Compounds > n(6)-carboxymethyllysine
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n(6)-carboxymethyllysine and Aging

n(6)-carboxymethyllysine has been researched along with Aging in 58 studies

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.72)18.7374
1990's17 (29.31)18.2507
2000's24 (41.38)29.6817
2010's14 (24.14)24.3611
2020's2 (3.45)2.80

Authors

AuthorsStudies
Baldensperger, T; Dau, T; Di Sanzo, S; Glomb, MA; Heller, R; Henning, C; Kirkpatrick, JM; Leheis, A; Marx, C; Ori, A; Parca, L; Rändler, TL; Spengler, K; Wang, ZQ1
Jakhotia, S; Reddy Addi, U; Reddy, GB; Reddy, SS1
He, W; Hu, S; Liu, Z; Ma, G; Xu, H1
Arnold, AM; Djousse, L; Hirsch, C; Ix, JH; Kizer, JR; Mukamal, KJ; Newman, AB; Siscovick, D; Thielke, SM; Tracy, RP; Whitson, HE; Yee, LM; Zieman, S1
Chao, PC; Mong, MC; Yin, MC1
Auger, F; Beuscart, JB; Boulanger, E; Durieux, N; Grossin, N; Jacolot, P; Montaigne, D; Niquet-Leridon, C; Schmidt, AM; Susen, S; Tessier, FJ1
Ferrucci, L; Garcia, M; Harris, TB; Newman, AB; Satterfield, S; Schwartz, AV; Semba, RD; Sun, K; Varadhan, R1
Chun, Y; Kim, CS; Kim, HJ; Kim, J; Park, S; Song, W1
Berishvili, E; de Graaff, HJ; Fuijkschot, WW; Houtman, M; Kakabadze, Z; Krijnen, PA; Kupreishvili, K; Meinster, E; Niessen, HW; Schalkwijk, CG; Smulders, YM; van Broekhoven, A; Vonk, AB1
Gustienė, O; Stanislovaitienė, D; Steponavičiūtė, R; Žaliūnas, R; Žaliūnienė, D; Žemaitienė, R1
Meyer, DM; Mills, LD; Mohammed, SF; Owan, TE; Redfield, MM; Schalkwijk, CG; Shapiro, BP1
Ershler, WB; Ferrucci, L; Guralnik, JM; Longo, DL; Patel, KV; Semba, RD; Sun, K1
Ferrucci, L; Lakatta, EG; Najjar, SS; Semba, RD; Sun, K1
Beck, J; Dalal, M; Ferrucci, L; Fried, LP; Semba, RD; Sun, K1
Beck, J; Dalal, M; Ferrucci, L; Fried, LP; Guralnik, JM; Semba, RD; Sun, K; Varadhan, R; Walston, J1
Bandinelli, S; Ferrucci, L; Guralnik, JM; Semba, RD; Sun, K1
Ferrucci, L; Fink, JC; Semba, RD; Sun, K; Windham, BG1
Eguchi, N; Hirohama, J; Jinno, M; Miyazaki, A; Takeuchi, M; Teruya, K; Watanabe, A1
Begall, S; Dammann, P; Monnier, VM; Sell, DR; Strauch, C1
Bandinelli, S; Ferrucci, L; Guralnik, JM; Patel, KV; Roy, CN; Semba, RD; Sun, K; Varadhan, R1
Black, MJ; Campbell, DJ; Jenkins, AJ; Kelly, DJ; Kenny, JF; Newcomb, AE; Prior, DL; Schalkwijk, CG; Somaratne, JB; Yii, M1
Dei, R; Horie, K; Inagaki, T; Li, M; Miyata, T; Nakagomi, Y; Niwa, H; Sobue, G; Takeda, A; Washimi, Y; Watanabe, M; Yasuda, Y1
Horiuchi, S; Jono, T; Kimura, T; Kitamura, T; Miyazaki, K; Nagai, R; Takamatsu, J; Yuzuriha, T1
