n(1),n(11)-diethylnorspermine has been researched along with Cancer of Lung in 10 studies
N(1),N(11)-diethylnorspermine: structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-nine patients were treated with DENSPM using a dosing schedule of once daily for 5 days." | 2.70 | Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer. ( Bowling, K; Casero, RA; Chen, TL; Ettinger, DS; Hahm, HA; Hoker, B; Zabelina, Y, 2002) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (80.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, AV | 1 |
| Goodwin, AC | 1 |
| Hacker-Prietz, A | 1 |
| Sugar, E | 1 |
| Woster, PM | 3 |
| Casero, RA | 7 |
| Gabrielson, EW | 2 |
| Pegg, AE | 3 |
| Shao, D | 1 |
| Xiao, L | 1 |
| Ha, HC | 1 |
| Wu, R | 1 |
| Saab, NH | 1 |
| Huang, H | 1 |
| Wiest, L | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Felschow, DM | 1 |
| Mi, Z | 1 |
| Stanek, J | 1 |
| Frei, J | 1 |
| Porter, CW | 2 |
| Bernacki, RJ | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| Bergeron, RJ | 1 |
| McCloskey, DE | 1 |
| Yang, J | 1 |
| Davidson, NE | 1 |
| Hahm, HA | 1 |
| Ettinger, DS | 1 |
| Bowling, K | 1 |
| Hoker, B | 1 |
| Chen, TL | 1 |
| Zabelina, Y | 1 |
2 trials available for n(1),n(11)-diethylnorspermine and Cancer of Lung
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response | 2002 |
8 other studies available for n(1),n(11)-diethylnorspermine and Cancer of Lung
| Article | Year |
|---|---|
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
Topics: Base Sequence; Blotting, Northern; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lung Neoplas | 2012 |
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Topics: Acetyltransferases; Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Drug Screening Assay | 1994 |
Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157.
Topics: Acetyltransferases; Antineoplastic Agents; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cel | 1996 |
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
Topics: Acetyltransferases; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Humans; Lung Neoplasms; Magne | 1996 |
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.
Topics: Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Cross-Linking | 1997 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |
Polyamine analogue induction of programmed cell death in human lung tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; DNA Fragmentation; Humans; Lung Ne | 1996 |
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.
Topics: Acetyltransferases; Antineoplastic Agents; Biomarkers; Carcinoma, Small Cell; Clinical Trials, Phase | 1999 |