Compounds > n(g),n(g')-dimethyl-l-arginine
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n(g),n(g')-dimethyl-l-arginine and Cardiovascular Diseases

n(g),n(g')-dimethyl-l-arginine has been researched along with Cardiovascular Diseases in 279 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
" ADMA, homocysteine, high sensitive C-reactive protein (hs-CRP) and homeostasis model assessment estimate of insulin resistance (HOMA-IR) were investigated."9.15Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment. ( Aydin, M; Batioglu, S; Erdogan, G; Kilic, S; Yilmaz, N; Zulfikaroglu, E, 2011)
"Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke."8.82ADMA and hyperhomocysteinemia. ( Dayal, S; Lentz, SR, 2005)
"Elevated plasma levels of asymmetric dimethylarginine (ADMA) have been reported to be associated with endothelial dysfunction, inflammation, and oxidative stress in multiple cardiovascular diseases."7.79Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram. ( Chang, SL; Chao, TF; Chen, SA; Hsieh, MH; Hu, YF; Lin, YJ; Lo, LW; Lu, TM; Tsao, HM; Tuan, TC, 2013)
"Endothelial dysfunction as assessed by asymmetric dimethylarginine (ADMA) and inflammation has been consistently linked to atherosclerosis, death, and cardiovascular (CV) events in ESRD patients."7.77Inflammation and asymmetric dimethylarginine for predicting death and cardiovascular events in ESRD patients. ( Boger, R; Maas, R; Malatino, L; Mallamaci, F; Mattace Raso, F; Rapisarda, F; Seck, MS; Sijbrands, E; Tripepi, G; Witteman, J; Zoccali, C, 2011)
"To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters."7.77Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome. ( Engin-Üstün, Y; Kafkasli, A; Kali, Z; Karabulut, AB; Meydanli, M; Turan, F; Türkçüoğlu, I, 2011)
"Homocysteine (Hcy) and asymmetric dimethylarginine (ADMA) recently were recognized as potential risk factors for atherosclerosis in the general population, and the metabolism of each of these substances seems to be closely related."7.73Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients. ( Hishida, A; Ikegaya, N; Kato, A; Kumagai, H; Maruyama, Y; Sakurai, M; Takita, T; Uno, S, 2006)
" Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) diabetes mellitus."6.41Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome? ( Chan, JC; Chan, NN, 2002)
"Global L-arginine bioavailability was diminished, whereas plasma arginase activity, ADMA, and SDMA levels were elevated, in patients with RA compared with healthy control subjects."5.48Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis. ( Chandrasekharan, UM; Elaine Husni, M; Hazen, SL; Wang, S; Wang, Z; Wilson Tang, WH; Wu, Y, 2018)
"Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis causing endothelial dysfunction, an early sign of atherogenesis."5.37Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease. ( Atzler, D; Benndorf, RA; Böger, RH; Darius, H; Diehm, C; Endres, HG; Lüneburg, N; Maas, R; Schwedhelm, E; Thiem, U; von Stritzky, B, 2011)
"Erectile dysfunction is related to penile arterial endothelial nitric oxide production."5.33Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. ( Jackson, G; Lambert-Hammill, M; Lumb, PJ; Lyttle, K; Solomon, H; Wierzbicki, AS, 2006)
"Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered a risk factor for the pathogenesis of cardiovascular diseases."5.22Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase. ( Guo, BC; Hsu, CP; Lee, TS; Lin, SJ; Lu, TM; Shyue, SK; Zhao, JF, 2016)
" At Weeks 0 and 20, weight, markers of endothelial function [vascular cell adhesion molecule-1 (sVCAM-1), inter-cellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor-1 (PAI-1) and asymmetric dimethylarginine (ADMA)], insulin resistance and hormonal profile were assessed."5.16The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome. ( Brinkworth, GD; Buckley, JD; Clifton, PM; Noakes, M; Norman, RJ; Thomson, RL, 2012)
" ADMA, homocysteine, high sensitive C-reactive protein (hs-CRP) and homeostasis model assessment estimate of insulin resistance (HOMA-IR) were investigated."5.15Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment. ( Aydin, M; Batioglu, S; Erdogan, G; Kilic, S; Yilmaz, N; Zulfikaroglu, E, 2011)
"Coadministration of intravenous methylcobalamin and oral folate in hemodialysis patients normalized hyperhomocysteinemia and decreased ADMA levels and arterial stiffness."5.14Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis. ( Dohi, Y; Ito, A; Itoh, T; Kajikuri, J; Koyama, K; Kumagai, H; Nakamura, H; Nishio, T; Ohte, N; Sano, A; Yamamoto, J, 2010)
"Patients with essential hypertension (n = 24) were administered a low-salt diet (2 g NaCl/day), a high-salt diet (20-23 g) and then a low-salt diet for 7 days, and plasma levels of nitrate and nitrite (NOx) and asymmetric dimethylarginine (ADMA) were examined."5.10Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. ( Fujiwara, N; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H, 2002)
"Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of nitric oxide synthase with a key role in the pathophysiology of endothelial dysfunction, in the progression of atherosclerosis and in cardiovascular diseases."4.91Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches. ( Georgakis, MK; Latsios, G; Oikonomou, E; Papageorgiou, N; Papaioannou, S; Siasos, G; Tousoulis, D; Zaromitidou, M, 2015)
" High circulating levels of asymmetric dimethylarginine predict adverse outcomes, specifically vascular events but there is now increasing experimental and epidemiological evidence that these molecules, and the enzymes that regulate this pathway, play a mechanistic role in cardiovascular diseases."4.88Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators? ( Caplin, B; Leiper, J, 2012)
" Moreover, homocysteine, advanced glycation end products, asymmetric dimethylarginine, and anemia may play a role in the development and progression of atherosclerosis in patients with diabetic nephropathy."4.84Cardiovascular disease in patients with diabetic nephropathy. ( Aso, Y, 2008)
"Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke."4.82ADMA and hyperhomocysteinemia. ( Dayal, S; Lentz, SR, 2005)
"We review the role inflammation [C-reactive protein (CRP)], hyperhomocysteinemia, high plasma norepinephrine, and accumulation of the endogenous inhibitor of the nitric oxide synthase asymmetric dimethylarginine (ADMA) in the high all-cause and CV mortality of patients on continuous ambulatory peritoneal dialysis (CAPD)."4.82Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients. ( Enia, G; Mallamaci, F; Panuccio, V; Tripepi, G; Zoccali, C, 2005)
" Here, we summarize some molecular mechanisms leading from hyperhomocysteinemia, elevated asymmetric dimethylarginine (ADMA) and advanced glycation end products (AGEs)-modified proteins to atherogenic endothelial phenotype and offer a model of endothelial dysfunction based on the interconnectedness of diverse functions."4.82Endothelial cell dysfunction: the syndrome in making. ( Brodsky, SV; Chen, J; Goligorsky, MS; Li, H; O'Riordan, E; Smirnova, I, 2005)
"Asymmetric dimethylguanidino valeric acid (ADGV), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are three arginine metabolites which have utility in the assessment of cardiovascular disease, renal disease and non-alcoholic fatty liver disease (NAFLD)."4.12Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma. ( Bonnitcha, P; Fitzpatrick, M; Ireland, A; Koay, YC; Nguyen, VL; O'Sullivan, J; Sullivan, D, 2022)
"The study included 53 men, 20 with hypertension (HTN), 18 with HTN and related diseases, 15 healthy controls Apart from general testing (BMI, biochemical analysis, SBP, DBP), we used the Griess reaction to assess the total amount of nitric oxide (NO), and used ELISA to verify the concentrations of malondialdehyde (MDA), nitrotyrosine (NT), asymmetric dimethylarginine (ADMA), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein 1 (MCP-1), and myeloperoxidase (MPO)."4.02Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension. ( Charkiewicz, AE; Garley, M; Jabłońska, E; Maślach, D; Nowak, K; Omeljaniuk, WJ; Ratajczak-Wrona, W, 2021)
" The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and highsensitivity C-reactive protein (hs-CRP) levels were measured."3.88Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome. ( Aydogdu, A; Azal, O; Basaran, Y; Demir, O; Demirci, I; Dinc, M; Haymana, C; Meric, C; Sonmez, A; Torun, D; Yesildal, F, 2018)
"Targeted and untargeted metabolomics were used to investigate the effect of COX-2 deletion or inhibition in mice and in osteoarthritis patients exposed to nonsteroidal anti-inflammatory drugs on the l-arginine/nitric oxide pathway."3.88Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs. ( Briggs, WTE; Castro, C; FitzGerald, GA; Griffin, JL; Karlson, EW; Lahens, NF; Li, X; Malik, D; Meng, H; Rhoades, SD; Ricciotti, E; Sparks, JA; Tang, SY; Weljie, AM; West, JA, 2018)
"The leukocyte-derived myeloperoxidase (MPO), the nitric oxidase synthase (NOS) inhibitor asymmetrical dimethyl-arginine (ADMA) and the renin-angiotensin-aldosterone-system (RAAS) are associated with cardiovascular diseases (CVD)."3.85Myeloperoxidase, asymmetric dimethyl-arginine and the renin-angiotensin-aldosterone-system in cardiovascular risk patients: Cross-sectional findings from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. ( Enko, D; März, W; Meinitzer, A; Pilz, S; Tomaschitz, A; Zelzer, S, 2017)
" We hypothesized that soluble receptor for advanced glycation end products (sRAGE) and asymmetric dimethyl arginine (ADMA) can correlate with carotid intima-media thickness (cIMT), a known index of subclinical atherosclerosis."3.83Soluble receptor and gene polymorphism for AGE: relationship with obesity and cardiovascular risks. ( Aly, H; El Melegy, S; El Shikh, T; El-Batch, M; Rowisha, M, 2016)
"Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases."3.83Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2. ( Bode-Böger, SM; Bornstein, SR; Brilloff, S; Brocker, C; Burdin, DV; Demyanov, AV; Gonzalez, F; Jarzebska, N; Kolobov, AA; Maas, R; Martens-Lobenhoffer, J; Mieth, M; Rodionov, RN; Samusik, N; Soshnev, AA; Weiss, N, 2016)
"In a prospective cohort study of 204 subjects (mean age 63±6 at study entry), we evaluated the effects of 4 years of aging on parameters of NO generation and effect, including platelet aggregability and responsiveness to NO, and plasma concentrations of the NO synthase inhibitor, asymmetric dimethylarginine (ADMA)."3.80Aging of the nitric oxide system: are we as old as our NO? ( Chan, WP; Chirkov, YY; Horowitz, JD; Ngo, DT; Sverdlov, AL, 2014)
"Elevated plasma levels of asymmetric dimethylarginine (ADMA) have been reported to be associated with endothelial dysfunction, inflammation, and oxidative stress in multiple cardiovascular diseases."3.79Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram. ( Chang, SL; Chao, TF; Chen, SA; Hsieh, MH; Hu, YF; Lin, YJ; Lo, LW; Lu, TM; Tsao, HM; Tuan, TC, 2013)
" Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing vascular tone regulation."3.78Ethnicity-specific differences in L-arginine status in South African men. ( Anderssohn, M; Böger, RH; Fourie, CM; Glyn, MC; Huisman, HW; Lüneburg, N; Malan, L; Malan, NT; Mels, CM; Schutte, AE; Schutte, R; Smith, W; Van Rooyen, JM, 2012)
" The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown."3.78Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome. ( Clifton, PM; Moran, LJ; Noakes, M; Norman, RJ; Wittert, GA, 2012)
"To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters."3.77Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome. ( Engin-Üstün, Y; Kafkasli, A; Kali, Z; Karabulut, AB; Meydanli, M; Turan, F; Türkçüoğlu, I, 2011)
"The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases."3.77Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. ( Atzler, D; Baldus, S; Blankenberg, S; Böger, RH; D'Alecy, LG; Ehmke, H; Gadegbeku, CA; Hellwinkel, O; Kielstein, JT; Klinke, A; Kubala, L; Lau, D; Lund, N; Maas, R; Meinertz, T; Pekarova, M; Schmidt-Haupt, R; Schwedhelm, E; Slocum, JL; Sydow, K; Tsikas, D; von Leitner, EC; Willems, S, 2011)
"Although asymmetric dimethylarginine (ADMA) is known to be involved in the developing process of cardiovascular diseases (CVD), little is known about the effects of ADMA on atherosclerosis in Asian patients with diabetes, who have the racial feature of lower body mass index (BMI) and decreased capacity of insulin secretion and sensitivity."3.77Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus. ( Kanazawa, I; Nabika, T; Notsu, Y; Sugimoto, T; Yamaguchi, T; Yano, S, 2011)
"Elevated plasma levels of asymmetric dimethylarginine (ADMA) has been reported to be associated with insulin resistance and micro/macrovascular diabetic complications, and may predict cardiovascular events in type 2 diabetic patients."3.77The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study. ( Chung, MY; Hsu, CP; Lin, MW; Lin, SJ; Lu, TM, 2011)
"Endothelial dysfunction as assessed by asymmetric dimethylarginine (ADMA) and inflammation has been consistently linked to atherosclerosis, death, and cardiovascular (CV) events in ESRD patients."3.77Inflammation and asymmetric dimethylarginine for predicting death and cardiovascular events in ESRD patients. ( Boger, R; Maas, R; Malatino, L; Mallamaci, F; Mattace Raso, F; Rapisarda, F; Seck, MS; Sijbrands, E; Tripepi, G; Witteman, J; Zoccali, C, 2011)