Bakala, H; Borot-Laloi, C; Friguet, B; Hamelin, M1
Bakala, H; Bismuth, J; Borot-Laloi, C; Corman, B; Delaval, E; Friguet, B; Hamelin, M1
Hattori, M; He, C; McEvoy, R; Peppa, M; Vlassara, H; Zheng, F1
Cruz-Sánchez, CZ; Cruz-Sánchez, FF; Gironès, X; Guimerà, A; Kalaria, R; Lafuente, JV; Makita, Z; Ortega, A; Sasaki, N1
Monnier, VM; Obrenovich, ME1
Amadio, L; Di Pippo, C; Iacobini, C; Menini, S; Oddi, G; Pricci, F; Pugliese, F; Pugliese, G; Ricci, C; Sorcini, M1
Amano, S; Horiuchi, S; Kaji, Y; Koito, W; Okamoto, F; Oshika, T1
Castellani, RJ; Moreira, PI; Nunomura, A; Perry, G; Smith, MA; Zhu, X1
Asghar, M; Lokhandwala, MF1
Hagino, N; Ishihara, A; Kikuchi, M; Kobayashi, S; Nagai, R; Nishioka, T; Nomura, M1
Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H1
Czeslik, E; Friedrich, I; Gursinsky, T; Nass, N; Scheubel, RJ; Schinzel, R; Silber, RE; Simm, A; Wagner, J1
Baynes, JW; Bell-Farrow, AD; Cefalu, WT; Fu, MX; Sonntag, WE; Thorpe, SR; Wang, ZQ1
Baynes, JW; Bichler, J; Reddy, S; Thorpe, SR; Wells-Knecht, KJ1
Höger, H; Lubec, B; Lubec, G; Radner, W; Salzer, H1
Nerlich, AG; Schleicher, ED; Wagner, E1
Bailey, AJ; Paul, RG1
Ahmed, MU; Baynes, JW; Brinkmann, E; Litchfield, JE; Reddy, S; Thorpe, SR; Wells-Knecht, KJ; Wells-Knecht, MC; Zyzak, DV1
Ahmed, MU; Baynes, JW; Brinkmann Frye, E; Degenhardt, TP; Thorpe, SR1
Horie, K; Kurokawa, K; Maeda, K; Miyata, T; Sobue, G; Takeda, A; Yasuda, T; Yasuda, Y1
Boos, N; Nerlich, AG; Schleicher, ED1
Higami, Y; Horiuchi, S; Ikeda, T; Iwasaki, M; Shimokawa, I1
Horiuchi, S; Kimura, T; Miyakawa, T; Miyata, T; Takamatsu, J1
Aotaki-Keen, A; Handa, JT; Hjelmeland, LM; Lutty, GA; Matsunaga, H; Miyata, T; te Koppele, JM; Verzijl, N1
Aotaki-Keen, A; Farboud, B; Handa, JT; Hjelmeland, LM; Miyata, T1
Requena, JR; Stadtman, ER1
Baynes, JW; Litchfield, JE; Thorpe, SR1
Bank, RA; Bayliss, MT; Baynes, JW; Bijlsma, JW; DeGroot, J; Lafeber, FP; Oldehinkel, E; Tekoppele, JM; Thorpe, SR; Verzijl, N1
Chellan, P; Duve, Y; Glomb, MA; Jiang, CL; Madhun, Z; Nagaraj, RH; Sady, C1
Dei, R; Goto, Y; Inagaki, T; Li, M; Miyata, T; Nakagomi, Y; Niwa, H; Sobue, G; Takeda, A; Wakai, M; Watanabe, M; Yamamoto, M; Yasuda, T; Yasuda, Y1
Faist, V; Heidland, A; Klvanová, J; Krajcoviová-Kudlácková, M; Schinzel, R; Sebeková, K1
Barja, G; Bellmun, MJ; Gredilla, R; Pamplona, R; Portero-Otín, M1
Baynes, JW; Dunn, JA; Lyons, TJ; McCance, DR; Thorpe, SR1
Baynes, JW; Dunn, JA; Knecht, KJ; Lyons, TJ; McCance, DR; McFarland, KF; Thorpe, SR1
Baynes, JW; Dunn, JA; Patrick, JS; Thorpe, SR1

