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n(g),n(g')-dimethyl-l-arginine and Peripheral Arterial Disease

n(g),n(g')-dimethyl-l-arginine has been researched along with Peripheral Arterial Disease in 13 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Peripheral Arterial Disease: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.

Research Excerpts

ExcerptRelevanceReference
"Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis causing endothelial dysfunction, an early sign of atherogenesis."5.37Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease. ( Atzler, D; Benndorf, RA; Böger, RH; Darius, H; Diehm, C; Endres, HG; Lüneburg, N; Maas, R; Schwedhelm, E; Thiem, U; von Stritzky, B, 2011)
" All the patients were followed up for 5 years to determine the development of cardiovascular adverse events (CVAEs) and major amputation."1.48Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up. ( Akkoca, M; Demirel Yilmaz, E; Köksoy, C; Tokgöz, S; Usanmaz, SE, 2018)
"Recent evidence suggests that abdominal obesity (AO) may play a role in PAD."1.39Abdominal obesity is associated with peripheral artery disease in hemodialysis patients. ( Hung, KY; Hung, PH; Lin, CH; Tsai, HB, 2013)
"Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis causing endothelial dysfunction, an early sign of atherogenesis."1.37Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease. ( Atzler, D; Benndorf, RA; Böger, RH; Darius, H; Diehm, C; Endres, HG; Lüneburg, N; Maas, R; Schwedhelm, E; Thiem, U; von Stritzky, B, 2011)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chu, R1
Yu, D1
Chu, J1
Lin, M1
Yu, H1
Paapstel, K1
Kals, J1
Eha, J1
Tootsi, K1
Ottas, A1
Piir, A1
Jakobson, M1
Lieberg, J1
Zilmer, M1
Akkoca, M1
Usanmaz, SE1
Tokgöz, S1
Köksoy, C1
Demirel Yilmaz, E1
Hung, PH1
Tsai, HB1
Lin, CH1
Hung, KY1
Yousefi, B1
Faghfoori, Z1
Samadi, N1
Karami, H1
Ahmadi, Y1
Badalzadeh, R1
Shafiei-Irannejad, V1
Majidinia, M1
Ghavimi, H1
Jabbarpour, M1
Kayacelebi, AA2
Willers, J1
Pham, VV1
Hahn, A1
Schneider, JY2
Rothmann, S2
Frölich, JC2
Tsikas, D2
Langen, J1
Weigt-Usinger, K1
Chobanyan-Jürgens, K1
Mariotti, F1
Atzler, D2
Choe, CU1
Schwedhelm, E2
Huneau, JF1
Lücke, T1
Torondel, B1
Nandi, M1
Kelly, P1
Wojciak-Stothard, B1
Fleming, I1
Leiper, J1
Wilson, AM1
Shin, DS1
Weatherby, C1
Harada, RK1
Ng, MK1
Nair, N1
Kielstein, J1
Cooke, JP1
Böger, RH1
Endres, HG1
Darius, H1
Lüneburg, N1
von Stritzky, B1
Maas, R1
Thiem, U1
Benndorf, RA1
Diehm, C1
Lilitkarntakul, P1
Dhaun, N1
Melville, V1
Blackwell, S1
Talwar, DK1
Liebman, B1
Asai, T1
Pollock, J1
Goddard, J1
Webb, DJ1
Tuygun, AK1
Tuygun, A1
Yurtseven, N1
Sensöz, Y1
Günay, R1
Keser, M1
Tuygun, UH1
Ketenci, B1
Sahin, S1
Yekeler, I1
Schlager, O1
Giurgea, A1
Schuhfried, O1
Seidinger, D1
Hammer, A1
Gröger, M1
Fialka-Moser, V1
Gschwandtner, M1
Koppensteiner, R1
Steiner, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00284076]0 participants Interventional2000-02-29Completed
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)[NCT03883412]Phase 460 participants (Anticipated)Interventional2019-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for n(g),n(g')-dimethyl-l-arginine and Peripheral Arterial Disease

ArticleYear
Prognostic efficacy of circulating asymmetric dimethylarginine in patients with peripheral arterial disease: A meta-analysis of prospective cohort studies.
    Vascular, 2018, Volume: 26, Issue:3

    Topics: Arginine; Atherosclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Peripheral Arterial Diseas

2018

Trials

4 trials available for n(g),n(g')-dimethyl-l-arginine and Peripheral Arterial Disease

ArticleYear
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Coronary Artery Disease; Female; Homoarginine; Homocysteine;

2015
Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adolescent; Adult; Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Chi

2015
Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.
    Vascular medicine (London, England), 2010, Volume: 15, Issue:4

    Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Arginine; Blood Glucose; Creatinine; Exercise Test; F

2010
Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.
    Atherosclerosis, 2011, Volume: 217, Issue:1

    Topics: Aged; Arginine; Cell Movement; Chemokine CXCL12; Endothelial Cells; Exercise; Female; Flow Cytometry

2011

Other Studies

8 other studies available for n(g),n(g')-dimethyl-l-arginine and Peripheral Arterial Disease

ArticleYear
Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018, Volume: 28, Issue:1

    Topics: Aged; Angiography, Digital Subtraction; Arginine; Biomarkers; Case-Control Studies; Coronary Artery

2018
Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up.
    Anatolian journal of cardiology, 2018, Volume: 20, Issue:4

    Topics: Arginine; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Endothelium, Vascular; Female; Follow

2018
Abdominal obesity is associated with peripheral artery disease in hemodialysis patients.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adiponectin; Ankle Brachial Index; Arginine; C-Reactive Protein; Cross-Sectional Studies; Female; Hu

2013
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
    European journal of clinical nutrition, 2014, Volume: 68, Issue:7

    Topics: Adult; Arginine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Artery Disease; Endoth

2014
Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.
    Vascular medicine (London, England), 2010, Volume: 15, Issue:3

    Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Carotid Arteries; Endothelial Cells; Gene Expressi

2010
Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
    Journal of internal medicine, 2011, Volume: 269, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Enzyme Inhibitors; E

2011
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
    Atherosclerosis, 2011, Volume: 216, Issue:1

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; C-Reactive Prote

2011
Asymmetric dimethylarginine levels in Buerger's disease.
    Annals of vascular surgery, 2011, Volume: 25, Issue:4

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Humans; Male; Mi

2011