n(g),n(g')-dimethyl-l-arginine has been researched along with Diabetes Mellitus in 28 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) and oxidative stress as potential mechanisms associated with changes in vascular health in patients with type 2 diabetes mellitus (T2DM)." | 9.12 | Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus. ( Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM, 2007) |
| "The purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA) level and microvascular complications in diabetes mellitus (DM) including diabetic retinopathy (DR), diabetic neuropathy (DN), and diabetic nephropathy." | 9.01 | Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. ( Chen, W; He, K; Li, C; Liu, J; Ma, B; Ma, H; Tian, L; Zhao, P, 2019) |
| "We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) and oxidative stress as potential mechanisms associated with changes in vascular health in patients with type 2 diabetes mellitus (T2DM)." | 5.12 | Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus. ( Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM, 2007) |
| "The purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA) level and microvascular complications in diabetes mellitus (DM) including diabetic retinopathy (DR), diabetic neuropathy (DN), and diabetic nephropathy." | 5.01 | Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. ( Chen, W; He, K; Li, C; Liu, J; Ma, B; Ma, H; Tian, L; Zhao, P, 2019) |
| "Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of nitric oxide synthase with a key role in the pathophysiology of endothelial dysfunction, in the progression of atherosclerosis and in cardiovascular diseases." | 4.91 | Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches. ( Georgakis, MK; Latsios, G; Oikonomou, E; Papageorgiou, N; Papaioannou, S; Siasos, G; Tousoulis, D; Zaromitidou, M, 2015) |
| " Moreover, homocysteine, advanced glycation end products, asymmetric dimethylarginine, and anemia may play a role in the development and progression of atherosclerosis in patients with diabetic nephropathy." | 4.84 | Cardiovascular disease in patients with diabetic nephropathy. ( Aso, Y, 2008) |
| " Thus, together with classic risk factors such as hypertension, dyslipidemia and diabetes, other situations such as microinflammation, increased concentration of asymmetrical dimethyl-L-arginine, disturbed phosphate metabolism and anemia may represent important risk factors for accelerated atherosclerosis in dialyzed patients." | 4.82 | Atherosclerosis in dialyzed patients. ( Ritz, E, 2004) |
| "Elevated blood concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide (NO) synthase, are found in association with diabetes, hypertension, congestive heart failure, and atherosclerosis." | 3.76 | Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. ( Lentz, SR; Murry, DJ; Rodionov, RN; Stevens, JW; Vaulman, SF, 2010) |
| " We tested whether the plasma levels of (1) asymmetric dimethylarginine (ADMA), (2) cortisol/cortisone (Cl/Cn) ratio, and (3) C-peptide predicted glycemic status, coronary artery disease, and death or myocardial infarction (MI) in a nested case-control cohort (N = 850) with normal fasting glucose (< 110 mg/dL), impaired fasting glucose (110-125), or diabetic (> or = 126) status." | 3.74 | Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk? ( Anderson, JL; Bair, TL; Carlquist, JF; Horne, BD; Kushnir, MM; May, HT; Muhlestein, JB; Nielson, R; Pasquali, M; Roberts, WL; Rockwood, AL; Schwarz, EL, 2007) |
| " However, poor polyphenol bioavailability and extensive metabolization restrict their applicability." | 2.72 | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases. ( Baião, DDS; da Silva, DVT; Paschoalin, VMF; Trindade, LR, 2021) |
