Page last updated: 2024-10-17

n(g),n(g')-dimethyl-l-arginine and Coronary Artery Disease

n(g),n(g')-dimethyl-l-arginine has been researched along with Coronary Artery Disease in 76 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Research Excerpts

ExcerptRelevanceReference
" We sought to investigate whether ranolazine, a novel antianginal medication with no effect on heart rate or blood pressure, improves endothelial function in patients with stable coronary artery disease (CAD)."9.14Ranolazine improves endothelial function in patients with stable coronary artery disease. ( Coppola, JT; Deshmukh, SH; Hermance, EV; Infantino, MN; Mindrescu, C; Patel, SR; Pinassi, E; Staniloae, CS, 2009)
"Studies regarding the predictive utility of the blood level of asymmetric dimethylarginine (ADMA) in patients with coronary artery disease (CAD) have yielded the conflicting findings."9.12Prognostic value of asymmetric dimethylarginine in patients with coronary artery disease: A meta-analysis. ( Dai, Y; Mao, H; Ye, J; Zhang, J; Zheng, W, 2021)
"Pioglitazone rapidly improves endothelial function in non-diabetic patients with coronary artery disease."9.12Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease. ( Ambrose, J; Bernaski, E; Coppola, J; El-Khally, Z; Kurian, D; Mandadi, V; Morlote, M; Pinassi, E; Staniloae, C, 2007)
"Previous studies have shown that Asymmetric Dimethyl Arginine (ADMA) is increased significantly during coronary artery diseases (CAD)."7.88Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors. ( Ayati, N; Elyasi, S; Ghayour-Mobarhan, M; Mohammadpour, AH; Moohebati, M; Sahebkar, A, 2018)
" The aim of our study was to determine the predictive value of plasma asymmetric dimethylarginine (ADMA), homocysteine, and high-sensitivity C-reactive protein (hsCRP) levels for occult coronary artery disease (CAD)."7.81Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study. ( Başaran, Y; Geçmen, Ç; Gürel, E; Karaahmet, T; Mutlu, B; Tigen, K, 2015)
"Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms."7.81Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy. ( Aşik, M; Aslantaş, Y; Bulur, S; Doğan, AS; Erkan, ME; Ilçe, HT; Memişoğullari, R; Uçgun, T; Yildirim, M; Yildiz, N; Yilmaz, A, 2015)
"To determine whether 3 biomarkers, L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), can predict outcomes in patients with Kawasaki disease (KD)."7.80Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease. ( Huang, YH; Kuo, HC; Lee, CP; Tain, YL, 2014)
"Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthesis inhibitor, and insulin resistance (IR) have been implicated in atherogenesis."7.79Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study. ( Golay, A; Kruszelnicka, O; Surdacki, A, 2013)
"The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (APCs) by small regulatory RNAs."7.76Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. ( Bauersachs, J; Ertl, G; Fiedler, J; Fleissner, F; Galuppo, P; Gupta, SK; Jazbutyte, V; Kneitz, S; Mayr, M; Thum, T; Xu, Q; Yin, X, 2010)
"Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis."7.75Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. ( Antoniades, C; Antonopoulos, A; Channon, KM; Cunnington, C; Leeson, P; Pillai, R; Ratnatunga, C; Shirodaria, C; Stefanadis, C; Tousoulis, D; Van-Assche, T; Warrick, N, 2009)
"In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoronary infusion of acetylcholine, adenosine, and nitroglycerin, respectively, and determined plasma ADMA and l-arginine concentrations by HPLC."7.74Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia. ( Böger, RH; Lüscher, TF; Maas, R; Quitzau, K; Rafflenbeul, W; Schwedhelm, E; Spieker, L; Steenpass, A, 2007)
" We investigated whether plasma levels of the NOS inhibitor asymmetric dimethylarginine (ADMA), of symmetric dimethylarginine (SDMA) and of the nitrogen oxide substrate l-arginine can serve as additional staging biomarkers in stable coronary artery disease, non-ST-segment myocardial infarction (NSTEMI) and ST-segment myocardial infarction (STEMI)."7.74Methylated arginines in stable and acute patients with coronary artery disease before and after percutaneous revascularization. ( Frøbert, O; Hjortshøj, SP; Ravkilde, J; Simonsen, U, 2008)
"Asymmetrical dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and has been associated with systemic atherosclerosis; however, the role of ADMA in patients with coronary artery disease (CAD) has not been investigated."7.72Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease. ( Charng, MJ; Ding, YA; Lin, SJ; Lu, TM, 2003)
"Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors."6.80Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease. ( Chyrchel, B; Golay, A; Kruszelnicka, O; Surdacki, A, 2015)
"Severity of coronary atherosclerosis was estimated by number of diseased vessels."5.46Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease. ( Guo, FF; He, GW; Liu, ZF; Lun, LM; Wang, Q; Xuan, C; Zhang, X, 2017)
"Early carotid atherosclerosis was defined as a mean CIMT > 1."5.42Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease. ( Atarashi, H; Kohashi, K; Kosugi, M; Kusama, Y; Morisawa, T; Nakagomi, A; Shimizu, W, 2015)
"ED is associated with established coronary atherosclerosis, but its relationship with early coronary atherosclerosis and CED is unknown."5.33Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. ( Elesber, AA; Lennon, RJ; Lerman, A; Lerman, LO; Mathew, V; McConnell, JP; Nelson, RE; Prasad, A; Pumper, G; Solomon, H, 2006)
" The reduced bioavailability of endothelium-derived nitric oxide (NO) may play a role in endothelial vasodilator dysfunction and the structural changes that are characteristic of GCAD."5.33Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. ( Cooke, JP; Gunawan, F; Jacobi, J; Robbins, RC; Sydow, K; Tanaka, M; Tsao, PS, 2005)
"We previously showed that treatment with folic acid (FA)/B12 was associated with more rapid progression of coronary artery disease (CAD)."5.17The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine. ( Bleie, O; Borgeraas, H; Løland, KH; Nordrehaug, JE; Nygård, O; Strand, E; Svardal, A; Ueland, PM, 2013)
" We sought to investigate whether ranolazine, a novel antianginal medication with no effect on heart rate or blood pressure, improves endothelial function in patients with stable coronary artery disease (CAD)."5.14Ranolazine improves endothelial function in patients with stable coronary artery disease. ( Coppola, JT; Deshmukh, SH; Hermance, EV; Infantino, MN; Mindrescu, C; Patel, SR; Pinassi, E; Staniloae, CS, 2009)
"Studies regarding the predictive utility of the blood level of asymmetric dimethylarginine (ADMA) in patients with coronary artery disease (CAD) have yielded the conflicting findings."5.12Prognostic value of asymmetric dimethylarginine in patients with coronary artery disease: A meta-analysis. ( Dai, Y; Mao, H; Ye, J; Zhang, J; Zheng, W, 2021)
"Pioglitazone rapidly improves endothelial function in non-diabetic patients with coronary artery disease."5.12Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease. ( Ambrose, J; Bernaski, E; Coppola, J; El-Khally, Z; Kurian, D; Mandadi, V; Morlote, M; Pinassi, E; Staniloae, C, 2007)
"Nutritional factors such as magnesium, folic acid, vitamins B12 and B6, L-arginine, and polyunsaturated fatty acids (PUFAs) appear to be significantly beneficial for patients with coronary artery disease (CAD), and in the prevention and arresting the progression of HF and cardiac arrhythmias."4.91Nutritional factors in the prevention and management of coronary artery disease and heart failure. ( Das, UN, 2015)
" Thus, together with classic risk factors such as hypertension, dyslipidemia and diabetes, other situations such as microinflammation, increased concentration of asymmetrical dimethyl-L-arginine, disturbed phosphate metabolism and anemia may represent important risk factors for accelerated atherosclerosis in dialyzed patients."4.82Atherosclerosis in dialyzed patients. ( Ritz, E, 2004)
"Previous studies have shown that Asymmetric Dimethyl Arginine (ADMA) is increased significantly during coronary artery diseases (CAD)."3.88Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors. ( Ayati, N; Elyasi, S; Ghayour-Mobarhan, M; Mohammadpour, AH; Moohebati, M; Sahebkar, A, 2018)
" The aim of our study was to determine the predictive value of plasma asymmetric dimethylarginine (ADMA), homocysteine, and high-sensitivity C-reactive protein (hsCRP) levels for occult coronary artery disease (CAD)."3.81Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study. ( Başaran, Y; Geçmen, Ç; Gürel, E; Karaahmet, T; Mutlu, B; Tigen, K, 2015)
"Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms."3.81Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy. ( Aşik, M; Aslantaş, Y; Bulur, S; Doğan, AS; Erkan, ME; Ilçe, HT; Memişoğullari, R; Uçgun, T; Yildirim, M; Yildiz, N; Yilmaz, A, 2015)
"To determine whether 3 biomarkers, L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), can predict outcomes in patients with Kawasaki disease (KD)."3.80Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease. ( Huang, YH; Kuo, HC; Lee, CP; Tain, YL, 2014)
"Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthesis inhibitor, and insulin resistance (IR) have been implicated in atherogenesis."3.79Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study. ( Golay, A; Kruszelnicka, O; Surdacki, A, 2013)
"Plasma levels of ADMA, SDMA, L-arginine, and L-arginine/ADMA ratio are reliable and feasible markers of an early ischemia-reperfusion injury."3.77Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. ( Ajtay, Z; Alotti, N; Bode-Böger, SM; Cziráki, A; Lenkey, Z; Martens-Lobenhoffer, J; Németh, Á; Sulyok, E; Szabados, S; Szabó, C, 2011)
"In the present study, we tested whether a novel genetic variant in dimethylarginine dimethylaminohydrolase 1 (DDAH1), an important ADMA hydrolyzing gene, was associated with stroke and coronary heart disease (CHD) susceptibility in the Chinese Han population."3.76A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. ( Ding, H; Hui, R; Lu, Z; Shaffer, JR; Wang, DW; Wang, H; Wang, X; Wu, B; Yan, J, 2010)
"The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (APCs) by small regulatory RNAs."3.76Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. ( Bauersachs, J; Ertl, G; Fiedler, J; Fleissner, F; Galuppo, P; Gupta, SK; Jazbutyte, V; Kneitz, S; Mayr, M; Thum, T; Xu, Q; Yin, X, 2010)
"Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis."3.75Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. ( Antoniades, C; Antonopoulos, A; Channon, KM; Cunnington, C; Leeson, P; Pillai, R; Ratnatunga, C; Shirodaria, C; Stefanadis, C; Tousoulis, D; Van-Assche, T; Warrick, N, 2009)
"We examine the relationship of related posttranslational modification products of arginine methylation and coronary artery disease (CAD) phenotypes."3.75Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. ( Brennan, DM; Cho, L; Hazen, SL; Tang, WH; Wang, Z, 2009)
" However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC."3.74Coronary artery calcification, ADMA, and insulin resistance in CKD patients. ( Hidekazu, M; Ikee, R; Kobayashi, S; Maesato, K; Mano, T; Ohtake, T; Oka, M, 2008)
"In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoronary infusion of acetylcholine, adenosine, and nitroglycerin, respectively, and determined plasma ADMA and l-arginine concentrations by HPLC."3.74Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia. ( Böger, RH; Lüscher, TF; Maas, R; Quitzau, K; Rafflenbeul, W; Schwedhelm, E; Spieker, L; Steenpass, A, 2007)
" We investigated whether plasma levels of the NOS inhibitor asymmetric dimethylarginine (ADMA), of symmetric dimethylarginine (SDMA) and of the nitrogen oxide substrate l-arginine can serve as additional staging biomarkers in stable coronary artery disease, non-ST-segment myocardial infarction (NSTEMI) and ST-segment myocardial infarction (STEMI)."3.74Methylated arginines in stable and acute patients with coronary artery disease before and after percutaneous revascularization. ( Frøbert, O; Hjortshøj, SP; Ravkilde, J; Simonsen, U, 2008)
"Given that the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, can decrease nitric oxide bioavailability and lead to atherosclerosis, its concentration can be a good predictor for coronary artery disease."3.73Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography. ( Biberoglu, G; Cengel, A; Hasanoglu, A; Sahinarslan, A; Timurkaynak, T; Turkoglu, S, 2006)
"Asymmetrical dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and has been associated with systemic atherosclerosis; however, the role of ADMA in patients with coronary artery disease (CAD) has not been investigated."3.72Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease. ( Charng, MJ; Ding, YA; Lin, SJ; Lu, TM, 2003)
"Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors."2.80Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease. ( Chyrchel, B; Golay, A; Kruszelnicka, O; Surdacki, A, 2015)
"Thus, subjects with chronic renal failure are exposed to increased morbidity and mortality from cardiovascular events."2.44Cardiac biomarkers and chronic renal diseases. ( Kristofova, B; Valocik, G; Valocikova, I, 2008)
" Hence they affect production and bioavailability of eNOS-derived nitric oxide (NO) and consequently healthy blood vessels."1.48AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians. ( Abdel Rahman, MF; Amir, M; Gad, MZ; Hassanein, SI, 2018)
"Severity of coronary atherosclerosis was estimated by number of diseased vessels."1.46Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease. ( Guo, FF; He, GW; Liu, ZF; Lun, LM; Wang, Q; Xuan, C; Zhang, X, 2017)
"Early carotid atherosclerosis was defined as a mean CIMT > 1."1.42Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease. ( Atarashi, H; Kohashi, K; Kosugi, M; Kusama, Y; Morisawa, T; Nakagomi, A; Shimizu, W, 2015)
"53 patients with chronic renal failure receiving hemodialysis treatment and 34 healthy persons were participated to the study."1.40Levels of arginine and its products in dialysis patients. ( Akyurek, F; Erdem, SS; Kiyici, A; Ozturk, B; Sivrikaya, A; Ugurcu, V; Unlu, A; Vatansev, H, 2014)
"Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries."1.36Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia. ( Ardic, I; Celik, A; Ceyhan, K; Erdem, S; Kadi, H; Kalay, N; Kaya, MG; Koc, F; Onalan, O; Ozbek, K; Sahin, S; Taner, A; Yarlioglues, M, 2010)
"While renal failure greatly increases coronary risk, mild renal impairment is not usually considered a major risk factor."1.35Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease. ( Moriatis, M; Naidoo, D; Salonikas, C; Sim, AS; Wang, J; Wang, XL; Wilcken, DE, 2008)
"Insulin sensitivity was quantified by a hyperinsulinemic euglycemic clamp technique and expressed as M."1.34Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance. ( Bode-Böger, SM; Dubiel, JS; Huszno, B; Kawecka-Jaszcz, K; Klecha, A; Martens-Lobenhoffer, J; Stochmal, A; Stochmal, E; Surdacki, A; Szurkowska, M; Szybiński, Z, 2007)
"ED is associated with established coronary atherosclerosis, but its relationship with early coronary atherosclerosis and CED is unknown."1.33Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. ( Elesber, AA; Lennon, RJ; Lerman, A; Lerman, LO; Mathew, V; McConnell, JP; Nelson, RE; Prasad, A; Pumper, G; Solomon, H, 2006)
" The reduced bioavailability of endothelium-derived nitric oxide (NO) may play a role in endothelial vasodilator dysfunction and the structural changes that are characteristic of GCAD."1.33Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. ( Cooke, JP; Gunawan, F; Jacobi, J; Robbins, RC; Sydow, K; Tanaka, M; Tsao, PS, 2005)

