n(1),n(11)-diethylnorspermine has been researched along with Cancer of Colon in 6 studies
N(1),N(11)-diethylnorspermine: structure given in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| "Exposure of HCT 116 colon cancer cells to DENSpm decreased cell viability in a dose- and time-dependent manner." | 1.42 | Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. ( Arisan, ED; Çoker-Gürkan, A; Obakan, P; Palavan-Unsal, N, 2015) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gurkan, AC | 1 |
| Arisan, ED | 2 |
| Yerlikaya, PO | 1 |
| Ilhan, H | 1 |
| Unsal, NP | 1 |
| Çoker-Gürkan, A | 1 |
| Obakan, P | 1 |
| Palavan-Unsal, N | 1 |
| Choi, W | 1 |
| Proctor, L | 1 |
| Xia, Q | 1 |
| Feng, Y | 1 |
| Gerner, EW | 1 |
| Chiao, PJ | 1 |
| Hamilton, SR | 1 |
| Zhang, W | 1 |
| Hector, S | 1 |
| Tummala, R | 1 |
| Kisiel, ND | 1 |
| Diegelman, P | 1 |
| Vujcic, S | 1 |
| Clark, K | 1 |
| Fakih, M | 1 |
| Kramer, DL | 1 |
| Porter, CW | 2 |
| Pendyala, L | 2 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Bernacki, RJ | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| Bergeron, RJ | 1 |
1 trial available for n(1),n(11)-diethylnorspermine and Cancer of Colon
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
5 other studies available for n(1),n(11)-diethylnorspermine and Cancer of Colon
| Article | Year |
|---|---|
Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Cycle Checkpoints; C | 2018 |
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells.
Topics: Apoptosis; Autophagy; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Male; Spermine; Tumor | 2015 |
Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.
Topics: Acetyltransferases; Antineoplastic Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Fluoroura | 2006 |
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tu | 2008 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |