Compounds > n(g),n(g')-dimethyl-l-arginine
Page last updated: 2024-10-17

n(g),n(g')-dimethyl-l-arginine and Disease Models, Animal

n(g),n(g')-dimethyl-l-arginine has been researched along with Disease Models, Animal in 88 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" A decrease in nitric oxide levels was reported in different hypertension models associated with increased concentrations of asymmetric dimethylarginine (ADMA) and homocysteine, and we recently described an increase in arginase type II expression under hypoxia."9.12Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes? ( López, V; Moraga, FA; Uribe, E, 2021)
"Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke."8.82ADMA and hyperhomocysteinemia. ( Dayal, S; Lentz, SR, 2005)
" The aim of this work was to characterize alterations in metabolites of the arginine pathway, energy metabolism, and structural and signalling lipids in plasma in the early and late stages of murine breast cancer metastasis."7.88Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics. ( Chlopicki, S; Jasztal, A; Kij, A; Kus, K; Stojak, M; Walczak, M; Zakrzewska, A, 2018)
"The study aimed to investigate the protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats (SHRs) through the Cys-C/Wnt signaling pathway."7.85Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. ( Chen, HW; Feng, J; Pi, LJ; Wang, J; Zhan, DQ, 2017)
"The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats."7.80Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. ( Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W, 2014)
"Availability of L-arginine, the exclusive substrate for nitric oxide synthases, plays an important role in kidney ischemia/reperfusion injury."7.79Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency. ( Betz, B; Böger, RH; Kniepert, J; Kress, T; Möller-Ehrlich, K; Sauvant, C; Schneider, R; Schwedhelm, E; Wanner, C, 2013)
": This study aimed to investigate the effects of salvianolic acid A (Sal A) on the time course of plasma and tissue dimethylarginine levels after myocardial infarction (MI) induced by left coronary artery ligation."7.79Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction. ( He, H; Jiang, H; Li, X; Liu, X; Liu, Y; Wang, H; Wang, S; Yuan, L; Zhang, W, 2013)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."7.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models."7.77The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. ( Akgul, EO; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Ceyhan, TS; Erbil, KM; Kurt, YG; Onguru, O; Yaman, H; Yasar, M, 2011)
"To observe the effect of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine (ADMA) level of the atherosclerosis rabbits."7.75[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits]. ( Jiang, H; Li, Y; Lin, G; Zeng, H; Zhao, A, 2009)
"Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, has been proposed to be a mediator of vascular dysfunction during hyperhomocysteinemia."7.74Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. ( Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN, 2008)
"Melatonin is an antioxidant; however, its role in MTX neuropathy is not well studied."5.56Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. ( Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC, 2020)
" Our results suggest that ADMA and oxidative stress likely reduce NO bioavailability under altitude hypoxia, which implies greater pulmonary vascular reactivity and tone, despite the more subdued effects observed under CIH."5.43Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? ( Arriaza, K; Böger, RH; Brito, J; Klose, H; Leon-Velarde, F; Lüneburg, N; Pena, E; Siques, P, 2016)
"Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes."5.42Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015)
"Proteinuria is an independent risk factor for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD)."5.38Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome. ( Ando, R; Fukami, K; Iwatani, R; Kaida, Y; Nakayama, Y; Okuda, S; Ueda, S; Yamagishi, S, 2012)
"Treatment with ramipril significantly reduced AV(BS) and improved aortic valve :outflow tract flow velocity ratio."5.37Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations. ( Horowitz, JD; Kelly, DJ; Kennedy, JA; Ngo, DT; Qi, W; Smith, MD; Stafford, I; Sverdlov, AL; Weedon, H; Wuttke, RD; Zhang, Y, 2011)
