | 29.6817 |
| 2010's | 25 (62.50) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, WT | 1 |
| Lu, Q | 2 |
| Ding, JJ | 1 |
| Gu, M | 1 |
| Türer Cabbar, A | 1 |
| Değertekin, MM | 1 |
| Şimşek, MA | 1 |
| Özveren, O | 1 |
| Güleç, S | 1 |
| Yanartaş, M | 1 |
| Gezer Taş, S | 1 |
| Olgun Yıldızeli, Ş | 1 |
| Mutlu, B | 1 |
| İşbir, T | 1 |
| Yıldızeli, B | 1 |
| Yildiz, M | 1 |
| Sahin, A | 1 |
| Behnes, M | 1 |
| Akin, İ | 1 |
| Farag, M | 1 |
| El Amrousy, D | 1 |
| El-Serogy, H | 1 |
| Zoair, A | 1 |
| El-Shanshory, M | 1 |
| Badraia, I | 1 |
| Donia, A | 1 |
| Abd El-Hameed, F | 1 |
| Mabrouk, M | 1 |
| Bakr, A | 1 |
| Pak, O | 1 |
| Taye, A | 1 |
| Hamada, F | 1 |
| Hemeida, R | 1 |
| Janssen, W | 1 |
| Gierhardt, M | 1 |
| Ghofrani, HA | 3 |
| Seeger, W | 3 |
| Grimminger, F | 3 |
| Schermuly, RT | 3 |
| Witzenrath, M | 1 |
| Brandes, RP | 1 |
| Huang, N | 1 |
| Cooke, JP | 2 |
| Weissmann, N | 3 |
| Sommer, N | 1 |
| Kline, JA | 1 |
| Watts, J | 1 |
| Courtney, D | 1 |
| Lee, YY | 1 |
| Hwang, S | 1 |
| Parikh, RV | 1 |
| Scherzer, R | 1 |
| Nitta, EM | 1 |
| Leone, A | 1 |
| Hur, S | 1 |
| Mistry, V | 1 |
| Macgregor, JS | 1 |
| Martin, JN | 1 |
| Deeks, SG | 1 |
| Ganz, P | 1 |
| Hsue, PY | 1 |
| Mohamed, el-S | 1 |
| Ibrahim, B | 1 |
| Amr, D | 1 |
| Noha, el-K | 1 |
| Mokhtar, M | 1 |
| Iannone, L | 1 |
| Zhao, L | 1 |
| Dubois, O | 1 |
| Duluc, L | 1 |
| Rhodes, CJ | 1 |
| Wharton, J | 2 |
| Wilkins, MR | 2 |
| Leiper, J | 2 |
| Wojciak-Stothard, B | 1 |
| Trittmann, JK | 1 |
| Peterson, E | 1 |
| Rogers, LK | 2 |
| Chen, B | 1 |
| Backes, CH | 1 |
| Klebanoff, MA | 1 |
| Nelin, LD | 2 |
| Aschner, JL | 1 |
| Fike, CD | 1 |
| Fang, ZF | 1 |
| Huang, YY | 1 |
| Tang, L | 1 |
| Hu, XQ | 1 |
| Shen, XQ | 1 |
| Tang, JJ | 1 |
| Zhou, SH | 1 |
| Henrohn, D | 1 |
| Sandqvist, A | 1 |
| Egeröd, H | 1 |
| Hedeland, M | 1 |
| Wernroth, L | 1 |
| Bondesson, U | 1 |
| Wikström, G | 1 |
| Pekarova, M | 1 |
| Koudelka, A | 1 |
| Kolarova, H | 1 |
| Ambrozova, G | 1 |
| Klinke, A | 1 |
| Cerna, A | 1 |
| Kadlec, J | 1 |
| Trundova, M | 1 |
| Sindlerova Svihalkova, L | 1 |
| Kuchta, R | 1 |
| Kuchtova, Z | 1 |
| Lojek, A | 1 |
| Kubala, L | 1 |
| Lüneburg, N | 1 |
| Siques, P | 1 |
| Brito, J | 1 |
| Arriaza, K | 1 |
| Pena, E | 1 |
| Klose, H | 1 |
| Leon-Velarde, F | 1 |
| Böger, RH | 1 |
| Chen, P | 1 |
| Huang, Y | 1 |
| Fang, Z | 1 |
| Hu, X | 1 |
| Shen, X | 1 |
| Zhou, S | 1 |
| Diller, GP | 1 |
| van Eijl, S | 1 |
| Okonko, DO | 1 |
| Howard, LS | 1 |
| Ali, O | 1 |
| Thum, T | 1 |
| Wort, SJ | 1 |
| Bédard, E | 1 |
| Gibbs, JS | 1 |
| Bauersachs, J | 1 |
