n(g),n(g')-dimethyl-l-arginine has been researched along with Alloxan Diabetes in 25 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and diabetic nephropathy (DN)." | 1.56 | Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. ( Awad, AS; Cooper, TK; Gao, T; Morris, SM; Stanley, K; Wetzel, MD, 2020) |
| "Diabetes and its complications, such as diabetic nephropathy, dramatically increase cardiovascular risk." | 1.46 | ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy. ( Bode-Böger, SM; Brilloff, S; Heinrich, A; Hohenstein, B; Hugo, CPM; Jarzebska, N; Martens-Lobenhoffer, J; Rodionov, RN; Todorov, VT; Weiss, N, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, CY | 1 |
| Zhou, T | 2 |
| Li, G | 1 |
| Li, MY | 1 |
| Xiong, XM | 1 |
| Wu, MT | 1 |
| Jiang, JL | 2 |
| Rodionov, RN | 2 |
| Jarzebska, N | 2 |
| Schneider, A | 1 |
| Rexin, A | 1 |
| Sradnick, J | 1 |
| Brilloff, S | 2 |
| Martens-Lobenhoffer, J | 2 |
| Bode-Böger, SM | 2 |
| Todorov, V | 1 |
| Hugo, C | 1 |
| Weiss, N | 2 |
| Hohenstein, B | 2 |
| Leffler, KE | 1 |
| Abdel-Rahman, AA | 1 |
| Wetzel, MD | 1 |
| Gao, T | 1 |
| Stanley, K | 1 |
| Cooper, TK | 1 |
| Morris, SM | 1 |
| Awad, AS | 1 |
| Hussein, J | 1 |
| El-Naggar, M | 2 |
| Badawy, E | 1 |
| El-Laithy, N | 1 |
| El-Waseef, M | 1 |
| Hassan, H | 1 |
| Abdel-Latif, Y | 1 |
| Xiong, Y | 6 |
| He, YL | 1 |
| Li, XM | 1 |
| Nie, F | 1 |
| Zhou, XK | 1 |
| Shi, L | 1 |
| Zhao, C | 1 |
| Wang, H | 1 |
| Lei, T | 1 |
| Liu, S | 1 |
| Cao, J | 1 |
| Lu, Z | 1 |
| Heinrich, A | 1 |
| Todorov, VT | 1 |
| Hugo, CPM | 1 |
| Du, MR | 1 |
| Yan, L | 1 |
| Li, NS | 1 |
| Wang, YJ | 1 |
| Hu, LL | 1 |
| Zhang, KQ | 1 |
| Tian, T | 1 |
| Zhang, H | 1 |
| Fu, Q | 1 |
| Hussein, JS | 1 |
| Rasheed, W | 1 |
| Ramzy, T | 1 |
| Nabeeh, M | 1 |
| Harvy, M | 1 |
| El-Toukhy, S | 1 |
| Ali, O | 1 |
| Raafat, J | 1 |
| Cheng, SL | 1 |
| Ramachandran, B | 1 |
| Behrmann, A | 1 |
| Shao, JS | 1 |
| Mead, M | 1 |
| Smith, C | 1 |
| Krchma, K | 1 |
| Bello Arredondo, Y | 1 |
| Kovacs, A | 1 |
| Kapoor, K | 1 |
| Brill, LM | 1 |
| Perera, R | 1 |
| Williams, BO | 1 |
| Towler, DA | 1 |
| Chen, Y | 1 |
| Xu, X | 1 |
| Sheng, M | 1 |
| Zhang, X | 1 |
| Gu, Q | 1 |
| Zheng, Z | 1 |
| Lu, CW | 1 |
| Guo, Z | 1 |
| Feng, M | 1 |
| Wu, ZZ | 1 |
| He, ZM | 1 |
| Soro-Paavonen, A | 1 |
| Zhang, WZ | 1 |
| Venardos, K | 1 |
| Coughlan, MT | 1 |
| Harris, E | 1 |
| Tong, DC | 1 |
| Brasacchio, D | 1 |
| Paavonen, K | 1 |
| Chin-Dusting, J | 1 |
| Cooper, ME | 1 |
| Kaye, D | 1 |
| Thomas, MC | 1 |
| Forbes, JM | 1 |
| Chen, N | 1 |
| Leng, YP | 1 |
| Xu, WJ | 1 |
| Luo, JD | 1 |
| Chen, MS | 1 |
| Salum, E | 1 |
| Kampus, P | 1 |
| Zilmer, M | 1 |
| Eha, J | 1 |
| Butlin, M | 1 |
| Avolio, AP | 1 |
| Põdramägi, T | 1 |
| Arend, A | 1 |
| Aunapuu, M | 1 |
| Kals, J | 1 |
| Ojima, A | 1 |
| Ishibashi, Y | 1 |
| Matsui, T | 1 |
| Maeda, S | 1 |
| Nishino, Y | 1 |
| Takeuchi, M | 1 |
| Fukami, K | 1 |
| Yamagishi, S | 1 |
| Lin, KY | 1 |
| Ito, A | 1 |
| Asagami, T | 1 |
| Tsao, PS | 1 |
| Adimoolam, S | 1 |
| Kimoto, M | 1 |
| Tsuji, H | 1 |
| Reaven, GM | 1 |
| Cooke, JP | 1 |
| Fu, YF | 1 |
| Fu, SH | 1 |
| Zhou, HH | 1 |
| Lei, M | 1 |
| Fu, S | 1 |
| Fu, Y | 1 |
| Palm, F | 1 |
| Buerk, DG | 1 |
| Carlsson, PO | 1 |
| Hansell, P | 1 |
| Liss, P | 1 |
| Yang, ZC | 1 |
| Xia, K | 1 |
| Wang, L | 1 |
| Jia, SJ | 1 |
| Li, D | 1 |
| Zhang, Z | 1 |
| Deng, S | 1 |
| Zhang, XH | 1 |
| Deng, HW | 2 |
| Li, YJ | 2 |
| Chobanyan, K | 1 |
| Thum, T | 1 |
| Suchy, MT | 1 |
| Zhu, B | 1 |
| Mitschke, A | 1 |
| Gutzki, FM | 1 |
| Beckmann, B | 1 |
| Stichtenoth, DO | 1 |
| Tsikas, D | 1 |
