Page last updated: 2024-10-17

n(g),n(g')-dimethyl-l-arginine and Chronic Disease

n(g),n(g')-dimethyl-l-arginine has been researched along with Chronic Disease in 52 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endothelium-independent vasodilator prostaglandin E1, and control patients."9.08Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. ( Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W, 1998)
"The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma."8.02Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. ( Guo, M; Jiang, GT; Liu, H; Liu, J; She, J; Zhou, B, 2021)
"The effects of eicosapentaenoic acid (EPA) on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear."7.80Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia. ( Atarashi, H; Kohashi, K; Kosugi, M; Kusama, Y; Morisawa, T; Nakagomi, A; Saiki, Y; Shimizu, W, 2014)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."7.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"To investigate the relationship between periodontal disease indexes (PDI) and endothelial dysfunction by means of asymmetric dimethyl-arginine (ADMA) in conditions of both increased and decreased systemic inflammation in the setting of hypertension."7.76The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects. ( Kasiakogias, A; Mostratou, E; Silvestros, S; Soldatos, N; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Thomopoulos, C; Tsioufis, C, 2010)
"Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is elevated in congestive heart failure (CHF) concomitantly with the higher levels of nitric oxide (NO) and cytokines."7.72High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level. ( Hanada, H; Ishizaka, H; Kamada, T; Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M, 2003)
"Hyperhomocysteinemia is associated with an enhanced risk for cardiovascular disease."7.72Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA. ( Arakawa, N; Bode-Böger, SM; Böger, RH; Hornig, B; Münzel, T; Sydow, K; Tsikas, D, 2004)
"Ramipril was given (5 mg daily for 12 weeks), and circulating ADMA, soluble Fas (sFas), myostatin and endothelial function [flow-mediated vasodilation (FMD); ultrasound)] were measured."5.36Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway? ( Axelsson, J; Caglar, K; Cayci, T; Eyileten, T; Kilic, S; Oguz, Y; Saglam, M; Sonmez, A; Vural, A; Yaman, H; Yenicesu, M; Yilmaz, MI, 2010)
"We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endothelium-independent vasodilator prostaglandin E1, and control patients."5.08Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. ( Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W, 1998)
"The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma."4.02Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. ( Guo, M; Jiang, GT; Liu, H; Liu, J; She, J; Zhou, B, 2021)
"The effects of eicosapentaenoic acid (EPA) on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear."3.80Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia. ( Atarashi, H; Kohashi, K; Kosugi, M; Kusama, Y; Morisawa, T; Nakagomi, A; Saiki, Y; Shimizu, W, 2014)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."3.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"To investigate the relationship between periodontal disease indexes (PDI) and endothelial dysfunction by means of asymmetric dimethyl-arginine (ADMA) in conditions of both increased and decreased systemic inflammation in the setting of hypertension."3.76The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects. ( Kasiakogias, A; Mostratou, E; Silvestros, S; Soldatos, N; Stefanadi, E; Stefanadis, C; Syrseloudis, D; Thomopoulos, C; Tsioufis, C, 2010)
