n(1),n(11)-diethylnorspermine has been researched along with Neoplasms in 5 studies
N(1),N(11)-diethylnorspermine: structure given in first source
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adult patients with refractory solid tumors were treated with DENSPM administered by intravenous infusion in 100 ml of normal saline over 30 minutes." | 2.70 | Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies. ( Bender, JF; Streiff, RR, 2001) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Minarini, A | 1 |
| Zini, M | 1 |
| Milelli, A | 1 |
| Tumiatti, V | 1 |
| Marchetti, C | 1 |
| Nicolini, B | 1 |
| Falconi, M | 1 |
| Farruggia, G | 1 |
| Cappadone, C | 1 |
| Stefanelli, C | 1 |
| Dong, Y | 1 |
| Li, J | 1 |
| Wu, C | 1 |
| Oupický, D | 1 |
| Jiang, R | 1 |
| Choi, W | 1 |
| Hu, L | 1 |
| Gerner, EW | 1 |
| Hamilton, SR | 1 |
| Zhang, W | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Streiff, RR | 1 |
| Bender, JF | 1 |
2 trials available for n(1),n(11)-diethylnorspermine and Neoplasms
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Humans; Infusions, Intravenous; | 2001 |
3 other studies available for n(1),n(11)-diethylnorspermine and Neoplasms
| Article | Year |
|---|---|
Synthetic polyamines activating autophagy: effects on cancer cell death.
Topics: Antineoplastic Agents; Autophagy; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screeni | 2013 |
Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; DNA; Drug Carrier | 2010 |
Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells.
Topics: Antineoplastic Agents; Cell Adhesion Molecules; Cell Line, Tumor; Down-Regulation; Glioblastoma; Hum | 2007 |