"Asymmetric dimethylarginine (ADMA) is an endogenous modulator of endothelial function and oxidative stress, and increased levels of this molecule have been reported in some metabolic disorders and cardiovascular diseases."5.37Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome. ( Collin, B; Cottin, Y; Duvillard, L; Goirand, F; Guilland, JC; Korandji, C; Lauzier, B; Moreau, D; Rochette, L; Sicard, P; Vergely, C; Zeller, M, 2011)
"Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH."5.36Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010)
" A decrease in nitric oxide levels was reported in different hypertension models associated with increased concentrations of asymmetric dimethylarginine (ADMA) and homocysteine, and we recently described an increase in arginase type II expression under hypoxia."5.12Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes? ( López, V; Moraga, FA; Uribe, E, 2021)
"Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke."4.82ADMA and hyperhomocysteinemia. ( Dayal, S; Lentz, SR, 2005)
" The aim of this work was to characterize alterations in metabolites of the arginine pathway, energy metabolism, and structural and signalling lipids in plasma in the early and late stages of murine breast cancer metastasis."3.88Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics. ( Chlopicki, S; Jasztal, A; Kij, A; Kus, K; Stojak, M; Walczak, M; Zakrzewska, A, 2018)
" In contrast, cDDAH1 KO mice exposed to TAC showed no increase in LV DDAH1 expression, slightly increased LV tissue ADMA levels, no increase in plasma ADMA, but significantly exacerbated LV hypertrophy, fibrosis, nitrotyrosine production, and LV dysfunction."3.85Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction. ( Atzler, D; Böger, RH; Chen, P; Chen, Y; Fassett, J; Guo, H; Hu, X; Kwak, D; Liu, X; Lu, Z; Schwedhelm, E; Wang, H; Xu, X; Yue, W; Zhang, P, 2017)
"The study aimed to investigate the protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats (SHRs) through the Cys-C/Wnt signaling pathway."3.85Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. ( Chen, HW; Feng, J; Pi, LJ; Wang, J; Zhan, DQ, 2017)
"The purpose of the work was to study the impact of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and its degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH1), on atherosclerosis in subtotally nephrectomized (SNX) ApoE-deficient mice."3.80Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass. ( Arend, M; Cordasic, N; Hilgers, KF; Jacobi, J; Maas, R, 2014)
"The present study was designed to investigate whether oxymatrine could attenuate isoproterenol-induced heart failure via regulation of asymmetric dimethylarginine (ADMA) metabolism in rats."3.80Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. ( Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W, 2014)
": This study aimed to investigate the effects of salvianolic acid A (Sal A) on the time course of plasma and tissue dimethylarginine levels after myocardial infarction (MI) induced by left coronary artery ligation."3.79Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction. ( He, H; Jiang, H; Li, X; Liu, X; Liu, Y; Wang, H; Wang, S; Yuan, L; Zhang, W, 2013)
"A low concentration of nitric oxide associated with a high concentration of asymmetric dimethylarginine (ADMA) can explain the lack of ischemic cardioprotection observed in the presence of hypercholesterolemia."3.79High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats. ( Casella-Filho, A; Chagas, AC; da-Luz, PL; Dourado, PM; Landim, MB, 2013)
"Availability of L-arginine, the exclusive substrate for nitric oxide synthases, plays an important role in kidney ischemia/reperfusion injury."3.79Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency. ( Betz, B; Böger, RH; Kniepert, J; Kress, T; Möller-Ehrlich, K; Sauvant, C; Schneider, R; Schwedhelm, E; Wanner, C, 2013)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."3.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models."3.77The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. ( Akgul, EO; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Ceyhan, TS; Erbil, KM; Kurt, YG; Onguru, O; Yaman, H; Yasar, M, 2011)
" We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH."3.77Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats. ( Aizawa, K; Ishizuka, N; Iwabuchi, S; Kitamura, H; Moriguchi, Y; Nishimura, T; Serizawa, K; Tashiro, Y; Yogo, K; Yorozu, K, 2011)
" The gastric tissues were collected for determination of the gastric ulcer index, asymmetric dimethylarginine (ADMA) and nitric oxide (NO) contents, the activity of dimethylarginine dimethylaminohydrolase (DDAH) and superoxide anion (O2(-)) or hydroxyl radical (OH*) formation."3.76The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury. ( Li, L; Liu, YZ; Luo, XJ; Peng, J; Tan, N; Xiang, DX; Yuan, Q; Zhang, YS, 2010)
