Compounds > n(alpha)-(4-amino-4-deoxy-n(10)--methylpteroyl-n(epsilon)-4--fluoresceinthiocarbamoyl)-l-lysine-trihydrate

n(alpha)-(4-amino-4-deoxy-n(10)--methylpteroyl-n(epsilon)-4--fluoresceinthiocarbamoyl)-l-lysine-trihydrate and Menopause--Premature

n(alpha)-(4-amino-4-deoxy-n(10)--methylpteroyl-n(epsilon)-4--fluoresceinthiocarbamoyl)-l-lysine-trihydrate has been researched along with Menopause--Premature* in 1 studies

Other Studies

1 other study(ies) available for n(alpha)-(4-amino-4-deoxy-n(10)--methylpteroyl-n(epsilon)-4--fluoresceinthiocarbamoyl)-l-lysine-trihydrate and Menopause--Premature

Article	Year
Effects of single-agent and combination chemotherapy for gestational trophoblastic tumors on risks of second malignancy and early menopause. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Feb-10, Volume: 33, Issue:5 To assess the risks of second malignancy and early menopause in a large cohort of patients with gestational trophoblastic tumor who were treated with chemotherapy.. A survey of patients treated at Charing Cross Hospital between 1958 and 2000 was performed in 2006 to assemble incidence data for subsequent malignancies and the age at menopause. Treatment records were reviewed for the regimens and durations, and the incidence of subsequent malignancies was compared with that in the national age-matched population.. Data were obtained for 1,903 patients, with a mean follow-up of 16.9 years. Eighty-six patients developed a subsequent malignancy compared with an expected number of 79 (standardized incidence ratio [SIR], 1.1; 95% CI, 0.9 to 1.3). The overall risk was low for patients treated with single-agent methotrexate and folinic acid (MTX-FA; SIR, 0.7; 95% CI, 0.5 to 1.1) and also for patients treated with etoposide, methotrexate, and dactinomycin followed by cyclophosphamide and vincristine on alternating weeks (EMA-CO) with an SIR of 0.9 (95% CI, 0.4 to 2.2), but there were significantly increased risks of oral cancer, melanoma, meningioma, and leukemia. The cumulative risk of early menopause was low after MTX-FA but was substantial after EMA-CO, reaching 13% by age 40 years and 36% by age 45 years.. Subsequent cancer risks for patients cured of gestational trophoblastic tumors with modern chemotherapy appear similar to those of the normal population with no overall increased risk of malignancy after MTX-FA or EMA-CO. However, there was evidence of an increased risk of leukemia after EMA-CO and some evidence of other site-specific increased risks based on small patient numbers. All major treatments except MTX-FA increased the risk of early menopause. Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cohort Studies; Cyclophosphamide; Dactinomycin; Etoposide; Female; Follow-Up Studies; Gestational Trophoblastic Disease; Humans; Incidence; Kaplan-Meier Estimate; Menopause, Premature; Methotrexate; Middle Aged; Neoplasms, Second Primary; Odds Ratio; Pregnancy; Risk Assessment; Risk Factors; Uterine Neoplasms; Vincristine; Young Adult	2015

Article

Year

Effects of single-agent and combination chemotherapy for gestational trophoblastic tumors on risks of second malignancy and early menopause.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Feb-10, Volume: 33, Issue:5

To assess the risks of second malignancy and early menopause in a large cohort of patients with gestational trophoblastic tumor who were treated with chemotherapy.. A survey of patients treated at Charing Cross Hospital between 1958 and 2000 was performed in 2006 to assemble incidence data for subsequent malignancies and the age at menopause. Treatment records were reviewed for the regimens and durations, and the incidence of subsequent malignancies was compared with that in the national age-matched population.. Data were obtained for 1,903 patients, with a mean follow-up of 16.9 years. Eighty-six patients developed a subsequent malignancy compared with an expected number of 79 (standardized incidence ratio [SIR], 1.1; 95% CI, 0.9 to 1.3). The overall risk was low for patients treated with single-agent methotrexate and folinic acid (MTX-FA; SIR, 0.7; 95% CI, 0.5 to 1.1) and also for patients treated with etoposide, methotrexate, and dactinomycin followed by cyclophosphamide and vincristine on alternating weeks (EMA-CO) with an SIR of 0.9 (95% CI, 0.4 to 2.2), but there were significantly increased risks of oral cancer, melanoma, meningioma, and leukemia. The cumulative risk of early menopause was low after MTX-FA but was substantial after EMA-CO, reaching 13% by age 40 years and 36% by age 45 years.. Subsequent cancer risks for patients cured of gestational trophoblastic tumors with modern chemotherapy appear similar to those of the normal population with no overall increased risk of malignancy after MTX-FA or EMA-CO. However, there was evidence of an increased risk of leukemia after EMA-CO and some evidence of other site-specific increased risks based on small patient numbers. All major treatments except MTX-FA increased the risk of early menopause.

Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cohort Studies; Cyclophosphamide; Dactinomycin; Etoposide; Female; Follow-Up Studies; Gestational Trophoblastic Disease; Humans; Incidence; Kaplan-Meier Estimate; Menopause, Premature; Methotrexate; Middle Aged; Neoplasms, Second Primary; Odds Ratio; Pregnancy; Risk Assessment; Risk Factors; Uterine Neoplasms; Vincristine; Young Adult

2015