| Hobbs, AJ | 1 |
| Gatzoulis, MA | 1 |
| Landburg, PP | 2 |
| Teerlink, T | 2 |
| van Beers, EJ | 1 |
| Muskiet, FA | 2 |
| Kappers-Klunne, MC | 1 |
| van Esser, JW | 1 |
| Mac Gillavry, MR | 1 |
| Biemond, BJ | 2 |
| Brandjes, DP | 2 |
| Duits, AJ | 2 |
| Schnog, JJ | 1 |
| Kato, GJ | 1 |
| Wang, Z | 2 |
| Machado, RF | 1 |
| Blackwelder, WC | 1 |
| Taylor, JG | 1 |
| Hazen, SL | 2 |
| Schnog, JB | 1 |
| Dimitroulas, T | 1 |
| Giannakoulas, G | 1 |
| Papadopoulou, K | 1 |
| Sfetsios, T | 1 |
| Karvounis, H | 1 |
| Dimitroula, H | 1 |
| Parcharidou, D | 1 |
| Koliakos, G | 1 |
| Garyfallos, A | 1 |
| Styliadis, I | 1 |
| Settas, L | 1 |
| Cua, CL | 1 |
| Chicoine, LG | 1 |
| Augustine, M | 1 |
| Jin, Y | 1 |
| Nash, PL | 1 |
| Pullamsetti, SS | 1 |
| Savai, R | 1 |
| Schaefer, MB | 1 |
| Wilhelm, J | 1 |
| Schudt, C | 1 |
| Fleming, I | 1 |
| Mayer, K | 1 |
| Zweier, JL | 1 |
| Talukder, MA | 1 |
| Shao, Z | 1 |
| Shrestha, K | 1 |
| Thakur, A | 1 |
| Borowski, AG | 1 |
| Sweet, W | 1 |
| Thomas, JD | 1 |
| Moravec, CS | 1 |
| Tang, WH | 1 |
| Sanli, C | 1 |
| Oguz, D | 1 |
| Olgunturk, R | 1 |
| Tunaoglu, FS | 1 |
| Kula, S | 1 |
| Pasaoglu, H | 1 |
| Gulbahar, O | 1 |
| Cevik, A | 1 |
| Sharma, S | 2 |
| Sun, X | 2 |
| Kumar, S | 2 |
| Rafikov, R | 2 |
| Aramburo, A | 1 |
| Kalkan, G | 1 |
| Tian, J | 1 |
| Rehmani, I | 1 |
| Kallarackal, S | 1 |
| Fineman, JR | 2 |
| Black, SM | 2 |
| Sirmagul, B | 1 |
| Ilgin, S | 1 |
| Atli, O | 1 |
| Usanmaz, SE | 1 |
| Demirel-Yilmaz, E | 1 |
| Fratz, S | 1 |
| Aggarwal, S | 1 |
| Rafikova, O | 1 |
| Burns, T | 1 |
| Dasarathy, S | 1 |
| Wright, J | 1 |
| Schreiber, C | 1 |
| Radman, M | 1 |
| Arrigoni, FI | 1 |
| Vallance, P | 2 |
| Haworth, SG | 1 |
| Leiper, JM | 3 |
| Millatt, LJ | 1 |
| Whitley, GS | 1 |
| Li, D | 1 |
| Siragy, HM | 1 |
| Carey, RM | 1 |
| Johns, RA | 1 |
| Pierce, CM | 1 |
| Krywawych, S | 1 |
| Petros, AJ | 1 |
| Pullamsetti, S | 1 |
| Kiss, L | 1 |
| Voswinckel, R | 1 |
| Haredza, P | 1 |
| Klepetko, W | 2 |
| Aigner, C | 1 |
| Fink, L | 1 |
| Muyal, JP | 1 |
| Kielstein, JT | 1 |
| Bode-Böger, SM | 1 |
| Hesse, G | 1 |
| Martens-Lobenhoffer, J | 1 |
| Takacs, A | 1 |
| Fliser, D | 1 |
| Hoeper, MM | 1 |
| Smith, CL | 1 |
| Anthony, S | 1 |
| Hubank, M | 1 |
| Skoro-Sajer, N | 1 |
| Mittermayer, F | 1 |
| Panzenboeck, A | 1 |
| Bonderman, D | 1 |
| Sadushi, R | 1 |
| Hitsch, R | 1 |
| Jakowitsch, J | 1 |
| Kneussl, MP | 1 |
| Wolzt, M | 1 |
| Lang, IM | 1 |
| Loukanov, T | 1 |
| Arnold, R | 1 |
| Gross, J | 1 |
| Sebening, C | 1 |
| Klimpel, H | 1 |
| Eichhorn, J | 1 |
| Hoss, K | 1 |
| Ulmer, HE | 2 |
