Page last updated: 2024-10-17

n(g),n(g')-dimethyl-l-arginine and Kidney Diseases

n(g),n(g')-dimethyl-l-arginine has been researched along with Kidney Diseases in 61 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"Since co-administration of ezetimibe, a specific inhibitor of cholesterol absorption into the intestine, has been shown to augment lipid-lowering effects of statins, ezetimibe plus statins is a novel therapeutic strategy for the treatment of dyslipidemia in high-risk patients."9.14Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner. ( Fujiwara, N; Fukami, K; Kawagoe, Y; Nakamura, T; Okuda, S; Sato, E; Suzuki, T; Ueda, S; Ueda, Y; Yamagishi, S, 2010)
" Asymmetric dimethylarginine (ADMA) is increased in diabetes mellitus, kidney disease, and hypertension."7.79Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. ( Hsu, CN; Huang, LT; Lee, CT; Lee, WC; Lin, CY; Tain, YL, 2013)
"Ramipril was given (5 mg daily for 12 weeks), and circulating ADMA, soluble Fas (sFas), myostatin and endothelial function [flow-mediated vasodilation (FMD); ultrasound)] were measured."5.36Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway? ( Axelsson, J; Caglar, K; Cayci, T; Eyileten, T; Kilic, S; Oguz, Y; Saglam, M; Sonmez, A; Vural, A; Yaman, H; Yenicesu, M; Yilmaz, MI, 2010)
"Since co-administration of ezetimibe, a specific inhibitor of cholesterol absorption into the intestine, has been shown to augment lipid-lowering effects of statins, ezetimibe plus statins is a novel therapeutic strategy for the treatment of dyslipidemia in high-risk patients."5.14Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner. ( Fujiwara, N; Fukami, K; Kawagoe, Y; Nakamura, T; Okuda, S; Sato, E; Suzuki, T; Ueda, S; Ueda, Y; Yamagishi, S, 2010)
" Here, we summarize some molecular mechanisms leading from hyperhomocysteinemia, elevated asymmetric dimethylarginine (ADMA) and advanced glycation end products (AGEs)-modified proteins to atherogenic endothelial phenotype and offer a model of endothelial dysfunction based on the interconnectedness of diverse functions."4.82Endothelial cell dysfunction: the syndrome in making. ( Brodsky, SV; Chen, J; Goligorsky, MS; Li, H; O'Riordan, E; Smirnova, I, 2005)
" Asymmetric dimethylarginine (ADMA) is increased in diabetes mellitus, kidney disease, and hypertension."3.79Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. ( Hsu, CN; Huang, LT; Lee, CT; Lee, WC; Lin, CY; Tain, YL, 2013)
" We explored the temporal progression of bile duct ligation (BDL)-induced cholestasis in developing rats, focusing on brain cognition and liver and kidney pathology, to elucidate whether these findings were associated with asymmetric dimethylarginine and oxidative stress alterations."3.76Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage. ( Chen, CC; Hsieh, CS; Huang, LT; Sheen, JM; Tain, YL; Wang, JY, 2010)
" However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC."3.74Coronary artery calcification, ADMA, and insulin resistance in CKD patients. ( Hidekazu, M; Ikee, R; Kobayashi, S; Maesato, K; Mano, T; Ohtake, T; Oka, M, 2008)
"The rationale of this study is based on the fact that, both proteinuria and elevated asymmetric dimethyl arginine (ADMA) levels have been linked to the progression of vascular disease."3.73ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease. ( Acikel, C; Bilgi, C; Caglar, K; Cakir, E; Eyileten, T; Kaya, A; Oguz, Y; Oktenli, C; Sonmez, A; Vural, A; Yenicesu, M; Yilmaz, MI; Zoccali, C, 2006)
"We assessed blood concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) as well as renal haemodynamics to compare normotensive patients with mild heart failure (n = 12, seven males, 70 +/- 1 years, 72."3.72Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure. ( Bode-Böger, SM; Fliser, D; Graf, S; Haller, H; Kielstein, JT; Klein, G, 2003)
") bioavailability and potentially limit atherosclerosis."2.71Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study. ( Abdulhayoglu, E; Barbato, D; Bustami, R; D'Alecy, LG; Desai, A; Handelman, GJ; Novak, JE; Rajagopalan, S; Saran, R; Warren, JS; Weitzel, W, 2003)
"Asymmetric dimethylarginine (ADMA) is a naturally occurring amino acid that reduces the bioavailability of nitric oxide."2.44Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease. ( Kielstein, JT; Zoccali, C, 2008)
" The ADMA-mediated regulation of nitric oxide (NO) production is determined by the quantitative bioavailability of intracellular and extracellular ADMA."2.44Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism. ( Sim, AS; Wang, J; Wang, XL; Wilcken, DE, 2007)
"Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD)."2.44Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. ( Fukami, K; Matsumoto, Y; Okuda, S; Ueda, S; Yamagishi, SI, 2007)
"Intradialytic hypotension is a major complication during hemodialysis session, associated with increased risk of cardiovascular events and mortality."1.51Intradialytic hypotension: beyond hemodynamics. ( Assaad, S; Chacra, D; Chelala, D; Fares, N; Hajal, J; Joubran, N; Saliba, Y; Sleilaty, G, 2019)
"Symmetric dimethylarginine (SDMA) was recently demonstrated to induce reactive oxygen species in monocytes."1.37Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease. ( Barreto, DV; Barreto, FC; Eloot, S; Glorieux, G; Liabeuf, S; Massy, Z; Schepers, E; Vanholder, R, 2011)
"Ramipril was given (5 mg daily for 12 weeks), and circulating ADMA, soluble Fas (sFas), myostatin and endothelial function [flow-mediated vasodilation (FMD); ultrasound)] were measured."1.36Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway? ( Axelsson, J; Caglar, K; Cayci, T; Eyileten, T; Kilic, S; Oguz, Y; Saglam, M; Sonmez, A; Vural, A; Yaman, H; Yenicesu, M; Yilmaz, MI, 2010)
" Among patients with ischemic heart disease, low progenitor cell bioavailability and kidney dysfunction are emerging as strong predictors of death and recurrent cardiovascular events."1.35Asymmetric dimethylarginine and impaired cardiovascular healing. ( Andreotti, F; Coluzzi, G; Marzo, F; Santucci, E, 2009)
"Reduced bioavailability of nitric oxide (NO) is thought to play an important role in progression of renal damage."1.33Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study. ( Bode-Böger, SM; Fliser, D; Haller, H; Kielstein, JT; Kronenberg, F; Morath, C; Ritz, E, 2005)