"To observe the effect of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine (ADMA) level of the atherosclerosis rabbits."3.75[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits]. ( Jiang, H; Li, Y; Lin, G; Zeng, H; Zhao, A, 2009)
"Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, has been proposed to be a mediator of vascular dysfunction during hyperhomocysteinemia."3.74Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. ( Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN, 2008)
"Melatonin is an antioxidant; however, its role in MTX neuropathy is not well studied."1.56Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. ( Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC, 2020)
"Hemorrhagic shock was induced by bleeding the animals."1.48Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks. ( Coskun, CN; Demirel-Yilmaz, E; Savci, V; Usanmaz, SE, 2018)
" Our results suggest that ADMA and oxidative stress likely reduce NO bioavailability under altitude hypoxia, which implies greater pulmonary vascular reactivity and tone, despite the more subdued effects observed under CIH."1.43Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? ( Arriaza, K; Böger, RH; Brito, J; Klose, H; Leon-Velarde, F; Lüneburg, N; Pena, E; Siques, P, 2016)
"Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes."1.42Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015)
"Melatonin-treated rats received daily melatonin 1 mg/kg/d via i."1.39Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C. ( Chen, CC; Huang, LT; Kao, YH; Lee, CT; Sheen, JM; Tain, YL; Yu, HR, 2013)
"Thirty five patients had persistent atrial fibrillation (AF)≥ 4months."1.38The impact of rapid atrial pacing on ADMA and endothelial NOS. ( Bode-Böger, SM; Bukowska, A; Dobrev, D; Goette, A; Hammwöhner, M; Lendeckel, U; Martens-Lobenhoffer, J; Medunjanin, S; Ravens, U; Scalera, F; Weinert, S, 2012)
"The development of pulmonary hypertension is a common accompaniment of congenital heart disease (CHD) with increased pulmonary blood flow."1.38Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. ( Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J, 2012)
"Proteinuria is an independent risk factor for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD)."1.38Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome. ( Ando, R; Fukami, K; Iwatani, R; Kaida, Y; Nakayama, Y; Okuda, S; Ueda, S; Yamagishi, S, 2012)
"Treatment with ramipril significantly reduced AV(BS) and improved aortic valve :outflow tract flow velocity ratio."1.37Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations. ( Horowitz, JD; Kelly, DJ; Kennedy, JA; Ngo, DT; Qi, W; Smith, MD; Stafford, I; Sverdlov, AL; Weedon, H; Wuttke, RD; Zhang, Y, 2011)
"Asymmetric dimethylarginine (ADMA) is an endogenous modulator of endothelial function and oxidative stress, and increased levels of this molecule have been reported in some metabolic disorders and cardiovascular diseases."1.37Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome. ( Collin, B; Cottin, Y; Duvillard, L; Goirand, F; Guilland, JC; Korandji, C; Lauzier, B; Moreau, D; Rochette, L; Sicard, P; Vergely, C; Zeller, M, 2011)
"Melatonin-treated BDL rats received daily melatonin 1 mg/kg/day via intraperitoneal injection."1.36Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation. ( Chen, CC; Hsieh, CS; Huang, LT; Lee, CT; Sheen, JM; Tain, YL, 2010)
"Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH."1.36Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010)
" Blood pressure and renal excretion were measured in adulthood, under different sodium conditions, and before and after chronic administration of either N(G)-nitro-l-arginine methyl ester (l-NAME) or l-arginine."1.35Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals. ( Brown, RD; Carlström, M; Edlund, J; Larsson, E; Palm, F; Persson, AE; Sällström, J; Teerlink, T; Wåhlin, N, 2008)
"Hindlimb ischemia was surgically induced in C57BL/6J mice, apo E-deficient mice, or transgenic mice overexpressing dimethylarginine dimethylaminohydrolase (DDAH)."1.33ADMA regulates angiogenesis: genetic and metabolic evidence. ( Achan, V; Cooke, JP; Heeschen, C; Ho, HK; Jang, JJ; Kimoto, M; Stuehlinger, M; Vallance, P, 2005)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's23 (26.14)29.6817
2010's61 (69.32)24.3611
2020's4 (4.55)2.80