| Kark, M | 1 |
| Gorenflo, M | 2 |
| Zheng, C | 1 |
| Werle, E | 1 |
| Fiehn, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism[NCT00368836] | Phase 2/Phase 3 | 475 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia[NCT00011648] | 986 participants (Actual) | Observational | 2008-02-19 | Completed | |||
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
D-dimer > 499 ng/ml, etCO2/O2 < 0.28, Pulmonary Embolism diagnosed by CT scan (NCT00368836)
Timeframe: Measured at 45 days
| Intervention | probability of PE diagnosis (Number) |
|---|---|
| CO2/O2 Plus D-dimer | 0.32 |
| D-dimer | 0.17 |
Median postoperative change in end tidal CO2/O2 ratio calculated as 100% * [(postoperative-preoperative)/(preoperative)] (NCT00368836)
Timeframe: Pre-op measurement: the morning of surgery. Post-op measurement: the latter of postoperative day 3 or hospital discharge
| Intervention | percent change (Median) | |
|---|---|---|
| end tidal CO2/O2 ratio | D-dimer concentration | |
| BreathScreen PE | 0 | 136 |
2 reviews available for n(g),n(g')-dimethyl-l-arginine and Pulmonary Hypertension
| Article | Year |
|---|---|
An Expanding Role of Biomarkers in Pulmonary Arterial Hypertension.
Topics: Arginine; Biomarkers; Endothelins; Humans; Hypertension, Pulmonary; Prognosis; Sensitivity and Speci | 2017 |
A novel mechanism for pulmonary arterial hypertension?
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; N | 2003 |
2 trials available for n(g),n(g')-dimethyl-l-arginine and Pulmonary Hypertension
| Article | Year |
|---|---|
Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arginine; Atrial Func | 2015 |
Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn.
Topics: Arginine; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Hypertension, Pulmon | 2004 |
36 other studies available for n(g),n(g')-dimethyl-l-arginine and Pulmonary Hypertension
| Article | Year |
|---|---|
Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn.
Topics: Arginine; Biomarkers; Humans; Hypertension, Pulmonary; Infant, Newborn; Prospective Studies | 2022 |
Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy.
Topics: Arginine; Chronic Disease; Endarterectomy; Humans; Hypertension, Pulmonary | 2022 |
Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD.
Topics: Arginine; Biomarkers; Child, Preschool; Echocardiography; Female; Follow-Up Studies; Heart Defects, | 2018 |
Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity.
Topics: Adolescent; Anemia, Sickle Cell; Arginine; Blood Transfusion; Case-Control Studies; Child; Cross-Sec | 2013 |
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.
