n(1),n(11)-diethylnorspermine has been researched along with Ovarian Neoplasms in 5 studies
N(1),N(11)-diethylnorspermine: structure given in first source
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results obtained in A2780 ovarian cancer cells by real-time quantitative RT-PCR and Northern blot analysis show that a 2-hour exposure of A2780 cells to platinum drugs induces expression of SSAT, a second SSAT (SSAT-2), spermine oxidase, and polyamine oxidase in a dose-dependent manner." | 1.32 | Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. ( Chen, Y; Clark, K; Diegelman, P; Hector, S; Kisiel, N; Kramer, DL; Pendyala, L; Porter, CW; Prey, J, 2004) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marverti, G | 2 |
| Ligabue, A | 1 |
| Guerrieri, D | 1 |
| Paglietti, G | 1 |
| Piras, S | 1 |
| Costi, MP | 1 |
| Farina, D | 1 |
| Frassineti, C | 1 |
| Monti, MG | 1 |
| Moruzzi, MS | 2 |
| Tummala, R | 1 |
| Diegelman, P | 2 |
| Hector, S | 2 |
| Kramer, DL | 2 |
| Clark, K | 2 |
| Zagst, P | 1 |
| Fetterly, G | 1 |
| Porter, CW | 3 |
| Pendyala, L | 2 |
| Prey, J | 1 |
| Kisiel, N | 1 |
| Chen, Y | 1 |
| Piccinini, G | 1 |
| Ghiaroni, S | 1 |
| Barbieri, D | 1 |
| Quaglino, D | 1 |
| Bernacki, RJ | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| Bergeron, RJ | 1 |
5 other studies available for n(1),n(11)-diethylnorspermine and Ovarian Neoplasms
| Article | Year |
|---|---|
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Cell Growth Processes; Cell Line | 2010 |
Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisp | 2011 |
Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Interactions; Female; G | 2004 |
N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines.
Topics: Acetyltransferases; Antineoplastic Agents; Cisplatin; Drug Interactions; Drug Resistance, Neoplasm; | 1998 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |