Page last updated: 2024-10-17

n(g),n(g')-dimethyl-l-arginine and Albuminuria

n(g),n(g')-dimethyl-l-arginine has been researched along with Albuminuria in 21 studies

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine

Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Sixty-one young people with Type 1 diabetes without macrovascular disease or nephropathy and 62 healthy volunteers underwent brachial artery flow-mediated dilatation (FMD) and assay of plasma ADMA and adhesion molecules."5.35A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria. ( Agarwal, SC; Böger, RH; Home, PD; Lüneburg, N; Schwedhelm, E; Sibal, L, 2009)
" The aim of this study is to evaluate the direct effects of losartan and/or pentoxifylline on expression of renal DDAH-1 and its relation to oxidative stress in the setting of albuminuria."3.79Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy. ( Ahn, JS; Cho, JH; Choi, JY; Hyun, SH; Kim, CD; Kim, YL; Oh, EJ; Oh, SH; Park, SH; Ryu, HM; Yoon, SH, 2013)
" Patients with metabolic syndrome (MS) had lower activity of gluthatione peroxidase, higher asymmetric dimethyloarginine (ADMA) and oxidized LDL cholesterol (oxyLDL) in comparison to patients without MS."3.78Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy. ( Janas, R; Litwin, M; Niemirska, A; Płudowski, P; Skorupa, E; Sladowska-Kozłowska, J; Wawer, ZT; Wierzbicka, A, 2012)
"Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD)."3.76Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype. ( Biemond, BJ; Brandjes, DP; Duits, AJ; Landburg, PP; Muskiet, FA; Schnog, JB; Teerlink, T, 2010)
"Asymmetric dimethylarginine (ADMA) and subclinical inflammation are associated with atherosclerosis progression, whereas microalbuminuria is an established index of hypertensive organ damage."3.76ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study. ( Andrikou, E; Dimitriadis, K; Mihas, C; Miliou, A; Papademetriou, V; Stefanadi, E; Stefanadis, C; Thomopoulos, C; Tsiachris, D; Tsioufis, C, 2010)
"Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and diabetic nephropathy (DN)."1.56Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. ( Awad, AS; Cooper, TK; Gao, T; Morris, SM; Stanley, K; Wetzel, MD, 2020)
"Albuminuria was calculated using urinary albumin and creatinine ratio (UACR)."1.46Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury. ( Balasubramanyam, M; Jayachandran, I; Manickam, N; Mohan, V; Paramasivam, P; Subramanian, SC; Sundararajan, S; Venkatesan, B, 2017)
"Diabetes and its complications, such as diabetic nephropathy, dramatically increase cardiovascular risk."1.46ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy. ( Bode-Böger, SM; Brilloff, S; Heinrich, A; Hohenstein, B; Hugo, CPM; Jarzebska, N; Martens-Lobenhoffer, J; Rodionov, RN; Todorov, VT; Weiss, N, 2017)
"Seventy patients with type 2 diabetes mellitus and 11 healthy subjects were assessed concerning urine albumin: creatinine ratio, plasma and urinary advanced glycation end-products, plasma asymmetric dimethyl-arginine, serum cystatin C, intima-media thickness in the common carotid arteries, the pulsatility index, the resistance index in the internal carotid arteries and the middle cerebral arteries, the cerebrovascular reactivity through the breath-holding test."1.42Glycated peptides are associated with the variability of endothelial dysfunction in the cerebral vessels and the kidney in type 2 diabetes mellitus patients: a cross-sectional study. ( Bob, F; Dumitrascu, V; Gadalean, F; Gluhovschi, C; Gluhovschi, G; Jianu, DC; Petrica, L; Petrica, M; Popescu, R; Ursoniu, S; Velciov, S; Vlad, A; Vlad, D, 2015)