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.32)18.2507
2000's26 (34.21)29.6817
2010's43 (56.58)24.3611
2020's6 (7.89)2.80

Authors

AuthorsStudies
Papageorgiou, N2
Theofilis, P2
Oikonomou, E2
Lazaros, G2
Sagris, M2
Tousoulis, D3
Huang, SS1
Huang, WC1
Tsai, CT1
Chen, YY1
Lee, SH2
Lu, TM2
Parikh, RV2
Pargaonkar, V1
Ball, RL1
Kobayashi, Y2
Kimura, T1
Yeung, AC2
Cooke, JP7
Tremmel, JA1
Szabo, Z1
Bartha, E1
Nagy, L1
Molnar, T1
Bening, C1
Sales, VL1
Alhussini, K1
Radakovic, D1
Benitez, RC1
Madrahimov, N1
Keller, D1
Leyh, R1
Ye, J1
Dai, Y1
Mao, H1
Zheng, W1
Zhang, J1
Khush, KK1
Luikart, H1
Pargaonkar, VS1
Lee, JH1
Sinha, S1
Cohen, G1
Valantine, HA2
Fearon, WF1
Paapstel, K1
Kals, J1
Eha, J1
Tootsi, K1
Ottas, A1
Piir, A1
Jakobson, M1
Lieberg, J1
Zilmer, M1
Rzepecka-Stojko, A1
Stojko, J1
Jasik, K1
Buszman, E1
Ghayour-Mobarhan, M1
Ayati, N2
Sahebkar, A1
Moohebati, M1
Elyasi, S1
Mohammadpour, AH1
Amir, M1
Hassanein, SI1
Abdel Rahman, MF1
Gad, MZ1
Wieczorek-Surdacka, E1
Hanff, E1
Chyrchel, B3
Kuźniewski, M1
Surdacki, A5
Tsikas, D6
Løland, KH1
Bleie, O1
Borgeraas, H2
Strand, E1
Ueland, PM2
Svardal, A1
Nordrehaug, JE1
Nygård, O2
Gopu, CL1
Hari, PR1
George, R1
Harikrishnan, S1
Sreenivasan, K1
Kruszelnicka, O3
Golay, A2
Gürel, E1
Tigen, K1
Karaahmet, T1
Geçmen, Ç1
Mutlu, B1
Başaran, Y1
Deftereos, S1
Bouras, G1
Tsounis, D1
Papadimitriou, C1
Hatzis, G1
Raisakis, K1
Panagopoulou, V1
Kaoukis, A1
Ioannidis, A1
Deftereos, G1
Kossyvakis, C1
Manolis, AS1
Alexopoulos, D1
Stefanadis, C2
Cleman, MW1
Giannopoulos, G1
Yousefi, B1
Faghfoori, Z1
Samadi, N1
Karami, H1
Ahmadi, Y1
Badalzadeh, R1
Shafiei-Irannejad, V1
Majidinia, M1
Ghavimi, H1
Jabbarpour, M1
Huang, YH1
Tain, YL1
Lee, CP1
Kuo, HC1
Masaki, N1
Hakuno, D1
Toya, T1
Shiraishi, Y1
Kujiraoka, T1
Namba, T1
Yada, H1
Kimura, K1
Miyazaki, K1
Adachi, T1
Ugurcu, V1
Vatansev, H1
Unlu, A1
Sivrikaya, A1
Akyurek, F1
Ozturk, B1
Kiyici, A1
Erdem, SS1
Das, UN1
Kayacelebi, AA2
Willers, J1
Pham, VV2
Hahn, A1
Schneider, JY2
Rothmann, S2
Frölich, JC2
Can, F1
Ziyrek, M1
Erdem, Ş2
Civan, M1
Görmüş, U1
Şahin, S2
Acar, Z1
Çiftçi, Ç1
Xuan, C2
Tian, QW1
Li, H1
Zhang, BB1
He, GW2
Lun, LM2
Riccioni, G1
Scotti, L1
Guagnano, MT1
Bosco, G1
Bucciarelli, V1
Di Ilio, E1
Speranza, L1
Martini, F1
Bucciarelli, T1
Yamazaki, H1
Yamaguchi, K1
Soeki, T1
Wakatsuki, T1
Niki, T1
Taketani, Y1
Kitaoka, A1
Kusunose, K1
Ise, T1
Tobiume, T1
Yagi, S1
Iwase, T1
Yamada, H1
Sata, M1
Langen, J1
Weigt-Usinger, K1
Chobanyan-Jürgens, K1
Mariotti, F1
Atzler, D1
Choe, CU1
Schwedhelm, E2
Huneau, JF1
Lücke, T1
Erkan, ME1
Aşik, M1
Uçgun, T1
Yildiz, N1
Yilmaz, A1
Aslantaş, Y1
Bulur, S1
Ilçe, HT1
Yildirim, M1
Memişoğullari, R1
Doğan, AS1
Morisawa, T1
Nakagomi, A1
Kohashi, K1
Kosugi, M1
Kusama, Y1
Atarashi, H1
Shimizu, W1
Hertel, JK1
Seifert, R1
Berge, RK1
Bohov, P1
Hjelmesæth, J1
Świerszcz, J1
Bednarek, J1
Nessler, J1
Ilic, MD1
Pavlovic, R1
Lazarevic, G1
Zivanovic, S1
Cvetkovic, T1
Kocic, G1
Ilic, S1
Ambrosio, G1
Sun, L1
Bai, Y1
Zhao, R1
Sun, T2
Cao, R1
Wang, F1
He, G1
Zhang, W1
Chen, Y1
Ye, P1
Du, G1
Mangiacapra, F1
Conte, M1
Demartini, C1
Muller, O1
Delrue, L1
Dierickx, K1
Di Sciascio, G1
Trimarco, B1
De Bruyne, B1
Wijns, W1
Bartunek, J1
Barbato, E1
Tariq, K1
Khan, MA1
Liu, ZF1
Wang, Q1
Guo, FF1
Zhang, X1
Kobayashi, S1
Oka, M1
Maesato, K1
Ikee, R1
Mano, T1
Hidekazu, M1
Ohtake, T1
Valocikova, I1
Kristofova, B1
Valocik, G1
Antoniades, C1
Shirodaria, C1
Leeson, P1
Antonopoulos, A1
Warrick, N1
Van-Assche, T1
Cunnington, C1
Pillai, R1
Ratnatunga, C1
Channon, KM1
Deshmukh, SH1
Patel, SR1
Pinassi, E2
Mindrescu, C1
Hermance, EV1
Infantino, MN1
Coppola, JT1
Staniloae, CS1
Wang, Z1
Tang, WH1
Cho, L1
Brennan, DM1
Hazen, SL1
Huang, Y1
Phillips, MI1
Luo, X1
Zhu, J1
