n(1),n(11)-diethylnorspermine and Carcinoma, Hepatocellular studies

Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Research Excerpts

Excerpt	Relevance	Reference
" Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD."	6.78	Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013)
" Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD."	2.78	Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013)

Research

Studies (1)

Authors

Trials

1 trial available for n(1),n(11)-diethylnorspermine and Carcinoma, Hepatocellular

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Goyal, L	1
Supko, JG	1
Berlin, J	1
Blaszkowsky, LS	1
Carpenter, A	1
Heuman, DM	1
Hilderbrand, SL	1
Stuart, KE	1
Cotler, S	1
Senzer, NN	1
Chan, E	1
Berg, CL	1
Clark, JW	1
Hezel, AF	1
Ryan, DP	1
Zhu, AX	1