n(2)-n(2)-dimethylguanosine has been researched along with Neoplasms* in 3 studies
3 other study(ies) available for n(2)-n(2)-dimethylguanosine and Neoplasms
| Article | Year |
|---|---|
Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers.
Analysis of urine from cancer patients by capillary gas chromatography/mass spectrometry positively identified 14 urinary nucleosides including several modified nucleosides. Levels of the modified nucleosides 1-methyl-adenosine, 2-methylguanosine, N2,N2-dimethylguanosine and 1-methylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N2,N2-dimethylguanosine were found to correlate with the stage of the cancer. Topics: Adenosine; Biomarkers, Tumor; Female; Gas Chromatography-Mass Spectrometry; Guanosine; Humans; Inosine; Male; Neoplasms; Nucleosides | 1993 |
Serum levels of N2, N2-dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy.
A sensitive, rapid, and specific radioimmunoassay procedure was used to determine levels of N2,N2-dimethylguanosine and pseudouridine in sera of patients with acute leukemia and breast cancer. Elevated levels of both nucleosides were above standard deviations of the normal mean for patients in both disease categories. Topics: Antibody Specificity; Breast Neoplasms; Guanosine; Humans; Leukemia; Methylation; Neoplasms; Pseudouridine; Radioimmunoassay; Uridine | 1975 |
The urinary excretion of nucleosides of ribonucleic acid by patients with advanced cancer.
By means of a sensitive and specific method utilizing gas-liquid chromatography, the excretion levels for three nucleosides, degradation minor base products of ribonucleic acid, primarily transfer ribonucleic acid, were determined in 24-hour urine specimens from over 200 patients with solid tumor malignancies. These nucleosides were N2,N2-dimethylguanosine, l-methylinosine, and pseudouridine. When compared to normal control values, elevated levels of these compounds were found for patients in each of several tumor types studied. Increases in pseudouridine excretion suggest increased tumor transfer ribonucleic acid turnover; in addition, for the methylated nucleosides, higher than normal values may reflect enhanced transfer ribonucleic acid methylase activity of the neoplastic cells. Topics: Chromatography, Gas; Guanosine; Humans; Inosine; Neoplasms; Pseudouridine; RNA; RNA, Transfer; tRNA Methyltransferases; Uridine | 1975 |