| "This case-cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1." | 1.91 | Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. ( Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 16 (57.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Schrauben, SJ | 1 |
| Sapa, H | 1 |
| Xie, D | 1 |
| Zhang, X | 1 |
| Anderson, AH | 1 |
| Shlipak, MG | 1 |
| Hsu, CY | 1 |
| Shafi, T | 1 |
| Mehta, R | 1 |
| Bhat, Z | 1 |
| Brown, J | 1 |
| Charleston, J | 1 |
| Chen, J | 2 |
| He, J | 2 |
| Ix, JH | 1 |
| Rao, P | 1 |
| Townsend, R | 1 |
| Kimmel, PL | 1 |
| Vasan, RS | 2 |
| Feldman, HI | 1 |
| Seegmiller, JC | 1 |
| Brunengraber, H | 1 |
| Hostetter, TH | 1 |
| Schelling, JR | 1 |
| Trindade, LR | 1 |
| da Silva, DVT | 1 |
| Baião, DDS | 1 |
| Paschoalin, VMF | 1 |
| Rodrigues-Krause, J | 1 |
| Krause, M | 1 |
| Rocha, IMGD | 1 |
| Umpierre, D | 1 |
| Fayh, APT | 1 |
| Liu, J | 1 |
| Li, C | 1 |
| Chen, W | 1 |
| He, K | 1 |
| Ma, H | 1 |
| Ma, B | 1 |
| Zhao, P | 1 |
| Tian, L | 1 |
| McEvoy, M | 1 |
| Schofield, P | 1 |
| Smith, W | 1 |
| Agho, K | 1 |
| Mangoni, AA | 1 |
| Soiza, RL | 1 |
| Peel, R | 1 |
| Attia, J | 1 |
| Obayashi, K | 1 |
| Saeki, K | 1 |
| Kurumatani, N | 1 |
| İn, E | 1 |
| Özdemir, C | 1 |
| Kaman, D | 1 |
| Sökücü, SN | 1 |
| Tousoulis, D | 1 |
| Georgakis, MK | 1 |
| Oikonomou, E | 1 |
| Papageorgiou, N | 1 |
| Zaromitidou, M | 1 |
| Latsios, G | 1 |
| Papaioannou, S | 1 |
| Siasos, G | 1 |
| Hamm, LL | 1 |
| Mohler, ER | 1 |
| Hudaihed, A | 1 |
| Arora, R | 1 |
| Chen, CS | 1 |
| Liu, Y | 1 |
| Browne, G | 1 |
| Mills, KT | 1 |
| Kleinpeter, MA | 1 |
| Simon, EE | 1 |
| Rifai, N | 1 |
| Klag, MJ | 1 |
| Amarasekera, AT | 1 |
| Sverdlov, AL | 1 |
| Horowitz, JD | 1 |
| Ngo, DT | 1 |
| Du, MR | 1 |
| Ju, GX | 1 |
| Li, NS | 1 |
| Jiang, JL | 1 |
| Heunisch, F | 1 |
| Chaykovska, L | 1 |
| von Einem, G | 1 |
| Alter, M | 1 |
| Dschietzig, T | 1 |
| Kretschmer, A | 1 |
| Kellner, KH | 1 |
| Hocher, B | 1 |
| Aso, Y | 1 |
| Krzyzanowska, K | 1 |
| Mittermayer, F | 1 |
| Wolzt, M | 1 |
| Schernthaner, G | 1 |
| Böger, RH | 1 |
| Sullivan, LM | 1 |
| Schwedhelm, E | 1 |
| Wang, TJ | 1 |
| Maas, R | 1 |
| Benjamin, EJ | 1 |
| Schulze, F | 1 |
| Xanthakis, V | 1 |
| Benndorf, RA | 1 |
| Lu, CW | 1 |
| Guo, Z | 1 |
| Feng, M | 1 |
| Wu, ZZ | 1 |
| He, ZM | 1 |
| Xiong, Y | 1 |
| Rodionov, RN | 1 |
| Murry, DJ | 1 |
| Vaulman, SF | 1 |
| Stevens, JW | 1 |
| Lentz, SR | 1 |
| Soro-Paavonen, A | 1 |
| Zhang, WZ | 1 |
| Venardos, K | 1 |
| Coughlan, MT | 1 |
| Harris, E | 1 |
| Tong, DC | 1 |
| Brasacchio, D | 1 |
| Paavonen, K | 1 |
| Chin-Dusting, J | 1 |
| Cooper, ME | 1 |
| Kaye, D | 1 |
| Thomas, MC | 1 |
| Forbes, JM | 1 |
| Li Volti, G | 1 |
| Salomone, S | 1 |
| Sorrenti, V | 1 |
| Mangiameli, A | 1 |
| Urso, V | 1 |
| Siarkos, I | 1 |
| Galvano, F | 1 |
| Salamone, F | 1 |
| Lee, JH | 1 |
| Park, GH | 1 |
| Lee, YK | 1 |
| Park, JH | 1 |
| Galal, O | 1 |
| Podlogar, J | 1 |
| Verspohl, EJ | 1 |
| Ritz, E | 1 |
| Vallance, P | 1 |
| Leiper, J | 1 |
| Siroká, R | 1 |
| Cibulka, R | 1 |
| Rajdl, D | 1 |
| Racek, J | 1 |
| Anderson, JL | 1 |
| Carlquist, JF | 1 |
| Roberts, WL | 1 |
| Horne, BD | 1 |
| May, HT | 1 |
| Schwarz, EL | 1 |
| Pasquali, M | 1 |
| Nielson, R | 1 |
| Kushnir, MM | 1 |
| Rockwood, AL | 1 |
| Bair, TL | 1 |
| Muhlestein, JB | 1 |
| Sugai, M | 1 |
| Ohta, A | 1 |
| Ogata, Y | 1 |
| Nakanishi, M | 1 |
| Ueno, S | 1 |
| Kawata, T | 1 |
| Saito, N | 1 |
| Tanaka, Y | 1 |
| Palm, F | 1 |
| Onozato, ML | 1 |
| Luo, Z | 1 |
| Wilcox, CS | 1 |
| Kelly, AS | 1 |
| Thelen, AM | 1 |
| Kaiser, DR | 1 |
| Gonzalez-Campoy, JM | 1 |
| Bank, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Dexamethasone Implant on Retinal Nerve Fiber and Optic Disc Morphology in Patients With Diabetic Maculopathy[NCT03927118] | 43 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for n(g),n(g')-dimethyl-l-arginine and Diabetes Mellitus
| Article | Year |
|---|---|
Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases.