Shi, H1
Li, J1
Aktoz, T1
Aktoz, M1
Tatlı, E1
Kaplan, M1
Turan, FN1
Barutcu, A1
Atakan, IH1
Demir, M1
Altun, A1
Ding, H1
Wu, B1
Wang, H1
Lu, Z1
Yan, J1
Wang, X1
Shaffer, JR1
Hui, R1
Wang, DW1
Sharma, P1
Bentley, P1
Guo, YJ1
Chen, L1
Bai, YP1
Li, L1
Sun, J1
Zhang, GG1
Yang, TL1
Xia, J1
Li, YJ1
Chen, XP1
Fleissner, F1
Jazbutyte, V1
Fiedler, J1
Gupta, SK1
Yin, X1
Xu, Q1
Galuppo, P1
Kneitz, S1
Mayr, M1
Ertl, G3
Bauersachs, J4
Thum, T4
Koc, F1
Ardic, I1
Kalay, N1
Ozbek, K1
Yarlioglues, M1
Ceyhan, K1
Celik, A1
Kadi, H1
Taner, A1
Onalan, O1
Kaya, MG1
Wolf, C1
Lorenzen, JM1
Stein, S2
Störk, S1
Weidemann, F1
Anker, SD2
Cziráki, A1
Ajtay, Z1
Németh, Á1
Lenkey, Z1
Sulyok, E1
Szabados, S1
Alotti, N1
Martens-Lobenhoffer, J2
Szabó, C1
Bode-Böger, SM2
Jang, JJ1
Berkheimer, SB1
Merchant, M1
Krishnaswami, A1
Işıklar, OO1
Barutcuoğlu, B1
Kabaroğlu, C1
Mutaf, I1
Özmen, D1
Bayındır, O1
Zoghi, M1
Uluer, H1
Weis, M2
Ding, YA1
Charng, MJ1
Lin, SJ1
Kledal, TN1
Lin, KY1
Panchal, SN1
Gao, SZ1
Mocarski, ES1
Ritz, E1
Tsuda, K1
Nishio, I1
Bae, SW1
Stühlinger, MC1
Yoo, HS1
Yu, KH1
Park, HK1
Choi, BY1
Lee, YS1
Pachinger, O1
Choi, YH1
Park, JE1
Tanaka, M1
Sydow, K2
Gunawan, F1
Jacobi, J1
Tsao, PS1
Robbins, RC1
Schultheiss, M1
Eigenthaler, M1
Poole-Wilson, PA1
Kawata, T1
Daimon, M1
Hasegawa, R1
Teramoto, K1
Toyoda, T1
Sekine, T1
Yamamoto, K1
Uchida, D1
Himi, T1
Yoshida, K1
Komuro, I1
Elesber, AA1
Solomon, H1
Lennon, RJ1
Mathew, V1
Prasad, A1
Pumper, G1
Nelson, RE1
McConnell, JP1
Lerman, LO1
Lerman, A1
Maas, R2
Quitzau, K1
Spieker, L1
Rafflenbeul, W1
Steenpass, A1
Lüscher, TF1
Böger, RH2
Becker, T1
Chobanyan, K1
Mitschke, A1
Beckmann, B1
Gutzki, FM1
Stichtenoth, DO1
Sahinarslan, A1
Cengel, A1
Biberoglu, G1
Hasanoglu, A1
Turkoglu, S1
Timurkaynak, T1
Staniloae, C1
Mandadi, V1
Kurian, D1
Coppola, J1
Bernaski, E1
El-Khally, Z1
Morlote, M1
Ambrose, J1
Stochmal, E1
Szurkowska, M1
Stochmal, A1
Klecha, A1
Kawecka-Jaszcz, K1
Dubiel, JS1
Huszno, B1
Szybiński, Z1
Kielstein, JT1
Weber, T1
Auer, J1
Lamm, G1
Lassnig, E1
Rammer, M1
O'Rourke, MF1
Eber, B1
Iribarren, C1
Husson, G1
Wang, BY1
Sidney, S1
Frøbert, O1
Hjortshøj, SP1
Simonsen, U1
Ravkilde, J1
Joyal, D1
Leya, F1
Obada Al-Chekakie, M1
Arab, D1
Dieter, RS1
Morshedi-Meibodi, A1
Lewis, B1
Steen, L1
Fareed, J1
Hoppenstead, D1
Akar, JG1
Wang, J1
Sim, AS1
Wang, XL1
Salonikas, C1
Moriatis, M1
Naidoo, D1
Wilcken, DE1
Miyazaki, H1
Matsuoka, H1
Usui, M1
Ueda, S1
Okuda, S1
Imaizumi, T1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sex Differences in Symptomatic Non-Obstructive Coronary Disease: Do Women Have a Unique Coronary Pathophysiology?[NCT00823563]126 participants (Anticipated)Observational2007-06-30Recruiting
A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography[NCT00354081]Phase 33,096 participants (Actual)Interventional1999-04-30Completed
Reduction of Symptomatic Ventricular Premature Beats With Ranolazine[NCT01996618]Phase 472 participants (Anticipated)Interventional2014-01-31Recruiting
Does Ranolazine Decrease Biomarkers That Indicate Evidence of Myocardial Damage in Diabetics With Stable Ischemic Heart Disease? A Double-blinded, Randomized, Placebo Controlled Trial[NCT02611596]0 participants (Actual)Interventional2016-11-30Withdrawn
Low Fat Vegan Diet or American Heart Association Diet, Impact on Biomarkers of Inflammation, Oxidative Stress and Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol: A Four Week Randomized Trial[NCT01817491]60 participants (Actual)Interventional2013-03-31Completed
Adiposity and Airway Inflammation in HIV-Associated Airway Disease[NCT02975258]102 participants (Actual)Observational2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in PAQ (Physical Activity Questionnaire)