Reviews

4 review(s) available for n(6)-carboxymethyllysine and Aging

ArticleYear
Apoptotic killing of fibroblasts by matrix-bound advanced glycation endproducts.
    Science of aging knowledge environment : SAGE KE, 2005, Jan-26, Volume: 2005, Issue:4

    Topics: Aging; Animals; Apoptosis; Cell Cycle; Extracellular Matrix; Fibroblasts; Glycation End Products, Advanced; Lysine; Maillard Reaction; Models, Biological; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Signal Transduction

2005
Oxidative stress and neurodegeneration.
    Annals of the New York Academy of Sciences, 2005, Volume: 1043

    Topics: Aging; Alzheimer Disease; Glycation End Products, Advanced; Humans; Lysine; Nerve Degeneration; Oxidative Stress

2005
Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes.
    The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:12

    Topics: Aging; Animals; Arginine; Collagen; Cross-Linking Reagents; Diabetes Complications; Diabetes Mellitus; Elastin; Glycation End Products, Advanced; Glycosylation; Humans; Imidazoles; Lysine; Maillard Reaction; Malondialdehyde; Norleucine; Pyrroles

1996
New biomarkers of Maillard reaction damage to proteins.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11 Suppl 5

    Topics: Aging; Arginine; Biomarkers; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Maillard Reaction; Molecular Structure; Norleucine; Oxidation-Reduction; Proteins; Pyrroles

1996

Other Studies

54 other study(ies) available for n(6)-carboxymethyllysine and Aging

ArticleYear
Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
    Nature communications, 2021, 11-18, Volume: 12, Issue:1

    Topics: Aging; Animals; Cell Line; Cell Proliferation; Endothelial Cells; Glycosylation; Glyoxal; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Microtubules; Primary Cell Culture; Protein Processing, Post-Translational; Proteins; Proteomics; Proteostasis; Tubulin

2021
Age-related neuronal damage by advanced glycation end products through altered proteostasis.
    Chemico-biological interactions, 2022, Mar-01, Volume: 355

    Topics: Aging; Animals; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Brain; Brain-Derived Neurotrophic Factor; Endoplasmic Reticulum Stress; Glycation End Products, Advanced; Lysine; Neurons; Proteostasis; Pyruvaldehyde; Rats; Rats, Wistar; Ubiquitin; Unfolded Protein Response

2022
The accumulation of the glycoxidation product N(ε)-carboxymethyllysine in cardiac tissues with age, diabetes mellitus and coronary heart disease.
    The Tohoku journal of experimental medicine, 2013, Volume: 230, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Coronary Artery Disease; Diabetes Mellitus; Female; Glycosylation; Humans; Infant; Lysine; Male; Middle Aged; Myocardium; Oxidation-Reduction; Smoking; Young Adult

2013
Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2014, Volume: 69, Issue:6

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Aging; Biomarkers; Cardiac Rehabilitation; Cardiovascular Diseases; Disabled Persons; Female; Follow-Up Studies; Frail Elderly; Health Status; Humans; Incidence; Lysine; Male; Prevalence; Prognosis; Retrospective Studies; United States

2014
Anti-apoptotic and anti-glycative effects of asiatic acid in the brain of D-galactose treated mice.
    Food & function, 2015, Volume: 6, Issue:2

    Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Dose-Response Relationship, Drug; Down-Regulation; Galactose; Glial Fibrillary Acidic Protein; Glutathione; Glutathione Peroxidase; Glycation End Products, Advanced; Interleukin-6; Lysine; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Protein Carbonylation; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation

2015
Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice.
    Molecular nutrition & food research, 2015, Volume: 59, Issue:5

    Topics: Aging; Animals; Arteries; Dietary Proteins; Endothelium, Vascular; Lysine; Male; Mice; Mice, Inbred C57BL; Pulse Wave Analysis; Receptor for Advanced Glycation End Products; Sirtuin 1; Vascular Cell Adhesion Molecule-1; Vascular Stiffness

