n(g),n(g')-dimethyl-l-arginine has been researched along with Cirrhosis in 21 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis, is a risk factor for endothelial dysfunction, a common pathophysiological denominator for both atherogenesis and cardiac fibrosis." | 8.31 | The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome. ( Bełtowski, J; Czechowska, G; Fornal, E; Góralczyk, A; Korolczuk, A; Kozub, A; Marzec-Kotarska, B; Nikolaichuk, H; Pradiuch, A; Stachniuk, A; Trzpil, A; Wójcicka, G, 2023) |
| "In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease." | 7.73 | Accumulation of symmetric dimethylarginine in hepatorenal syndrome. ( Del Olmo, JA; Lluch, P; Mauricio, MD; Medina, P; Rodrigo, JM; Segarra, G; Serra, MA; Vila, JM, 2006) |
| "Fibrosis is a reparative process with very few therapeutic options to prevent its progression to organ dysfunction." | 6.61 | Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis. ( Huang, CY; Jiang, JL; Li, G; Zhao, WC, 2019) |
| "Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis, is a risk factor for endothelial dysfunction, a common pathophysiological denominator for both atherogenesis and cardiac fibrosis." | 4.31 | The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome. ( Bełtowski, J; Czechowska, G; Fornal, E; Góralczyk, A; Korolczuk, A; Kozub, A; Marzec-Kotarska, B; Nikolaichuk, H; Pradiuch, A; Stachniuk, A; Trzpil, A; Wójcicka, G, 2023) |
| " In contrast, cDDAH1 KO mice exposed to TAC showed no increase in LV DDAH1 expression, slightly increased LV tissue ADMA levels, no increase in plasma ADMA, but significantly exacerbated LV hypertrophy, fibrosis, nitrotyrosine production, and LV dysfunction." | 3.85 | Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction. ( Atzler, D; Böger, RH; Chen, P; Chen, Y; Fassett, J; Guo, H; Hu, X; Kwak, D; Liu, X; Lu, Z; Schwedhelm, E; Wang, H; Xu, X; Yue, W; Zhang, P, 2017) |
| " We found that mild hypertension, increased plasma levels of creatinine, inorganic phosphate, asymmetric dimethylarginine (ADMA), and parathyroid hormone (PTH) were observed in the present SNx rats without LVH." | 3.77 | Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats. ( Aizawa, K; Ishizuka, N; Iwabuchi, S; Kitamura, H; Moriguchi, Y; Nishimura, T; Serizawa, K; Tashiro, Y; Yogo, K; Yorozu, K, 2011) |
| "In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease." | 3.73 | Accumulation of symmetric dimethylarginine in hepatorenal syndrome. ( Del Olmo, JA; Lluch, P; Mauricio, MD; Medina, P; Rodrigo, JM; Segarra, G; Serra, MA; Vila, JM, 2006) |
| "Fibrosis is a reparative process with very few therapeutic options to prevent its progression to organ dysfunction." | 2.61 | Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis. ( Huang, CY; Jiang, JL; Li, G; Zhao, WC, 2019) |
| "Cardiac fibrosis is the main pathological basis of diabetic cardiomyopathy (DCM), and endothelial-to-meschenymal transition (EndMT) is a key driver to cardiac fibrosis and plays an important role in the pathogenesis of DCM." | 1.91 | LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway. ( He, S; Huang, C; Jiang, J; Li, G; Li, N; Li, T; Niu, B; Tong, W; Wang, S; Wu, M; Wu, T; Yan, L, 2023) |
| "Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and diabetic nephropathy (DN)." | 1.56 | Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. ( Awad, AS; Cooper, TK; Gao, T; Morris, SM; Stanley, K; Wetzel, MD, 2020) |
