Page last updated: 2024-09-05

n(4)-hydroxycytidine and 2019 Novel Coronavirus Disease

n(4)-hydroxycytidine has been researched along with 2019 Novel Coronavirus Disease in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's11 (100.00)2.80

Authors

AuthorsStudies
Agostini, ML; Baric, RS; Bluemling, GR; Brown, AJ; Chappell, JD; Denison, MR; Dinnon, KH; George, AS; Graham, RL; Harcourt, J; Hill, CS; Hughes, TM; Kolykhalov, AA; Leist, SR; Lu, X; Montgomery, SA; Natchus, MG; Painter, G; Pruijssers, AJ; Saindane, M; Schäfer, A; Sheahan, TP; Sims, AC; Stevens, LJ; Swanstrom, R; Tamin, A; Thornburg, NJ; Zhou, S1
Beccari, AR; Cannalire, R; Cerchia, C; Di Leva, FS; Summa, V1
Cherrington, NJ; Ekins, S; McGrath, ME; Miller, SR; Wright, SH; Zorn, KM1
Schinazi, RF; Swanstrom, R1
Cao, R; Chen, X; Dai, Q; Guo, X; Li, W; Li, Y; Liu, M; Wang, Z; Yan, Y; Yang, X; Zhong, W1
Dobrovolsky, VN; McKinzie, PB; Miranda, JA; Revollo, JR1
Ahmed, S; Hirao, Y; Kato, S; Kawanishi, S; Kobayashi, H; Mori, Y; Murata, M; Oikawa, S1
Ahn, SB; An, YJ; Cho, JH; Choi, ER; Choi, SM; Jang, Y; Kim, M; Nam, YE; Seo, EW1
Andrei, G; Herdewijn, P; Li, LY; Liu, C; Liu, ZP; Snoeck, R; Wang, MM; Wen, ZH1
Ahmed, A; Bhardwaj, M; Dhiman, S; Gour, A; Khajuria, P; Manhas, D; Mukherjee, D; Nandi, U; Wazir, P1
Gordon, CJ; Götte, M; Schinazi, RF; Tchesnokov, EP1

Reviews

1 review(s) available for n(4)-hydroxycytidine and 2019 Novel Coronavirus Disease

ArticleYear
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities.
    Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4

    Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Structure; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2

2022

Other Studies

10 other study(ies) available for n(4)-hydroxycytidine and 2019 Novel Coronavirus Disease

ArticleYear
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
    Science translational medicine, 2020, 04-29, Volume: 12, Issue:541

    Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotic Prophylaxis; Antiviral Agents; Betacoronavirus; Cell Line; Coronavirus Infections; COVID-19; Cytidine; Disease Models, Animal; Drug Resistance, Viral; Humans; Hydroxylamines; Lung; Mice; Mice, Inbred C57BL; Middle East Respiratory Syndrome Coronavirus; Models, Molecular; Mutation; Pandemics; Pneumonia, Viral; Primary Cell Culture; Random Allocation; Respiratory System; Ribonucleosides; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication

2020
Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.
    Molecular pharmacology, 2021, Volume: 100, Issue:6

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Dose-Response Relationship, Drug; Drug Interactions; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; HeLa Cells; Humans; Protein Binding; SARS-CoV-2

2021
Lethal mutagenesis as an antiviral strategy.
    Science (New York, N.Y.), 2022, Feb-04, Volume: 375, Issue:6580

    Topics: Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; DNA; Evolution, Molecular; Genome, Viral; Humans; Hydroxylamines; Mutagenesis; Mutagenicity Tests; Phosphorylation; Ribonucleosides; RNA Virus Infections; RNA Viruses; RNA, Viral; SARS-CoV-2

2022
Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo.
    Viruses, 2022, 05-25, Volume: 14, Issue:6

    Topics: Animals; Antigens, Viral; Antiviral Agents; Child, Preschool; COVID-19; Cytidine; Enterovirus; Enterovirus A, Human; Enterovirus Infections; Humans; Hydroxylamines; Mice; Mice, Inbred ICR

2022
Evaluation of the mutagenic effects of Molnupiravir and N4-hydroxycytidine in bacterial and mammalian cells by HiFi sequencing.
    Environmental and molecular mutagenesis, 2022, Volume: 63, Issue:7

    Topics: Animals; COVID-19; DNA; Escherichia coli; Humans; Mammals; Mice; Mutagens; RNA, Viral; SARS-CoV-2

2022
Oxidative DNA Damage by N4-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir.
    The Journal of infectious diseases, 2023, 04-26, Volume: 227, Issue:9

    Topics: Antiviral Agents; COVID-19; DNA Damage; Humans; Hydrogen Peroxide; Hydroxylamines; Oxidative Stress; SARS-CoV-2

2023
Synthesis and biological evaluation of new β-D-N
    Bioorganic & medicinal chemistry letters, 2023, 03-01, Volume: 83

    Topics: Antiviral Agents; COVID-19; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; SARS-CoV-2; Virus Replication

2023
Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of β-D-N
    Bioorganic chemistry, 2023, Volume: 135

    Topics: Antiviral Agents; COVID-19; Humans; Lipids; Prodrugs; SARS-CoV-2

2023
Impact of Disease States on the Oral Pharmacokinetics of EIDD-1931 (an Active Form of Molnupiravir) in Rats for Implication in the Dose Adjustment.
    Molecular pharmaceutics, 2023, 09-04, Volume: 20, Issue:9

    Topics: Animals; COVID-19; Cytidine; Hydroxylamines; Rats

2023
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
    The Journal of biological chemistry, 2021, Volume: 297, Issue:1

    Topics: Antiviral Agents; COVID-19; Cytidine; Humans; Hydroxylamines; Mutagenesis; Point Mutation; RNA, Viral; SARS-CoV-2

2021