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's32 (52.46)29.6817
2010's27 (44.26)24.3611
2020's2 (3.28)2.80

Authors

AuthorsStudies
Lee, Y1
Steinbach, SML1
Basile, D1
Singh, J1
Hajal, J1
Joubran, N1
Sleilaty, G1
Chacra, D1
Saliba, Y1
Assaad, S1
Chelala, D1
Fares, N1
Wu, M2
Yuan, M1
Wang, Y1
Tan, B1
Huang, D1
Wang, C2
Zou, Y1
Ye, C2
Shi, L1
Zhao, C1
Wang, H1
Lei, T1
Liu, S1
Cao, J1
Lu, Z1
Salmas, RE1
Gulhan, MF1
Durdagi, S1
Sahna, E1
Abdullah, HI1
Selamoglu, Z1
Hu, XL1
Li, MP1
Song, PY1
Tang, J1
Chen, XP1
Lin, P1
Li, L1
Chen, D1
Yang, X1
Xu, L1
Zhou, B1
Zhang, Y1
Luo, C1
Tain, YL3
Lee, WC2
Hsu, CN2
Huang, LT3
Lee, CT1
Lin, CY1
Günebakmaz, O1
Duran, M1
Karakaya, E1
Tanrıkulu, E1
Akpek, M1
Ergin, A1
Kaya, MG1
Schepers, E2
Speer, T1
Bode-Böger, SM6
Fliser, D9
Kielstein, JT12
Yilmaz, BA1
Caliskan, Y1
Yilmaz, A1
Ozkok, A1
Bilge, AK1
Deniz, G1
Sariyar, M1
Yildiz, A1
Alpoim, PN1
Sousa, LP1
Mota, AP1
Rios, DR1
Dusse, LM1
Kobayashi, S1
Oka, M1
Maesato, K1
Ikee, R1
Mano, T1
Hidekazu, M1
Ohtake, T1
Nanayakkara, PW1
Kiefte-de Jong, JC1
ter Wee, PM1
Stehouwer, CD1
van Ittersum, FJ1
Olthof, MR1
Teerlink, T1
Twisk, JW1
van Guldener, C1
Smulders, YM1
Ueda, S4
Matsumoto, Y3
Kaida, Y1
Okuda, S4
Yamagishi, S3
Mora-Fernández, C1
Jarque, A1
Getino, MA1
Sánchez, R1
Lozano, L1
Navarro, JF1
Zoccali, C9
Mallamaci, F1
Kato, GJ1
Wang, Z1
Machado, RF1
Blackwelder, WC1
Taylor, JG1
Hazen, SL1
Nakamura, T1
Sato, E1
Fujiwara, N1
Kawagoe, Y1
Ueda, Y1
Suzuki, T1
Fukami, K3
Abedini, S1
Meinitzer, A1
Holme, I1
März, W1
Weihrauch, G1
Fellstrøm, B1
Jardine, A1
Holdaas, H1
David, S1
Kümpers, P1
Lukasz, A1
Martens-Lobenhoffer, J1
Kliem, V1
Haller, H6
Yilmaz, MI5
Sonmez, A4
Saglam, M3
Yaman, H3
Cayci, T1
Kilic, S2
Eyileten, T4
Caglar, K4
Oguz, Y3
Vural, A4
Yenicesu, M3
Axelsson, J2
Demirkaya, E1
Sheen, JM1
Hsieh, CS1
Chen, CC1
Wang, JY1
Marín, M1
Máñez, S1
Lilitkarntakul, P1
Dhaun, N1
Melville, V1
Blackwell, S1
Talwar, DK1
Liebman, B1
Asai, T1
Pollock, J1
Goddard, J1
Webb, DJ1
Lu, TM1
Chung, MY1
Lin, CC1
Hsu, CP1
Lin, SJ1
Barreto, DV1
Liabeuf, S1
Glorieux, G1
Eloot, S1
Barreto, FC1
Massy, Z2
Vanholder, R1
Grassi, G1
Seravalle, G1
Ghiadoni, L1
Tripepi, G1
Bruno, RM1
Mancia, G1
Baylis, C3
Wilcox, CS2
Celik, M1
Iyisoy, A1
Celik, T1