"Adipokines such as leptin and adiponectin are adipocyte-specific secretory proteins that play important roles in the metabolic regulation of body weight, insulin resistance and cardiovascular complications."3.76Adipokines, endothelial dysfunction and nutritional status in peritoneal dialysis patients. ( Aleksandrowicz-Wrona, E; Lichodziejewska-Niemierko, M; Małgorzewicz, S; Rutkowski, B; Świetlik, D; Łysiak-Szydłowska, W, 2010)
"We compared plasma markers of endothelial dysfunction, asymmetric dimethylarginine (ADMA) and endothelin-1 (ET-1), and atherosclerosis progression (soluble fraction of the CD40 ligand, sCD40L) in OSAS patients with (n = 23) and without (n = 18) concurrent CV risk factors, as well as in healthy subjects (n = 23)."3.75Increased plasma levels of asymmetric dimethylarginine and soluble CD40 ligand in patients with sleep apnea. ( Agustí, AG; Alonso, A; Ayllón, O; Barceló, A; de la Peña, M; González, C; Pérez, G; Piérola, J; Vega-Agapito, MV, 2009)
"We examine the relationship of related posttranslational modification products of arginine methylation and coronary artery disease (CAD) phenotypes."3.75Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. ( Brennan, DM; Cho, L; Hazen, SL; Tang, WH; Wang, Z, 2009)
"This study was performed to test whether plasma asymmetric dimethylarginine (ADMA) concentrations are related to obesity and obesity complications including decrement in insulin sensitivity and adiponectin levels, dyslipidemia and low-grade inflammation."3.74Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease. ( Bekpinar, S; Can, A; Cetinalp-Demircan, P; Orhan, Y; Unlucerci, Y, 2007)
"Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis."3.73Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. ( Anthony, S; Hubank, M; Leiper, JM; Smith, CL; Vallance, P, 2005)
"In a cohort of 246 dialysis patients without heart failure at baseline we tested the combined prognostic power of three well-established biomarkers: brain natriuretic peptide (BNP), C-reactive protein (CRP), and asymmetric dimethyl arginine (ADMA)."3.73Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD. ( Cutrupi, S; Malatino, LS; Mallamaci, F; Tripepi, G; Zoccali, C, 2005)
"Homocysteine (Hcy) and asymmetric dimethylarginine (ADMA) recently were recognized as potential risk factors for atherosclerosis in the general population, and the metabolism of each of these substances seems to be closely related."3.73Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients. ( Hishida, A; Ikegaya, N; Kato, A; Kumagai, H; Maruyama, Y; Sakurai, M; Takita, T; Uno, S, 2006)
"Rosiglitazone (4 mg/d for 4 weeks and then 4 mg twice daily for 8 weeks), an insulin-sensitizing agent, was given to 7 insulin-resistant subjects with hypertension."3.71Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. ( Abbasi, F; Chu, JW; Cooke, JP; Lamendola, C; McLaughlin, TL; Reaven, GM; Stühlinger, MC; Tsao, PS, 2002)
"Since women with gestational diabetes mellitus (GDM) are at high risk of future CVD, we conducted a systematic review and meta-analysis to compare ADMA concentrations between women with and without GDM during pregnancy and postpartum."3.01Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis. ( Andraweera, PH; Arstall, MA; Kosmider, L; Lassi, ZS; Tiong, P, 2023)
"Treatment with febuxostat resulted in a significant decrease in the serum ADMA level from 1."2.84Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study. ( Alshahawey, M; Elsaid, TW; Sabri, NA; Shahin, SM, 2017)
"In study II, 41 patients with type 2 diabetes and mild hyperhomocysteinaemia were analysed after 6 months treatment with 5 mg of folic acid or placebo."2.72No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk. ( Brouwer, CB; Rauwerda, JA; Smulders, YM; Spoelstra-de Man, AM; Stehouwer, CD; Teerlink, T, 2006)
" Part of this effect is ascribed to increased production or bioavailability of nitric oxide (NO)."2.71Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women. ( de Jong, S; Neele, SJ; Netelenbos, JC; Stehouwer, CD; Teerlink, T, 2003)
" NO bioavailability indicates the production and utilization of endothelial NO in organisms, its decrease is related to oxidative stress, lipid infiltration, the expressions of some inflammatory factors and the alteration of vascular tone, which plays an important role in endothelial dysfunction."2.58Nitric oxide bioavailability dysfunction involves in atherosclerosis. ( Chang, J; Chen, JY; Hong, FF; Wang, XF; Yang, MW; Yang, SL; Ye, ZX; Zhong, HH, 2018)
"Low and high birth weights have been linked to increased susceptibility to cardiovascular and metabolic alterations."2.50Is asymmetric dimethylarginine associated with being born small and large for gestational age? ( Chiarelli, F; Chiavaroli, V; de Giorgis, T; Diesse, L; Giannini, C; Marcovecchio, ML; Mohn, A, 2014)
" Nebivolol and carvedilol preserve NOS activity by reducing asymmetrical dimethylarginine (AMDA) and enhance the bioavailability of nitric oxide (NO) because of their antioxidant properties."2.49Beta blockers, nitric oxide, and cardiovascular disease. ( Gao, Y; Vanhoutte, PM, 2013)
"Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD)."2.44Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. ( Fukami, K; Matsumoto, Y; Okuda, S; Ueda, S; Yamagishi, SI, 2007)
" It is well established that a decreased bioavailability of nitric oxide (NO) contributes to endothelial dysfunction."2.43Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. ( Cooke, JP; Mondon, CE; Sydow, K, 2005)
"Hyperhomocysteinemia is an emerging risk factor for cardiovascular disease and stroke."2.42Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. ( Dayal, S; Lentz, SR; Rodionov, RN, 2003)
" Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) diabetes mellitus."2.41Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome? ( Chan, JC; Chan, NN, 2002)
"This case-cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1."1.91Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. ( Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X, 2023)
" Wound character seems to affect NO bioavailability and wound etiology-arginine bioavailability."1.51Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS). ( Bednarz-Misa, I; Bronowicka-Szydełko, A; Fleszar, MG; Gacka, M; Gamian, A; Kędzior, K; Krzystek-Korpacka, M; Masłowski, L; Wiśniewski, J; Witkiewicz, W, 2019)
"HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk."1.48Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction. ( Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J, 2018)
"Global L-arginine bioavailability was diminished, whereas plasma arginase activity, ADMA, and SDMA levels were elevated, in patients with RA compared with healthy control subjects."1.48Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis. ( Chandrasekharan, UM; Elaine Husni, M; Hazen, SL; Wang, S; Wang, Z; Wilson Tang, WH; Wu, Y, 2018)
"Since the diagnosis of gestational diabetes mellitus (GDM) identifies a patient population at increased future risk of cardiovascular disease later in life, we sought to characterize arginine metabolism in women with and without a history of recent GDM."1.46Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes. ( Arya, S; Connelly, PW; Hanley, AJ; Retnakaran, R; Sermer, M; Ye, C; Zinman, B, 2017)
"Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease."1.46Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population. ( Choi, HR; Jeon, DH; Kim, HC; Lee, SW; Yeom, H; Youm, Y, 2017)
"Patients with type I diabetes mellitus (T1DM) have increased incidence of atherosclerosis and cardiovascular disease."1.46Osteoprotegerin, RANKL, ADMA, and Fetuin-A serum levels in children with type I diabetes mellitus. ( Chrysis, D; Efthymiadou, A; Kritikou, D; Mermigka, A; Spiliotis, BE, 2017)
"Participants with COPD (N = 41) and controls (N = 35) did not differ in terms of AIx (30 vs 28."1.46Relationship between FEV ( Antonelli-Incalzi, R; Battistoni, F; Chiurco, D; Costanzo, L; Pedone, C; Santangelo, S, 2017)
"Childhood acute lymphoblastic leukemia (ALL) survivors are at higher cardiovascular risk than the general population, which may result from anthracycline-related endothelial dysfunction (ED)."1.43Elevated plasma ADMA contributes to development of endothelial dysfunction in children with acute lymphoblastic leukemia. ( Chybicka, A; Doroszko, A; Jakubowski, M; Mazur, G; Niedzielska, E; Porwolik, J; Szahidewicz-Krupska, E; Szuba, A; Turek-Jakubowska, A, 2016)
"L-Homoarginine (hArg) has recently emerged as a novel cardiovascular risk factor and to herald a poor prognosis in heart failure patients."1.40GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples. ( Beckmann, B; Gutzki, FM; Jordan, J; Kayacelebi, AA; Tsikas, D, 2014)
"Hypothyroidism is associated with increased oxidative stress."1.39Association of lipid peroxidation with endothelial dysfunction in patients with overt hypothyroidism. ( Bitla, AR; Reddy, VS; Sachan, A; Srinivas Rao, PV; Suchitra, MM; Suresh, V; Tejovathi, B, 2013)
"ADMA is elevated in adult childhood ALL survivors, which can reflect late detrimental chemotherapy effects, partially related to minor lipid profile changes."1.38Elevated asymmetric dimethylarginine in young adult survivors of childhood acute lymphoblastic leukemia: a preliminary report. ( Balwierz, W; Ćwiklińska, M; Grodzicki, TK; Gryglewska, B; Kwater, A; Strach, M; Sulicka, J; Surdacki, A, 2012)
"Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis causing endothelial dysfunction, an early sign of atherogenesis."1.37Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease. ( Atzler, D; Benndorf, RA; Böger, RH; Darius, H; Diehm, C; Endres, HG; Lüneburg, N; Maas, R; Schwedhelm, E; Thiem, U; von Stritzky, B, 2011)
"Obesity is associated with vascular dysfunction."1.37Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity. ( Drexel, V; Emslander, I; Halle, M; Hanssen, H; Hertel, G; Kotliar, KE; Lorang, D; Nickel, T; Pressler, A; Schmidt-Trucksäss, A; Schuster, T; Sisic, Z; Weis, M, 2011)
"Obesity is associated with an increased risk of developing insulin resistance, hyperinsulinemia, glucose intolerance, dyslipidemia, hypertension, premature atherosclerosis, and coronary artery disease."1.36Serum asymmetric dimethylarginine levels in normotensive obese individuals. ( Ayhan, S; Demir, K; Erdem, S; Karabag, T; Kaya, A; Kaya, C; Koc, F; Tokac, M; Unlu, A; Vatankulu, MA, 2010)
"In the multivariate analysis dyslipidemia, left ventricular hypertrophy, age and LDL-c (negatively) were associated with CVD."1.36[Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors]. ( Azqueta, M; Cases, A; Coll, E; Collado, S; Cruzado, JM; de la Torre, B; Deulofeu, R; Guerrero, L; Nicolau, C; Pons, M; Vera, M, 2010)
"Asymmetric dimethylarginine (ADMA) has been suggested as a possible marker of endothelial dysfunction, and interest in its use in clinical practice is increasing."1.36HPLC determination of plasma dimethylarginines: method validation and preliminary clinical application. ( Artusi, C; Boffa, GM; Ivanova, M; Plebani, M; Zaninotto, M, 2010)
"Aortic sclerosis is associated with platelet NO resistance rather than conventional coronary risk factors: this might explain the increased thrombotic risk in ASc."1.35Determinants of occurrence of aortic sclerosis in an aging population. ( Chirkov, YY; Horowitz, JD; McNeil, JJ; Ngo, DT; Nightingale, AK; Sverdlov, AL; Willoughby, SR, 2009)
"Asymmetric dimethylarginine (ADMA) has raised considerable interest, as it is an endogenous inhibitor of nitric oxide synthesis."1.35Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population. ( Egger, G; Holt, DW; Kiechl, S; Lee, T; Mayr, M; Santer, P; Thompson, G; Tsimikas, S; Willeit, J; Xu, Q, 2009)
" Among patients with ischemic heart disease, low progenitor cell bioavailability and kidney dysfunction are emerging as strong predictors of death and recurrent cardiovascular events."1.35Asymmetric dimethylarginine and impaired cardiovascular healing. ( Andreotti, F; Coluzzi, G; Marzo, F; Santucci, E, 2009)
"Methionine is an essential amino acid and methyl donor for most transmethylation reactions in mammals."1.35Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats. ( Boeger, RH; Deussen, A; Henle, T; Pexa, A; Schwedhelm, E, 2008)
" We aimed to investigate elevated plasma ADMA concentrations as a prospective risk marker for adverse events in patients undergoing noncardiac surgery."1.34Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery. ( Böger, RH; Dentz, L; Haddad, M; Hiltmeyer, N; Klöss, T; Kuss, O; Maas, R; Schwedhelm, E; Standl, T; Thoms, W, 2007)
"Erectile dysfunction is related to penile arterial endothelial nitric oxide production."1.33Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. ( Jackson, G; Lambert-Hammill, M; Lumb, PJ; Lyttle, K; Solomon, H; Wierzbicki, AS, 2006)
"Asymmetric dimethylarginine (ADMA) is an emerging cardiovascular risk factor."1.32High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde. ( Bonfigli, AR; Coppa, G; Gambini, A; Marra, M; Testa, I; Testa, R, 2003)
"In end-stage renal disease (ESRD), Framingham risk factors do not fully explain the cardiovascular burden of these patients."1.31Endothelial damage, asymmetric dimethylarginine and cardiovascular risk in end-stage renal disease. ( Zoccali, C, 2002)