Topics: Amidohydrolases; Animals; Arginine; Blood Vessels; Cyclic GMP; Gene Expression; Hemodynamics; Hypert | 2013 |
Severe pulmonary embolism decreases plasma L-arginine.
Topics: Arginase; Arginine; Chromatography, High Pressure Liquid; Echocardiography, Doppler; Hemolysis; Huma | 2014 |
Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.
Topics: Adult; Arginine; Biomarkers; Blood Pressure; Catheterization, Swan-Ganz; Cohort Studies; Echocardiog | 2014 |
Asymmetric dimethylarginine levels in children with β-thalassemia and their correlations to tricuspid regurgitant jet velocity.
Topics: Adolescent; Arginine; beta-Thalassemia; Case-Control Studies; Child; Echocardiography, Doppler; Fema | 2014 |
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Familial Primary | 2014 |
Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
Topics: Arginine; Bronchopulmonary Dysplasia; Case-Control Studies; Humans; Hypertension, Pulmonary; Infant, | 2015 |
Plasma asymmetric dimethylarginine in infants with bronchopulmonary dysplasia: a promising biomarker despite uncertain pathogenic significance.
Topics: Arginine; Bronchopulmonary Dysplasia; Humans; Hypertension, Pulmonary | 2015 |
Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease.
Topics: Adult; Arginine; Biomarkers; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Hypertens | 2015 |
Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
Topics: Amidohydrolases; Arginine; Calcium; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Dose-Response | 2015 |
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
Topics: Altitude Sickness; Amidohydrolases; Animals; Arginine; Disease Models, Animal; Hypertension, Pulmona | 2016 |
[Clinical value of ADMA in patients with pulmonary arterial hypertension combination with congenital heart disease].
Topics: Adult; Arginine; Biomarkers; Echocardiography; Female; Heart Defects, Congenital; Hemodynamics; Huma | 2017 |
Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.
Topics: AC133 Antigen; Aged; Antigens, CD; Antigens, CD34; Arginine; Cells, Cultured; Cyclic GMP; Down Syndr | 2008 |
Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension.
Topics: Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Humans; Hypertension, Pulmonary; Male; Mid | 2008 |
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Human | 2009 |
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
Topics: Adult; Albuminuria; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Cholelithiasis; Female; Hemolys | 2010 |
Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
Topics: Aged; Arginine; Biomarkers; Blood Pressure; Cross-Sectional Studies; Female; Follow-Up Studies; Hear | 2010 |
Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
Topics: Arginine; Biomarkers; Down Syndrome; Female; Humans; Hypertension, Pulmonary; Infant; Male; Nitrates | 2011 |
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amidohydrolases; Apoptosis; Arginine; Cell Proliferation; Cell | 2011 |
Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?
Topics: Amidohydrolases; Arginine; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Nitric Oxi | 2011 |
Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1.
Topics: Aged; Amidohydrolases; Arginine; Disease Progression; Female; Heart Failure, Systolic; Humans; Hyper | 2012 |
Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease.
Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiac Catheterization; Case-Control Studies; Child; Child | 2012 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopteri | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; | 2013 |
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Hea | 2013 |
Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia.
Topics: Amidohydrolases; Animals; Animals, Newborn; Arginine; Hypertension, Pulmonary; Hypoxia; Immunohistoc | 2003 |
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzy | 2003 |
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzy | 2005 |
Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
Topics: Adult; Arginine; Biomarkers; Cardiac Catheterization; Female; Follow-Up Studies; Humans; Hypertensio | 2005 |
Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.
Topics: Arginine; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type | 2005 |
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
Topics: Aged; Arginine; Chronic Disease; Endothelial Cells; Enzyme Inhibitors; Female; Humans; Hypertension, | 2007 |
Endothelin-1 and asymmetric dimethylarginine in children with left-to-right shunt after intracardiac repair.
Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiopulmonary Bypass; Child; Child, Preschool; Endothelin | 2008 |
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension.
Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Enzyme Inhibitors; Heart Defects, Congenital; | 2001 |