n(1),n(11)-diethylnorspermine has been researched along with Malignant Melanoma in 14 studies
N(1),N(11)-diethylnorspermine: structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold." | 7.68 | Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993) |
| " Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line." | 5.29 | Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994) |
| " Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity." | 5.29 | Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993) |
| "We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis in human melanoma SK-MEL-28 cells via a series of events that include mitochondrial release of cytochrome c and activation of the caspase cascade." | 3.72 | Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. ( Chen, Y; Kramer, DL; Li, F; Porter, CW, 2003) |
| " We have found that treatment of MALME-3M human melanoma cells for 6 h with 10 micrograms/ml cycloheximide (CHX) increases ODC and SSAT mRNA 6-9-fold." | 3.69 | Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. ( Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S, 1996) |
| "In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold." | 3.68 | Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| " Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line." | 1.29 | Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994) |
| " Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity." | 1.29 | Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (71.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 3 |
| Alm, K | 1 |
| Vujcic, S | 5 |
| Kramer, DL | 7 |
| Kee, K | 1 |
| Diegelman, P | 5 |
| Porter, CW | 12 |
| Li, F | 1 |
| Minchin, RF | 1 |
| Knight, S | 1 |
| Arulpragasam, A | 1 |
| Fogel-Petrovic, M | 4 |
| Ganis, B | 1 |
| Rustum, Y | 1 |
| Wrzosek, C | 1 |
| Bergeron, RJ | 7 |
| Shappell, NW | 1 |
| Bernacki, RJ | 4 |
| Miller, J | 2 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Cooley, JM | 1 |
| McManis, JS | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| White, C | 1 |
| Black, JD | 2 |
| Alderfer, J | 1 |
| Miller, JT | 1 |
1 review available for n(1),n(11)-diethylnorspermine and Malignant Melanoma
| Article | Year |
|---|---|
Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.
Topics: Acetyltransferases; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme In | 1998 |
1 trial available for n(1),n(11)-diethylnorspermine and Malignant Melanoma
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
12 other studies available for n(1),n(11)-diethylnorspermine and Malignant Melanoma
| Article | Year |
|---|---|
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Enzyme Activation; Flavonoids; Humans; Kinetics; Melanoma; Mitogen | 2003 |
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Humans; Inhibitor of Apoptosis Proteins; Melanoma; Polyamines; Pro | 2003 |
Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neopla | 2006 |
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
Topics: Adenosylmethionine Decarboxylase; Amidines; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1994 |
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Base Sequence; Blotting, Northern; Dactinomyci | 1993 |
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Dose-Response | 1993 |
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymo | 1996 |
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Cycle; Cell Division | 1997 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; Cyclin-Dependent Kinase | 1999 |
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.
Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Caspase 3; Caspases; Cyto | 2001 |
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Sc | 1992 |