Research

Studies (279)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's112 (40.14)29.6817
2010's152 (54.48)24.3611
2020's15 (5.38)2.80

Authors

AuthorsStudies
Bonnitcha, P1
Sullivan, D1
Fitzpatrick, M1
Ireland, A1
Nguyen, VL1
Koay, YC1
O'Sullivan, J1
Wołoszyk-Chojecka, P1
Malgorzewicz, S1
Chamienia, A1
Puchalska-Reglińska, E1
Dębska-Ślizień, A2
Tiong, P3
Kosmider, L3
Lassi, ZS3
Arstall, MA3
Andraweera, PH3
Schrauben, SJ1
Sapa, H1
Xie, D1
Zhang, X1
Anderson, AH1
Shlipak, MG1
Hsu, CY1
Shafi, T2
Mehta, R1
Bhat, Z1
Brown, J1
Charleston, J1
Chen, J3
He, J1
Ix, JH1
Rao, P1
Townsend, R1
Kimmel, PL1
Vasan, RS3
Feldman, HI1
Seegmiller, JC1
Brunengraber, H1
Hostetter, TH2
Schelling, JR1
Al-Abdulla, N1
Bakhsh, A1
Mannocci, F1
Proctor, G1
Moyes, D1
Niazi, SA1
Krzystek-Korpacka, M1
Wiśniewski, J1
Fleszar, MG1
Bednarz-Misa, I1
Bronowicka-Szydełko, A1
Gacka, M1
Masłowski, L1
Kędzior, K1
Witkiewicz, W1
Gamian, A1
Jarzebska, N2
Mangoni, AA5
Martens-Lobenhoffer, J5
Bode-Böger, SM7
Rodionov, RN5
Hu, W1
Wang, W1
Ma, Q1
Liu, T1
Zhang, J2
Gać, P1
Poręba, M1
Jurdziak, M1
Trzmielewska, E1
Gocławska, K1
Derkacz, A1
Mazur, G2
Szuba, A3
Poręba, R1
Gawrys, J1
Gajecki, D1
Szahidewicz-Krupska, E2
Doroszko, A2
Ashokachakkaravarthy, K1
Rajappa, M1
Parameswaran, S1
Satheesh, S1
Priyadarshini, G1
Mohan Raj, PS1
Revathy, G1
Priyadarssini, M1
Ochoa-Martínez, ÁC4
Orta-García, ST2
Varela-Silva, JA1
Pérez-Maldonado, IN4
Du, Q1
Gao, J1
Lu, R1
Jin, Y1
Zou, Y1
Yu, C1
Yan, Y1
Dragičević, M1
Košuta, I1
Kruezi, E1
Lovrenčić, MV1
Mrzljak, A1
Post, A1
Bollenbach, A2
Bakker, SJL2
Tsikas, D4
Charkiewicz, AE1
Garley, M1
Ratajczak-Wrona, W1
Nowak, K1
Jabłońska, E1
Maślach, D1
Omeljaniuk, WJ1
Zhang, H1
Xiang, S1
Dai, Z1
Fan, Y1
Zelzer, S1
Enko, D1
Pilz, S2
Tomaschitz, A1
März, W4
Meinitzer, A6
Yu, E1
Ruiz-Canela, M1
Hu, FB1
Clish, CB1
Corella, D1
Salas-Salvadó, J1
Hruby, A1
Fitó, M1
Liang, L1
Toledo, E1
Ros, E1
Estruch, R1
Gómez-Gracia, E1
Lapetra, J1
Arós, F1
Romaguera, D1
Serra-Majem, L1
Guasch-Ferré, M1
Wang, DD1
Martínez-González, MA1
Hove-Skovsgaard, M2
Gaardbo, JC2
Kolte, L1
Winding, K1
Seljeflot, I3
Svardal, A1
Berge, RK1
Gerstoft, J3
Ullum, H2
Trøseid, M3
Nielsen, SD3
Arya, S1
Ye, C1
Connelly, PW1
Hanley, AJ1
Sermer, M1
Zinman, B1
Retnakaran, R1
Tain, YL2
Hsu, CN1
Alshahawey, M1
Shahin, SM1
Elsaid, TW1
Sabri, NA1
Venkatesh, R1
Srinivasan, K1
Singh, SA1
Tommasi, S1
Elliot, DJ1
Hulin, JA1
Lewis, BC1
McEvoy, M2
Choi, HR1
Lee, SW1
Yeom, H1
Jeon, DH1
Kim, HC1
Youm, Y1
Javn, SB1
Thomas, S1
Ramachandran, S1
Loganathan, S1
Sundari, M1
Mala, K1
Ruíz-Vera, T2
Almendarez-Reyna, CI2
Mels, CMC1
Schutte, AE2
Huisman, HW2
Smith, W2
Kruger, R1
van Rooyen, JM2
Schwedhelm, E17
Atzler, D9
Böger, RH27
Malan, NT3
Malan, L3
Hu, XL1
Li, MP1
Song, PY1
Tang, J1
Chen, XP1
Chen, JY1
Ye, ZX1
Wang, XF1
Chang, J1
Yang, MW1
Zhong, HH1
Hong, FF1
Yang, SL1
Emrich, IE1
Zawada, AM1
Fliser, D5
Wagenpfeil, S1
Heine, GH1
Cardona-Lozano, ED1
Carrizales-Yáñez, L2
Wang, F1
Xiong, R1
Feng, S1
Lu, X1
Li, H2
Wang, S2
Haymana, C2
Aydogdu, A1
Demirci, I1
Dinc, M1
Demir, O1
Torun, D1
Yesildal, F1
Meric, C1
Basaran, Y1
Sonmez, A3
Azal, O1
Triches, CB1
Mayer, S1
Quinto, BMR1
Batista, MC1
Zanella, MT1
Hoel, H1
Hov, JR1
Holm, K1
Kummen, M1
Rudi, K1
Nwosu, F1
Valeur, J1
Gelpi, M1
Ueland, PM1
Aukrust, P2
Chandrasekharan, UM1
Wang, Z3
Wu, Y1
Wilson Tang, WH1
Hazen, SL2
Elaine Husni, M1
Ricciotti, E1
Castro, C1
Tang, SY1
Briggs, WTE1
West, JA1
Malik, D1
Rhoades, SD1
Meng, H1
Li, X2
Lahens, NF1
Sparks, JA1
Karlson, EW1
Weljie, AM1
Griffin, JL1
FitzGerald, GA1
Jud, P1
Hafner, F1
Verheyen, N1
Gary, T1
Brodmann, M1
Seinost, G1
Hackl, G1
Wieczór, AM1
Wieczór, R1
Kulwas, A1
Rość, D1
Sheikh Rezaei, S1
Weisshaar, S1
Litschauer, B1
Gouya, G1
Ohrenberger, G1
Wolzt, M5
Zarazúa, S1
Małgorzewicz, S2
Heleniak, Z1
Lichodziejewska-Niemierko, M2
Rutkowski, R1
Aleksandrowicz-Wrona, E2
Takahashi, K2
Ueda, S3
Kobayashi, T1
Nishiyama, A1
Fujisawa, Y1
Sugaya, T1
Shiota, S1
Gohda, T1
Horikoshi, S1
Suzuki, Y1
Rodrigues-Krause, J1
Krause, M1
Rocha, IMGD1
Umpierre, D1
Fayh, APT1
Taghikhani, E1
Maas, R17
Fromm, MF3
König, J2
Said, MY1
Minović, I1
van Londen, M1
Frenay, AR1
de Borst, MH1
van den Berg, E1
Kayacelebi, AA2
van Goor, H1
Navis, G1
Dimitroulas, T4
Kitas, GD4
Oliva-Damaso, E1
Oliva-Damaso, N1
Rodriguez-Esparragon, F1
Payan, J1
Baamonde-Laborda, E1
Gonzalez-Cabrera, F1
Santana-Estupiñan, R1
Rodriguez-Perez, JC1
Gessner, A1
Mieth, M4
Auge, D2
Chafai, A1
Müller, F1
Linz, TH1
Lunte, SM1
Tejovathi, B1
Suchitra, MM1
Suresh, V1
Reddy, VS1
Sachan, A1
Srinivas Rao, PV1
Bitla, AR1
Bouras, G2
Deftereos, S2
Tousoulis, D4
Giannopoulos, G1
Chatzis, G1
Tsounis, D1
Cleman, MW1
Stefanadis, C4
Pizzarelli, F1
Dattolo, P1
Tripepi, G6
Michelassi, S1
D'Arrigo, G1
Bandinelli, S1
Ferrucci, L1
Zoccali, C14
Ignjatović, AM1
Cvetković, TP1
Pavlović, RM1
Đorđević, VM1
Milošević, ZG1
Đorđević, VB1
Pavlović, DD1
Stojanović, IR1
Bogdanović, D1
Witasp, A1
Rydén, M1
Carrero, JJ2
Qureshi, AR1
Nordfors, L1
Näslund, E1
Hammarqvist, F1
Arefin, S1
Kublickiene, K1
Stenvinkel, P2
Ghebremariam, YT2
LePendu, P1
Lee, JC1
Erlanson, DA1
Slaviero, A1
Shah, NH1
Leiper, J5
Cooke, JP11
Maeda, S1
Miyaki, A1
Kumagai, H3
Eto, M1
So, R1
Tanaka, K1
Ajisaka, R1
Chao, TF1
Lu, TM4
Lin, YJ1
Tsao, HM1
Chang, SL1
Lo, LW1
Hu, YF1
Tuan, TC1
Hsieh, MH1
Chen, SA1
Reimann, M2
Hamer, M1
Schlaich, MP1
Lambert, GW1
Ziemssen, T1
Boeger, RH2
Gore, MO1
Lüneburg, N4
Ayers, CR1
Anderssohn, M3
Khera, A1
de Lemos, JA1
Grant, PJ2
McGuire, DK1
Hudson, CL1
Zemlin, AE1
Ipp, H1
McLachlan, S1
Robertson, C1
Williamson, RM1
Strachan, MW1
Ajjan, R1
Price, JF1
Strauchmann, J1
Wallbach, M1
Bramlage, C1
Puls, M1
Konstantinides, S1
Mueller, GA1
Koziolek, MJ1
Chiavaroli, V1
Diesse, L1
de Giorgis, T1
Giannini, C1
Marcovecchio, ML2
Chiarelli, F1
Mohn, A1
Sandoo, A3
Smith, JP2
Abd El Dayem, SM1
Battah, AA1
El-Shehaby, A1
El Bohy, Ael M1
Baranyi, A1
Putz-Bankuti, C1
Stauber, R1
Kapfhammer, HP1
Rothenhäusler, HB1
Yousefi, B1
Faghfoori, Z1
Samadi, N1
Karami, H1
Ahmadi, Y1
Badalzadeh, R1
Shafiei-Irannejad, V1
Majidinia, M1
Ghavimi, H1
Jabbarpour, M1
Schepers, E1
Speer, T1
Kielstein, JT9
Wallaschofski, H1
Dörr, M1
Nauck, M2
Völker, U1
Kroemer, HK1
Völzke, H1
Friedrich, N2
Beckmann, B1
Gutzki, FM1
Jordan, J1
Ittermann, T1
Lattanzio, S1
Santilli, F1
Liani, R1
Vazzana, N1
Ueland, T1
Di Fulvio, P1
Formoso, G1
Consoli, A1
Davì, G1
Sverdlov, AL2
Ngo, DT2
Chan, WP1
Chirkov, YY2
Horowitz, JD2
Krebs, A1
Doerfer, J1
Grünert, SC1
Wöhrl, J1
Stier, B1
Schmidt-Trucksäss, A2
Lichte, K1
Winkler, K1
Grulich-Henn, J1
Holder, M1
Schwab, KO1
Hodson, J1
Douglas, KM1
Yilmaz, BA1
Caliskan, Y1
Yilmaz, A1
Ozkok, A1
Bilge, AK1
Deniz, G1
Sariyar, M1
Yildiz, A1
Pedersen, KK1
Manner, IW1
Kvale, D1
Os, I1
Alpoim, PN1
Sousa, LP1
Mota, AP1
Rios, DR1
Dusse, LM1
Ahmetaj-Shala, B1
Kirkby, NS1
Knowles, R1
Al'Yamani, M1
Mazi, S1
Tucker, AT1
Mackenzie, L1
Armstrong, PC1
Nüsing, RM1
Tomlinson, JA1
Warner, TD1
Mitchell, JA1
Yilmazer, B1
Sahin, T1
Unlu, BÖ1
Kir, HM1
Cefle, A1
Gremmel, T1
Perkmann, T1
Kopp, CW1
Seidinger, D1
Eichelberger, B1
Koppensteiner, R1
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Saglam, M3
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Kaneko, K1
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Tekinalp, M1
Akilli, H1
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Yildirim, S1
Gunduz, M1
Taner, A2
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Laukkanen, JA1
Chowdhury, S1
Gobin, R1
Mayr, M2
Di Angelantonio, E1
Chowdhury, R1
İn, E1
Özdemir, C1
Kaman, D1
Sökücü, SN1
Georgakis, MK1
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Papageorgiou, N2
Zaromitidou, M1
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Papaioannou, S1
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Johannsen, SS1
Zeller, T1
Ojeda, FM1
Wild, PS1
Sinning, CR1
Lackner, KJ2
Gori, T1
Blankenberg, S4
Münzel, T3
Schnabel, RB1
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Banderali, G1
Moretti, F1
Lassandro, C1
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Radaelli, G1
Salvatici, E1
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Rowisha, M1
El-Batch, M1
El Shikh, T1
El Melegy, S1
Aly, H1
Costanzo, L1
Pedone, C1
Battistoni, F1
Chiurco, D1
Santangelo, S1
Antonelli-Incalzi, R1
Kanbay, M1
Afsar, B1
Siriopol, D1
Gezer, M1
Verim, S1
Ortiz, A1
Johnson, RJ1
Covic, A1
Chrysis, D1
Efthymiadou, A1
Mermigka, A1
Kritikou, D1
Spiliotis, BE1
Hsu, CP3
Zhao, JF1
Lin, SJ3
Shyue, SK1
Guo, BC1
Lee, TS1
Niedzielska, E1
Jakubowski, M1
Porwolik, J1
Turek-Jakubowska, A1
Chybicka, A1
Ganz, T1
Wainstein, J1
Gilad, S1
Limor, R1
Boaz, M1
Stern, N1
Lao, MC1
Liu, LJ1
Luo, CF1
Lu, GH1
Zhai, YS1
Chen, XL1
Gao, XR1
Burdin, DV1
Kolobov, AA1
Brocker, C1
Soshnev, AA1
Samusik, N1
Demyanov, AV1
Brilloff, S1
Bornstein, SR1
Gonzalez, F1
Weiss, N1
Meyer, TW1
Hwang, S1
Hai, X1
Melamed, ML1
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Powe, NR1
Hirata, T1
Arai, Y1
Takayama, M1
Abe, Y1
Ohkuma, K1
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Nair, N1
Gongora, E1
El-Mesallamy, HO1
Abdel Hamid, SG1
Gad, MZ1
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Kähönen, M3
Lehtimäki, T2
Raitakari, OT4
Jula, A1
Viikari, J2
Alfthan, G3
Juonala, M3
Laaksonen, R4
Hutri-Kähönen, N2
Zsuga, J2
Thomopoulos, C1
Tsioufis, C1
Dimitriadis, K1
Tsiachris, D1
Manolis, A1
Alchanatis, M1
Kallikazaros, I1
Aso, Y1
Matsumoto, Y2
Kaida, Y1
Okuda, S2
Yamagishi, S1
Mittermayer, F4
Krzyzanowska, K4
Mora-Fernández, C1
Jarque, A1
Getino, MA1
Sánchez, R1
Lozano, L1
Navarro, JF1
Barceló, A2
de la Peña, M2
Ayllón, O2
Vega-Agapito, MV1
Piérola, J2
Pérez, G1
González, C1
Alonso, A2
Agustí, AG2
Yilmaz, MB1
Yontar, OC1
Schernthaner, G2
Vida, G1
Sulyok, E1
Lakatos, O1
Ertl, T1
Celik, T1
Iyisoy, A1
Yuksel, C1
Jata, B1
Kiechl, S1
Lee, T1
Santer, P1
Thompson, G1
Tsimikas, S1
Egger, G1
Holt, DW1
Willeit, J1
Xu, Q1
Mallamaci, F6
Sullivan, LM2
Wang, TJ1
Benjamin, EJ1
Schulze, F5
Xanthakis, V2
Benndorf, RA3
Wadham, C1
De Gennaro Colonna, V1
Bianchi, M1
Pascale, V1
Ferrario, P1
Morelli, F1
Pascale, W1
Tomasoni, L1
Turiel, M1
Ayer, JG1
Harmer, JA1
Nakhla, S1
Xuan, W1
Ng, MK1
Marks, GB1
Celermajer, DS1
Riederer, U1
Tang, WH1
Cho, L1
Brennan, DM1
Kurz, K1
Teerlink, T7
Sarcletti, M1
Weiss, G1
Zangerle, R1
Fuchs, D1
Willoughby, SR1
Nightingale, AK1
McNeil, JJ1
Pope, AJ2
Karuppiah, K1
Cardounel, AJ2
Luo, Z2
Palm, F2
Wilcox, CS3
Abedini, S1
Holme, I1
Weihrauch, G1
Fellstrøm, B1
Jardine, A1
Holdaas, H1
Sydow, K4
Fortmann, SP1
Fair, JM1
Varady, A1
Hlatky, MA1
Go, AS1
Iribarren, C1
Tsao, PS2
Blackwell, S1
David, S1
Kümpers, P1
Lukasz, A1
Kliem, V1
Haller, H2
Förstermann, U1
Jacobi, J1
Arend, M1
Cordasic, N1
Heusinger-Ribeiro, J1
Strobel, J2
Hilgers, KF1
O'Doherty, MG1
Gilchrist, SE1
Young, IS1
McKinley, MC1
Yarnell, JW1
Gey, KF1
Evans, A1
Skidmore, PM1
Woodside, JV1
Koyama, K1
Ito, A1
Yamamoto, J1
Nishio, T1
Kajikuri, J1
Dohi, Y1
Ohte, N1
Sano, A1
Nakamura, H1
Itoh, T1
Bacaksiz, A1
Vatankulu, MA2
Ayhan, SS1
Yazici, M1
Ulgen, MS1
Collado, S1
Coll, E1
Deulofeu, R1
Guerrero, L1
Pons, M1
Cruzado, JM1
de la Torre, B1
Vera, M1
Azqueta, M1
Nicolau, C1
Cases, A1
Ivanova, M1
Artusi, C1
Boffa, GM1
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Kressel, G1
Hülsmann, O1
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Kühn-Velten, WN1
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Stichtenoth, DO1
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Mlekusch, W1
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Minar, E1
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Halwachs-Baumann, G1
Podgórski, M1
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Franzini, L1
Valtueña, S1
Piatti, PM1
Pachinger, O1
Reaven, GM2
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Haddad, M1
Klöss, T1
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Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment (ASCENT)[NCT04765644]Phase 444 participants (Actual)Interventional2021-06-10Completed
The Prospective Cohort Study to Investigate the Role of Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio To Predict Cardiovascular Outcomes in Chronic Kidney Disease.[NCT02113462]197 participants (Actual)Observational2009-01-31Completed
Low Fat Vegan Diet or American Heart Association Diet, Impact on Biomarkers of Inflammation, Oxidative Stress and Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol: A Four Week Randomized Trial[NCT01817491]60 participants (Actual)Interventional2013-03-31Completed
Adiposity and Airway Inflammation in HIV-Associated Airway Disease[NCT02975258]102 participants (Actual)Observational2015-09-30Completed
The Effect of Dexamethasone Implant on Retinal Nerve Fiber and Optic Disc Morphology in Patients With Diabetic Maculopathy[NCT03927118]43 participants (Actual)Observational2018-02-01Completed
Treatment of Periodontal Disease in Patients With Acute Myocardial Infarction: Randomized Controlled Trial[NCT02543502]54 participants (Actual)Interventional2012-08-31Completed
Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population (ExAMIN AGE)[NCT02796976]158 participants (Actual)Interventional2016-03-31Completed
Prevalence of Obstructive Sleep Apnea Syndrome and CPAP Adherence in the Elderly Chinese Population[NCT02085720]819 participants (Actual)Interventional2007-09-30Completed
The Effect of Semaglutide Compared to Metformin in Obese Women With Polycystic Ovary Syndrome (PCOS): a Randomised Controlled Study (Semaglutide-PCOS Trial).[NCT05646199]Phase 2/Phase 360 participants (Anticipated)Interventional2024-03-01Not yet recruiting
Efficacy of L-arginine Treatment on Blood Pressure Control Patients With Stage 1 Hypertension[NCT02894723]Phase 440 participants (Anticipated)Interventional2016-09-30Not yet recruiting
EXerCise Introduction To Enhance Performance in Dialysis: the EXCITE Study[NCT01255969]Phase 4500 participants (Actual)Interventional2010-04-30Completed
Glycemic Variability Predicts Endothelial Dysfunction[NCT01083043]28 participants (Actual)Observational2006-12-31Completed
Effect of Oral Supplementation With the Amino Acid L-arginine on Peri- Operative Cardio-vascular Risk in Non-selected Patients - Role of Pre-operative Determination of Plasma ADMA Levels for Therapeutic Stratification.[NCT01413815]269 participants (Actual)Interventional2010-10-31Completed
Influence of Preoperative Hemodialysis or Intraoperative Modified Ultrafiltration on Postoperative Outcome for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery: Randomized, Controlled, Multicenter Clinical Trial[NCT00720967]Phase 3450 participants (Anticipated)Interventional2008-11-30Not yet recruiting
Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy (BESTinDN Study)[NCT01796418]102 participants (Anticipated)Interventional2013-03-31Recruiting
A Multicenter, Randomized Trial to Compare Xience and Vision Coronary Stents in the Same Multivessel Patient With Chronic Kidney Disease[NCT00818792]Phase 2215 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in PAQ (Physical Activity Questionnaire)