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: baseline, 4 weeks

Interventionunits on a scale (Mean)
Reduced Fat Vegan Diet0.22
American Heart Association Diet-0.16

Children Change in BMI Z Score

Body mass index z-scores, also called BMI standard deviation (s.d.) scores, are measures of relative weight adjusted for child age and sex. Given a child's age, sex, BMI, and an appropriate reference standard, a BMI z-score (or its equivalent BMI-for-age percentile) can be determined. Negative BMI z-scores indicate a BMI that is lower than the population mean, while positive BMI scores indicate a value that is higher than the population mean. A decrease in the BMI z-score over time indicate a lowering of the BMI. Z-scores of 1.03 and 1.64 correspond to the 85th and 95th percentiles of BMI-for-age, which are the definitions of overweight and obesity in children. (NCT01817491)
Timeframe: baseline, 4 weeks

InterventionZ Score (Mean)
Reduced Fat Vegan Diet-0.14
American Heart Association Diet-0.03

PB/AHA - Adjusted Mean Difference BMI Z Score Children

(NCT01817491)
Timeframe: Baseline, 4 weeks

InterventionZ score (Mean)
PB/AHA-0.13

PB/AHA - Adjusted Mean Difference PAQ Children

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionunits on a scale (Mean)
PB/AHA0.39

Change in Blood Pressure (BP)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmm Hg (Mean)
Children Systolic BPParents Systolic BPChildren Diastolic BPParent Diastolic BP
American Heart Association Diet-5.14-3.14-4.36-6.64
Reduced Fat Vegan Diet-6.43-7.96-2.61-3.46

Change in Body Mass Index BMI Percentile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionBMI percentile (Mean)
ChildrenParents
American Heart Association Diet-0.08-0.73
Reduced Fat Vegan Diet-1.12-1.29

Change in Circumference

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventioncm (Mean)
Children Waist CircumferenceParents Waist CircumferenceChildren Midarm CircumferenceParents Midarm Circumference
American Heart Association Diet-2.96-0.49-1.140.35
Reduced Fat Vegan Diet-1.53-1.94-2.02-1.32

Change in Glucose

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
ChildrenParent
American Heart Association Diet-.64-5.43
Reduced Fat Vegan Diet0.934.93

Change in HgbA1c (Hemoglobin A1c)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpercentage (Mean)
ChildrenParent
American Heart Association Diet0.210.14
Reduced Fat Vegan Diet0.17-0.16

Change in hsCRP (High-sensitivity C-reactive Protein)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/L (Mean)
ChildrenParent
American Heart Association Diet2.780.21
Reduced Fat Vegan Diet-2.09-0.24

Change in IL-6 (Interleukin-6)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpg/ml (Mean)
ChildrenParent
American Heart Association Diet-0.19-0.19
Reduced Fat Vegan Diet-0.170.16