" However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC."3.74Coronary artery calcification, ADMA, and insulin resistance in CKD patients. ( Hidekazu, M; Ikee, R; Kobayashi, S; Maesato, K; Mano, T; Ohtake, T; Oka, M, 2008)
"The rationale of this study is based on the fact that, both proteinuria and elevated asymmetric dimethyl arginine (ADMA) levels have been linked to the progression of vascular disease."3.73ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease. ( Acikel, C; Bilgi, C; Caglar, K; Cakir, E; Eyileten, T; Kaya, A; Oguz, Y; Oktenli, C; Sonmez, A; Vural, A; Yenicesu, M; Yilmaz, MI; Zoccali, C, 2006)
"Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is elevated in congestive heart failure (CHF) concomitantly with the higher levels of nitric oxide (NO) and cytokines."3.72High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level. ( Hanada, H; Ishizaka, H; Kamada, T; Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M, 2003)
"Hyperhomocysteinemia is associated with an enhanced risk for cardiovascular disease."3.72Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA. ( Arakawa, N; Bode-Böger, SM; Böger, RH; Hornig, B; Münzel, T; Sydow, K; Tsikas, D, 2004)
") bioavailability and potentially limit atherosclerosis."2.71Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study. ( Abdulhayoglu, E; Barbato, D; Bustami, R; D'Alecy, LG; Desai, A; Handelman, GJ; Novak, JE; Rajagopalan, S; Saran, R; Warren, JS; Weitzel, W, 2003)
"Asymmetric dimethylarginine (ADMA) is a naturally occurring amino acid that reduces the bioavailability of nitric oxide."2.44Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease. ( Kielstein, JT; Zoccali, C, 2008)
"Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD)."2.44Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. ( Fukami, K; Matsumoto, Y; Okuda, S; Ueda, S; Yamagishi, SI, 2007)
"Patients with type 2 diabetes represent 50% of all sudden cardiac deaths."1.62Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication. ( Adamiec, R; Dumas, I; Fiodorenko-Dumas, Z; Małecki, R; Paprocka-Borowicz, M; Rabczynski, M, 2021)
"Relatively young 109 biopsy-proven IgA nephropathy (IgAN) patients (age: 32."1.37Association of asymmetric dimethylarginine with severity of kidney injury and decline in kidney function in IgA nephropathy. ( Ando, R; Fujimi-Hayashida, A; Fukami, K; Kaida, Y; Nakayama, Y; Okuda, S; Ueda, S; Yamagishi, S, 2011)
"Symmetric dimethylarginine (SDMA) was recently demonstrated to induce reactive oxygen species in monocytes."1.37Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease. ( Barreto, DV; Barreto, FC; Eloot, S; Glorieux, G; Liabeuf, S; Massy, Z; Schepers, E; Vanholder, R, 2011)
"Ramipril was given (5 mg daily for 12 weeks), and circulating ADMA, soluble Fas (sFas), myostatin and endothelial function [flow-mediated vasodilation (FMD); ultrasound)] were measured."1.36Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway? ( Axelsson, J; Caglar, K; Cayci, T; Eyileten, T; Kilic, S; Oguz, Y; Saglam, M; Sonmez, A; Vural, A; Yaman, H; Yenicesu, M; Yilmaz, MI, 2010)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (3.85)18.2507
2000's27 (51.92)29.6817
2010's19 (36.54)24.3611
2020's4 (7.69)2.80