"Patients with type 2 diabetes mellitus were divided into three groups according to daily albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria (n=30 in each)."1.42The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes. ( Aycan-Ustyol, E; Bekpinar, S; Dinccag, N; Gurdol, F; Unlucerci, Y; Yenidunya, G, 2015)
"Sixty-one young people with Type 1 diabetes without macrovascular disease or nephropathy and 62 healthy volunteers underwent brachial artery flow-mediated dilatation (FMD) and assay of plasma ADMA and adhesion molecules."1.35A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria. ( Agarwal, SC; Böger, RH; Home, PD; Lüneburg, N; Schwedhelm, E; Sibal, L, 2009)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's15 (71.43)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Wołyniec, W1
Kasprowicz, K1
Giebułtowicz, J1
Korytowska, N1
Zorena, K1
Bartoszewicz, M1
Rita-Tkachenko, P1
Renke, M1
Ratkowski, W1
Wetzel, MD1
Gao, T1
Stanley, K1
Cooper, TK1
Morris, SM1
Awad, AS1
Jayachandran, I1
Sundararajan, S1
Paramasivam, P1
Venkatesan, B1
Subramanian, SC1
Balasubramanyam, M1
Mohan, V1
Manickam, N1
Haymann, JP1
Hammoudi, N1
Stankovic Stojanovic, K1
Galacteros, F1
Habibi, A1
Avellino, V1
Bartolucci, P1
Benzerara, Y1
Arlet, JB1
Djebbar, M1
Letavernier, E1
Grateau, G1
Tabibzadeh, N1
Girshovich, A1
Chaignon, M1
Girot, R1
Levy, P1
Lionnet, F1
Rodionov, RN1
Heinrich, A1
Brilloff, S1
Jarzebska, N1
Martens-Lobenhoffer, J1
Bode-Böger, SM1
Todorov, VT1
Hugo, CPM1
Weiss, N1
Hohenstein, B1
Triches, CB1
Quinto, M1
Mayer, S1
Batista, M1
Zanella, MT1
Park, SH1
Hyun, SH1
Ryu, HM1
Ahn, JS1
Oh, SH1
Oh, EJ1
Yoon, SH1
Choi, JY1
Cho, JH1
Kim, CD1
Kim, YL1
Petrica, L1
Vlad, A1
Gluhovschi, G1
Gadalean, F1
Dumitrascu, V1
Vlad, D1
Popescu, R1
Velciov, S1
Gluhovschi, C1
Bob, F1
Ursoniu, S1
Petrica, M1
Jianu, DC1
Chen, J1
Hamm, LL1
Mohler, ER1
Hudaihed, A1
Arora, R1
Chen, CS1
Liu, Y1
Browne, G1
Mills, KT1
Kleinpeter, MA1
Simon, EE1
Rifai, N1
Klag, MJ1
He, J1
Bekpinar, S1
Yenidunya, G1
Gurdol, F1
Unlucerci, Y1
Aycan-Ustyol, E1
Dinccag, N1
Hanai, K1
Babazono, T1
Nyumura, I1
Toya, K1
Tanaka, N1
Tanaka, M1
Ishii, A1
Iwamoto, Y1
Guagnano, MT1
Ferroni, P1
Santilli, F1
Paoletti, V1
Manigrasso, MR1
Pescara, L1
Cuccurullo, C1
Ciabattoni, G1
Davì, G1
Sibal, L1
Agarwal, SC1
Schwedhelm, E1
Lüneburg, N1
Böger, RH1
Home, PD1
Landburg, PP1
Teerlink, T1
Biemond, BJ1
Brandjes, DP1
Muskiet, FA1
Duits, AJ1
Schnog, JB1
Tsioufis, C2
Dimitriadis, K2
Andrikou, E1
Thomopoulos, C2
Tsiachris, D1
Stefanadi, E1
Mihas, C1
Miliou, A1
Papademetriou, V2
Stefanadis, C2
Marcovecchio, ML1
Widmer, B1
Turner, C1
Dunger, DB1
Dalton, RN1
Lu, TM1
Chung, MY1
Lin, CC1
Hsu, CP1
Lin, SJ1
Aggelis, A1
Kasiakogias, A1
Tzamou, V1
Kyvelou, SM1
Mikhailidis, DP1
Sladowska-Kozłowska, J1
Litwin, M1
Niemirska, A1
Płudowski, P1
Wierzbicka, A1
Skorupa, E1
Wawer, ZT1
Janas, R1
Schiffrin, EL1
Lipman, ML1
Mann, JF1
Stenvinkel, P1
Carrero, JJ1
Axelsson, J1
Lindholm, B1
Heimbürger, O1
Massy, Z1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Dexamethasone Implant on Retinal Nerve Fiber and Optic Disc Morphology in Patients With Diabetic Maculopathy[NCT03927118]43 participants (Actual)Observational2018-02-01Completed
Influence of Preoperative Hemodialysis or Intraoperative Modified Ultrafiltration on Postoperative Outcome for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery: Randomized, Controlled, Multicenter Clinical Trial[NCT00720967]Phase 3450 participants (Anticipated)Interventional2008-11-30Not yet recruiting
Effect of Beraprost Sodium on Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy (BESTinDN Study)[NCT01796418]102 participants (Anticipated)Interventional2013-03-31Recruiting
A Multicenter, Randomized Trial to Compare Xience and Vision Coronary Stents in the Same Multivessel Patient With Chronic Kidney Disease[NCT00818792]Phase 2215 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for n(g),n(g')-dimethyl-l-arginine and Albuminuria

