n(g),n(g')-dimethyl-l-arginine has been researched along with Asthma in 16 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Alterations in the L-arginine metabolism resulting in reduced availability of the substrate L-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, contribute to the reduced NO formation and airway dysfunction in asthma." | 8.90 | Arginine metabolism in asthma. ( Grasemann, H; Scott, JA, 2014) |
| "The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma." | 8.02 | Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. ( Guo, M; Jiang, GT; Liu, H; Liu, J; She, J; Zhou, B, 2021) |
| " measured asymmetric dimethylarginine (ADMA) in the exhaled breath condensate (EBC) obtained from children with asthma and from healthy subjects." | 7.81 | Asymmetric dimethylarginine (ADMA): will be or will not be a new revolutionary biomarker of bronchial asthma? ( Calabrese, C; Carpagnano, GE; Patella, V; Santus, P; Vatrella, A, 2015) |
| "In late-onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to Fe(NO)." | 7.79 | An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. ( Bleecker, ER; Busse, WW; Calhoun, WJ; Castro, M; Chung, KF; Comhair, SA; Erzurum, SC; Fitzpatrick, AM; Gaston, B; Hazen, SL; Holguin, F; Israel, E; Jarjour, NN; Khatri, SS; Moore, WC; Peters, SP; Powers, RW; Teague, WG; Wenzel, SE, 2013) |
| "Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma." | 7.77 | Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011) |
| "Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH." | 5.36 | Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010) |
| " Alterations in the L-arginine metabolism resulting in reduced availability of the substrate L-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, contribute to the reduced NO formation and airway dysfunction in asthma." | 4.90 | Arginine metabolism in asthma. ( Grasemann, H; Scott, JA, 2014) |
| "The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma." | 4.02 | Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells. ( Guo, M; Jiang, GT; Liu, H; Liu, J; She, J; Zhou, B, 2021) |
| " measured asymmetric dimethylarginine (ADMA) in the exhaled breath condensate (EBC) obtained from children with asthma and from healthy subjects." | 3.81 | Asymmetric dimethylarginine (ADMA): will be or will not be a new revolutionary biomarker of bronchial asthma? ( Calabrese, C; Carpagnano, GE; Patella, V; Santus, P; Vatrella, A, 2015) |
| "In late-onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to Fe(NO)." | 3.79 | An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. ( Bleecker, ER; Busse, WW; Calhoun, WJ; Castro, M; Chung, KF; Comhair, SA; Erzurum, SC; Fitzpatrick, AM; Gaston, B; Hazen, SL; Holguin, F; Israel, E; Jarjour, NN; Khatri, SS; Moore, WC; Peters, SP; Powers, RW; Teague, WG; Wenzel, SE, 2013) |
| "Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma." | 3.77 | Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011) |
| "Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress." | 1.72 | Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases. ( Beckmann, B; Brinkmann, F; Dillenhöfer, S; Frank, M; Hamelmann, E; Hanusch, B; Holtmann, M; Jöckel, KH; Koerner-Rettberg, C; Langrock, C; Legenbauer, T; Lücke, T; Maasjosthusmann, P; Reinehr, T; Sinningen, K; Tsikas, D, 2022) |
| "Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH." | 1.36 | Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (87.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, B | 1 |
| Jiang, GT | 1 |
| Liu, H | 1 |
| Guo, M | 1 |
| Liu, J | 1 |
| She, J | 1 |
| Hanusch, B | 1 |
| Sinningen, K | 1 |
| Brinkmann, F | 1 |
| Dillenhöfer, S | 1 |
| Frank, M | 1 |
| Jöckel, KH | 1 |
| Koerner-Rettberg, C | 1 |
| Holtmann, M | 1 |
| Legenbauer, T | 1 |
| Langrock, C | 1 |
| Reinehr, T | 1 |
| Maasjosthusmann, P | 1 |
| Beckmann, B | 1 |
| Hamelmann, E | 1 |
| Tsikas, D | 1 |
| Lücke, T | 1 |
| Holguin, F | 2 |
| Grasemann, H | 3 |
| Sharma, S | 1 |
| Winnica, D | 1 |
| Wasil, K | 1 |
| Smith, V | 1 |
| Cruse, MH | 1 |
| Perez, N | 1 |
| Coleman, E | 1 |
| Scialla, TJ | 1 |