| "Symmetric dimethylarginine (SDMA) seems to be a good marker of multiorgan failure, especially renal failure." | 1.38 | Diagnostic value of plasma asymmetric and symmetric dimethylarginine levels in liver transplant recipients. ( Kokot, F; Kunsdorf-Wnuk, A; Wnuk, Z, 2012) |
| "The treatment with amlodipine reduced SBP but failed to ameliorate the ADMA-induced histological changes." | 1.34 | Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. ( Hasegawa, K; Hayashi, K; Homma, K; Itoh, H; Kimoto, M; Sugano, N; Tatematsu, S; Wakino, S; Yoshioka, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 13 (61.90) | 24.3611 |
| 2020's | 5 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, M | 2 |
| Li, T | 1 |
| Li, G | 2 |
| Niu, B | 1 |
| Wu, T | 1 |
| Yan, L | 1 |
| Wang, S | 1 |
| He, S | 1 |
| Huang, C | 1 |
| Tong, W | 1 |
| Li, N | 1 |
| Jiang, J | 1 |
| Wójcicka, G | 1 |
| Pradiuch, A | 1 |
| Fornal, E | 1 |
| Stachniuk, A | 1 |
| Korolczuk, A | 1 |
| Marzec-Kotarska, B | 1 |
| Nikolaichuk, H | 1 |
| Czechowska, G | 1 |
| Kozub, A | 1 |
| Trzpil, A | 1 |
| Góralczyk, A | 1 |
| Bełtowski, J | 1 |
| Wetzel, MD | 1 |
| Gao, T | 1 |
| Stanley, K | 1 |
| Cooper, TK | 1 |
| Morris, SM | 1 |
| Awad, AS | 1 |
| Yuan, M | 1 |
| Wang, Y | 1 |
| Tan, B | 1 |
| Huang, D | 1 |
| Wang, C | 1 |
| Zou, Y | 1 |
| Ye, C | 1 |
| Jayachandran, I | 1 |
| Sundararajan, S | 1 |
| Venkatesan, S | 1 |
| Paadukaana, S | 1 |
| Balasubramanyam, M | 1 |
| Mohan, V | 1 |
| Manickam, N | 1 |
| Shi, L | 1 |
| Zhao, C | 1 |
| Wang, H | 2 |
| Lei, T | 1 |
| Liu, S | 1 |
| Cao, J | 1 |
| Lu, Z | 2 |
| Xu, X | 1 |
| Zhang, P | 1 |
| Kwak, D | 1 |
| Fassett, J | 1 |
| Yue, W | 1 |
| Atzler, D | 1 |
| Hu, X | 1 |
| Liu, X | 1 |
| Guo, H | 1 |
| Schwedhelm, E | 1 |
| Böger, RH | 1 |
| Chen, P | 1 |
| Chen, Y | 1 |
| Zhu, ZD | 1 |
| Ye, JM | 1 |
| Fu, XM | 1 |
| Wang, XC | 1 |
| Ye, JY | 1 |
| Wu, XR | 1 |
| Hua, P | 1 |
| Liao, YQ | 1 |
| Xuan, W | 1 |
| Duan, JL | 1 |
| Li, WY | 1 |
| Fu, H | 1 |
| Xia, ZH | 1 |
| Zhang, X | 1 |
| Zhao, WC | 1 |
| Huang, CY | 1 |
| Jiang, JL | 1 |
| Ciurzyński, M | 1 |
| Bienias, P | 1 |
| Irzyk, K | 1 |
| Kostrubiec, M | 1 |
| Bartoszewicz, Z | 1 |
| Siwicka, M | 1 |
| Stelmaszczyk-Emmel, A | 1 |
| Górska, E | 1 |
| Demkow, U | 1 |
| Pruszczyk, P | 1 |
| Sheen, JM | 1 |
| Chen, YC | 1 |
| Tain, YL | 1 |
| Huang, LT | 1 |
| Givvimani, S | 1 |
| Kundu, S | 1 |
| Pushpakumar, S | 1 |
| Doyle, V | 1 |
| Narayanan, N | 1 |
| Winchester, LJ | 1 |
| Veeranki, S | 1 |
| Metreveli, N | 1 |
| Tyagi, SC | 1 |
| Parrish, AR | 1 |
| Sasser, JM | 1 |
| Moningka, NC | 1 |
| Cunningham, MW | 1 |
| Croker, B | 1 |
| Baylis, C | 1 |
| Mihout, F | 1 |
| Shweke, N | 1 |
| Bigé, N | 1 |
| Jouanneau, C | 1 |
| Dussaule, JC | 1 |
| Ronco, P | 1 |
| Chatziantoniou, C | 1 |
| Boffa, JJ | 1 |
| Moriguchi, Y | 1 |
| Yogo, K | 1 |
| Aizawa, K | 1 |
| Serizawa, K | 1 |
| Tashiro, Y | 1 |
| Yorozu, K | 1 |
| Ishizuka, N | 1 |
| Iwabuchi, S | 1 |
| Kitamura, H | 1 |
| Nishimura, T | 1 |
| Pullamsetti, SS | 1 |
| Savai, R | 1 |
| Dumitrascu, R | 1 |
| Dahal, BK | 1 |
| Wilhelm, J | 1 |
| Konigshoff, M | 1 |
| Zakrzewicz, D | 1 |
| Ghofrani, HA | 1 |
| Weissmann, N | 1 |
| Eickelberg, O | 1 |
| Guenther, A | 1 |
| Leiper, J | 1 |
| Seeger, W | 1 |
| Grimminger, F | 1 |
| Schermuly, RT | 1 |
| Wnuk, Z | 1 |
| Kokot, F | 1 |
| Kunsdorf-Wnuk, A | 1 |
| Lluch, P | 1 |
| Mauricio, MD | 1 |
| Vila, JM | 1 |
| Segarra, G | 1 |
| Medina, P | 1 |
| Del Olmo, JA | 1 |
| Rodrigo, JM | 1 |
| Serra, MA | 1 |
