n(g),n(g')-dimethyl-l-arginine has been researched along with Aging in 32 studies
N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased circulating methylarginines (MA) have been linked to the metabolic syndrome to explain endothelial dysfunction and cardiovascular disease risk." | 7.73 | Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. ( Adegoke, OA; Chevalier, S; Gougeon, R; Lamarche, M; Marliss, EB; Morais, JA; Wu, G, 2006) |
| "We investigated here the effect of l-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial aging." | 7.73 | Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. ( Bode-Böger, SM; Bukowska, A; Lendeckel, U; Martens-Lobenhoffer, J; Scalera, F; Täger, M, 2006) |
| "To investigate the significance of nitric oxide (NO) -mediated neuron death in aging and Alzheimer's disease (AD), the concentration of asymmetrical dimethylarginine (ADMA), an endogenous NO synthase inhibitor, in the cerebrospinal fluid was determined in neurologically normal controls and patients with AD." | 7.71 | Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. ( Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H, 2001) |
| "In a prospective cohort study of 204 subjects (mean age 63±6 at study entry), we evaluated the effects of 4 years of aging on parameters of NO generation and effect, including platelet aggregability and responsiveness to NO, and plasma concentrations of the NO synthase inhibitor, asymmetric dimethylarginine (ADMA)." | 3.80 | Aging of the nitric oxide system: are we as old as our NO? ( Chan, WP; Chirkov, YY; Horowitz, JD; Ngo, DT; Sverdlov, AL, 2014) |
| "Increased circulating methylarginines (MA) have been linked to the metabolic syndrome to explain endothelial dysfunction and cardiovascular disease risk." | 3.73 | Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. ( Adegoke, OA; Chevalier, S; Gougeon, R; Lamarche, M; Marliss, EB; Morais, JA; Wu, G, 2006) |
| "We investigated here the effect of l-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial aging." | 3.73 | Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. ( Bode-Böger, SM; Bukowska, A; Lendeckel, U; Martens-Lobenhoffer, J; Scalera, F; Täger, M, 2006) |
| " We assessed blood concentrations of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) as well as renal hemodynamics, comparing young (n=24, 13 men, 25+/-1 years) and elderly (n=24, 13 men, 69+/-2 years) healthy subjects and elderly subjects with essential hypertension (n=24, 13 men, 70+/-2 years)." | 3.72 | Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. ( Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E, 2003) |
| "These results strongly suggest that impaired endothelium dependent and NO mediated cavernous relaxation with aging is due to decreased NO production, which would result from increased arginase activity and probably from decreased L-arginine content." | 3.72 | Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit. ( Azuma, H; Kihara, K; Kurosaki, E; Masuda, H; Sakai, Y; Yamauchi, Y, 2004) |
| "To investigate the significance of nitric oxide (NO) -mediated neuron death in aging and Alzheimer's disease (AD), the concentration of asymmetrical dimethylarginine (ADMA), an endogenous NO synthase inhibitor, in the cerebrospinal fluid was determined in neurologically normal controls and patients with AD." | 3.71 | Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. ( Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H, 2001) |
| "Inflammation plays an important role in Alzheimer's disease and the inhibition of endothelial nitric oxide by ADMA may increase the concentration of inflammatory mediators in the brain." | 2.71 | Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease. ( Selley, ML, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 16 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, L | 1 |