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: baseline, 4 weeks

Interventionunits on a scale (Mean)
Reduced Fat Vegan Diet0.22
American Heart Association Diet-0.16

Children Change in BMI Z Score

Body mass index z-scores, also called BMI standard deviation (s.d.) scores, are measures of relative weight adjusted for child age and sex. Given a child's age, sex, BMI, and an appropriate reference standard, a BMI z-score (or its equivalent BMI-for-age percentile) can be determined. Negative BMI z-scores indicate a BMI that is lower than the population mean, while positive BMI scores indicate a value that is higher than the population mean. A decrease in the BMI z-score over time indicate a lowering of the BMI. Z-scores of 1.03 and 1.64 correspond to the 85th and 95th percentiles of BMI-for-age, which are the definitions of overweight and obesity in children. (NCT01817491)
Timeframe: baseline, 4 weeks

InterventionZ Score (Mean)
Reduced Fat Vegan Diet-0.14
American Heart Association Diet-0.03

PB/AHA - Adjusted Mean Difference BMI Z Score Children

(NCT01817491)
Timeframe: Baseline, 4 weeks

InterventionZ score (Mean)
PB/AHA-0.13

PB/AHA - Adjusted Mean Difference PAQ Children

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionunits on a scale (Mean)
PB/AHA0.39

Change in Blood Pressure (BP)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmm Hg (Mean)
Children Systolic BPParents Systolic BPChildren Diastolic BPParent Diastolic BP
American Heart Association Diet-5.14-3.14-4.36-6.64
Reduced Fat Vegan Diet-6.43-7.96-2.61-3.46

Change in Body Mass Index BMI Percentile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionBMI percentile (Mean)
ChildrenParents
American Heart Association Diet-0.08-0.73
Reduced Fat Vegan Diet-1.12-1.29

Change in Circumference

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventioncm (Mean)
Children Waist CircumferenceParents Waist CircumferenceChildren Midarm CircumferenceParents Midarm Circumference
American Heart Association Diet-2.96-0.49-1.140.35
Reduced Fat Vegan Diet-1.53-1.94-2.02-1.32

Change in Glucose

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
ChildrenParent
American Heart Association Diet-.64-5.43
Reduced Fat Vegan Diet0.934.93