Authors

AuthorsStudies
Zhou, B1
Jiang, GT1
Liu, H1
Guo, M1
Liu, J1
She, J1
Yilmaz, MI6
Romano, M1
Basarali, MK1
Elzagallaai, A1
Karaman, M1
Demir, Z1
Demir, MF1
Akcay, F1
Seyrek, M1
Haksever, N1
Piskin, D1
Cimaz, R1
Rieder, MJ1
Demirkaya, E2
Fiodorenko-Dumas, Z1
Dumas, I1
Rabczynski, M1
Małecki, R1
Adamiec, R1
Paprocka-Borowicz, M1
Türer Cabbar, A1
Değertekin, MM1
Şimşek, MA1
Özveren, O1
Güleç, S1
Yanartaş, M1
Gezer Taş, S1
Olgun Yıldızeli, Ş1
Mutlu, B1
İşbir, T1
Yıldızeli, B1
Mangoni, AA2
Rodionov, RN1
McEvoy, M1
Zinellu, A1
Carru, C1
Sotgia, S1
Reimann, M1
Hamer, M1
Malan, NT1
Schlaich, MP1
Lambert, GW1
Ziemssen, T1
Boeger, RH1
Malan, L1
Kohashi, K1
Nakagomi, A1
Saiki, Y1
Morisawa, T1
Kosugi, M1
Kusama, Y1
Atarashi, H1
Shimizu, W1
Lüneburg, N1
Harbaum, L1
Hennigs, JK1
Pilz, S1
Putz-Bankuti, C1
Meinitzer, A1
März, W1
Kienreich, K1
Stojakovic, T1
Pieber, TR1
Stauber, RE1
Mayer-Pickel, K1
Kolovetsiou-Kreiner, V1
Mörtl, MG1
Schlembach, D1
Eberhard, K1
Obermayer-Pietsch, B1
Lang, U1
Cervar-Zivkovic, M1
Kobayashi, S1
Oka, M1
Maesato, K1
Ikee, R1
Mano, T1
Hidekazu, M1
Ohtake, T1
Kato, A1
Odamaki, M1
Ishida, J1
Hishida, A1
Nanayakkara, PW1
Kiefte-de Jong, JC1
ter Wee, PM1
Stehouwer, CD1
van Ittersum, FJ1
Olthof, MR1
Teerlink, T2
Twisk, JW1
van Guldener, C1
Smulders, YM1
Ueda, S4
Matsumoto, Y3
Kaida, Y2
Okuda, S4
Yamagishi, S3
Mora-Fernández, C1
Jarque, A1
Getino, MA1
Sánchez, R1
Lozano, L1
Navarro, JF1
Kielstein, JT4
Zoccali, C7
Vida, G1
Sulyok, E1
Lakatos, O1
Ertl, T1
Martens-Lobenhoffer, J2
Bode-Böger, SM4
Zakrzewicz, D1
Eickelberg, O1
Tsioufis, C1
Thomopoulos, C1
Soldatos, N1
Syrseloudis, D1
Kasiakogias, A1
Silvestros, S1
Stefanadi, E1
Mostratou, E1
Stefanadis, C1
Paul, B1
Whiting, MJ1
De Pasquale, CG1
David, S1
Kümpers, P1
Lukasz, A1
Fliser, D2
Kliem, V1
Haller, H1
Sonmez, A5
Saglam, M4
Yaman, H2
Cayci, T1
Kilic, S2
Eyileten, T5
Caglar, K5
Oguz, Y4
Vural, A5
Yenicesu, M4
Axelsson, J3
Ahmad, T1
Mabalirajan, U1
Sharma, A1
Aich, J1
Makhija, L1
Ghosh, B1
Agrawal, A1
Fujimi-Hayashida, A1
Ando, R1
Nakayama, Y1
Fukami, K3
Lilitkarntakul, P1
Dhaun, N1
Melville, V1
Blackwell, S1
Talwar, DK1
Liebman, B1
Asai, T1
Pollock, J1
Goddard, J1
Webb, DJ1
Tsarouhas, K1
Karatzaferi, C1
Tsitsimpikou, C1
Haliassos, A1
Kouretas, D1
Pavlidis, P1
Veskoukis, A1
Adamopoulos, S1
Kyriakides, Z1
Constantinou, L1
Koutedakis, Y1
Rentoukas, E1
Schepers, E1
Barreto, DV1
Liabeuf, S1
Glorieux, G1
Eloot, S1
Barreto, FC1
Massy, Z2
Vanholder, R1
Grassi, G1
Seravalle, G1
Ghiadoni, L1
Tripepi, G1
Bruno, RM1
Mancia, G1
Baylis, C4
Millatt, LJ1
Whitley, GS1
Li, D1
Leiper, JM1
Siragy, HM1
Carey, RM1
Johns, RA1
Saitoh, M1
Osanai, T1
Kamada, T1