2015
Serum carboxymethyl-lysine, an advanced glycation end product, is associated with arterial stiffness in older adults.
    Journal of hypertension, 2015, Volume: 33, Issue:4

    Topics: Aged; Aging; Aorta; Body Composition; Cardiovascular Diseases; Diabetes Mellitus; Female; Glycation End Products, Advanced; Humans; Hypertension; Inflammation; Linear Models; Lipoproteins, HDL; Logistic Models; Lysine; Male; Odds Ratio; Pulse Wave Analysis; Smoking; Vascular Stiffness

2015
Treadmill Exercise Attenuates Retinal Oxidative Stress in Naturally-Aged Mice: An Immunohistochemical Study.
    International journal of molecular sciences, 2015, Sep-02, Volume: 16, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Deoxyguanosine; Lysine; Male; Mice; Oxidative Stress; Physical Conditioning, Animal; Retina; Tyrosine

2015
Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature.
    European journal of clinical investigation, 2016, Volume: 46, Issue:4

    Topics: Aging; Animals; Apolipoproteins E; Brain; Coronary Vessels; Endothelium, Vascular; Lysine; Mice, Inbred Strains; Microvessels; Superoxide Dismutase; Survival Rate

2016
N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration.
    Medicina (Kaunas, Lithuania), 2016, Volume: 52, Issue:2

    Topics: Aged; Aging; Biomarkers; Body Mass Index; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipoproteins; Lysine; Macular Degeneration; Male; Middle Aged; Oxidative Stress; Prevalence; Risk Factors

2016
Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines.
    Circulation, 2008, Sep-02, Volume: 118, Issue:10

    Topics: Aging; Animals; Aorta; Collagen; Dogs; Drug Evaluation, Preclinical; Elastin; Glycation End Products, Advanced; Heart Ventricles; Hypertension; Lysine; Muscle, Smooth, Vascular; Thiazoles; Vasa Vasorum; Vascular Resistance; Ventricular Function, Left

2008
Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and anemia in adults: the Baltimore longitudinal study of aging.
    Journal of the American Geriatrics Society, 2008, Volume: 56, Issue:11

    Topics: Adult; Aging; Anemia; Baltimore; Female; Humans; Longitudinal Studies; Lysine; Male

2008
Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults.
    American journal of hypertension, 2009, Volume: 22, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aorta; Exercise Test; Female; Follow-Up Studies; Glycation End Products, Advanced; Heart Rate; Humans; Lysine; Male; Middle Aged; Prognosis; Prospective Studies; Reference Values; Risk Factors; Vascular Resistance

2009
Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Volume: 64, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Disability Evaluation; Female; Glycation End Products, Advanced; Humans; Lysine; Muscle Strength; Muscle Weakness; Prognosis; Women's Health

2009
Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women.
    Aging clinical and experimental research, 2009, Volume: 21, Issue:2

    Topics: Aged; Aging; Cardiovascular Diseases; Diabetes Mellitus; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Lysine; Predictive Value of Tests; Prospective Studies; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renal Insufficiency; Residence Characteristics; Risk Factors

2009
Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study.
    European journal of applied physiology, 2010, Volume: 108, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Community Health Planning; Female; Glycation End Products, Advanced; Humans; Logistic Models; Lysine; Male; Muscle Strength; Odds Ratio; Walking

2010
Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of aging.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2010, Volume: 20, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Baltimore; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Kidney Diseases; Linear Models; Longitudinal Studies; Lysine; Male; Middle Aged; Racial Groups; Smoking

2010
Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology.
    Human reproduction (Oxford, England), 2011, Volume: 26, Issue:3

    Topics: Aging; Arginine; Embryo Implantation; Embryonic Development; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Follicular Fluid; Glycation End Products, Advanced; Humans; Infertility; Lysine; Ovulation Induction; Pregnancy; Pregnancy Rate; Reproductive Techniques, Assisted; Retrospective Studies