Change in HgbA1c (Hemoglobin A1c)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpercentage (Mean)
ChildrenParent
American Heart Association Diet0.210.14
Reduced Fat Vegan Diet0.17-0.16

Change in hsCRP (High-sensitivity C-reactive Protein)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/L (Mean)
ChildrenParent
American Heart Association Diet2.780.21
Reduced Fat Vegan Diet-2.09-0.24

Change in IL-6 (Interleukin-6)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpg/ml (Mean)
ChildrenParent
American Heart Association Diet-0.19-0.19
Reduced Fat Vegan Diet-0.170.16

Change in Insulin

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionuU/ml (Mean)
ChildrenParents
American Heart Association Diet3.16-3.15
Reduced Fat Vegan Diet-5.42-3.11

Change in Lipid Profile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
total cholesterol childrentriglycerides childrenhigh-density lipoprotein cholesterol childrenlow-density lipoprotein cholesterol childrentotal cholesterol parentstriglycerides parentshigh-density lipoprotein cholesterol parentslow-density lipoprotein cholesterol parents
American Heart Association Diet-16.50-13.14-2.93-11.00-7.1416.8616.86-5.50
Reduced Fat Vegan Diet-22.50-25.50-5.93-13.14-33.796.21-8.14-27.00

Change in Liver Enzymes

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionU/L (Mean)
alanine aminotransferase (ALT) childrenaspartate aminotransferase (AST) childrenalanine aminotransferase (ALT) parentsaspartate aminotransferase (AST) parents
American Heart Association Diet-1.140.004.574.43
Reduced Fat Vegan Diet0.792.790.860.14

Change in MPO (Myeloperoxidase)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpmol/L (Mean)
ChildrenParent
American Heart Association Diet-69.231.78
Reduced Fat Vegan Diet-75.3416.91

Change in Weight

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionkg (Mean)
ChildrenParents
American Heart Association Diet-1.55-2.01
Reduced Fat Vegan Diet-3.05-3.64

PB/AHA - Adjusted Mean BP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
Children adj mean ratio systolic BPChildren adj mean ratio diastolic BPparents adj mean ratio systolic BPparents adj mean ratio diastolic BP
PB/AHA1.871.010.971.03

PB/AHA - Adjusted Mean Difference BMI

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionpercentile (Mean)
Children Change in BMIParents Change in BMI
PB/AHA-1.17-0.69

PB/AHA - Adjusted Mean Difference Circumference

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventioncm (Mean)
children waist circumferenceparents waist circumferencechildren arm circumferenceparents arm circumference
PB/AHA1.32-1.14-1.25-1.68

PB/AHA - Adjusted Mean Difference Weight

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionkg (Mean)
Children WeightParents Weight
PB/AHA-1.71-1.95

PB/AHA - Adjusted Mean Lipid Profile

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionmg/dL (Mean)
CHOL childrenTRIG childrenHDL childrenLDL childrenCHOL parentsTRIG parentsHDL parentsLDL parents
PB/AHA-10.341.010.170.95-27.290.950.94-21.92

PB/AHA - Adjusted Mean Ratio Glucose

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA1.011.06

PB/AHA - Adjusted Mean Ratio HgbA1c

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.990.96

PB/AHA - Adjusted Mean Ratio hsCRP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.460.68

PB/AHA - Adjusted Mean Ratio IL-6

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.261.14

PB/AHA - Adjusted Mean Ratio Insulin

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.70.87

PB/AHA - Adjusted Mean Ratio Liver Enzymes

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ALT childrenAST childrenALT parentsAST parents
PB/AHA11.130.850.83

PB/AHA - Adjusted Mean Ratio MPO

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.950.93

CPAP Compliance Among Chinese Elderly

Elderly subjects who agree for home CPAP treatment are prescribed nasal CPAP units with time clocks to assess objective compliance (run time). (NCT02085720)
Timeframe: 1 year

Interventionhours (Mean)
Chinese Elderly OSAS4.2

Prevalence of Obstructive Sleep Apnea Syndrome in Chinese Elderly

Subjects who have completed the questionnaires and consented for sleep study are invited to undergo a portable at-home sleep study (EMBLETTA). It is a multi-channel screening tool that measures airflow through a nasal cannula connected to a pressure transducer, providing an apnea hypopnea index (AHI) based on recording time. AHI is the average number of events per hour while 5-15 events per hour denotes mild OSA, 16-30 events moderate OSA, and >30 events severe OSA. Obstructive sleep apnea syndrome is defined as AHI 15 events or above or AHI being 5 or above pulus ESS 10 or more. This measure is reporting the percentage of participants with OSAS. (NCT02085720)
Timeframe: 3 years

Intervention% of participants (Number)
Chinese Elderly OSAS15

Prevalence of Restless Leg Syndrome (RLS)

RLS is a disorder characterized by disagreeable leg sensations that usually occur before sleep onset, causing an almost irresistible urge to move the legs. As minimal criteria for diagnosis, the following four features were required: (1) desire to move the extremities, often associated with paresthesias and/or dysesthesias; (2) motor restlessness; (3) worsening of symptoms at rest, with at least temporary relief by activity; and (4) worsening of symptoms in the evening or at night. (NCT02085720)
Timeframe: 3 years

Intervention% of participants (Number)
Chinese Elderly OSAS13.8

AHI Result

(NCT02085720)
Timeframe: 1 year

Intervention% of participants (Number)
AHI >/5AHI >/10AHI >/15AHI >/20
AHI Result66.743.629.919.2

Sleep and Health Questionnaire Result

(NCT02085720)
Timeframe: 1 year

Intervention% of participants (Number)
Impaired performance ability (mild)Impaired performance ability (moderate)Impaired performance abilitySleepiness interfered with daily tasks (mild)Sleepiness interfered with daily tasks (moderate)Sleepiness interfered with daily tasks(severe)Impaired energy level (mild)Impaired energy level (moderate)Impaired energy level (severe)Daytime sleepiness (mild)Daytime sleepiness (moderate)Daytime sleepiness (severe)Snoring intensity (past month) (mild)Snoring intensity (past month) (moderate)Snoring intensity (past month) (severe)Frequent awakenings (mild)Frequent awakenings (moderate)Frequent awakenings (severe)Difficulty falling asleep (mild)Difficulty falling asleep (moderate)Difficulty falling asleep (severe)observed awakenings (mild)observed awakenings (moderate)observed awakenings (severe)observed choking (mild)observed choking (moderate)observed choking (severe)Observed apnea (mild)Observed apnea (moderate)Observed apnea (severe)
Sleep Heatlh Questionnaire Result41.58.58.710.23.43.839.28.09.441.18.522.833.08.25.138.38.619.348.47.89.96.60.70.82.81.10.71.70.40.6

Reviews

88 reviews available for n(g),n(g')-dimethyl-l-arginine and Cardiovascular Diseases

ArticleYear
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnan

2023
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnan

2023
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnan

2023
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnan

2023
The Second Life of Methylarginines as Cardiovascular Targets.
    International journal of molecular sciences, 2019, Sep-17, Volume: 20, Issue:18

    Topics: Amidohydrolases; Animals; Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cardi

2019
Intraplatelet L-Arginine-Nitric Oxide Metabolic Pathway: From Discovery to Clinical Implications in Prevention and Treatment of Cardiovascular Disorders.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Amidohydrolases; Arginine; Blood Platelets; Cardiovascular Diseases; Endothelium, Vascular; Humans;

2020
Asymmetric dimethylarginine level as biomarkers of cardiovascular or all-cause mortality in patients with chronic kidney disease: a meta-analysis.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:7

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Humans; Mortality; Renal Insufficienc

2021
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.
    International journal of molecular sciences, 2017, Apr-15, Volume: 18, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Energy Metabolism; Humans; Nitri

2017
Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination.
    Diabetes & metabolic syndrome, 2017, Volume: 11 Suppl 2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Glycation End Products, Advanced; Homocystein

2017
AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems.
    Journal of molecular and cellular cardiology, 2017, Volume: 113

    Topics: Animals; Arginine; Cardiovascular Diseases; Cardiovascular System; Humans; Kidney Diseases; Transami

2017
Nitric oxide bioavailability dysfunction involves in atherosclerosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Arginine; Atherosclerosis; Biological Availability; Cardiovascular Diseases; Endothelium, V

2018
Association of Circulating Levels of ADMA with Carotid Intima-Media Thickness in Patients with CKD: a Systematic Review and Meta-Analysis.
    Kidney & blood pressure research, 2018, Volume: 43, Issue:1

    Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Intima-Media Thickness; Humans; Renal In

2018
Asymmetric dimethylarginine and angiogenesis: biological significance.
    International angiology : a journal of the International Union of Angiology, 2018, Volume: 37, Issue:6

    Topics: Animals; Arginine; Atherosclerosis; Cardiovascular Diseases; Endothelial Cells; Humans; Neovasculari

2018
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Nutrients, 2018, Dec-20, Volume: 11, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium,

2018
Genetic regulation of dimethylarginines and endothelial dysfunction in rheumatoid arthritis.
    Amino acids, 2019, Volume: 51, Issue:7

    Topics: Arginine; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium,

2019
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
    International journal of molecular sciences, 2019, Jul-26, Volume: 20, Issue:15

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks

2019
Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease?
    Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Aging; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Ch

2013
Is asymmetric dimethylarginine associated with being born small and large for gestational age?
    Antioxidants & redox signaling, 2014, May-20, Volume: 20, Issue:15

    Topics: Arginine; Biomarkers; Birth Weight; Cardiovascular Diseases; Female; Gestational Age; Humans; Metabo

2014
Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?
    Seminars in nephrology, 2014, Volume: 34, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Humans; Kidney Diseases; Water

2014
Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-02, Volume: 440

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Ni

2015
Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies.
    Journal of the American Heart Association, 2015, May-28, Volume: 4, Issue:6

    Topics: Arginine; Cardiovascular Diseases; Humans; Odds Ratio; Prospective Studies; Stroke

2015
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
    Current medicinal chemistry, 2015, Volume: 22, Issue:24

    Topics: Alzheimer Disease; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hy

2015
Diet in children with phenylketonuria and risk of cardiovascular disease: A narrative overview.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016, Volume: 26, Issue:3

    Topics: Adiponectin; Arginine; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol, HDL; Cholesterol

2016
Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA.
    Current cardiology reviews, 2017, Volume: 13, Issue:3

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; NF-E2-Related Fact

2017
Cardiovascular disease in patients with diabetic nephropathy.
    Current molecular medicine, 2008, Volume: 8, Issue:6

    Topics: Anemia; Arginine; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Nephr

2008
[Endothelial injury and CKD].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:9

    Topics: Animals; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney D

2008
[Asymmetric dimethylarginine (ADMA): A cardiovascular risk factor].
    Wiener klinische Wochenschrift, 2008, Volume: 120, Issue:15-16

    Topics: Adult; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Male; Prevalence; Risk Assess

2008
[Novelties in the field of progression factors in chronic kidney disease].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2008, Volume: 28 Suppl 5

    Topics: Adult; Amidohydrolases; Animals; Arginine; Carbon; Cardiovascular Diseases; Chronic Disease; Clinica

2008
ADMA, cardiovascular disease and diabetes.
    Diabetes research and clinical practice, 2008, Dec-15, Volume: 82 Suppl 2

    Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus; Humans; Models, Biological

2008
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease.
    Expert opinion on drug metabolism & toxicology, 2009, Volume: 5, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Agents; Cardiovascular Diseases; Disease Progress

2009
Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.
    Medical science monitor : international medical journal of experimental and clinical research, 2009, Volume: 15, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney; Nitric Oxide Synthase

2009
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Prospectiv

2009
Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Huma

2009
Cellular ADMA: regulation and action.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide Synthase; Signal

2009
The emerging role of symmetric dimethylarginine in vascular disease.
    Advances in clinical chemistry, 2009, Volume: 48

    Topics: Arginine; Cardiovascular Diseases; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III

2009
The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine.
    Annals of clinical biochemistry, 2010, Volume: 47, Issue:Pt 1

    Topics: Amidohydrolases; Animals; Arginine; Biochemistry; Cardiovascular Diseases; Enzyme Inhibitors; Humans

2010
Nitric oxide and oxidative stress in vascular disease.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxid

2010
The biology and therapeutic potential of the DDAH/ADMA pathway.
    Current pharmaceutical design, 2010, Volume: 16, Issue:37

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Molecula

2010
Novel endothelial biomarkers: implications for periodontal disease and CVD.
    Journal of dental research, 2011, Volume: 90, Issue:9

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cell-Derived Microparticles; Endothelial Cel

2011
Asymmetric dimethylarginine: clinical applications in pediatric medicine.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2011, Volume: 110, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Child, Preschool; Endothelium, Vascular; Enzyme Inhib