Matsunaga, T1
Ishizaka, H1
Hanada, H1
Okumura, K1
Saran, R1
Novak, JE1
Desai, A1
Abdulhayoglu, E1
Warren, JS1
Bustami, R1
Handelman, GJ1
Barbato, D1
Weitzel, W1
D'Alecy, LG1
Rajagopalan, S1
Sydow, K1
Hornig, B1
Arakawa, N1
Tsikas, D1
Münzel, T1
Böger, RH2
Siroen, MP1
Warlé, MC1
Nijveldt, RJ1
Kuipers, EJ1
Metselaar, HJ1
Tilanus, HW1
Kuik, DJ1
van der Sijp, JR1
Meijer, S1
van der Hoven, B1
van Leeuwen, PA1
Cakir, E3
Ozgurtas, T1
Aydin, A1
Ozcan, O1
Acikel, C2
Tasar, M1
Genctoy, G1
Erbil, K1
Kaya, A1
Bilgi, C1
Oktenli, C1
Matsuguma, K1
Shibata, R1
Matsuoka, H1
Imaizumi, T1
Yamagishi, SI1
Schiffrin, EL1
Lipman, ML1
Mann, JF1
Boykin, JV1
Skoro-Sajer, N1
Mittermayer, F1
Panzenboeck, A1
Bonderman, D1
Sadushi, R1
Hitsch, R1
Jakowitsch, J1
Klepetko, W1
Kneussl, MP1
Wolzt, M1
Lang, IM1
Stenvinkel, P2
Carrero, JJ2
Lindholm, B2
Heimbürger, O1
Qureshi, AR1
Cengel, A1
Sahinarslan, A1
Biberoğlu, G1
Hasanoğlu, A1
Tavil, Y1
Tulmaç, M1
Ozdemir, M1
Arese, M1
Strasly, M1
Ruva, C1
Costamagna, C1
Ghigo, D1
MacAllister, R1
Verzetti, G1
Tetta, C1
Bosia, A1
Bussolino, F1
Thiele, W1
Creutzig, A1
Alexander, K1
Frölich, JC1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of an Oxidative-Stress-Reducing Strategy Consisting of Pravastatin, Vitamin E and Homocysteine-Lowering on Carotid Intima-Media Thickness in Patients With Mild-to-Moderate Chronic Kidney Disease[NCT00384618]Phase 4100 participants Interventional2001-05-31Terminated
Effect of Paricalcitol on Endothelial Function in Chronic Kidney Disease (CKD) Patients (the PENNY Study)[NCT01680198]Phase 388 participants (Actual)Interventional2011-06-30Completed
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]Phase 1/Phase 260 participants (Anticipated)Interventional2023-11-01Recruiting
Influence of Preoperative Hemodialysis or Intraoperative Modified Ultrafiltration on Postoperative Outcome for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery: Randomized, Controlled, Multicenter Clinical Trial[NCT00720967]Phase 3450 participants (Anticipated)Interventional2008-11-30Not yet recruiting
Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy (BESTinDN Study)[NCT01796418]102 participants (Anticipated)Interventional2013-03-31Recruiting
A Multicenter, Randomized Trial to Compare Xience and Vision Coronary Stents in the Same Multivessel Patient With Chronic Kidney Disease[NCT00818792]Phase 2215 participants (Actual)Interventional2009-01-31Completed
Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.[NCT02221466]45 participants (Actual)Observational2014-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for n(g),n(g')-dimethyl-l-arginine and Chronic Disease