Authors

AuthorsStudies
Chen, YC2
Sheen, JM4
Hsu, MH1
Hsiao, CC1
Wang, SC1
Huang, LT4
Hu, W1
Wang, W1
Ma, Q1
Liu, T1
Zhang, J3
Wu, M1
Yuan, M1
Wang, Y4
Tan, B1
Huang, D1
Wang, C1
Zou, Y1
Ye, C1
López, V1
Uribe, E1
Moraga, FA1
Tain, YL4
Hsu, CN1
Shi, L1
Zhao, C1
Wang, H3
Lei, T2
Liu, S1
Cao, J1
Lu, Z3
Xu, X3
Zhang, P2
Kwak, D1
Fassett, J1
Yue, W2
Atzler, D1
Hu, X2
Liu, X2
Guo, H1
Schwedhelm, E2
Böger, RH4
Chen, P1
Chen, Y3
Janić, M2
Lunder, M2
France Štiglic, A1
Jerin, A2
Skitek, M2
Černe, D2
Marc, J2
Drevenšek, G2
Šabovič, M2
Coskun, CN1
Usanmaz, SE2
Savci, V1
Demirel-Yilmaz, E2
Xiao, HB1
Sui, GG1
Lu, XY1
Sun, ZL1
Pang, P1
Abbott, M1
Abdi, M1
Fucci, QA1
Chauhan, N1
Mistri, M1
Proctor, B1
Chin, M1
Wang, B1
Yin, W1
Lu, TS1
Halim, A1
Lim, K1
Handy, DE1
Loscalzo, J1
Siedlecki, AM1
Verkaik, M1
Juni, RP1
van Loon, EPM1
van Poelgeest, EM1
Kwekkeboom, RFJ1
Gam, Z1
Richards, WG1
Ter Wee, PM1
Hoenderop, JG1
Eringa, EC1
Vervloet, MG1
Dovinová, I1
Hrabárová, E1
Jansen, E1
Kvandová, M1
Majzúnová, M1
Berenyiová, A1
Barančík, M1
Kus, K1
Kij, A1
Zakrzewska, A1
Jasztal, A1
Stojak, M1
Walczak, M1
Chlopicki, S1
Takahashi, K2
Ueda, S6
Kobayashi, T1
Nishiyama, A1
Fujisawa, Y1
Sugaya, T1
Shiota, S1
Gohda, T1
Horikoshi, S1
Suzuki, Y1
He, H1
Li, X1
Zhang, W3
Jiang, H2
Wang, S1
Yuan, L1
Liu, Y1
Karaaslan, O1
Sonmez, E1
Kankaya, Y1
Silistreli, OK1
Can, MM1
Bedir, YK1
Caliskan, G1
Landim, MB1
Dourado, PM1
Casella-Filho, A1
Chagas, AC1
da-Luz, PL1
Betz, B1
Möller-Ehrlich, K1
Kress, T1
Kniepert, J1
Wanner, C1
Sauvant, C1
Schneider, R1
Ghebremariam, YT1
LePendu, P1
Lee, JC1
Erlanson, DA1
Slaviero, A1
Shah, NH1
Leiper, J1
Cooke, JP6
Pacurari, M1
Xing, D1
Hilgers, RH1
Guo, YY1
Yang, Z1
Hage, FG1
Han, X1
Zhang, DL1
Yin, DX1
Zhang, QD1
Liu, WH1
Aggarwal, S2
Gross, CM1
Kumar, S4
Dimitropoulou, C1
Sharma, S4
Gorshkov, BA1
Sridhar, S1
Lu, Q3
Bogatcheva, NV1
Jezierska-Drutel, AJ1
Lucas, R1
Verin, AD1
Catravas, JD2
Black, SM5
Jacobi, J1
Maas, R4
Arend, M1
Cordasic, N1
Hilgers, KF1
Rodionov, RN3
Martens-Lobenhoffer, J2
Brilloff, S1
Hohenstein, B1
Jarzebska, N1
Jabs, N1
Kittel, A1
Weiss, N1
Bode-Böger, SM2
Ferrigno, A3
Rizzo, V2
Bianchi, A1
Di Pasqua, LG2
Berardo, C2
Richelmi, P2
Vairetti, M3
Sasser, JM1
Cunningham, MW1
Baylis, C1
Liu, YK1
Liu, J1
Wang, X1
Xu, Q1
Dai, G1
Garcia-Martinez, R1
Andreola, F1
Mehta, G1
Poulton, K1
Oria, M1
Jover, M1
Soeda, J1
Macnaughtan, J1
De Chiara, F1
Habtesion, A1
Mookerjee, RP2
Davies, N1
Jalan, R2
Zhao, D1
Liu, Q1
Ji, Y1
Wang, G1
He, X1
Tian, W1
Xu, H1
Luo, Y1
Quan, X1
Zhao, B1
Magné, J1
Huneau, JF1
Borderie, D1
Mathé, V1
Bos, C1
Mariotti, F1
Greco, R1
Demartini, C1
Zanaboni, A1
Mangione, AS1
Blandini, F1
Nappi, G1
Tassorelli, C1
Sun, X4
Kellner, M1
Desai, AA1
Wang, T1
Kangath, A1
Qu, N1
Klinger, C1
Fratz, S3
Yuan, JX1
Jacobson, JR1
Garcia, JG1
Rafikov, R4
Fineman, JR4
Sun, L1
Bai, Y1
Zhao, R1
Sun, T1
Cao, R1
Wang, F1
He, G1
Ye, P1
Du, G1
Lüneburg, N2
Siques, P1
Brito, J1
Arriaza, K1
Pena, E1
Klose, H1
Leon-Velarde, F1
Croce, AC1
Feng, J1
Chen, HW1
Pi, LJ1
Wang, J1
Zhan, DQ1
Fassett, JT1
Zhu, G1
Li, J1
Bache, RJ1
Durmus, N1
Toylu, A1
Evcim, S1
Soner, BC1
Demir, O1
Kahraman, E1
Demir, T1
Irer, B1
Gidener, S1
Atabey, N1
Esen, A1
Dayal, S2
Arning, E1
Bottiglieri, T1
Kimoto, M3
Murry, DJ1
Faraci, FM1
Lentz, SR3
Shibata, R2
Yamagishi, S4
Kaida, Y3
Matsumoto, Y3
Fukami, K4
Hayashida, A1