Yuksel, UC1
Aldámiz-Echevarría, L1
Andrade, F1
Huang, CF1
Chien, SJ1
Lin, YJ1
Klein, G1
Graf, S1
Saran, R1
Novak, JE1
Desai, A1
Abdulhayoglu, E1
Warren, JS1
Bustami, R1
Handelman, GJ1
Barbato, D1
Weitzel, W1
D'Alecy, LG1
Rajagopalan, S1
O'Riordan, E1
Chen, J1
Brodsky, SV1
Smirnova, I1
Li, H1
Goligorsky, MS1
Kronenberg, F1
Morath, C1
Ritz, E1
Vallance, P1
Leiper, J1
Cakir, E2
Ozgurtas, T1
Aydin, A1
Ozcan, O1
Acikel, C2
Tasar, M1
Genctoy, G1
Erbil, K1
Kaya, A1
Bilgi, C1
Oktenli, C1
Matsuguma, K1
Shibata, R1
Matsuoka, H1
Imaizumi, T1
Wilcken, DE1
Sim, AS1
Wang, J1
Wang, XL1
Yamagishi, SI1
Schiffrin, EL1
Lipman, ML1
Mann, JF1
Palm, F1
Onozato, ML1
Luo, Z1
Coluzzi, G2
Santucci, E2
Marzo, F1
Andreotti, F2
Stenvinkel, P1
Carrero, JJ1
Lindholm, B1
Heimbürger, O1
Rodionov, RN1
Lentz, SR1
Frölich, JC1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of an Oxidative-Stress-Reducing Strategy Consisting of Pravastatin, Vitamin E and Homocysteine-Lowering on Carotid Intima-Media Thickness in Patients With Mild-to-Moderate Chronic Kidney Disease[NCT00384618]Phase 4100 participants Interventional2001-05-31Terminated
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia[NCT00011648]986 participants (Actual)Observational2008-02-19Completed
Effect of Paricalcitol on Endothelial Function in Chronic Kidney Disease (CKD) Patients (the PENNY Study)[NCT01680198]Phase 388 participants (Actual)Interventional2011-06-30Completed
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]Phase 1/Phase 260 participants (Anticipated)Interventional2023-11-01Recruiting
Influence of Preoperative Hemodialysis or Intraoperative Modified Ultrafiltration on Postoperative Outcome for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery: Randomized, Controlled, Multicenter Clinical Trial[NCT00720967]Phase 3450 participants (Anticipated)Interventional2008-11-30Not yet recruiting
Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy (BESTinDN Study)[NCT01796418]102 participants (Anticipated)Interventional2013-03-31Recruiting
A Multicenter, Randomized Trial to Compare Xience and Vision Coronary Stents in the Same Multivessel Patient With Chronic Kidney Disease[NCT00818792]Phase 2215 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