| Lu, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Dexamethasone Implant on Retinal Nerve Fiber and Optic Disc Morphology in Patients With Diabetic Maculopathy[NCT03927118] | 43 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 other studies available for n(g),n(g')-dimethyl-l-arginine and Alloxan Diabetes
| Article | Year |
|---|---|
Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes.
Topics: Animals; Apoptosis; Arginine; Blood-Retinal Barrier; Cell Communication; Cell Membrane Permeability; | 2019 |
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
Topics: Amidohydrolases; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomeru | 2019 |
Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.
Topics: Adiponectin; Animals; Arginine; Connexin 43; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2020 |
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experim | 2020 |
Homocysteine and Asymmetrical Dimethylarginine in Diabetic Rats Treated with Docosahexaenoic Acid-Loaded Zinc Oxide Nanoparticles.
Topics: Animals; Arginine; Cellulose; Diabetes Mellitus, Experimental; Docosahexaenoic Acids; Homocysteine; | 2020 |
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats.
Topics: Acetylcysteine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2021 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Ex | 2017 |
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
Topics: Albuminuria; Amidohydrolases; Animals; Arginine; Cell Proliferation; Creatinine; Diabetes Mellitus, | 2017 |
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cell Line; Diabetes Mellitus, Experimental; Diabet | 2018 |
Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats.
Topics: Amidohydrolases; Animals; Arginine; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Exper | 2018 |
Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes.
Topics: Animals; Arginine; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; DNA Damag | 2019 |
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Topics: Animals; Arginine; Arteriosclerosis; Calcinosis; Diabetes Mellitus, Experimental; Dietary Fats; Friz | 2015 |
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Cyclic GMP; Diabetes Mellitu | 2009 |
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endot | 2010 |
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Arginine; Cattle; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, E | 2010 |
Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats.
Topics: Adenosine Triphosphate; Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Experimental; Enzyme | 2011 |
Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Arginine; Biomarkers; Blood Pressure; Cholecalciferol; Di | 2012 |
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Evaluation, Preclin | 2013 |
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Dia | 2002 |
Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes.
Topics: Animals; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimen | 2003 |
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
Topics: Adult; Aged; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; | 2005 |
Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Kidney Cortex; Male; Microcirculation; NG-Nitroa | 2005 |
Asymmetric dimethylarginine reduced erythrocyte deformability in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Erythroc | 2007 |
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
Topics: Amidohydrolases; Animals; Arginine; Catalysis; Diabetes Mellitus, Experimental; Dimethylamines; Enzy | 2007 |
Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum.
Topics: Animals; Aorta; Arginine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Nitric Oxide Syn | 1997 |