ArticleYear
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarker

2007
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:2

    Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidn

2008

Trials

2 trials available for n(g),n(g')-dimethyl-l-arginine and Albuminuria

ArticleYear
Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients.
    British journal of haematology, 2017, Volume: 179, Issue:5

    Topics: Adult; Albuminuria; Anemia, Sickle Cell; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomark

2017
Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cell Adhesion Molecules; Comorbidity;

2015

Other Studies

17 other studies available for n(g),n(g')-dimethyl-l-arginine and Albuminuria

ArticleYear
Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.
    International journal of environmental research and public health, 2019, 10-28, Volume: 16, Issue:21

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Albuminuria; Arginine; Biomarkers; Creatinine; Fem

2019
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
    American journal of physiology. Renal physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experim

2020
Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury.
    Clinical biochemistry, 2017, Volume: 50, Issue:15

    Topics: Adult; Albuminuria; Animals; Arginine; Asian People; Biomarkers; Cell Line; Creatinine; Diabetes Mel

2017
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
    Atherosclerosis. Supplements, 2017, Volume: 30

    Topics: Albuminuria; Amidohydrolases; Animals; Arginine; Cell Proliferation; Creatinine; Diabetes Mellitus,

2017
Relation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitus.
    Journal of diabetes and its complications, 2018, Volume: 32, Issue:3

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Case-Control Studies; Diabetes Complications; Diabetes Mell

2018
Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy.
    American journal of nephrology, 2013, Volume: 37, Issue:5

    Topics: Acetylglucosaminidase; Albuminuria; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animal

2013
Glycated peptides are associated with the variability of endothelial dysfunction in the cerebral vessels and the kidney in type 2 diabetes mellitus patients: a cross-sectional study.
    Journal of diabetes and its complications, 2015, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Breath Holding; Cohort Studies; Cross-Sectional Studies; Di

2015
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes.
    Clinical biochemistry, 2015, Volume: 48, Issue:18

    Topics: Albuminuria; Apolipoproteins; Apolipoproteins M; Arginine; Biological Transport; Cholesterol, HDL; C

2015
Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Cohort Studies; Cross-Sectional Studies; Diabetes Me

2009
Determinants of platelet activation in hypertensives with microalbuminuria.
    Free radical biology & medicine, 2009, Apr-01, Volume: 46, Issue:7

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Disease Progression; Endothelium; Female; Humans; Hypertens

2009
A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria.
    Cardiovascular diabetology, 2009, Jun-01, Volume: 8

    Topics: Adolescent; Adult; Albuminuria; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Cell Ad

2009
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
    Blood cells, molecules & diseases, 2010, Apr-15, Volume: 44, Issue:4

    Topics: Adult; Albuminuria; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Cholelithiasis; Female; Hemolys

2010
ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Adult; Albuminuria; Arginine; Blood Pressure; C-Reactive Protein; Creatinine; Cross-Sectional Studie

2010
Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA(1c).
    Diabetic medicine : a journal of the British Diabetic Association, 2011, Volume: 28, Issue:6

    Topics: Adolescent; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Child; Diabet

2011
Asymmetric dimethylarginine and clinical outcomes in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:7

    Topics: Aged; Aged, 80 and over; Albuminuria; Arginine; Biomarkers; Chi-Square Distribution; Chromatography,

2011
Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: integrating vascular dysfunction.
    Expert opinion on therapeutic targets, 2011, Volume: 15, Issue:12

    Topics: Adult; Albuminuria; Arginine; Blood Pressure; Cross-Sectional Studies; Echocardiography; Endothelium

2011
Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy.
    Pediatric nephrology (Berlin, Germany), 2012, Volume: 27, Issue:10

    Topics: Adiposity; Adolescent; Albuminuria; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; A

2012