| Zhao, C | 1 |
| Wang, H | 1 |
| Lei, T | 1 |
| Liu, S | 1 |
| Cao, J | 1 |
| Lu, Z | 1 |
| Simandi, Z | 1 |
| Pajer, K | 1 |
| Karolyi, K | 1 |
| Sieler, T | 1 |
| Jiang, LL | 1 |
| Kolostyak, Z | 1 |
| Sari, Z | 1 |
| Fekecs, Z | 1 |
| Pap, A | 1 |
| Patsalos, A | 1 |
| Contreras, GA | 1 |
| Reho, B | 1 |
| Papp, Z | 1 |
| Guo, X | 1 |
| Horvath, A | 1 |
| Kiss, G | 1 |
| Keresztessy, Z | 1 |
| Vámosi, G | 1 |
| Hickman, J | 1 |
| Xu, H | 1 |
| Dormann, D | 1 |
| Hortobagyi, T | 1 |
| Antal, M | 1 |
| Nógrádi, A | 1 |
| Nagy, L | 1 |
| Nakamura, A | 1 |
| Kajitani, S | 1 |
| Sato, K | 1 |
| Kanazawa, M | 1 |
| Kondo, M | 1 |
| Endo, H | 1 |
| Nozaki, E | 1 |
| Mangoni, AA | 2 |
| Rodionov, RN | 1 |
| McEvoy, M | 2 |
| Zinellu, A | 3 |
| Carru, C | 3 |
| Sotgia, S | 1 |
| Oliva-Damaso, E | 1 |
| Oliva-Damaso, N | 1 |
| Rodriguez-Esparragon, F | 1 |
| Payan, J | 1 |
| Baamonde-Laborda, E | 1 |
| Gonzalez-Cabrera, F | 1 |
| Santana-Estupiñan, R | 1 |
| Rodriguez-Perez, JC | 1 |
| Bouras, G | 1 |
| Deftereos, S | 1 |
| Tousoulis, D | 1 |
| Giannopoulos, G | 1 |
| Chatzis, G | 1 |
| Tsounis, D | 1 |
| Cleman, MW | 1 |
| Stefanadis, C | 1 |
| Sverdlov, AL | 2 |
| Ngo, DT | 2 |
| Chan, WP | 1 |
| Chirkov, YY | 1 |
| Horowitz, JD | 2 |
| Obayashi, K | 1 |
| Saeki, K | 1 |
| Kurumatani, N | 1 |
| Rroji, M | 1 |
| Eloot, S | 1 |
| Dhondt, A | 1 |
| Van Biesen, W | 1 |
| Glorieux, G | 1 |
| Neirynck, N | 1 |
| Vandennoortgate, N | 1 |
| Liabeuf, S | 1 |
| Massy, Z | 1 |
| Vanholder, R | 1 |
| Sandri, M | 1 |
| Viehmann, M | 1 |
| Adams, V | 1 |
| Rabald, K | 1 |
| Mangner, N | 1 |
| Höllriegel, R | 1 |
| Lurz, P | 1 |
| Erbs, S | 1 |
| Linke, A | 1 |
| Kirsch, K | 1 |
| Möbius-Winkler, S | 1 |
| Thiery, J | 1 |
| Teupser, D | 1 |
| Hambrecht, R | 1 |
| Schuler, G | 1 |
| Gielen, S | 1 |
| Campesi, I | 1 |
| Occhioni, S | 1 |
| Tonolo, G | 1 |
| Cherchi, S | 1 |
| Basili, S | 1 |
| Franconi, F | 1 |
| Cui, K | 1 |
| Luan, Y | 1 |
| Tang, Z | 1 |
| Rao, K | 1 |
| Wang, T | 1 |
| Chen, Z | 1 |
| Wang, S | 1 |
| Liu, J | 1 |
| Wang, D | 1 |
| Hirata, T | 1 |
| Arai, Y | 1 |
| Takayama, M | 1 |
| Abe, Y | 1 |
| Ohkuma, K | 1 |
| Takebayashi, T | 1 |
| Nair, N | 1 |
| Gongora, E | 1 |
| Cottart, CH | 1 |
| Laguillier, C | 1 |
| Nivet-Antoine, V | 1 |
| Klimczak, C | 1 |
| Sebban, C | 1 |
| Beaudeux, JL | 1 |
| McNeil, JJ | 1 |
| Fabian, E | 1 |
| Bogner, M | 1 |
| Elmadfa, I | 1 |
| Attia, JR | 1 |
| Lu, R | 2 |
| Zhu, HQ | 1 |
| Peng, J | 1 |
| Li, NS | 1 |
| Li, YJ | 3 |
| Kielstein, JT | 2 |
| Bode-Böger, SM | 4 |
| Frölich, JC | 2 |
| Ritz, E | 1 |
| Haller, H | 2 |
| Fliser, D | 2 |
| Selley, ML | 1 |
| Sakai, Y | 1 |
| Masuda, H | 1 |
| Kihara, K | 1 |
| Kurosaki, E | 1 |
| Yamauchi, Y | 1 |
| Azuma, H | 1 |
| Schulze, F | 1 |
| Maas, R | 1 |
| Freese, R | 1 |
| Schwedhelm, E | 1 |
| Silberhorn, E | 1 |
| Böger, RH | 2 |
| Marliss, EB | 1 |
| Chevalier, S | 1 |
| Gougeon, R | 1 |
| Morais, JA | 1 |
| Lamarche, M | 1 |
| Adegoke, OA | 1 |
| Wu, G | 1 |
| Scalera, F | 1 |
| Martens-Lobenhoffer, J | 1 |
| Täger, M | 1 |
| Bukowska, A | 1 |
| Lendeckel, U | 1 |
| Gates, PE | 1 |
| Boucher, ML | 1 |
| Silver, AE | 1 |
| Monahan, KD | 1 |
| Seals, DR | 1 |
| Yudkoff, M | 1 |
| Nissim, I | 1 |
| Pereira, G | 1 |
| Segal, S | 1 |
| Thiele, W | 1 |
| Junker, W | 1 |
| Alexander, K | 1 |
| Xiong, Y | 1 |
| Yuan, LW | 1 |
| Deng, HW | 1 |
| Chen, BM | 1 |
| Abe, T | 1 |
| Tohgi, H | 1 |
| Murata, T | 1 |
| Isobe, C | 1 |
| Sato, C | 1 |
| Hu, CP | 1 |
| Wu, XP | 1 |
| Liao, EY | 1 |
6 reviews available for n(g),n(g')-dimethyl-l-arginine and Aging
| Article | Year |
|---|---|
New horizons in arginine metabolism, ageing and chronic disease states.