Matsuoka, H2
Kato, S1
Okuda, S5
Fujimi-Hayashida, A1
Koike, K1
Tanaka, H1
Banday, AA1
Lokhandwala, MF1
Böger, R1
Nurten, T1
Nihal, S1
Gonca, O1
Ozgür, A1
Halil, Y1
Filiz, B1
Barbaros, B1
Li, Y1
Zhao, A1
Zeng, H1
Lin, G1
Hsieh, CS1
Chen, CC2
Lee, CT2
Li, L1
Luo, XJ1
Liu, YZ1
Zhang, YS1
Yuan, Q1
Tan, N1
Xiang, DX1
Peng, J1
Ahmad, T1
Mabalirajan, U1
Sharma, A1
Aich, J1
Makhija, L1
Ghosh, B1
Agrawal, A1
Hou, Y1
Rehmani, I2
Tian, J2
Smith, A1
Schreiber, C2
Reiser, J1
Naumann, S1
Haag, S1
Hess, J1
Patterson, C1
Klein, E1
Weigel, J1
Buford, MC1
Holian, A1
Wells, SM1
Goette, A1
Hammwöhner, M1
Bukowska, A1
Scalera, F1
Dobrev, D1
Ravens, U1
Weinert, S1
Medunjanin, S1
Lendeckel, U1
Ngo, DT1
Stafford, I1
Sverdlov, AL1
Qi, W1
Wuttke, RD1
Zhang, Y1
Kelly, DJ1
Weedon, H1
Smith, MD1
Kennedy, JA1
Horowitz, JD1
Korandji, C1
Zeller, M1
Guilland, JC1
Collin, B1
Lauzier, B1
Sicard, P1
Duvillard, L1
Goirand, F1
Moreau, D1
Cottin, Y1
Rochette, L1
Vergely, C1
Cayci, T1
Akgul, EO1
Kurt, YG1
Ceyhan, TS1
Aydin, I1
Onguru, O1
Yaman, H1
Cakir, E1
Yasar, M1
Bilgi, C1
Erbil, KM1
Moriguchi, Y1
Yogo, K1
Aizawa, K1
Serizawa, K1
Tashiro, Y1
Yorozu, K1
Ishizuka, N1
Iwabuchi, S1
Kitamura, H1
Nishimura, T1
Bugnicourt, JM1
Da Silveira, C1
Bengrine, A1
Godefroy, O1
Baumbach, G1
Sevestre, H1
Bode-Boeger, SM1
Kielstein, JT1
Massy, ZA1
Chillon, JM1
Li Volti, G1
Salomone, S1
Sorrenti, V1
Mangiameli, A1
Urso, V1
Siarkos, I1
Galvano, F1
Salamone, F1
Kleinedler, JJ1
Orchard, EA1
Foley, JD1
Rogers, LK1
Hebert, VY1
Dugas, TR1
Wilcox, CS1
Kajimoto, H1
Kai, H1
Aoki, H1
Yasuoka, S1
Anegawa, T1
Aoki, Y1
Imaizumi, T2
Sharma, V1
Ten Have, GA1
Ytrebo, L1
Sen, S1
Rose, CF1
Dalton, RN1
Turner, C1
Revhaug, A1
van-Eijk, HM1
Deutz, NE1
Davies, NA1
Northcott, CA1
Billecke, S1
Craig, T1
Hinojosa-Laborde, C1
Patel, KP1
Chen, AF1
D'Alecy, LG1
Haywood, JR1
Kimura, K1
Aramburo, A1
Kalkan, G1
Kallarackal, S1
Nakayama, Y1
Ando, R1
Iwatani, R1
Sirmagul, B1
Ilgin, S1
Atli, O1
Rafikova, O1
Burns, T1
Dasarathy, S1
Wright, J1
Radman, M1
Kao, YH1
Yu, HR1
Millatt, LJ1
Whitley, GS1
Li, D1
Leiper, JM1
Siragy, HM1
Carey, RM1
Johns, RA1
Dai, Z1
Zhu, HQ1
Jiang, DJ1
Jiang, JL1
Deng, HW1
Li, YJ1
Jung, CS1
Iuliano, BA1
Harvey-White, J1
Espey, MG1
Oldfield, EH1
Pluta, RM1
Pullamsetti, S1
Kiss, L1
Ghofrani, HA1
Voswinckel, R1
Haredza, P1
Klepetko, W1
Aigner, C1
Fink, L1
Muyal, JP1
Weissmann, N1
Grimminger, F1
Seeger, W1
Schermuly, RT1
Achan, V1
Ho, HK1
Heeschen, C1
Stuehlinger, M1
Jang, JJ1
Vallance, P1
Konishi, H1
Sydow, K1
Potena, L1
Ferrara, R1
Mocarski, ES1
Lewis, DB1
Grigioni, F1
Coccolo, F1
Magnani, G1
Fallani, F1
Magelli, C1
Valantine, HA1
Branzi, A1
Matsuguma, K1
Carlström, M1
Brown, RD1
Edlund, J1
Sällström, J1
Larsson, E1
Teerlink, T1
Palm, F1
Wåhlin, N1
Persson, AE1
Matrougui, K1
Loufrani, L1
Lévy, BI1
Henrion, D1
Masuda, H1
Tsujii, T1
Okuno, T1
Kihara, K1
Goto, M1
Azuma, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Adiposity and Airway Inflammation in HIV-Associated Airway Disease[NCT02975258]102 participants (Actual)Observational2015-09-30Completed
Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369]Phase 10 participants (Actual)Interventional2014-12-31Withdrawn (stopped due to Changes to cardiac surgery program)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for n(g),n(g')-dimethyl-l-arginine and Disease Models, Animal