| Que, LG | 1 |
| Carraro, S | 1 |
| Giordano, G | 1 |
| Piacentini, G | 1 |
| Kantar, A | 1 |
| Moser, S | 1 |
| Cesca, L | 1 |
| Berardi, M | 1 |
| Di Gangi, IM | 1 |
| Baraldi, E | 1 |
| Lau, EM | 1 |
| Morgan, PE | 1 |
| Belousova, EG | 1 |
| Toelle, BG | 1 |
| Ayer, JG | 1 |
| Celermajer, DS | 1 |
| Marks, GB | 1 |
| Scott, JA | 2 |
| Pattnaik, B | 1 |
| Bodas, M | 1 |
| Bhatraju, NK | 1 |
| Ahmad, T | 4 |
| Pant, R | 1 |
| Guleria, R | 1 |
| Ghosh, B | 4 |
| Agrawal, A | 4 |
| Calabrese, C | 1 |
| Carpagnano, GE | 1 |
| Patella, V | 1 |
| Vatrella, A | 1 |
| Santus, P | 1 |
| Mabalirajan, U | 3 |
| Sharma, A | 1 |
| Aich, J | 1 |
| Makhija, L | 1 |
| Klein, E | 1 |
| Weigel, J | 1 |
| Buford, MC | 1 |
| Holian, A | 1 |
| Wells, SM | 1 |
| Gaston, B | 2 |
| Comhair, SA | 1 |
| Hazen, SL | 1 |
| Powers, RW | 1 |
| Khatri, SS | 1 |
| Bleecker, ER | 1 |
| Busse, WW | 1 |
| Calhoun, WJ | 1 |
| Castro, M | 1 |
| Fitzpatrick, AM | 1 |
| Israel, E | 1 |
| Jarjour, NN | 1 |
| Moore, WC | 1 |
| Peters, SP | 1 |
| Teague, WG | 1 |
| Chung, KF | 1 |
| Erzurum, SC | 1 |
| Wenzel, SE | 1 |
| Sterk, PJ | 1 |
| Ricciardolo, FL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics[NCT01715844] | Phase 1 | 10 participants (Actual) | Interventional | 2013-09-07 | Completed | ||
| Adiposity and Airway Inflammation in HIV-Associated Airway Disease[NCT02975258] | 102 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for n(g),n(g')-dimethyl-l-arginine and Asthma
| Article | Year |
|---|---|
Arginine metabolism in asthma.
Topics: Animals; Anti-Asthmatic Agents; Arginine; Asthma; Bronchial Hyperreactivity; Humans; Molecular Targe | 2014 |
Emerging interface between metabolic syndrome and asthma.
Topics: Animals; Arginase; Arginine; Asthma; Humans; Hyperinsulinism; Inflammation; Insulin; Insulin Resista | 2011 |
The biochemistry of asthma.
Topics: Aldehyde Oxidoreductases; Animals; Arginase; Arginine; Asthma; Humans; Hydrogen-Ion Concentration; N | 2011 |
1 trial available for n(g),n(g')-dimethyl-l-arginine and Asthma
| Article | Year |
|---|---|
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
Topics: Adult; Aged; Arginine; Asthma; Citrulline; Dietary Supplements; Female; Forced Expiratory Volume; Hu | 2019 |
12 other studies available for n(g),n(g')-dimethyl-l-arginine and Asthma
| Article | Year |
|---|---|
Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.
Topics: Adult; Arginine; Asthma; Bronchi; Case-Control Studies; Cell Culture Techniques; Chronic Disease; Ci | 2021 |
Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases.
Topics: Arginine; Asthma; Child; Dermatitis, Atopic; Female; Homoarginine; Humans; Male; Malondialdehyde; Ni | 2022 |
Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma.
Topics: Adolescent; Arginine; Asthma; Breath Tests; Case-Control Studies; Child; Child, Preschool; Chromatog | 2013 |
Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study.
Topics: Arginine; Asthma; Australia; Child; Cohort Studies; Cross-Sectional Studies; Female; Humans; Inflamm | 2013 |
Asymmetric dimethylarginine: a disease marker for asthma?
Topics: Arginine; Asthma; Female; Humans; Male | 2013 |
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.
Topics: Amidohydrolases; Apoptosis; Arginine; Asthma; Calpain; Cell Line; Cells, Cultured; Cytokines; Epithe | 2016 |
Asymmetric dimethylarginine (ADMA): will be or will not be a new revolutionary biomarker of bronchial asthma?
Topics: Adult; Arginine; Asthma; Biomarkers; Case-Control Studies; Child; Enzyme Inhibitors; Evidence-Based | 2015 |
Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Collagen; Cytosol; Inflammation; Lung; Male; Mice; Mice, | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flui | 2011 |
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; En | 2010 |
An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.
Topics: Adolescent; Adult; Age of Onset; Aged; Arginine; Asthma; Body Mass Index; Cross-Sectional Studies; F | 2013 |
Clinical-biological phenotyping beyond inflammation in asthma delivers.
Topics: Age of Onset; Arginine; Asthma; Humans; Obesity | 2013 |