Topics: Antioxidant Response Elements; Antioxidants; Arginine; Cardiotonic Agents; Diabetes Mellitus; Drug C | 2021 |
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium, | 2018 |
Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis.
Topics: Arginine; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; D | 2019 |
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
Topics: Alzheimer Disease; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hy | 2015 |
Role of Asymmetrical Dimethylarginine in Diabetic Microvascular Complications.
Topics: Animals; Arginine; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Enzyme Inhibitors; Humans; | 2016 |
Cardiovascular disease in patients with diabetic nephropathy.
Topics: Anemia; Arginine; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Nephr | 2008 |
ADMA, cardiovascular disease and diabetes.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus; Humans; Models, Biological | 2008 |
Atherosclerosis in dialyzed patients.
Topics: Anemia; Animals; Arginine; Arteriosclerosis; Biomarkers; Cause of Death; Comorbidity; Coronary Arter | 2004 |
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; | 2004 |
[Asymmetric dimethylarginine--a novel cardiovascular risk factor].
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Kid | 2006 |
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Endothelium-Dependen | 2007 |
2 trials available for n(g),n(g')-dimethyl-l-arginine and Diabetes Mellitus
| Article | Year |
|---|---|
Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease.
Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cell Adhesion Molecules; Comorbidity; | 2015 |
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protei | 2007 |
15 other studies available for n(g),n(g')-dimethyl-l-arginine and Diabetes Mellitus
| Article | Year |
|---|---|
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; D | 2023 |
Memory impairment is associated with serum methylarginines in older adults.
Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cohort Studies; Diabetes Mellitus; Education | 2014 |
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-S | 2014 |
Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Disease Susceptibilit | 2015 |
Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Diabetes Mellitus; Female; Humans; Linear Models; Male; Mi | 2016 |
ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Contrast Media; Coronary Angiography; Diabetes Mellit | 2017 |
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
Topics: Aged; Arginine; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus; Follow-Up Studies; Human | 2009 |
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endot | 2010 |
Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.
Topics: Adenoviridae; Animals; Arginine; Atherosclerosis; Chlorocebus aethiops; Citrulline; COS Cells; Diabe | 2010 |
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Arginine; Cattle; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, E | 2010 |
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; En | 2011 |
Changes in the arginine methylation of organ proteins during the development of diabetes mellitus.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Diabetes Mellitus; Male; Methylation; Mice; N | 2011 |
Impact of ADMA (asymmetric dimethylarginine) on physiology with respect to diabetes mellitus and respiratory system BEAS-2B cells (human bronchial epithelial cells).
Topics: Animals; Arginine; Blood Glucose; Cell Line; Chemokine CXCL2; Diabetes Mellitus; Epithelial Cells; F | 2013 |
Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
Topics: Arginine; Biomarkers; Blood Glucose; C-Peptide; Case-Control Studies; Coronary Disease; Cortisone; D | 2007 |
Asymmetric dimethylarginine (ADMA) in the aqueous humor of diabetic patients.
Topics: Aged; Aqueous Humor; Arginine; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Melli | 2007 |