Change in Insulin

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionuU/ml (Mean)
ChildrenParents
American Heart Association Diet3.16-3.15
Reduced Fat Vegan Diet-5.42-3.11

Change in Lipid Profile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
total cholesterol childrentriglycerides childrenhigh-density lipoprotein cholesterol childrenlow-density lipoprotein cholesterol childrentotal cholesterol parentstriglycerides parentshigh-density lipoprotein cholesterol parentslow-density lipoprotein cholesterol parents
American Heart Association Diet-16.50-13.14-2.93-11.00-7.1416.8616.86-5.50
Reduced Fat Vegan Diet-22.50-25.50-5.93-13.14-33.796.21-8.14-27.00

Change in Liver Enzymes

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionU/L (Mean)
alanine aminotransferase (ALT) childrenaspartate aminotransferase (AST) childrenalanine aminotransferase (ALT) parentsaspartate aminotransferase (AST) parents
American Heart Association Diet-1.140.004.574.43
Reduced Fat Vegan Diet0.792.790.860.14

Change in MPO (Myeloperoxidase)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpmol/L (Mean)
ChildrenParent
American Heart Association Diet-69.231.78
Reduced Fat Vegan Diet-75.3416.91

Change in Weight

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionkg (Mean)
ChildrenParents
American Heart Association Diet-1.55-2.01
Reduced Fat Vegan Diet-3.05-3.64

PB/AHA - Adjusted Mean BP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
Children adj mean ratio systolic BPChildren adj mean ratio diastolic BPparents adj mean ratio systolic BPparents adj mean ratio diastolic BP
PB/AHA1.871.010.971.03

PB/AHA - Adjusted Mean Difference BMI

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionpercentile (Mean)
Children Change in BMIParents Change in BMI
PB/AHA-1.17-0.69

PB/AHA - Adjusted Mean Difference Circumference

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventioncm (Mean)
children waist circumferenceparents waist circumferencechildren arm circumferenceparents arm circumference
PB/AHA1.32-1.14-1.25-1.68

PB/AHA - Adjusted Mean Difference Weight

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionkg (Mean)
Children WeightParents Weight
PB/AHA-1.71-1.95

PB/AHA - Adjusted Mean Lipid Profile

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionmg/dL (Mean)
CHOL childrenTRIG childrenHDL childrenLDL childrenCHOL parentsTRIG parentsHDL parentsLDL parents
PB/AHA-10.341.010.170.95-27.290.950.94-21.92

PB/AHA - Adjusted Mean Ratio Glucose

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA1.011.06

PB/AHA - Adjusted Mean Ratio HgbA1c

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.990.96

PB/AHA - Adjusted Mean Ratio hsCRP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.460.68

PB/AHA - Adjusted Mean Ratio IL-6

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.261.14

PB/AHA - Adjusted Mean Ratio Insulin

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.70.87

PB/AHA - Adjusted Mean Ratio Liver Enzymes

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ALT childrenAST childrenALT parentsAST parents
PB/AHA11.130.850.83

PB/AHA - Adjusted Mean Ratio MPO

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.950.93

Reviews

6 reviews available for n(g),n(g')-dimethyl-l-arginine and Coronary Artery Disease

ArticleYear
Prognostic value of asymmetric dimethylarginine in patients with coronary artery disease: A meta-analysis.
    Nitric oxide : biology and chemistry, 2021, 05-01, Volume: 109-110

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Humans; Prognosis

2021
Nutritional factors in the prevention and management of coronary artery disease and heart failure.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:2

    Topics: Alprostadil; Anti-Inflammatory Agents; Arginine; CD59 Antigens; Coronary Artery Disease; Diabetes Me

2015
Levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and risk of coronary artery disease: A meta-analysis based on 4713 participants.
    European journal of preventive cardiology, 2016, Volume: 23, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Female; Humans; Ma

2016
Cardiac biomarkers and chronic renal diseases.
    Bratislavske lekarske listy, 2008, Volume: 109, Issue:8

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Disease Progression; Hom

2008
Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Apr-01, Volume: 23, Issue:4

    Topics: Animals; Arginine; Cardiovascular Agents; Coronary Artery Disease; Endothelium, Vascular; Graft Reje

2003
Atherosclerosis in dialyzed patients.
    Blood purification, 2004, Volume: 22, Issue:1

    Topics: Anemia; Animals; Arginine; Arteriosclerosis; Biomarkers; Cause of Death; Comorbidity; Coronary Arter

2004

Trials

8 trials available for n(g),n(g')-dimethyl-l-arginine and Coronary Artery Disease

ArticleYear
Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation.
    The American journal of cardiology, 2017, Sep-15, Volume: 120, Issue:6

    Topics: Arginine; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationshi

2017
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethio

2013
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Coronary Artery Disease; Female; Homoarginine; Homocysteine;

2015
Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Aged, 80 and over; Arginine; Cell Adhesion Molecules; Coronary Artery Disease; Diabetes Mellit

2015
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound.
    Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:8

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Indican; Male; Middle Aged; Pla

2015
Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adolescent; Adult; Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Chi

2015
Ranolazine improves endothelial function in patients with stable coronary artery disease.
    Coronary artery disease, 2009, Volume: 20, Issue:5

    Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery

2009
Ranolazine improves endothelial function in patients with stable coronary artery disease.
    Coronary artery disease, 2009, Volume: 20, Issue:5

    Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery

2009
Ranolazine improves endothelial function in patients with stable coronary artery disease.
    Coronary artery disease, 2009, Volume: 20, Issue:5

    Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery

2009
Ranolazine improves endothelial function in patients with stable coronary artery disease.
    Coronary artery disease, 2009, Volume: 20, Issue:5

    Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery

2009
Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease.
    Cardiology, 2007, Volume: 108, Issue:3

    Topics: Adult; Aged; Arginine; Blood Sedimentation; Brachial Artery; C-Reactive Protein; Cardiovascular Agen

2007

Other Studies

62 other studies available for n(g),n(g')-dimethyl-l-arginine and Coronary Artery Disease

ArticleYear
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors

2023
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors

2023
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors

2023
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors

2023
Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease.
    Scientific reports, 2023, 05-09, Volume: 13, Issue:1