ArticleYear
New horizons in arginine metabolism, ageing and chronic disease states.
    Age and ageing, 2019, 11-01, Volume: 48, Issue:6

    Topics: Aged; Aging; Arginine; Chronic Disease; Homoarginine; Humans

2019
The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.
    BioMed research international, 2014, Volume: 2014

    Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Humans; Hypoxia; Nitric Oxide; Respiratory Trac

2014
[Endothelial injury and CKD].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:9

    Topics: Animals; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney D

2008
[Novelties in the field of progression factors in chronic kidney disease].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2008, Volume: 28 Suppl 5

    Topics: Adult; Amidohydrolases; Animals; Arginine; Carbon; Cardiovascular Diseases; Chronic Disease; Clinica

2008
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
    Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chronic Disease; Disease Progression; Genetic Therap

2008
From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases.
    BMC pulmonary medicine, 2009, Jan-29, Volume: 9

    Topics: Arginine; Biomarkers; Chronic Disease; Humans; Lung Diseases; Methylation; Protein Processing, Post-

2009
Nitric oxide synthase derangements and hypertension in kidney disease.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Disease Progression; Humans; Hypertension; Kidn

2012
Biomarkers in chronic kidney disease: utility and issues towards better understanding.
    Current opinion in nephrology and hypertension, 2005, Volume: 14, Issue:6

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Chronic Disease; Disease Progression; Glomerular

2005
Arginine, arginine analogs and nitric oxide production in chronic kidney disease.
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:4

    Topics: Absorption; Amidohydrolases; Arginine; Biological Availability; Cardiovascular Diseases; Chronic Dis

2006
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
    Clinical and experimental nephrology, 2007, Volume: 11, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases;

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Nitric oxide deficiency in chronic kidney disease.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:1

    Topics: Arginine; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase

2008
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:2

    Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidn

2008

Trials

7 trials available for n(g),n(g')-dimethyl-l-arginine and Chronic Disease

ArticleYear
The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.
    Scientific reports, 2020, 06-02, Volume: 10, Issue:1

    Topics: Adult; Aged; Antioxidants; Arginine; Atherosclerosis; C-Reactive Protein; Chronic Disease; Dietary S

2020
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 53, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Doub

2009
Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2010, Volume: 20, Issue:5

    Topics: Aged; Arginine; Chronic Disease; Endothelium, Vascular; Female; Heart Failure; Hemodynamics; Humans;

2010
Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2011, Volume: 18, Issue:4

    Topics: Aged; Analysis of Variance; Arginine; Biomarkers; Chronic Disease; Endothelium, Vascular; Exercise T

2011
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:11

    Topics: Adult; Aged; alpha-Tocopherol; Antioxidants; Arginine; Chronic Disease; Female; Humans; Kidney; Kidn

2003
Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study.
    Advances in skin & wound care, 2007, Volume: 20, Issue:7

    Topics: Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Diabetes Mellitus, Type 1; Diabetes

2007
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5

    Topics: Aged; Aged, 80 and over; Alprostadil; Arginine; Arterial Occlusive Diseases; Blood Flow Velocity; Ch

1998

Other Studies

32 other studies available for n(g),n(g')-dimethyl-l-arginine and Chronic Disease

ArticleYear
Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.
    Nutrients, 2021, Nov-17, Volume: 13, Issue:11

    Topics: Adult; Arginine; Asthma; Bronchi; Case-Control Studies; Cell Culture Techniques; Chronic Disease; Ci

2021
Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication.
    Acta biochimica Polonica, 2021, Feb-05, Volume: 68, Issue:1

    Topics: Adult; Aged; Arginine; Atherosclerosis; Carotid Artery, Internal; Carotid Intima-Media Thickness; Ca

2021
Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy.
    Heart, lung & circulation, 2022, Volume: 31, Issue:1

    Topics: Arginine; Chronic Disease; Endarterectomy; Humans; Hypertension, Pulmonary

2022
Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study.
    Psychosomatic medicine, 2013, Volume: 75, Issue:8

    Topics: Acute Disease; Adult; Arginine; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory;

2013
Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia.
    Journal of atherosclerosis and thrombosis, 2014, Volume: 21, Issue:7

    Topics: Aged; Arginine; Biomarkers; Chemokine CCL2; Chromatography, High Pressure Liquid; Chronic Disease; D

2014
Association of homoarginine and methylarginines with liver dysfunction and mortality in chronic liver disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adult; Aged; Arginine; Chronic Disease; Disease-Free Survival; Female; Follow-Up Studies; Homoargini

2015
Endothelin 1, ADMA and SDMA in pregnancies with obstetric and thrombotic antiphospholipid syndrome.
    Journal of reproductive immunology, 2016, Volume: 116