2011
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; K

2012
Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Binding Sites; Binding, Competitive; Biomarkers; Cardiovascular

2012
[Methylarginies-induced endothelial dysfunction in chronic kidney disease].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2012, Volume: 132, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme In

2012
New directions in cardiovascular risk assessment: the role of secondary risk stratification markers.
    International journal of clinical practice, 2012, Volume: 66, Issue:7

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adrenomedullin; Ankle Brachial Index; Arginine; Biom

2012
Cardiovascular risk in autoimmune disorders: role of asymmetric dimethylarginine.
    European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3

    Topics: Animals; Arginine; Autoimmune Diseases; Cardiovascular Diseases; Humans; Risk

2012
Asymmetric dimethylarginine, endothelial dysfunction and renal disease.
    International journal of molecular sciences, 2012, Volume: 13, Issue:9

    Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Child; Disease Progression; E

2012
Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases.
    International journal of molecular sciences, 2012, Sep-26, Volume: 13, Issue:10

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthas

2012
Beta blockers, nitric oxide, and cardiovascular disease.
    Current opinion in pharmacology, 2013, Volume: 13, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Arginine; Cardiovascular Diseases; Humans; Nitri

2013
Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?
    Diabetologia, 2002, Volume: 45, Issue:12

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Syndrome

2002
[Cardiovascular events in chronic advanced renal insufficiency. Current concepts].
    Recenti progressi in medicina, 2003, Volume: 94, Issue:3

    Topics: Anemia; Arginine; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Hyperli

2003
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?
    Kidney international. Supplement, 2003, Issue:84

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Risk Factors

2003
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor.
    Cardiovascular research, 2003, Oct-01, Volume: 59, Issue:4

    Topics: Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibi

2003
ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Kidney Failure,

2003
ADMA and oxidative stress.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Sy

2003
NO and angiogenesis.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Angiogenesis Inhibitors; Arginine; Cardiovascular Diseases; Cell Movement; Cell Survival; Endothelia

2003
Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperh

2003
Novel cardiovascular risk factors in end-stage renal disease.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15 Suppl 1

    Topics: Arginine; Calcinosis; Cardiovascular Diseases; Humans; Hypertension; Inflammation; Kidney Failure, C

2004
Asymmetric dimethylarginine (ADMA) modulates endothelial function--therapeutic implications.
    Vascular medicine (London, England), 2003, Volume: 8, Issue:3

    Topics: Animals; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Endothelium, Vascular; Enzyme

2003
[Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data].
    Deutsche medizinische Wochenschrift (1946), 2004, Apr-08, Volume: 129, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Arteriosclerosis; Biomarkers; Cardiovascular Dise

2004
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Cardiovascular Physiological Phenomena;

2004
The pivotal role of nitric oxide for vascular health.
    The Canadian journal of cardiology, 2004, Volume: 20 Suppl B

    Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Disease Progression; Endothelium, Vascular; Fem

2004
Asymmetric dimethylarginine (ADMA) and acute vascular events.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 348, Issue:1-2

    Topics: Acute Disease; Angina Pectoris; Arginine; Cardiovascular Diseases; Humans; Myocardial Infarction; St

2004
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor.
    The Journal of nutrition, 2004, Volume: 134, Issue:10 Suppl

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric

2004
[Asymmetric dimethylarginine and endothelial dysfunction].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Amidohydrolases; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Cardiovascular Disease

2004
L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor.
    Alternative medicine review : a journal of clinical therapeutic, 2005, Volume: 10, Issue:1

    Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Ni

2005
Endothelial cell dysfunction: the syndrome in making.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Animals; Apoptosis; Arginine; Cardiovascular Diseases; Cellular Senescence; Endothelium, Vascular; G

2005
Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients.
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2005, Volume: 25 Suppl 3

    Topics: Arginine; Autonomic Nervous System Diseases; C-Reactive Protein; Cardiovascular Diseases; Humans; Hy

2005
Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Carotid Arteries; Carotid S

2005
Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality.
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Pro

2005
Measurement of asymmetric dimethylarginine in plasma: methodological considerations and clinical relevance.
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Animals; Arginine; Cardiovascular Diseases; Homocysteine; Humans; Risk Factors; Sensitivity and Spec

2005
[Molecular mechanisms of dysfunction of vascular endothelium].
    Kardiologiia, 2005, Volume: 45, Issue:12

    Topics: Adult; Animals; Apoptosis; Arginine; Atherosclerosis; Cardiovascular Diseases; Cells, Cultured; Chil

2005
ADMA: its role in vascular disease.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitor

2005
Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Endothelium, Vascular; Enzy

2005
ADMA and hyperhomocysteinemia.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Va

2005
Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Animals; Arginine; Cardiovascular Diseases; Drug Evaluation, Preclinical; Endothelium, Vascular; Enz

2005
DDAH gene and cardiovascular risk.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Humans; Hypertension; Male; Mutation; Polymorphi

2005
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors;

2005
[The best of epidemiology and cardiovascular prevention in 2005].
    Archives des maladies du coeur et des vaisseaux, 2006, Volume: 99 Spec No 1, Issue:1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Complications; Environmental Pollutants; Hum

2006
Asymmetric dimethylarginine (ADMA): a cardiovascular and renal risk factor on the move.
    Journal of hypertension, 2006, Volume: 24, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Humans; Renal Insufficiency; Risk Factors

2006
[Asymmetric dimethylarginine--a novel cardiovascular risk factor].
    Vnitrni lekarstvi, 2006, Volume: 52, Issue:3

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Kid

2006
[The importance of regulation of endogenous methylarginine concentrations in clinical practice].
    Przeglad lekarski, 2005, Volume: 62, Issue:12

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Protein-Arginin

2005
[Nitric oxide].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 5

    Topics: Adiponectin; Aldosterone; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Endothelium, V

2006
Arginine, arginine analogs and nitric oxide production in chronic kidney disease.
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:4

    Topics: Absorption; Amidohydrolases; Arginine; Biological Availability; Cardiovascular Diseases; Chronic Dis

2006
Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor--evidence from epidemiological and prospective clinical trials.
    Pharmacological reports : PR, 2006, Volume: 58 Suppl

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Cross-Sectional Studies; En

2006
The past, presence and future of ADMA in nephrology.
    Nephrologie & therapeutique, 2007, Volume: 3, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney Diseases; Kidney Function Tests

2007
C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders?
    Current pharmaceutical design, 2007, Volume: 13, Issue:16

    Topics: Animals; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Humans;

2007
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
    Clinical and experimental nephrology, 2007, Volume: 11, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases;

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Arginase: a critical regulator of nitric oxide synthesis and vascular function.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:9

    Topics: Animals; Arginase; Arginine; Cardiovascular Diseases; Cell Proliferation; Collagen; Endothelium, Vas

2007
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Endothelium-Dependen

2007
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:2

    Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidn

2008

Trials

15 trials available for n(g),n(g')-dimethyl-l-arginine and Cardiovascular Diseases

ArticleYear
Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study.
    American journal of nephrology, 2017, Volume: 45, Issue:5

    Topics: Administration, Oral; Adult; Alanine Transaminase; Arginine; Aspartate Aminotransferases; C-Reactive

2017
Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men.
    Coronary artery disease, 2013, Volume: 24, Issue:7

    Topics: Adult; Animals; Ankle Brachial Index; Arginine; Biomarkers; Caloric Restriction; Cardiovascular Dise

2013
Decreased levels of homoarginine and asymmetric dimethylarginine in children with type 1 diabetes: associations with cardiovascular risk factors but no effect by atorvastin.
    Journal of pediatric endocrinology & metabolism : JPEM, 2015, Volume: 28, Issue:1-2

    Topics: Adolescent; Anticholesteremic Agents; Arginine; Atorvastatin; Cardiovascular Diseases; Diabetes Mell

2015
Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.
    Journal of the American Heart Association, 2016, Apr-18, Volume: 5, Issue:4

    Topics: Aged; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Activation; Female;

2016
Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 70, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Morbidity; Prospective Studies

2017
Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial.
    European journal of nutrition, 2010, Volume: 49, Issue:8

    Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; beta Carotene; Biomarkers; Blood Pressure; C-Reactive

2010
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Fo

2010
Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study.
    Clinical chemistry, 2011, Volume: 57, Issue:1

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary Disease; Female;

2011
Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Contraceptives, Oral; Female; Homocystein

2011
The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2012, Volume: 27, Issue:7

    Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Diet; Endothelium, Vascular; Exercise; Ex

2012
Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.
    Blood purification, 2002, Volume: 20, Issue:5

    Topics: Arginine; Blood Pressure; Cardiovascular Diseases; Female; Humans; Hypertension; Kidney Failure, Chr

2002
Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:1

    Topics: Analysis of Variance; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Doubl

2003
Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Dydrogesterone;

2003
No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk.
    Clinical endocrinology, 2006, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Do

2006
Effects of combined supplementation with B vitamins and antioxidants on plasma levels of asymmetric dimethylarginine (ADMA) in subjects with elevated risk for cardiovascular disease.
    Atherosclerosis, 2007, Volume: 193, Issue:1

    Topics: Adult; Aged; Antioxidants; Arginine; Cardiovascular Diseases; Double-Blind Method; Female; Humans; L

2007

Other Studies

176 other studies available for n(g),n(g')-dimethyl-l-arginine and Cardiovascular Diseases

ArticleYear
Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma.
    Pathology, 2022, Volume: 54, Issue:5

    Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fem

2022
Prevalence of cardiovascular diseases in kidney transplant recipients and its relationship with asymmetric dimethylarginine, fibroblast growth factor-23 and multiple inflammatory markers.
    Acta biochimica Polonica, 2022, Nov-08, Volume: 69, Issue:4

    Topics: Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Fibroblast Growth Factor-23; Humans; Interl

2022
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, Nov-30, Volume: 38, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; D

2023
Successful endodontic treatment reduces serum levels of cardiovascular disease risk biomarkers-high-sensitivity C-reactive protein, asymmetric dimethylarginine, and matrix metalloprotease-2.
    International endodontic journal, 2023, Volume: 56, Issue:12

    Topics: Biomarkers; C-Reactive Protein; Cardiovascular Diseases; COVID-19; COVID-19 Vaccines; Glycated Hemog

2023
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chemokines; Citrulline; Cytokines; Fe

2019
Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Anthocyanins; Aortic Valve Stenosis; Apoptosis; Arginine; Blueberry Plants

2020
Cardiovascular risk factors and the concentration of asymmetric dimethylarginine.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2020, Volume: 29, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Middl

2020
Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients.
    International urology and nephrology, 2020, Volume: 52, Issue:7

    Topics: Adolescent; Adult; Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Arginine; Biomarkers; Ca

2020
Influence of Human Paraoxonase-1 Polymorphism (Q192R) on Serum Levels of Clinical Biomarkers Indicatives of Cardiovascular Diseases Risk in Mexican Women.
    Biochemical genetics, 2020, Volume: 58, Issue:5

    Topics: Adult; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studie

2020
Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis.
    Renal failure, 2020, Volume: 42, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Creatinine; Humans; Kidney Failure, Chronic; Male; Middle

2020
Association of Asymmetric Dimethylarginine and Nitric Oxide with Cardiovascular Risk in Patients with End-Stage Liver Disease.
    Medicina (Kaunas, Lithuania), 2020, Nov-18, Volume: 56, Issue:11

    Topics: Adult; Arginine; Cardiovascular Diseases; End Stage Liver Disease; Heart Disease Risk Factors; Human

2020
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients.
    Amino acids, 2021, Volume: 53, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Female; Heart Disease Ri

2021
Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension.
    Advances in medical sciences, 2021, Volume: 66, Issue:1

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; F

2021
Myeloperoxidase, asymmetric dimethyl-arginine and the renin-angiotensin-aldosterone-system in cardiovascular risk patients: Cross-sectional findings from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
    Clinical biochemistry, 2017, Volume: 50, Issue:13-14

    Topics: Aged; Aldosterone; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Cohort Studies; Coronary

2017
Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study.
    The Journal of clinical endocrinology and metabolism, 2017, 06-01, Volume: 102, Issue:6

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chromatography, Liquid; Citrulline; C

2017
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation.
    BMC infectious diseases, 2017, 03-29, Volume: 17, Issue:1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure L

2017
Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes.
    Journal of diabetes and its complications, 2017, Volume: 31, Issue:6

    Topics: Adult; Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Follow-Up Studies; Glucose

2017
Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: A study with hypercholesterolemic rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Administration, Oral; Amino Acids; Animals; Arginine; Biomarkers; Body Weight; Cardiovascular Diseas

2017
Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
    Scientific reports, 2017, 06-06, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Amidohydrolases; Arginine; Australia; Biomarkers; Cardiovascular Diseases;

2017
Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population.
    Maturitas, 2017, Volume: 102