    Topics: Calcium; Calcium, Dietary; Coronary Artery Disease; Humans; Lipids; Percutaneous Coronary Interventi

2023
Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease.
    International journal of cardiology, 2020, 01-15, Volume: 299

    Topics: Angina Pectoris; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vesse

2020
Increased symmetric dimethylarginine, but not asymmetric dimethylarginine, concentrations are associated with transient myocardial ischemia and predict outcome.
    The Journal of international medical research, 2020, Volume: 48, Issue:6

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dipyrid

2020
Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease.
    BMC cardiovascular disorders, 2021, 03-05, Volume: 21, Issue:1

    Topics: Aged; Arginine; Asymptomatic Diseases; Biomarkers; C-Reactive Protein; Calcium; Coronary Artery Bypa

2021
Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018, Volume: 28, Issue:1

    Topics: Aged; Angiography, Digital Subtraction; Arginine; Biomarkers; Case-Control Studies; Coronary Artery

2018
Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen.
    Nutrients, 2017, Dec-18, Volume: 9, Issue:12

    Topics: Angiotensin II; Animals; Arginine; Atherosclerosis; Bees; Cholesterol; Coronary Artery Disease; Diet

2017
Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors.
    Acta bio-medica : Atenei Parmensis, 2018, 06-07, Volume: 89, Issue:2

    Topics: Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Coronary Stenosis; Female; Huma

2018
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
    Molecular biology reports, 2018, Volume: 45, Issue:6

    Topics: Adult; Amidohydrolases; Arginine; Case-Control Studies; Coronary Artery Disease; Egypt; Female; Gene

2018
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease.
    Amino acids, 2019, Volume: 51, Issue:6

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Homoarginine; Humans; Male; Middle Aged; Osteop

2019
Simultaneous determination of homocysteine and asymmetric dimethylarginine in human urine by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Nov-15, Volume: 939

    Topics: Arginine; Biomarkers; Chromatography, Liquid; Coronary Artery Disease; Homocysteine; Humans; Limit o

2013
Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study.
    Cardiovascular diabetology, 2013, Oct-09, Volume: 12

    Topics: Adult; Aged; Angina, Stable; Arginine; Biomarkers; Blood Glucose; Case-Control Studies; Coronary Ang

2013
Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study.
    Herz, 2015, Volume: 40, Issue:3

    Topics: Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Female; Homocysteine; Humans; Mal

2015
Association of asymmetric dimethylarginine levels with treadmill-stress-test-derived prognosticators.
    Clinical biochemistry, 2014, Volume: 47, Issue:7-8

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Exercise Test; Female; Humans; Male; Middle Age

2014
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
    European journal of clinical nutrition, 2014, Volume: 68, Issue:7

    Topics: Adult; Arginine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Artery Disease; Endoth

2014
Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease.
    The Journal of pediatrics, 2014, Volume: 165, Issue:2

    Topics: Arginine; Biomarkers; Child, Preschool; Coronary Artery Disease; Coronary Vessels; Female; Humans; I

2014
Association between brachial-ankle pulse wave velocity and the ratio of l-arginine to asymmetric dimethylarginine in patients undergoing coronary angiography.
    Journal of cardiology, 2015, Volume: 65, Issue:4

    Topics: Aged; Ankle Brachial Index; Arginine; Blood Pressure; Coronary Angiography; Coronary Artery Disease;

2015
Levels of arginine and its products in dialysis patients.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:16

    Topics: Adult; Aged; Arginine; Coronary Artery Disease; Female; Humans; Kidney Failure, Chronic; Male; Middl

2014
The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2014, Volume: 42, Issue:8

    Topics: Aged; Arginine; Biomarkers; Brachial Artery; Carotid Intima-Media Thickness; Cholesterol; Cholestero

2014
Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg.
    Frontiers in bioscience (Elite edition), 2015, 06-01, Volume: 7, Issue:3

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Exercise; Female; Humans; Male; Middle Aged; Nitric O

2015
Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:4

    Topics: Arginine; Coronary Artery Disease; Echocardiography; Female; Humans; Ischemia; Male; Middle Aged; My

2015
Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease.
    International heart journal, 2015, Volume: 56, Issue:6

    Topics: Aged; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Coronary Angiog

2015
Serum trans fatty acids, asymmetric dimethylarginine and risk of acute myocardial infarction and mortality in patients with suspected coronary heart disease: a prospective cohort study.
    Lipids in health and disease, 2016, Feb-27, Volume: 15

    Topics: Aged; Arginine; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; P

2016
Asymmetric Dimethylarginine versus Proton Pump Inhibitors Usage in Patients with Stable Coronary Artery Disease: A Cross-Sectional Study.
    International journal of molecular sciences, 2016, Apr-15, Volume: 17, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Arginine; Coronary Artery Disease; Cross-Sectional St

2016
Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2017, Volume: 18, Issue:8

    Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Echocardiography;

2017
Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:7

    Topics: Animals; Arginine; Carotid Artery Diseases; Carotid Artery Injuries; Cell Differentiation; Cell Move

2016
Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis.
    International journal of cardiology, 2016, Oct-01, Volume: 220

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Female

2016
Asymmetrical dimethyl arginine in type 2 diabetic patients with coronary artery disease.
    JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:8

    Topics: Adult; Arginine; Blood Glucose; Case-Control Studies; Coronary Artery Disease; Cross-Sectional Studi

2016
Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease.
    Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 464

    Topics: Age of Onset; Arginine; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged

2017
Coronary artery calcification, ADMA, and insulin resistance in CKD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:5

    Topics: Aged; Arginine; Calcinosis; Case-Control Studies; Chronic Disease; Coronary Angiography; Coronary Ar

2008
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
    European heart journal, 2009, Volume: 30, Issue:9

    Topics: Aged; Arginine; Atherosclerosis; Coronary Artery Bypass; Coronary Artery Disease; Endothelium, Vascu

2009
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:9

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressu

2009
Growth differentiation factor 15 and coronary collateral formation.
    Clinical cardiology, 2010, Volume: 33, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Collateral Circulation; Coronary Angiography; Coronary Artery

2010
Assessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery disease.
    International urology and nephrology, 2010, Volume: 42, Issue:4