2011
Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2012, Volume: 67, Issue:6

    Topics: Aging; Animals; Arginine; Biomarkers; Collagen; Female; Glycation End Products, Advanced; Longevity; Lysine; Male; Mole Rats; Skin

2012
Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults.
    Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:7-8

    Topics: Aged; Aged, 80 and over; Aging; Anemia; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Incidence; Italy; Longitudinal Studies; Lysine; Male; Oxidative Stress; Predictive Value of Tests; Prevalence; Proportional Hazards Models; Selenium

2012
Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adult; Aged; Aging; Blood Chemical Analysis; Collagen; Coronary Artery Disease; Diastole; Echocardiography; Glycation End Products, Advanced; Hemodynamics; Humans; Lysine; Male; Middle Aged; Myocardium; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Ventricular Dysfunction, Left

2012
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease.
    Acta neuropathologica, 2002, Volume: 104, Issue:2

    Topics: Adolescent; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipid Peroxidation; Lysine; Male; Malondialdehyde; Neuroglia; Neurons; Oxidative Stress

2002
Accumulation of imidazolone, pentosidine and N(epsilon)-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain.
    Pathology international, 2002, Volume: 52, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Female; Glycation End Products, Advanced; Humans; Imidazoles; Immunohistochemistry; Lysine; Male; Middle Aged; Pyramidal Cells

2002
Increased level of glycoxidation product N(epsilon)-(carboxymethyl)lysine in rat serum and urine proteins with aging: link with glycoxidative damage accumulation in kidney.
    Archives of biochemistry and biophysics, 2003, Mar-15, Volume: 411, Issue:2

    Topics: Aging; Animals; Antibodies; Antibody Specificity; Basement Membrane; Biomarkers; Collagen; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Immunohistochemistry; Kidney; Lysine; Male; Oxidative Stress; Proteins; Rats; Rats, Wistar

2003
Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix.
    European journal of biochemistry, 2003, Volume: 270, Issue:10

    Topics: Adenosine Triphosphate; Aging; Animals; Blotting, Western; Cell Survival; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Immunochemistry; Lysine; Male; Methylation; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Oxygen; Oxygen Consumption; Peptides; Rats; Rats, Wistar; Stress, Physiological; Time Factors

2003
Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.
    Diabetes, 2003, Volume: 52, Issue:6

    Topics: Administration, Oral; Aging; Albuminuria; Animals; Animals, Newborn; Blood Glucose; Creatinine; Crosses, Genetic; Diabetes Mellitus, Type 1; Female; Glycation End Products, Advanced; Islets of Langerhans; Lysine; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Pyruvaldehyde

2003
N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease.
    Free radical biology & medicine, 2004, May-15, Volume: 36, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cytoplasm; Diabetes Mellitus; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins

2004
Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.
    American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:3

    Topics: Age Factors; Aging; Aldehydes; Animals; Body Weight; Dinoprost; Extracellular Matrix; Galectin 3; Glomerulonephritis; Glycation End Products, Advanced; Kidney Glomerulus; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1

2005
Immunohistochemical localization of advanced glycation end products in pinguecula.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:1

    Topics: Adult; Aged; Aging; Antibodies, Monoclonal; Arginine; Conjunctival Diseases; Female; Glycation End Products, Advanced; Humans; Imidazoles; Immunoenzyme Techniques; Lysine; Male; Middle Aged; Norleucine; Pyrroles

2006
Antioxidant tempol lowers age-related increases in insulin resistance in Fischer 344 rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2006, Volume: 28, Issue:5

    Topics: Age Factors; Aging; Animals; Antioxidants; Biomarkers; Blood Glucose; Blood Proteins; Cyclic N-Oxides; Dietary Supplements; Homeostasis; Insulin; Insulin Resistance; Kidney Tubules, Proximal; Lysine; Male; Malondialdehyde; Models, Animal; Oxidative Stress; Rats; Rats, Inbred F344; Spin Labels; Triglycerides

2006
Overproduction of N(epsilon)-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of aged rat.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:1