    Topics: Aged; Aged, 80 and over; Arginine; Asian People; Biomarkers; Cardiovascular Diseases; Cross-Sectiona

2017
Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.
    Chemosphere, 2017, Volume: 186

    Topics: Adult; Alleles; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Creatinine; E

2017
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study.
    Amino acids, 2017, Volume: 49, Issue:11

    Topics: Adult; Arginine; Black People; Cardiovascular Diseases; Carotid Intima-Media Thickness; Follow-Up St

2017
Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2018, Volume: 107, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, Liquid; Disease Progression; Fe

2018
Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead.
    Archives of environmental contamination and toxicology, 2018, Volume: 74, Issue:2

    Topics: Adiponectin; Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseas

2018
Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome.
    Endocrine, metabolic & immune disorders drug targets, 2018, Volume: 18, Issue:4

    Topics: Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studi

2018
Association of endothelial dysfunction with cardiovascular risk factors and new-onset diabetes mellitus in patients with hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:5

    Topics: Aged; Arginine; Brazil; C-Reactive Protein; Cardiovascular Diseases; Diabetes Complications; Diabete

2018
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
    Scientific reports, 2018, 04-30, Volume: 8, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointe

2018
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
    Arthritis research & therapy, 2018, 06-08, Volume: 20, Issue:1

    Topics: Aged; Arginase; Arginine; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Comorbidity; F

2018
Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.
    Circulation, 2018, 11-20, Volume: 138, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Blood Pressure; Blood Urea Nitrogen; Car

2018
Homoarginine/ADMA ratio and homoarginine/SDMA ratio as independent predictors of cardiovascular mortality and cardiovascular events in lower extremity arterial disease.
    Scientific reports, 2018, 09-21, Volume: 8, Issue:1

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Female; Homoarginine; Hu

2018
ADMA and NT pro-BNP are associated with overall mortality in elderly.
    European journal of clinical investigation, 2019, Volume: 49, Issue:1

    Topics: Age Distribution; Aged; Aged, 80 and over; Arginine; Austria; Biomarkers; Body Mass Index; Cardiovas

2019
Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women.
    Ecotoxicology and environmental safety, 2019, Volume: 169

    Topics: Adult; Aged; Arginine; Arsenic; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Drinki

2019
Protein-energy wasting and asymmetric dimethylarginine in peritoneal dialysis patients.
    Acta biochimica Polonica, 2018, Dec-03, Volume: 65, Issue:4

    Topics: Adiponectin; Adult; Aged; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Ca

2018
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.
    Scientific reports, 2018, 12-18, Volume: 8, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensins; Animals; Arginine; Cardiovascular Diseases; Deoxyguanosin

2018
The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.
    PloS one, 2019, Volume: 14, Issue:3

    Topics: Arginine; Cardiovascular Diseases; HEK293 Cells; Homoarginine; Humans; Inhibitory Concentration 50;

2019
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients.
    Amino acids, 2019, Volume: 51, Issue:6

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Creatinine; Female; Gas Chromatography-Mass Sp

2019
Establishment of reference values for the lysine acetylation marker N
    Amino acids, 2019, Volume: 51, Issue:9

    Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Carnitine; Chromatography, Liquid;

2019
Heat-assisted extraction for the determination of methylarginines in serum by CE.
    Electrophoresis, 2013, Volume: 34, Issue:11

    Topics: Arginine; Cardiovascular Diseases; Electrophoresis, Capillary; Hot Temperature; Humans; omega-N-Meth

2013
Association of lipid peroxidation with endothelial dysfunction in patients with overt hypothyroidism.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2013, Volume: 121, Issue:5

    Topics: Adult; Antioxidants; Arginine; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular;

2013
Editorial (hot topic: cardiovascular disease biomarkers: from tradition to modernity).
    Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Adiponectin; Arginine; Biomarkers; Cardiovascular Diseases; Cystatin C; Endothelins; Glycopeptides;

2013
Asymmetric dimethylarginine predicts survival in the elderly.
    Age (Dordrecht, Netherlands), 2013, Volume: 35, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Chromatograp

2013
Endothelial dysfunction, inflammation and malnutrition markers as predictors of mortality in dialysis patients: multimarker approach.
    International urology and nephrology, 2013, Volume: 45, Issue:6

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Fem

2013
Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies

2013
Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
    Circulation, 2013, Aug-20, Volume: 128, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cells, Cultured; Disease Mo

2013
Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cardiovascular Diseases; Coronary Angiograph

2013
Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study.
    Psychosomatic medicine, 2013, Volume: 75, Issue:8

    Topics: Acute Disease; Adult; Arginine; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory;

2013
Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:11

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Male; Middle Aged

2013
The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression.
    Annals of clinical biochemistry, 2014, Volume: 51, Issue:Pt 5

    Topics: Adenosine Deaminase; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD4

2014
Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.
    Diabetes care, 2014, Volume: 37, Issue:3

    Topics: Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Environme

2014
Lipoprotein apheresis reduces biomarkers of plaque destabilization and cardiovascular risk.
    Journal of clinical apheresis, 2014, Volume: 29, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Component Removal; C-Reactive Protein; Cardiovascular Disea

2014
Asymmetric dimethylarginine is not associated with subendocardial viability ratio in Rheumatoid Arthritis.
    International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Cardiovascular Diseases; Endocardium; Female; Humans; Male; M

2014
Asymmetric dimethyl L-arginine, nitric oxide and cardiovascular disease in adolescent type 1 diabetics.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adolescent; Arginine; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Me

2014
Asymmetric dimethylarginine responses during interferon-α-induced depression in patients with chronic hepatitis C infection.
    Psychosomatic medicine, 2014, Volume: 76, Issue:3

    Topics: Adult; Analysis of Variance; Antiviral Agents; Arginine; Cardiovascular Diseases; Chromatography, Li

2014
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
    European journal of clinical nutrition, 2014, Volume: 68, Issue:7

    Topics: Adult; Arginine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Artery Disease; Endoth

2014
Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Humans; Incidence; Male;

2014
GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples.
    Amino acids, 2014, Volume: 46, Issue:9

    Topics: Arginine; Cardiovascular Diseases; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Human

2014
Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
    Clinical chemistry and laboratory medicine, 2014, Volume: 52, Issue:12

    Topics: Adult; Aged; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Chromatography, High Pr

2014
Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
    Journal of the American Heart Association, 2014, Jul-18, Volume: 3, Issue:4

    Topics: Aged; Arginine; Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Cro

2014
Aging of the nitric oxide system: are we as old as our NO?
    Journal of the American Heart Association, 2014, Aug-18, Volume: 3, Issue:4

    Topics: Aged; Aging; Arginine; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up S

2014
Cumulative inflammation associates with asymmetric dimethylarginine in rheumatoid arthritis: a 6 year follow-up study.
    Rheumatology (Oxford, England), 2015, Volume: 54, Issue:7

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiova

2015
Cardiovascular-renal changes after kidney donation: one-year follow-up study.
    Transplantation, 2015, Volume: 99, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Follow-Up Studies; Glomerular Fi

2015
Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART.
    Journal of acquired immune deficiency syndromes (1999), 2014, Dec-01, Volume: 67, Issue:4

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Arginine; Bacterial Translocati

2014
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.
    Circulation, 2015, Feb-17, Volume: 131, Issue:7

    Topics: Adult; Animals; Anti-Inflammatory Agents; Arginine; Biomarkers; Cardiovascular Diseases; Cyclooxygen

2015
Investigation of subclinical atherosclerosis in psoriatic arthritis patients with minimal disease activity.
    Rheumatology international, 2015, Volume: 35, Issue:8

    Topics: Adult; Arginine; Arthritis, Psoriatic; Asymptomatic Diseases; Atherosclerosis; Brachial Artery; Card

2015
Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Blood Platelets; C-Reactive Protein; Cardiovascular

2015
The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease.
    Lipids in health and disease, 2015, Apr-16, Volume: 14

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Fe

2015
Asymmetric dimethylarginine is negatively correlated with hyperglycemia in children.
    Endocrine journal, 2015, Volume: 62, Issue:6

    Topics: Adolescent; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Child; Cross-Sectional S

2015
The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus.
    The Korean journal of internal medicine, 2015, Volume: 30, Issue:3

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Chi-Square Distribution; Chromatography, High

2015
Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome.
    Archivos de bronconeumologia, 2015, Volume: 51, Issue:11

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Disease Susceptibilit

2015
ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.
    Atherosclerosis, 2016, Volume: 244

    Topics: Adult; Aged; Arginine; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Cross-Sectiona

2016
Soluble receptor and gene polymorphism for AGE: relationship with obesity and cardiovascular risks.
    Pediatric research, 2016, Volume: 80, Issue:1

    Topics: Adolescent; Alleles; Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Cardiovascular Diseases;

2016
Relationship between FEV
    Aging clinical and experimental research, 2017, Volume: 29, Issue:2

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Fema

2017
Relevance of uric acid and asymmetric dimethylarginine for modeling cardiovascular risk prediction in chronic kidney disease patients.
    International urology and nephrology, 2016, Volume: 48, Issue:7

    Topics: Academic Medical Centers; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Cohor

2016
Osteoprotegerin, RANKL, ADMA, and Fetuin-A serum levels in children with type I diabetes mellitus.
    Pediatric diabetes, 2017, Volume: 18, Issue:4

    Topics: Adolescent; alpha-2-HS-Glycoprotein; Arginine; Biomarkers; Cardiovascular Diseases; Child; Cohort St

2017
Elevated plasma ADMA contributes to development of endothelial dysfunction in children with acute lymphoblastic leukemia.
    Postepy higieny i medycyny doswiadczalnej (Online), 2016, Jun-01, Volume: 70, Issue:0

    Topics: Adolescent; Arginine; Cardiovascular Diseases; Child; Child, Preschool; Endothelial Cells; Endotheli

2016
Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus.
    Diabetes/metabolism research and reviews, 2017, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cross-

2017
[Effect of asymmetrical dimethylarginine for predicting pro-thrombotic risk in atrial fibrillation].
    Zhonghua yi xue za zhi, 2016, Jul-12, Volume: 96, Issue:26

    Topics: Arginine; Atrial Fibrillation; Cardiovascular Diseases; Heart Atria; Humans; Stereoisomerism; Thromb

2016
Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
    Scientific reports, 2016, 10-18, Volume: 6

    Topics: Aminoisobutyric Acids; Animals; Arginine; Cardiovascular Diseases; Cell Line; Diabetes Mellitus, Typ

2016
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
    Journal of atherosclerosis and thrombosis, 2018, Jan-01, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies;

2018
Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: improvements by L-arginine intake.
    Kidney & blood pressure research, 2008, Volume: 31, Issue:3

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Homocysteine; Humans; Kidney Failure,

2008
Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.
    American journal of hypertension, 2008, Volume: 21, Issue:8

    Topics: Adult; Arginine; Blood Pressure; Cardiovascular Diseases; Female; Finland; Humans; Kidney; Lipids; M

2008
[Asymmetric dimethil-arginine (ADMA) as a link between insulin resistance and atherosclerosis].
    Ideggyogyaszati szemle, 2008, May-30, Volume: 61, Issue:5-6

    Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Stenosis; Chromatography; Enzyme

2008
Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives.
    Journal of human hypertension, 2009, Volume: 23, Issue:1

    Topics: Adult; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studi

2009
Increased plasma levels of asymmetric dimethylarginine and soluble CD40 ligand in patients with sleep apnea.
    Respiration; international review of thoracic diseases, 2009, Volume: 77, Issue:1

    Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Endoth

2009
Smoker's paradox in heart failure: might asymmetric dimethylarginine be the possible explanation?
    European heart journal, 2008, Volume: 29, Issue:23

    Topics: Arginine; Cardiovascular Diseases; Heart Failure; Hospital Mortality; Humans; Smoking

2008
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:3

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Female; Humans; Infan

2009
The beneficial effects of angiotensin-converting enzyme inhibitors on serum asymmetric dimethylarginine levels in the patients with cardiovascular disease.
    International journal of cardiology, 2010, Jun-25, Volume: 142, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Cardiovascular Diseases; Humans

2010
Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population.
    Atherosclerosis, 2009, Volume: 205, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cohort Studies; Female; Humans; Male; Mass Spectrome

2009
Clinical implications of elevated asymmetric dimethylarginine in chronic kidney disease and end-stage renal disease.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2009, Volume: 19, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Carotid Arteries; Humans; Kidney Diseases; Kidney Failure, Chroni

2009
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
    Circulation, 2009, Mar-31, Volume: 119, Issue:12

    Topics: Aged; Arginine; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus; Follow-Up Studies; Human

2009
HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:6

    Topics: Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Carotid Arteries; Carotid Artery Dise

2009
Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.
    Clinical chemistry, 2009, Volume: 55, Issue:8