    Topics: Arginine; Coronary Artery Disease; Erectile Dysfunction; Humans; Male; Middle Aged; Severity of Illn

2010
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.
    Circulation research, 2010, Apr-02, Volume: 106, Issue:6

    Topics: Aged; Amidohydrolases; Arginine; Asian People; Binding Sites; Biomarkers; Case-Control Studies; Cell

2010
Down but not out: candidate gene-based studies still have value in a world dominated by whole genome approaches.
    Circulation research, 2010, Apr-02, Volume: 106, Issue:6

    Topics: Amidohydrolases; Arginine; Asian People; Biomarkers; China; Coronary Artery Disease; Evidence-Based

2010
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
    Atherosclerosis, 2010, Volume: 211, Issue:2

    Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Arginine; China; Coronary Arter

2010
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
    Circulation research, 2010, Jul-09, Volume: 107, Issue:1

    Topics: Angiogenesis Inhibitors; Arginine; Coronary Artery Disease; Gene Expression Regulation; Humans; Micr

2010
Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.
    Coronary artery disease, 2010, Volume: 21, Issue:8

    Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Ang

2010
Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.
    International journal of cardiology, 2012, May-03, Volume: 156, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Male;

2012
Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine.
    Coronary artery disease, 2011, Volume: 22, Issue:4

    Topics: Aged; Arginine; Biomarkers; Cardiopulmonary Bypass; Chromatography, High Pressure Liquid; Coronary A

2011
Asymmetric dimethylarginine and coronary artery calcium scores are increased in patients infected with human immunodeficiency virus.
    Atherosclerosis, 2011, Volume: 217, Issue:2

    Topics: Adult; Arginine; Biomarkers; Calcinosis; California; Case-Control Studies; Chi-Square Distribution;

2011
Do cardiac risk factors affect the homocysteine and asymmetric dimethylarginine relationship in patients with coronary artery diseases?
    Clinical biochemistry, 2012, Volume: 45, Issue:16-17

    Topics: Adult; Aged; Arginine; Atherosclerosis; Coronary Artery Disease; Female; Homocysteine; Humans; Male;

2012
Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease.
    Clinical cardiology, 2003, Volume: 26, Issue:10

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Exercise Test; Female; Hu

2003
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
    Circulation, 2004, Feb-03, Volume: 109, Issue:4

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Cells, Cultured; Coronary Angiography; Coronary

2004
Sex hormones and asymmetric dimethylarginine in transplant arteriosclerosis.
    Circulation, 2004, Jul-20, Volume: 110, Issue:3

    Topics: Arginine; Coronary Artery Disease; Endothelium, Vascular; Estrogens; Female; Gonadal Steroid Hormone

2004
Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment.
    The American journal of cardiology, 2005, Mar-15, Volume: 95, Issue:6

    Topics: Adult; Aged; alpha-Tocopherol; Angina, Unstable; Angioplasty, Balloon, Coronary; Arginine; C-Reactiv

2005
Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease.
    Circulation, 2005, Sep-13, Volume: 112, Issue:11

    Topics: Amidohydrolases; Animals; Arginine; Coronary Artery Disease; Cytokines; Enzyme Inhibitors; Female; H

2005
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
    Journal of the American College of Cardiology, 2005, Nov-01, Volume: 46, Issue:9

    Topics: Arginine; Cell Count; Cells, Cultured; Coronary Artery Disease; Endothelium, Vascular; Enzyme Inhibi

2005
Serum asymmetric dimethylarginine as a marker of coronary microcirculation in patients with non-insulin dependent diabetes mellitus: correlation with coronary flow reserve.
    Heart (British Cardiac Society), 2005, Volume: 91, Issue:12

    Topics: Aged; Arginine; Biomarkers; Blood Flow Velocity; Coronary Artery Disease; Coronary Circulation; Diab

2005
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
    European heart journal, 2006, Volume: 27, Issue:7

    Topics: Arginine; C-Reactive Protein; Coronary Artery Disease; Endothelium, Vascular; Erectile Dysfunction;

2006
Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.
    Atherosclerosis, 2007, Volume: 191, Issue:1

    Topics: Acetylcholine; Adenosine; Aged; Arginine; Coronary Artery Disease; Endothelium, Vascular; Female; Hu

2007
Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Acetazolamide; Adult; Arginine; Benzamides; Circadian Rhythm; Coronary Artery Disease; Dimethylamine

2007
Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography.
    Coronary artery disease, 2006, Volume: 17, Issue:7

    Topics: Adolescent; Adult; Aged; Angina Pectoris; Arginine; Coronary Angiography; Coronary Artery Disease; F

2006
Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:1

    Topics: Adult; Aged; Arginine; Blood Glucose; C-Reactive Protein; Cholesterol; Coronary Artery Disease; Disc

2007
Should we measure asymmetric dimethylarginine in patients with coronary artery disease?
    Clinical chemistry, 2007, Volume: 53, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Coronary Artery Disease; Humans; Mortality; Predictiv

2007
Arterial wave reflections and determinants of endothelial function a hypothesis based on peripheral mode of action.
    American journal of hypertension, 2007, Volume: 20, Issue:3

    Topics: Age Factors; Aged; Aorta; Arginine; Blood Flow Velocity; Blood Pressure; Coronary Artery Disease; Cr

2007
Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2007, Volume: 14, Issue:2

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Calcinosis; Case-Control Studies; Coronary Artery

2007
Methylated arginines in stable and acute patients with coronary artery disease before and after percutaneous revascularization.
    International journal of cardiology, 2008, Sep-26, Volume: 129, Issue:2

    Topics: Angioplasty, Balloon, Coronary; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary

2008
Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease.
    Coronary artery disease, 2007, Volume: 18, Issue:6

    Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Arginine; Atherosclerosis; Biomarkers; Coronary Artery D

2007
Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease.
    Atherosclerosis, 2008, Volume: 197, Issue:2

    Topics: Age Factors; Aged; Arginine; Biomarkers; Cohort Studies; Coronary Artery Disease; Cystatin C; Cystat

2008
[Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis].
    Journal of cardiology, 1999, Volume: 33, Issue:2

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Enzyme Inhibitors; Female; Humans; Male; Middle Aged;

1999