Topics: Aged; Aging; Arginine; Chronic Disease; Homoarginine; Humans | 2019 |
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks | 2019 |
Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease?
Topics: Aging; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Ch | 2013 |
Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA.
Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; NF-E2-Related Fact | 2017 |
[Biology of arterial ageing and arteriosclerosis].
Topics: Adult; Aged; Aging; Arginine; Arteriosclerosis; Atherosclerosis; Calcinosis; Diagnostic Techniques, | 2009 |
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
Topics: Adult; Aged; Aging; Arginine; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases | 2003 |
2 trials available for n(g),n(g')-dimethyl-l-arginine and Aging
| Article | Year |
|---|---|
Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study.
Topics: Aged; Aging; Arginine; Blood Flow Velocity; Cell Count; Chemokine CXCL12; Endothelial Progenitor Cel | 2016 |
Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginine; Enzyme Inhibitors; Female; Homocysteine | 2003 |
24 other studies available for n(g),n(g')-dimethyl-l-arginine and Aging
| Article | Year |
|---|---|
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Ex | 2017 |
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
Topics: Aging; Amino Acid Sequence; Animals; Arginine; Cell Line; Cyclic AMP Response Element-Binding Protei | 2018 |
Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men.
Topics: Adult; Age Factors; Aging; Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Male; M | 2019 |
Aging of the nitric oxide system: are we as old as our NO?
Topics: Aged; Aging; Arginine; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up S | 2014 |
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-S | 2014 |
Association of advanced age with concentrations of uraemic toxins in CKD.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; beta 2-Microglobulin; Biomarkers; Bloo | 2016 |
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters.
Topics: Adult; Aging; Arginine; Blood; Body Weight; Female; Humans; Interleukin-6; Male; Malondialdehyde; Mi | 2016 |
Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats.
Topics: Aging; Amidohydrolases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cytochrome P-45 | 2017 |
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies; | 2018 |
Correlates of arterial stiffness in an ageing population: role of asymmetric dimethylarginine.
Topics: Aged; Aging; Arginine; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Risk | 2009 |
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
Topics: Aged; Aged, 80 and over; Aging; Apolipoproteins A; Arginine; Cardiovascular Diseases; Catalase; Enzy | 2012 |
Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aging; Amidohydrolases; Arginine; Australia; C | 2013 |
Endothelium-dependent vasorelaxation and the expression of calcitonin gene-related peptide in aged rats.
Topics: Aging; Animals; Arginine; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Gene Expression; M | 2002 |
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects.
Topics: Adult; Aged; Aging; Arginine; Blood Pressure; Female; Glomerular Filtration Rate; Hemodynamics; Huma | 2003 |
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
Topics: Aging; Animals; Arginase; Arginine; Carbachol; Cholinergic Agonists; Endothelium, Vascular; Male; Mu | 2004 |
Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
Topics: Adult; Aged; Aging; Arginine; Biomarkers; Cardiovascular Diseases; Enzyme Inhibitors; Enzyme-Linked | 2005 |
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Blood Glucose; Body Composition; Female; Glucose; G | 2006 |
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
Topics: Aging; Arginine; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Hom | 2006 |
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
Topics: Adolescent; Adult; Aged; Aging; Amidohydrolases; Arginine; Biological Availability; Brachial Artery; | 2007 |
Urinary excretion of dimethylarginines in premature infants.
Topics: Adolescent; Adult; Aging; Arginine; Body Weight; Child; Child, Preschool; Diet; Gestational Age; Hum | 1984 |
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Pr | 1997 |
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Kidney; Male; Nitri | 2001 |
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Arginine; Brain; Female; Humans; Male; Middle Aged; Neurons; Nitric | 2001 |
Effect of age on bone mineral density and the serum concentration of endogenous nitric oxide synthase inhibitors in rats.
Topics: Absorptiometry, Photon; Aging; Animals; Arginine; Bone and Bones; Bone Density; Enzyme Inhibitors; M | 2002 |