24 reviews available for n(g),n(g')-dimethyl-l-arginine and Kidney Diseases

ArticleYear
AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems.
    Journal of molecular and cellular cardiology, 2017, Volume: 113

    Topics: Animals; Arginine; Cardiovascular Diseases; Cardiovascular System; Humans; Kidney Diseases; Transami

2017
Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?
    Seminars in nephrology, 2014, Volume: 34, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Humans; Kidney Diseases; Water

2014
Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-02, Volume: 440

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Ni

2015
[Endothelial injury and CKD].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:9

    Topics: Animals; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney D

2008
[Novelties in the field of progression factors in chronic kidney disease].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2008, Volume: 28 Suppl 5

    Topics: Adult; Amidohydrolases; Animals; Arginine; Carbon; Cardiovascular Diseases; Chronic Disease; Clinica

2008
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
    Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chronic Disease; Disease Progression; Genetic Therap

2008
Pharmacological interventions on asymmetric dimethylarginine, a clinical marker of vascular disease.
    Current medicinal chemistry, 2011, Volume: 18, Issue:5

    Topics: Adrenergic Antagonists; Angiotensins; Arginine; Diabetes Complications; Humans; Hydroxymethylglutary

2011
Nitric oxide synthase derangements and hypertension in kidney disease.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Disease Progression; Humans; Hypertension; Kidn

2012
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; K

2012
Asymmetric dimethylarginine, endothelial dysfunction and renal disease.
    International journal of molecular sciences, 2012, Volume: 13, Issue:9

    Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Child; Disease Progression; E

2012
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?
    Kidney international. Supplement, 2003, Issue:84

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Risk Factors

2003
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:7

    Topics: Adult; Aged; Aging; Arginine; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases

2003
Endothelial cell dysfunction: the syndrome in making.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Animals; Apoptosis; Arginine; Cardiovascular Diseases; Cellular Senescence; Endothelium, Vascular; G

2005
Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Carotid Arteries; Carotid S

2005
Biomarkers in chronic kidney disease: utility and issues towards better understanding.
    Current opinion in nephrology and hypertension, 2005, Volume: 14, Issue:6

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Chronic Disease; Disease Progression; Glomerular

2005
Arginine, arginine analogs and nitric oxide production in chronic kidney disease.
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:4

    Topics: Absorption; Amidohydrolases; Arginine; Biological Availability; Cardiovascular Diseases; Chronic Dis

2006
The past, presence and future of ADMA in nephrology.
    Nephrologie & therapeutique, 2007, Volume: 3, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney Diseases; Kidney Function Tests

2007
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism.
    Molecular genetics and metabolism, 2007, Volume: 91, Issue:4

    Topics: Arginine; Citrulline; Dietary Supplements; Hepatocytes; Homocysteine; Humans; Kidney Diseases; Liver

2007
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
    Clinical and experimental nephrology, 2007, Volume: 11, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases;

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Nitric oxide deficiency in chronic kidney disease.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:1

    Topics: Arginine; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase

2008
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Endothelium-Dependen

2007
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:2

    Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidn

2008
ADMA (asymmetric dimethylarginine): an atherosclerotic disease mediating agent in patients with renal disease?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:9

    Topics: Animals; Arginine; Arteriosclerosis; Enzyme Inhibitors; Humans; Kidney Diseases; Nitric Oxide Syntha

2001

Trials

3 trials available for n(g),n(g')-dimethyl-l-arginine and Kidney Diseases

ArticleYear
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 53, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Doub

2009
Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner.
    Pharmacological research, 2010, Volume: 61, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Anticholesteremic Agents; Arginine; Azetidines; Cholesterol; Cho

2010
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:11

    Topics: Adult; Aged; alpha-Tocopherol; Antioxidants; Arginine; Chronic Disease; Female; Humans; Kidney; Kidn

2003

Other Studies

34 other studies available for n(g),n(g')-dimethyl-l-arginine and Kidney Diseases

ArticleYear
A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood.
    Blood purification, 2022, Volume: 51, Issue:11

    Topics: Animals; Arginine; Kidney Diseases; Swine

2022
Intradialytic hypotension: beyond hemodynamics.
    Physiological research, 2019, 10-25, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme 2; Arginine; Biomarkers; Blood P

2019
Renal asymmetric dimethylarginine inhibits fibrosis.
    FEBS open bio, 2020, Volume: 10, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney D

2020
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
    Antioxidants & redox signaling, 2017, Dec-01, Volume: 27, Issue:16

    Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Ex

2017
Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach.
    Cell biochemistry and function, 2017, Volume: 35, Issue:6