    Topics: Age Factors; Aging; Animals; Antibodies; Capillaries; Choroid; Choroidal Neovascularization; Glycation End Products, Advanced; Lysine; Macular Degeneration; Male; Organ Culture Techniques; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2007
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lysine; Male; Middle Aged; Oxidative Stress; Pyruvaldehyde

2007
Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery?
    Experimental gerontology, 2007, Volume: 42, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Coronary Artery Bypass; Glycation End Products, Advanced; Heart; Humans; Lysine; Middle Aged; Pericardial Effusion; Predictive Value of Tests; Treatment Outcome

2007
Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:6

    Topics: Aging; Animals; Arginine; Blood Proteins; Chromatography, High Pressure Liquid; Collagen; Energy Intake; Female; Food Deprivation; Glycation End Products, Advanced; Lysine; Oxidation-Reduction; Rats; Rats, Inbred BN; Skin

1995
N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins.
    Biochemistry, 1995, Aug-29, Volume: 34, Issue:34

    Topics: Aging; Antigens; Chromatography, Gel; Crystallins; Enzyme-Linked Immunosorbent Assay; Fructose; Glucose; Glycation End Products, Advanced; Glyoxal; Humans; Kinetics; Lysine; Maillard Reaction; Serum Albumin, Bovine

1995
L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse.
    Journal of gerontology, 1994, Volume: 49, Issue:2

    Topics: Aging; Animals; Arginine; Basement Membrane; Collagen; Electrophoresis, Polyacrylamide Gel; Female; Glycosylation; Hydroxyproline; Kidney; Kidney Glomerulus; Lysine; Mice

1994
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
    The Journal of clinical investigation, 1997, Feb-01, Volume: 99, Issue:3

    Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Child; Deferoxamine; Diabetes Mellitus; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Fetus; Foam Cells; Guanidines; Humans; Immunohistochemistry; Intervertebral Disc; Intestinal Mucosa; Kidney; Lung; Lysine; Middle Aged; Molecular Structure; Myocardium; Oxidation-Reduction; Oxidative Stress; Pregnancy; Skin; Superoxide Dismutase; Thioctic Acid; Time Factors; Vitamin E

1997
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
    The Biochemical journal, 1997, Jun-01, Volume: 324 ( Pt 2)

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbohydrate Metabolism; Child; Collagen; Crystallins; Humans; Lens, Crystalline; Lysine; Middle Aged; Oxidative Stress; Pyruvaldehyde; Ribonucleases; Skin

1997
Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons.
    Biochemical and biophysical research communications, 1997, Jul-18, Volume: 236, Issue:2

    Topics: Adolescent; Aged; Aging; Alzheimer Disease; Arginine; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipofuscin; Lysine; Nerve Degeneration; Nerve Tissue Proteins; Neurons

1997
1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs.
    Spine, 1997, Dec-15, Volume: 22, Issue:24

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Child; Child, Preschool; Fetus; Humans; Immunohistochemistry; Infant; Infant, Newborn; Intervertebral Disc; Lumbar Vertebrae; Lysine; Middle Aged

1997
Advanced glycosylation end products in adrenal lipofuscin.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1998, Volume: 53, Issue:1

    Topics: Adrenal Cortex; Adrenal Glands; Aging; Animals; Antibodies; Brain; Cerebellum; Cerebral Cortex; Cytoplasmic Granules; Fluorescent Antibody Technique, Direct; Glycation End Products, Advanced; Immunoenzyme Techniques; Immunohistochemistry; Lipofuscin; Lysine; Male; Neurons; Purkinje Cells; Rats; Rats, Inbred F344; Zona Reticularis

1998
Localization of identified advanced glycation end-product structures, N epsilon(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains.
    Pathology international, 1998, Volume: 48, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Brain; Entorhinal Cortex; Glycation End Products, Advanced; Hippocampus; Humans; Immunoenzyme Techniques; Inclusion Bodies; Lipofuscin; Lysine; Maillard Reaction; Middle Aged; Ubiquitins