ArticleYear
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
    Hypertension research : official journal of the Japanese Society of Hypertension, 2021, Volume: 44, Issue:3

    Topics: Animals; Arginase; Arginine; Disease Models, Animal; Homocysteine; Hypertension; Hypoxia; Nitric Oxi

2021
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.
    International journal of molecular sciences, 2017, Apr-15, Volume: 18, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Energy Metabolism; Humans; Nitri

2017
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
    International journal of molecular sciences, 2014, Mar-05, Volume: 15, Issue:3

    Topics: Animals; Arginine; Bile Ducts; Disease Models, Animal; Fibrosis; Ligation; Liver; Liver Cirrhosis; M

2014
ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Animals, Genetically Modified; Arginine; Disease Models, Animal; Humans; Polymorphism, Gene

2009
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; K

2012
[Methylarginies-induced endothelial dysfunction in chronic kidney disease].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2012, Volume: 132, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme In

2012
A novel mechanism for pulmonary arterial hypertension?
    Circulation, 2003, Sep-23, Volume: 108, Issue:12

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; N

2003
[Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data].
    Deutsche medizinische Wochenschrift (1946), 2004, Apr-08, Volume: 129, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Arteriosclerosis; Biomarkers; Cardiovascular Dise

2004
ADMA and hyperhomocysteinemia.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Va

2005
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors;

2005
[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].
    Giornale italiano di cardiologia (2006), 2007, Volume: 8, Issue:2

    Topics: Animals; Arginine; Clinical Trials as Topic; Coronary Disease; Cytomegalovirus Infections; Disease M

2007

Other Studies

77 other studies available for n(g),n(g')-dimethyl-l-arginine and Disease Models, Animal

ArticleYear
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
    Life sciences, 2020, Feb-01, Volume: 242

    Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippoc

2020
Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Anthocyanins; Aortic Valve Stenosis; Apoptosis; Arginine; Blueberry Plants

2020
Renal asymmetric dimethylarginine inhibits fibrosis.
    FEBS open bio, 2020, Volume: 10, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney D

2020
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
    Antioxidants & redox signaling, 2017, Dec-01, Volume: 27, Issue:16

    Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Ex

2017
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
    Basic research in cardiology, 2017, 08-17, Volume: 112, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Gen

2017
Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.
    Vascular pharmacology, 2017, Volume: 99

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cholest

2017
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cel

2018
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Dinoprost; Disease Models, Animal; Down-Regulation; Endometriosi