    Topics: Adult; Antiphospholipid Syndrome; Arginine; Chronic Disease; Endothelin-1; Endothelium, Vascular; Fe

2016
Coronary artery calcification, ADMA, and insulin resistance in CKD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:5

    Topics: Aged; Arginine; Calcinosis; Case-Control Studies; Chronic Disease; Coronary Angiography; Coronary Ar

2008
Relationship between serum pre-B cell colony-enhancing factor/visfatin and atherosclerotic parameters in chronic hemodialysis patients.
    American journal of nephrology, 2009, Volume: 29, Issue:1

    Topics: Aged; Aorta; Arginine; Arteries; Atherosclerosis; B-Lymphocytes; Body Mass Index; C-Reactive Protein

2009
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:3

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Female; Humans; Infan

2009
The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects.
    Atherosclerosis, 2010, Volume: 208, Issue:1

    Topics: Arginine; Chronic Disease; Cross-Sectional Studies; Female; Humans; Hypertension; Inflammation; Male

2010
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:8

    Topics: Adult; Aged; Angiopoietin-2; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Ch

2010
Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Chronic Disease; Diabetic Nephropat

2010
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4

    Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flui

2011
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.
    Kidney international, 2010, Volume: 78, Issue:7

    Topics: Adult; Arginine; Chronic Disease; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fo

2010
Do sea stars have low ADMA levels? High ADMA and low EPC count--duo infernal for the kidney.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Animals; Arginine; Cell Count; Chronic Disease; Endothelial Cells; Glomerular Filtration Rate; Human

2010
Association of asymmetric dimethylarginine with severity of kidney injury and decline in kidney function in IgA nephropathy.
    American journal of nephrology, 2011, Volume: 33, Issue:1

    Topics: Adult; Arginine; Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Female; Glomerular

2011
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
    Atherosclerosis, 2011, Volume: 216, Issue:1

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; C-Reactive Prote

2011
Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:10

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Arginine; Belgium; Biomarkers; Case-Control Studies; Cell L

2011
Sympathetic nerve traffic and asymmetric dimethylarginine in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chronic Disease; Cross-Sectional Studies; Disease Pro

2011
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
    Circulation, 2003, Sep-23, Volume: 108, Issue:12

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzy

2003
High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level.
    Heart and vessels, 2003, Volume: 18, Issue:4

    Topics: Acute Disease; Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Cytokines; Enzyme In

2003
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
    Vascular medicine (London, England), 2004, Volume: 9, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Chronic Disease; Endothelium,

2004
The transplanted liver graft is capable of clearing asymmetric dimethylarginine.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2004, Volume: 10, Issue:12

    Topics: Acute Disease; Arginine; Biomarkers; Case-Control Studies; Chronic Disease; Graft Rejection; Humans;

2004
The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:1

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chronic Disease; Copper; Endothelium, Vas

2006
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease.
    Kidney international, 2006, Volume: 70, Issue:4

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Chronic Disease; Disease Prog

2006
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Pr

2007
A new perspective for the treatment of renal diseases?
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Chronic Disease; Humans; Kidney Diseases; Nitric

2007
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2007, Dec-01, Volume: 176, Issue:11

    Topics: Aged; Arginine; Chronic Disease; Endothelial Cells; Enzyme Inhibitors; Female; Humans; Hypertension,

2007
ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction.
    Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:2

    Topics: Adult; Amyloidosis; Arginine; Chronic Disease; Endothelium; Female; Glomerulonephritis; Humans; Male

2008
Asymmetrical dimethylarginine level in atrial fibrillation.
    Acta cardiologica, 2008, Volume: 63, Issue:1

    Topics: Acute Disease; Arginine; Atrial Fibrillation; Chromatography, High Pressure Liquid; Chronic Disease;

2008
Regulation of nitric oxide synthesis in uraemia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1995, Volume: 10, Issue:8

    Topics: Analysis of Variance; Animals; Arginine; Chronic Disease; Dialysis Solutions; Endothelium, Vascular;

1995