1998
Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Bruch Membrane; Choroid; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Infant; Lysine; Middle Aged; Pigment Epithelium of Eye; Retinal Drusen

1999
Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye.
    Molecular vision, 1999, Jul-14, Volume: 5

    Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Aging; Animals; Antibodies; Antibody Specificity; Arginine; Bruch Membrane; Cattle; Choroid Plexus; Extracellular Matrix Proteins; Glycation End Products, Advanced; Humans; Immunohistochemistry; Infant; Lysine; Middle Aged

1999
Conversion of lysine to N(epsilon)-(carboxymethyl)lysine increases susceptibility of proteins to metal-catalyzed oxidation.
    Biochemical and biophysical research communications, 1999, Oct-14, Volume: 264, Issue:1

    Topics: Aging; Animals; Catalysis; Cattle; Lysine; Metals; Oxidation-Reduction; Serum Albumin, Bovine

1999
Oxygen is not required for the browning and crosslinking of protein by pentoses: relevance to Maillard reactions in vivo.
    The international journal of biochemistry & cell biology, 1999, Volume: 31, Issue:11

    Topics: Aging; Animals; Antioxidants; Arabinose; Arginine; Cattle; Cross-Linking Reagents; Diabetes Mellitus; Fluorescence; Glucose; In Vitro Techniques; Lysine; Maillard Reaction; Oxidation-Reduction; Oxygen; Pentoses; Proteins; Ribonucleases

1999
Age-related accumulation of Maillard reaction products in human articular cartilage collagen.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; Cartilage, Articular; Child; Child, Preschool; Collagen; Collagenases; Cross-Linking Reagents; Female; Femur; Glycation End Products, Advanced; Humans; Lysine; Maillard Reaction; Male; Middle Aged; Skin; Spectrometry, Fluorescence

2000
Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins.
    Biochimica et biophysica acta, 2000, Sep-29, Volume: 1481, Issue:2

    Topics: Aged; Aging; Antibodies; Cataract; Diabetes Mellitus; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Lens, Crystalline; Lysine; Maillard Reaction; Proteins; Serum Albumin; Serum Albumin, Bovine; Serum Albumin, Human

2000
Neuronal and glial advanced glycation end product [Nepsilon-(carboxymethyl)lysine]] in Alzheimer's disease brains.
    Acta neuropathologica, 2001, Volume: 101, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Neuroglia; Neurons

2001
Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet.
    European journal of nutrition, 2001, Volume: 40, Issue:6

    Topics: Adult; Aging; Diabetes Mellitus; Diet; Diet, Vegetarian; Edible Grain; Enzyme-Linked Immunosorbent Assay; Fabaceae; Fluorescence; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Kidney; Lysine

2001
Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.
    Free radical research, 2002, Volume: 36, Issue:1

    Topics: Aging; Animals; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Food Deprivation; Gas Chromatography-Mass Spectrometry; Lysine; Male; Malondialdehyde; Mitochondria; Models, Statistical; Myocardium; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors

2002
Age-dependent accumulation of N epsilon-(carboxymethyl)lysine and N epsilon-(carboxymethyl)hydroxylysine in human skin collagen.
    Biochemistry, 1991, Feb-05, Volume: 30, Issue:5

    Topics: Aging; Collagen; Gas Chromatography-Mass Spectrometry; Glycosylation; Humans; Hydroxylysine; Lens, Crystalline; Lysine; Oxidation-Reduction; Skin

1991
Effect of diabetes and aging on carboxymethyllysine levels in human urine.
    Diabetes, 1991, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Diabetes Mellitus, Type 1; Humans; Lysine; Middle Aged; Oxidation-Reduction

1991
Oxidation of glycated proteins: age-dependent accumulation of N epsilon-(carboxymethyl)lysine in lens proteins.
    Biochemistry, 1989, Nov-28, Volume: 28, Issue:24

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Chromatography, Ion Exchange; Crystallins; Humans; Infant; Lysine; Middle Aged; Oxidation-Reduction

1989