2018
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018, 06-01, Volume: 33, Issue:6

    Topics: Animals; Arginine; Disease Models, Animal; Glutathione Peroxidase; Heart Diseases; Mice; Mice, Knock

2018
FGF23 impairs peripheral microvascular function in renal failure.
    American journal of physiology. Heart and circulatory physiology, 2018, 11-01, Volume: 315, Issue:5

    Topics: Animals; Arginine; Cells, Cultured; Coronary Circulation; Coronary Vessels; Disease Models, Animal;

2018
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; H

2018
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
    Breast cancer research : BCR, 2018, 12-04, Volume: 20, Issue:1

    Topics: Animals; Arginase; Arginine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Chromatography,

2018
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.
    Scientific reports, 2018, 12-18, Volume: 8, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensins; Animals; Arginine; Cardiovascular Diseases; Deoxyguanosin

2018
Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction.
    Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Caffeic Acids; Chromatography, High Pressure Liquid; Creatinine;

2013
Monitorization of asymmetric dimethylarginine (ADMA) levels in an experimental ischemia-reperfusion flap model: a preliminary report.
    Journal of reconstructive microsurgery, 2013, Volume: 29, Issue:6

    Topics: Abdominal Muscles; Animals; Arginine; Disease Models, Animal; Graft Rejection; Graft Survival; Male;

2013
High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:5

    Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hypercholesterolemia;

2013
Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency.
    Translational research : the journal of laboratory and clinical medicine, 2013, Volume: 162, Issue:2

    Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Blotting, Western; Chromatography, High Pre

2013
Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
    Circulation, 2013, Aug-20, Volume: 128, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cells, Cultured; Disease Mo

2013
Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats.
    American journal of physiology. Heart and circulatory physiology, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Disease Models, Animal; Endothelial Cells;

2013
Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:9

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothe

2013
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
    American journal of respiratory cell and molecular biology, 2014, Volume: 50, Issue:3

    Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Capillary Perme

2014
Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass.
    International journal of molecular sciences, 2014, Mar-31, Volume: 15, Issue:4

    Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Disease Models, Anima

2014
Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Volume: 29, Issue:11

    Topics: Acute Kidney Injury; Alanine; Animals; Arginine; Biomarkers; Blotting, Western; Disease Models, Anim

2014
Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile.
    BioMed research international, 2014, Volume: 2014

    Topics: Amidohydrolases; Animals; Arginine; Bile; Cationic Amino Acid Transporter 2; Disease Models, Animal;

2014
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
    American journal of physiology. Renal physiology, 2014, Dec-15, Volume: 307, Issue:12

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Arginine; Arterial Pressure; Dinopro

2014
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; H

2014
Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure.
    Journal of hepatology, 2015, Volume: 62, Issue:4

    Topics: Albumins; Animals; Arginine; Disease Models, Animal; End Stage Liver Disease; Endothelium, Vascular;

2015
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
    Neurological research, 2015, Volume: 37, Issue:6

    Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal

2015
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
    Free radical biology & medicine, 2015, Volume: 79

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Arginine; Caenorha

2015
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene

2015
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
    The journal of headache and pain, 2015, Volume: 16

    Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Mal

2015
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Animals; Arginine; Carrier Proteins; Disease Models, Animal; Endothelial Cells; Genes, Dominant; HSP

2016
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
    Journal of cardiovascular pharmacology, 2016, Volume: 68, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Atorvastatin; Cardiovas

2016
Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:7

    Topics: Animals; Arginine; Carotid Artery Diseases; Carotid Artery Injuries; Cell Differentiation; Cell Move

2016
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
    Pulmonary medicine, 2016, Volume: 2016

    Topics: Altitude Sickness; Amidohydrolases; Animals; Arginine; Disease Models, Animal; Hypertension, Pulmona

2016
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
    Molecular and cellular biochemistry, 2016, Volume: 419, Issue:1-2

    Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver

2016
Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway.
    Oncotarget, 2017, Feb-07, Volume: 8, Issue:6

    Topics: Abietanes; Animals; Arginine; Cardiomegaly; Cardiovascular Agents; Collagen Type I; Collagen Type I,

2017
Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
    Vascular medicine (London, England), 2017, Volume: 22, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cells, Cultured; Collateral Circulation; Coronary

2017
Time-course changes of nLDL-induced erectile dysfunction.
    International journal of impotence research, 2017, Volume: 29, Issue:3

    Topics: Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Erectile Dysfunction; Hyperlipidem