    Topics: Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Binding Sites; Caffeic Acids; Glutathione R

2017
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:6

    Topics: Animals; Arginine; Cell Line; Gene Expression Regulation, Enzymologic; Humans; Kidney Diseases; Male

2019
Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Arginine; Blotting, Western; Electron Spin Resonance Spectroscopy; Female; Hypertension; Ki

2013
Increased serum asymmetric dimethylarginine level is an independent predictor of contrast-induced nephropathy.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2013, Volume: 41, Issue:7

    Topics: Aged; Angina Pectoris; Arginine; Contrast Media; Coronary Angiography; Creatinine; Female; Humans; K

2013
Cardiovascular-renal changes after kidney donation: one-year follow-up study.
    Transplantation, 2015, Volume: 99, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Follow-Up Studies; Glomerular Fi

2015
Coronary artery calcification, ADMA, and insulin resistance in CKD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:5

    Topics: Aged; Arginine; Calcinosis; Case-Control Studies; Chronic Disease; Coronary Angiography; Coronary Ar

2008
Clinical implications of elevated asymmetric dimethylarginine in chronic kidney disease and end-stage renal disease.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2009, Volume: 19, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Carotid Arteries; Humans; Kidney Diseases; Kidney Failure, Chroni

2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
    British journal of haematology, 2009, Volume: 145, Issue:4

    Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Human

2009
Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and all-cause mortality in renal transplant recipients.
    Kidney international, 2010, Volume: 77, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Graft Rejection; Humans; Kidney Diseases; Kidney Transplan

2010
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:8

    Topics: Adult; Aged; Angiopoietin-2; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Ch

2010
Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Chronic Disease; Diabetic Nephropat

2010
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.
    Kidney international, 2010, Volume: 78, Issue:7

    Topics: Adult; Arginine; Chronic Disease; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fo

2010
Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage.
    Journal of pediatric surgery, 2010, Volume: 45, Issue:8

    Topics: Animals; Arginine; Bile Ducts; Brain; Brain Diseases; Cholestasis; Disease Progression; End Stage Li

2010
Do sea stars have low ADMA levels? High ADMA and low EPC count--duo infernal for the kidney.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Animals; Arginine; Cell Count; Chronic Disease; Endothelial Cells; Glomerular Filtration Rate; Human

2010
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
    Atherosclerosis, 2011, Volume: 216, Issue:1

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; C-Reactive Prote

2011
Asymmetric dimethylarginine and clinical outcomes in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:7

    Topics: Aged; Aged, 80 and over; Albuminuria; Arginine; Biomarkers; Chi-Square Distribution; Chromatography,

2011
Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:10

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Arginine; Belgium; Biomarkers; Case-Control Studies; Cell L

2011
Sympathetic nerve traffic and asymmetric dimethylarginine in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chronic Disease; Cross-Sectional Studies; Disease Pro

2011
The relationship between L-arginine/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate.
    Cardiology journal, 2012, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Chi-Square Distribution; Collateral Circulatio

2012
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Citrulline; Guanidines; Hypertension; Indazoles;

2013
Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure.
    European journal of clinical investigation, 2003, Volume: 33, Issue:5

    Topics: Aged; Arginine; Endothelium, Vascular; Heart Failure; Humans; Kidney Diseases; Male; Renal Circulati

2003
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Adult; Arginine; Creatinine; Disease Progression; Female; Glomerular Filtration Rate; Hemoglobins; H

2005
Asymmetric dimethylarginine and kidney disease--marker or mediator?
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Animals; Arginine; Biomarkers; Humans; Kidney; Kidney Diseases; Nitric Oxide; Renal Insufficiency; R

2005
The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:1

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chronic Disease; Copper; Endothelium, Vas

2006
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease.
    Kidney international, 2006, Volume: 70, Issue:4

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Chronic Disease; Disease Prog

2006
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Pr

2007
A new perspective for the treatment of renal diseases?
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Chronic Disease; Humans; Kidney Diseases; Nitric

2007
Asymmetric dimethylarginine and impaired cardiovascular healing.
    Journal of thrombosis and thrombolysis, 2009, Volume: 27, Issue:2

    Topics: Apoptosis; Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Myocardial Ischemia; Nitric O

2009
Contrast-induced nephropathy and mortality: possible crucial role of asymmetric dimethylarginine.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2007, Volume: 8, Issue:12

    Topics: Acetylcysteine; Angioplasty, Balloon, Coronary; Antioxidants; Arginine; Biomarkers; Contrast Media;

2007
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Aci

2008