| Matsumoto, Y | 1 |
| Ueda, S | 1 |
| Yamagishi, S | 1 |
| Matsuguma, K | 1 |
| Shibata, R | 1 |
| Fukami, K | 1 |
| Matsuoka, H | 1 |
| Imaizumi, T | 1 |
| Okuda, S | 1 |
| Hasegawa, K | 1 |
| Wakino, S | 1 |
| Tatematsu, S | 1 |
| Yoshioka, K | 1 |
| Homma, K | 1 |
| Sugano, N | 1 |
| Kimoto, M | 1 |
| Hayashi, K | 1 |
| Itoh, H | 1 |
3 reviews available for n(g),n(g')-dimethyl-l-arginine and Cirrhosis
| Article | Year |
|---|---|
Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis.
Topics: Animals; Arginine; Fibrosis; Humans | 2019 |
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
Topics: Animals; Arginine; Bile Ducts; Disease Models, Animal; Fibrosis; Ligation; Liver; Liver Cirrhosis; M | 2014 |
The cytoskeleton as a novel target for treatment of renal fibrosis.
Topics: Actins; Animals; Arginine; Cytoskeleton; Disease Progression; Epithelial Cells; Fibrosis; Humans; Ki | 2016 |
18 other studies available for n(g),n(g')-dimethyl-l-arginine and Cirrhosis
| Article | Year |
|---|---|
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
Topics: Amidohydrolases; Animals; Arginine; Endothelial Cells; Fibrosis; Forkhead Box Protein O1; Glucose; H | 2023 |
The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chromatography, Liquid; Dipeptidyl-Peptidase IV Inhi | 2023 |
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experim | 2020 |
Renal asymmetric dimethylarginine inhibits fibrosis.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney D | 2020 |
Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.
Topics: Animals; Arginine; Cell Line; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetic Retinopat | 2020 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Ex | 2017 |
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Gen | 2017 |
DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; Diabetic Cardiomyopathies; Fibrosis; Male; Matrix Met | 2019 |
Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis.
Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Case-Control Studies; Collagen; Echocardiography; E | 2014 |
Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
Topics: Amidohydrolases; Animals; Arginine; Aryldialkylphosphatase; Atherosclerosis; Blood Pressure; Connexi | 2015 |
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Fibrosis; Hypertension, Renal; K | 2010 |
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis.
Topics: Animals; Arginine; Collagen; Endothelin-1; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; | 2011 |
Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
Topics: Animals; Arginine; Creatinine; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ven | 2011 |
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Topics: Amidohydrolases; Animals; Antibiotics, Antineoplastic; Apoptosis; Arginine; Bleomycin; Cell Line; Ce | 2011 |
Diagnostic value of plasma asymmetric and symmetric dimethylarginine levels in liver transplant recipients.
Topics: Alanine Transaminase; Arginine; Aspartate Aminotransferases; Biomarkers; Cadaver; Fibrosis; Humans; | 2012 |
Accumulation of symmetric dimethylarginine in hepatorenal syndrome.
Topics: Arginine; Case-Control Studies; Creatinine; Fibrosis; Hepatorenal Syndrome; Humans; Kidney; Liver; M | 2006 |
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Pr | 2007 |
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
Topics: Amidohydrolases; Amlodipine; Angiotensin II; Animals; Arginine; Blood Pressure; Coronary Circulation | 2007 |