2017
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Diseas

2008
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:4

    Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Diabetic Nephropathies; Disease Models, Animal; Ge

2009
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).
    Life sciences, 2009, Jun-05, Volume: 84, Issue:23-24

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Disease Models, Animal; Glomerulosclerosis, Focal S

2009
Inhibition of natriuretic factors increases blood pressure in rats.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:2

    Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-O

2009
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
    Annals of the New York Academy of Sciences, 2009, Volume: 1173 Suppl 1

    Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Mal

2009
[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:12

    Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Disease Models, Animal; Drugs, Chinese Herbal; Huma

2009
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
    Journal of pineal research, 2010, Volume: 48, Issue:3

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Bile Ducts; Cholestasis, Intrahepatic; Dis

2010
The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury.
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:5

    Topics: Amidohydrolases; Animals; Anti-Ulcer Agents; Arginine; Disease Models, Animal; Ethanol; Hydroxyl Rad

2010
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4

    Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flui

2011
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:1

    Topics: Animals; Anthracenes; Arginine; Blood Flow Velocity; Disease Models, Animal; Female; GTP Cyclohydrol

2011
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2010, Volume: 299, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; En

2010
The impact of rapid atrial pacing on ADMA and endothelial NOS.
    International journal of cardiology, 2012, Jan-26, Volume: 154, Issue:2

    Topics: Aged; Animals; Arginine; Atrial Fibrillation; Calcium-Binding Proteins; Disease Models, Animal; Endo

2012
Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.
    British journal of pharmacology, 2011, Volume: 162, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Aortic Valve Stenosis; Arginine; Ca

2011
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
    Atherosclerosis, 2011, Volume: 214, Issue:2

    Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-R

2011
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model.
    The journal of obstetrics and gynaecology research, 2011, Volume: 37, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Disease Models, Animal; Endometriosis; F

2011
Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
    Biomedical research (Tokyo, Japan), 2011, Volume: 32, Issue:2

    Topics: Animals; Arginine; Creatinine; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ven

2011
Chronic renal failure alters endothelial function in cerebral circulation in mice.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3

    Topics: Analysis of Variance; Animals; Apolipoproteins E; Arginine; Arterioles; Blotting, Western; Caveolin

2011
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
    Cardiovascular diabetology, 2011, Jul-14, Volume: 10

    Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; En

2011
A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting.
    Atherosclerosis, 2011, Volume: 219, Issue:2

    Topics: Angioplasty, Balloon; Animals; Arginine; Biomarkers; Carotid Arteries; Carotid Artery Injuries; Caro

2011
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.
    Kidney international, 2012, Volume: 81, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Human Umbilical V

2012
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Aug-01, Volume: 303, Issue:3

    Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Female; Liver; Liver Failure, Acute

2012
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
    American journal of physiology. Heart and circulatory physiology, 2012, Jun-01, Volume: 302, Issue:11

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension, Renal; K

2012
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
    Free radical biology & medicine, 2012, Jul-15, Volume: 53, Issue:2

    Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopteri

2012
Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.
    Life sciences, 2012, Sep-24, Volume: 91, Issue:9-10

    Topics: Acetylcysteine; Animals; Antioxidants; Arginine; Cells, Cultured; Disease Models, Animal; Doxorubici

2012
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2013, Volume: 35, Issue:3

    Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide;

2013
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
    Antioxidants & redox signaling, 2013, May-10, Volume: 18, Issue:14

    Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Hea

2013
Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
    Pediatric research, 2013, Volume: 73, Issue:4 Pt 1

    Topics: Animals; Arginase; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cholestasis, E

2013
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
    Circulation, 2003, Sep-23, Volume: 108, Issue:12

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzy

2003
17beta-estradiol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
    International journal of cardiology, 2004, Volume: 96, Issue:2

    Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Cholesterol, LDL; Disease Models, Animal;

2004
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
    Journal of neurosurgery, 2004, Volume: 101, Issue:5

    Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral A

2004
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzy

2005
ADMA regulates angiogenesis: genetic and metabolic evidence.
    Vascular medicine (London, England), 2005, Volume: 10, Issue:1

    Topics: Animals; Arginine; Blotting, Western; Disease Models, Animal; Female; Hypercholesterolemia; Ischemia

2005
Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
    Journal of the American College of Cardiology, 2007, Mar-13, Volume: 49, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Disease Models, Animal; Endothelium, Vascula

2007
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Pr

2007
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephros

2008
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Aci

2008
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:4

    Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh

2001
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:6

    Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dos

2002