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n(g),n(g')-dimethyl-l-arginine and Angiospasm, Intracranial

n(g),n(g')-dimethyl-l-arginine has been researched along with Angiospasm, Intracranial in 11 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Research Excerpts

ExcerptRelevanceReference
"Elevated cerebrospinal fluid (CSF) concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been found in patients with subarachnoid hemorrhage (SAH)."7.80Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients. ( Hang, CH; Li, H; Liu, M; Ni, L; Wu, W; Zhang, QR; Zhang, X, 2014)
"Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes."5.42Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015)
"Elevated cerebrospinal fluid (CSF) concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been found in patients with subarachnoid hemorrhage (SAH)."3.80Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients. ( Hang, CH; Li, H; Liu, M; Ni, L; Wu, W; Zhang, QR; Zhang, X, 2014)
"Increased cerebrospinal fluid (CSF) levels of asymmetric dimethyl L-arginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), are associated with delayed vasospasm after subarachnoid hemorrhage (SAH); however, the source, cellular mechanisms, and pharmacological inhibition of ADMA production following SAH are unknown."3.73In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates. ( Espey, MG; Harvey-White, J; Jung, CS; Oldfield, EH; Pluta, RM; Shilad, S; Whitehead, A, 2005)
"Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is characterized by the severe constriction of an artery, which often leads to unfavorable outcomes."1.42Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats. ( He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D, 2015)
"After aneurysmal subarachnoid hemorrhage (SAH) disturbance of this equilibrium may evoke delayed cerebral vasospasm (CVS) leading to delayed cerebral ischemia (DCI)."1.38The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage. ( Jung, CS; Lange, B; Seifert, V; Zimmermann, M, 2012)
"Delayed cerebral vasospasm after subarachnoid hemorrhage (SAH) may be evoked by the decreased availability of nitric oxide (NO)."1.34Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. ( Espey, MG; Harvey-White, J; Jung, CS; Oldfield, EH; Pluta, RM; Seifert, V; Zimmermann, M, 2007)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's7 (63.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sabanci, PA1
Omay, B1
Aras, Y1
Aydoseli, A1
Ali, A1
Erdem, T1
Sencer, A1
Kiris, T1
Staalsø, JM2
Bergström, A2
Edsen, T1
Weikop, P1
Romner, B2
Olsen, NV2
Li, H1
Wu, W1
Liu, M1
Zhang, X1
Zhang, QR1
Ni, L1
Hang, CH1
Zhao, D1
Liu, Q1
Ji, Y1
Wang, G1
He, X1
Tian, W1
Xu, H1
Lei, T1
Wang, Y1
Jung, CS5
Lange, B1
Zimmermann, M2
Seifert, V2
Iuliano, BA1
Harvey-White, J3
Espey, MG3
Oldfield, EH3
Pluta, RM4
Whitehead, A1
Shilad, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.[NCT02221466]45 participants (Actual)Observational2014-02-28Completed
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453]150 participants (Actual)Observational2021-08-18Active, not recruiting
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265]32 participants (Anticipated)Observational2023-05-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for n(g),n(g')-dimethyl-l-arginine and Angiospasm, Intracranial

ArticleYear
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
    Neurological research, 2006, Volume: 28, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Humans; Muscle,

2006

Other Studies

10 other studies available for n(g),n(g')-dimethyl-l-arginine and Angiospasm, Intracranial

ArticleYear
Effect of Visible Light on Vasospasticity of Post-Subarachnoid Hemorrhage Cerebrospinal Fluid.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2017, Volume: 78, Issue:6

    Topics: Animals; Arginine; Bilirubin; Female; Humans; Light; Male; Middle Aged; Nitric Oxide; Nitric Oxide S

2017
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture.
    Stroke, 2013, Volume: 44, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Arginine; Biomarkers; Blood Flow Velocity; Femal

2013
Impaired endothelial function after aneurysmal subarachnoid haemorrhage correlates with arginine:asymmetric dimethylarginine ratio.
    British journal of anaesthesia, 2014, Volume: 112, Issue:2

    Topics: Adult; Arginine; Biomarkers; Blood Flow Velocity; Endothelium; Female; Follow-Up Studies; Humans; Hy

2014
Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2014, Volume: 21, Issue:8

    Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up

2014
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
    Neurological research, 2015, Volume: 37, Issue:6

    Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal

2015
Nitric oxide synthase inhibitors and cerebral vasospasm.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 1

    Topics: Animals; Arginine; Citrulline; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibi

2011
The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage.
    Neuroscience letters, 2012, Aug-22, Volume: 524, Issue:1

    Topics: Adult; Arginine; Brain Ischemia; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Retr

2012
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
    Journal of neurosurgery, 2004, Volume: 101, Issue:5

    Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral A

2004
In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.
    Journal of neurosurgery, 2005, Volume: 103, Issue:4

    Topics: Animals; Antioxidants; Arginine; Bilirubin; Cell Culture Techniques; Double-Blind Method; Endothelia

2005
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2007, Volume: 107, Issue:5

    Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In

2007
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2007, Volume: 107, Issue:5

    Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In

2007
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2007, Volume: 107, Issue:5

    Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In

2007
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2007, Volume: 107, Issue:5

    Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; In

2007