    Topics: Age Factors; Aged; Arginine; Cardiovascular Diseases; Chromatography, Liquid; Cohort Studies; Female

2009
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:9

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressu

2009
Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cohort Studies; Female; HIV Infections;

2009
Determinants of occurrence of aortic sclerosis in an aging population.
    JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:8

    Topics: Age Factors; Aged; Aorta; Aortic Valve; Aortic Valve Stenosis; Arginine; Biomarkers; Blood Platelets

2009
Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and all-cause mortality in renal transplant recipients.
    Kidney international, 2010, Volume: 77, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Graft Rejection; Humans; Kidney Diseases; Kidney Transplan

2010
Asymmetric dimethylarginine: understanding the physiology, genetics, and clinical relevance of this novel biomarker. Proceedings of the 4th International Symposium on ADMA.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Internationality; Nitric Oxide

2009
Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities.
    Clinical chemistry, 2010, Volume: 56, Issue:1

    Topics: Aged; Arginine; Asian People; Black People; Cardiovascular Diseases; Cystatin C; Enzyme-Linked Immun

2010
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:8

    Topics: Adult; Aged; Angiopoietin-2; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Ch

2010
Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
    The American journal of pathology, 2010, Volume: 176, Issue:5

    Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Blood Pressure; Cardi

2010
Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
    Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:6

    Topics: Adult; Arginine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Cas

2010
[Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Proteins; Cardiovascular Diseases; Comorbidity;

2010
HPLC determination of plasma dimethylarginines: method validation and preliminary clinical application.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Nov-11, Volume: 411, Issue:21-22

    Topics: Adolescent; Adult; Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cr

2010
Increased production of asymmetric dimethylarginine (ADMA) in ankylosing spondylitis: association with other clinical and laboratory parameters.
    Joint bone spine, 2011, Volume: 78, Issue:2

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Osteo

2011
Adipokines, endothelial dysfunction and nutritional status in peritoneal dialysis patients.
    Scandinavian journal of urology and nephrology, 2010, Volume: 44, Issue:6

    Topics: Adiponectin; Adult; Aged; Aldehydes; Arginine; Biomarkers; Body Mass Index; Body Weight; C-Reactive

2010
Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
    Atherosclerosis, 2010, Volume: 212, Issue:2

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Coh

2010
Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cholesterol; Female

2011
Serum asymmetric dimethylarginine levels in normotensive obese individuals.
    Medical science monitor : international medical journal of experimental and clinical research, 2010, Volume: 16, Issue:11

    Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Enzyme Inhibitors; Humans

2010
Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus.
    Clinical endocrinology, 2011, Volume: 74, Issue:4

    Topics: Aged; Arginine; Asian People; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, T

2011
Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
    Journal of internal medicine, 2011, Volume: 269, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Enzyme Inhibitors; E

2011
Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA(1c).
    Diabetic medicine : a journal of the British Diabetic Association, 2011, Volume: 28, Issue:6

    Topics: Adolescent; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Child; Diabet

2011
The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study.
    Cardiovascular diabetology, 2011, Feb-09, Volume: 10

    Topics: Aged; Amidohydrolases; Analysis of Variance; Arginine; Biomarkers; Blood Glucose; Cardiovascular Dis

2011
NO problem: arterial and venous endothelial function and erectile dysfunction.
    European urology, 2011, Volume: 59, Issue:6

    Topics: Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular;

2011
Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction.
    European urology, 2011, Volume: 59, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascul

2011
Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.
    Endocrine, 2011, Volume: 39, Issue:3

    Topics: Adult; Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Endot

2011
Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity.
    Atherosclerosis, 2011, Volume: 216, Issue:2

    Topics: Adult; Arginine; Athletes; Cardiovascular Diseases; Enzyme-Linked Immunosorbent Assay; Exercise; Hum

2011
Arginine/asymmetric dimethylarginine ratio and cardiovascular risk factors in patients with predialytic chronic kidney disease.
    Clinical biochemistry, 2011, Volume: 44, Issue:8-9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Glomerular Fi

2011
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endoth

2011
Vascular function in the diagnostic categories of polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2011, Volume: 26, Issue:8

    Topics: Adult; Arginine; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium,

2011
Inflammation and asymmetric dimethylarginine for predicting death and cardiovascular events in ESRD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:7

    Topics: Adult; Aged; Analysis of Variance; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases

2011
DDAH says NO to ADMA.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide

2011
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
    European journal of clinical investigation, 2012, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Apolipoproteins A; Arginine; Cardiovascular Diseases; Catalase; Enzy

2012
Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography.
    International journal of cardiology, 2011, Dec-01, Volume: 153, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Death;

2011
Day-night variations in endothelial dysfunction markers and haemostatic factors in sleep apnoea.
    The European respiratory journal, 2012, Volume: 39, Issue:4

    Topics: Adult; Arginine; Blood Coagulation; Body Mass Index; Cardiovascular Diseases; CD40 Ligand; Circadian

2012
Asymmetric dimethylarginine (ADMA): is really a biomarker for cardiovascular prognosis?
    International journal of cardiology, 2011, Dec-01, Volume: 153, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Coronary Angiography; Female; Humans; Male; Referral and Consulta

2011
Endothelial dysfunction and high cardiovascular risk profile in severe alcoholics improve only partially following a medium-term alcohol withdrawal.
    Alcoholism, clinical and experimental research, 2012, Volume: 36, Issue:2

    Topics: Adult; Age of Onset; Aged; Alcoholism; Arginine; Biomarkers; Blood Pressure; Brachial Artery; Cardio

2012
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
    Circulation, 2011, Dec-13, Volume: 124, Issue:24

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Dose-Response Relationship, Drug; Femal

2011
Ethnicity-specific differences in L-arginine status in South African men.
    Journal of human hypertension, 2012, Volume: 26, Issue:12

    Topics: Adult; Aged; Arginine; Black People; Cardiovascular Diseases; Cross-Sectional Studies; Humans; Hyper

2012
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
    The American journal of pathology, 2012, Volume: 180, Issue:3

    Topics: Animals; Apoptosis; Arginine; Autophagy; Azoles; Cardiovascular Diseases; Cathepsins; Cell Membrane

2012
High tea and vegetable consumption is associated with low ADMA generation in older healthy subjects.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:8

    Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Coffee; Enzyme Inhibi

2012
Asymmetric dimethylarginine: a novel cardiovascular risk factor in end-stage renal disease.
    The Journal of international medical research, 2012, Volume: 40, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Carotid Intima-Media Thickness; Demography; Female; Humans; Indon

2012
The association between serum asymmetric dimethyl arginine levels and a history of gestational diabetes among healthy women.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:5

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Blood Glucose; Body Mass Index; Cardiovascular D

2012
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
    Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:3

    Topics: Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cationic Amino Acid Transporter

2012
Elevated asymmetric dimethylarginine in young adult survivors of childhood acute lymphoblastic leukemia: a preliminary report.
    Disease markers, 2012, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Arginine; Cardiovascular Diseases; Female; Humans; Male; Precursor Cell Lymphobla

2012
Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome.
    Reproductive biomedicine online, 2012, Volume: 25, Issue:5

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Intercellular Adhesion Molecul

2012
Exploring disease activity and cardiovascular events by raised serum asymmetric dimethyl arginine among systemic lupus erythematosus patients.
    The Egyptian journal of immunology, 2011, Volume: 18, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Cholesterol; Complement C3; Cross-Sectional Studies; Egypt

2011
Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals.
    Cardiovascular diabetology, 2012, Nov-15, Volume: 11

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Carotid Arteries; Cholest

2012
The relationship of plasma ADMA levels with cardiac functions and metabolic parameters in peritoneal dialysis patients.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:3

    Topics: Adolescent; Aged; Arginine; Aspirin; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studi

2013
Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aging; Amidohydrolases; Arginine; Australia; C

2013
Endothelial damage, asymmetric dimethylarginine and cardiovascular risk in end-stage renal disease.
    Blood purification, 2002, Volume: 20, Issue:5

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Kidney Failure, Chronic; Models, C

2002
Homocysteine and ADMA--emerging risk factors for cardiovascular disease?
    Blood pressure, 2002, Volume: 11, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Homocysteine; Humans; Predictive Value of Tests; Risk Factors

2002
High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde.
    Analytical biochemistry, 2003, Jul-01, Volume: 318, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Humans; Indicators and Reag

2003
When the endothelium cannot say 'NO' anymore. ADMA, an endogenous inhibitor of NO synthase, promotes cardiovascular disease.
    European heart journal, 2003, Volume: 24, Issue:21

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthas

2003
Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.
    Kidney international, 2003, Volume: 64, Issue:6

    Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cross-Sectional Studi

2003
Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Homeostasis; Humans; Hy

2003
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
    Circulation, 2004, Feb-03, Volume: 109, Issue:4

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Cells, Cultured; Coronary Angiography; Coronary

2004
Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD.
    Kidney international, 2005, Volume: 67, Issue:6

    Topics: Adult; Aged; Arginine; Arteriosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; En

2005
Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction.
    Atherosclerosis, 2006, Volume: 185, Issue:2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Arginine; Blood Pressure; C-Reactive Protein; Cardiovascular Di

2006
The effects of thyroxine replacement on the levels of serum asymmetric dimethylarginine (ADMA) and other biochemical cardiovascular risk markers in patients with subclinical hypothyroidism.
    Clinical endocrinology, 2005, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Choleste

2005
Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study.
    Circulation research, 2005, Sep-02, Volume: 97, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Coronary Disease; Cr

2005
Raised plasma levels of asymmetric dimethylarginine are associated with cardiovascular events, disease activity, and organ damage in patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:9

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Lupus Erythematosus, Systemic;

2005
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
    Journal of hypertension, 2005, Volume: 23, Issue:10

    Topics: Adult; Aged; Amino Acid Substitution; Analysis of Variance; Arginine; Aspartic Acid; Cardiovascular

2005
Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
    European journal of clinical investigation, 2005, Volume: 35, Issue:10

    Topics: Adult; Aged; Aging; Arginine; Biomarkers; Cardiovascular Diseases; Enzyme Inhibitors; Enzyme-Linked

2005
Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.
    PLoS medicine, 2005, Volume: 2, Issue:10

    Topics: Arginine; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type

2005
ADMA, endothelial progenitor cells, and cardiovascular risk.
    Circulation research, 2005, Oct-14, Volume: 97, Issue:8

    Topics: Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Risk Factors; Stem Cells

2005
The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:1

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chronic Disease; Copper; Endothelium, Vas

2006
Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:6

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cyclic GMP; Exercise; Female; Humans; Male; Middle A

2005
Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide.
    Climacteric : the journal of the International Menopause Society, 2006, Volume: 9, Issue:3

    Topics: Aged; Arginine; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Estrogen Receptor

2006
Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:11

    Topics: Aged; Arginine; Arteries; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Stud

2006
Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:5

    Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Comorbidity; Female; Homocysteine; Humans; Kidne

2006
Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study).
    Clinical chemistry, 2007, Volume: 53, Issue:2

    Topics: Analysis of Variance; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary

2007
Should we measure asymmetric dimethylarginine in patients with coronary artery disease?
    Clinical chemistry, 2007, Volume: 53, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Coronary Artery Disease; Humans; Mortality; Predictiv

2007
ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk.
    European journal of clinical investigation, 2007, Volume: 37, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Female;

2007
A new perspective for the treatment of renal diseases?
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Chronic Disease; Humans; Kidney Diseases; Nitric

2007
Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes.
    Diabetes care, 2007, Volume: 30, Issue:7

    Topics: Aged; Arginine; C-Reactive Protein; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Midd

2007
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
    Critical care medicine, 2007, Volume: 35, Issue:8

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Logistic Models; Male; Middle Aged; M

2007
Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Endo

2007
Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease.
    Endocrine, 2007, Volume: 31, Issue:2

    Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Fem

2007
Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Hemorheology;

2007
Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow.
    Coronary artery disease, 2007, Volume: 18, Issue:7

    Topics: Adult; Aged; Arginine; Blood Flow Velocity; Cardiovascular Diseases; Case-Control Studies; Chromatog

2007
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.
    Stroke, 2008, Volume: 39, Issue:1

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Arterioles; Cardiovascular Diseases; Carot

2008
Asymmetric dimethylarginine and impaired cardiovascular healing.
    Journal of thrombosis and thrombolysis, 2009, Volume: 27, Issue:2

    Topics: Apoptosis; Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Myocardial Ischemia; Nitric O

2009
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
    The British journal of nutrition, 2008, Volume: 99, Issue:5

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet;

2008
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Aci

2008
Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.
    JAMA, 2002, Mar-20, Volume: 287, Issue:11

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cross-Sectional Studies; Enzyme Inhibitors; Female;

2002
Insulin resistance, ADMA levels, and cardiovascular disease.
    JAMA, 2002, Mar-20, Volume: 287, Issue:11

    Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Insulin Resistance; Metabolic Syndrome

2002