n(1),n(11)-diethylnorspermine has been researched along with Breast Neoplasms in 16 studies
N(1),N(11)-diethylnorspermine: structure given in first source
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Polyamine analogs down-regulate ornithine decarboxylase, induce spermidine/spermine N1-acetyltransferase, deplete natural polyamine pools, inhibit growth, and induce programmed cell death in breast cancer models." | 9.10 | A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. ( Armstrong, DK; Bender, JF; Carducci, MK; Casero, RA; Davidson, NE; Fetting, JH; Riley, CD; Wolff, AC, 2003) |
| " Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient to overcome Bcl-2 mediated drug resistance mechanism." | 7.83 | DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery. ( Akyol, Z; Arisan, ED; Çoker-Gürkan, A; Obakan-Yerlikaya, P; Palavan-Ünsal, N, 2016) |
| " We studied the effect of 2ME on apoptosis of MCF-7 breast cancer cells and explored a combination therapy using 2ME and a polyamine analogue, bis(ethyl)norspermine (BE-3-3-3)." | 7.74 | Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. ( Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A, 2007) |
| " To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1." | 7.74 | Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. ( Alm, K; Hegardt, C; Jönsson, G; Larsson, S; Myhre, L; Oredsson, SM; Staaf, J, 2008) |
| "We studied the effects of ICI 182780 and bis(ethyl)norspermine (BE-3-3-3) on cell growth and apoptosis of estrogen receptor-positive MCF-7 breast cancer cells." | 7.73 | Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. ( Balabhadrapathruni, S; Gallo, MA; Santhakumaran, LM; Shirahata, A; Thomas, T; Thomas, TJ, 2005) |
| "Using three cytotoxicity assays, we have investigated the effect of the spermine analogue N1,N11-diethylnorspermine (DENSPM) on four human breast cancer cell lines with different known genetic lesions." | 7.73 | Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines. ( Holst, CM; Oredsson, SM, 2005) |
| "Four different breast cancer cell lines were treated with DENSPM." | 5.35 | Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. ( Hegardt, C; Holst, CM; Jönsson, G; Oredsson, SM; Staaf, J, 2008) |
| "The ability of both normal-like and breast cancer cells to recover from DENSPM treatment was also studied." | 5.35 | Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine. ( Alm, K; Johansson, M; Myhre, L; Oredsson, SM, 2009) |
| "Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue." | 5.32 | Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. ( Casero, RA; Davidson, NE; Gabrielson, E; Hacker, A; Pegg, AE; Tully, E, 2004) |
| " Polyamine analogs down-regulate ornithine decarboxylase, induce spermidine/spermine N1-acetyltransferase, deplete natural polyamine pools, inhibit growth, and induce programmed cell death in breast cancer models." | 5.10 | A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. ( Armstrong, DK; Bender, JF; Carducci, MK; Casero, RA; Davidson, NE; Fetting, JH; Riley, CD; Wolff, AC, 2003) |
| " Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient to overcome Bcl-2 mediated drug resistance mechanism." | 3.83 | DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery. ( Akyol, Z; Arisan, ED; Çoker-Gürkan, A; Obakan-Yerlikaya, P; Palavan-Ünsal, N, 2016) |
| "BENSpm exhibited synergistic inhibitory effect on cell proliferation in combination with 5-FU or paclitaxel in human breast cancer cell lines (MDA-MB-231 and MCF-7) and was either antagonistic or less effective in the non-tumorigenic MCF-10A cell line." | 3.76 | The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. ( Billam, M; Casero, RA; Davidson, NE; Hacker, A; Pledgie-Tracy, A; Sobolewski, MD; Woster, PM; Zhang, Z, 2010) |
| " We studied the effect of 2ME on apoptosis of MCF-7 breast cancer cells and explored a combination therapy using 2ME and a polyamine analogue, bis(ethyl)norspermine (BE-3-3-3)." | 3.74 | Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. ( Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A, 2007) |
| "The spermine analogue N(1),N(11)-diethylnorspermine (DENSPM) efficiently depletes the polyamine pools in the breast cancer cell line L56Br-C1 and induces apoptotic cell death via the mitochondrial pathway." | 3.74 | Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. ( Alm, K; Holst, CM; Johansson, VM; Oredsson, SM, 2008) |
| " To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1." | 3.74 | Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. ( Alm, K; Hegardt, C; Jönsson, G; Larsson, S; Myhre, L; Oredsson, SM; Staaf, J, 2008) |
| "We studied the effects of ICI 182780 and bis(ethyl)norspermine (BE-3-3-3) on cell growth and apoptosis of estrogen receptor-positive MCF-7 breast cancer cells." | 3.73 | Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. ( Balabhadrapathruni, S; Gallo, MA; Santhakumaran, LM; Shirahata, A; Thomas, T; Thomas, TJ, 2005) |
| "Using three cytotoxicity assays, we have investigated the effect of the spermine analogue N1,N11-diethylnorspermine (DENSPM) on four human breast cancer cell lines with different known genetic lesions." | 3.73 | Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines. ( Holst, CM; Oredsson, SM, 2005) |
| "Treatment of human breast cancer cell lines in culture with these analogues has been shown to decrease cell proliferation and induce programmed cell death." | 2.40 | Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment. ( Casero, RA; Davidson, NE; Hahm, HA; McCloskey, DE; Woster, PM, 1999) |
| "Four different breast cancer cell lines were treated with DENSPM." | 1.35 | Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. ( Hegardt, C; Holst, CM; Jönsson, G; Oredsson, SM; Staaf, J, 2008) |
| "The ability of both normal-like and breast cancer cells to recover from DENSPM treatment was also studied." | 1.35 | Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine. ( Alm, K; Johansson, M; Myhre, L; Oredsson, SM, 2009) |
| "Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue." | 1.32 | Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. ( Casero, RA; Davidson, NE; Gabrielson, E; Hacker, A; Pegg, AE; Tully, E, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casero, RA | 7 |
| Woster, PM | 5 |
| Akyol, Z | 1 |
| Çoker-Gürkan, A | 1 |
| Arisan, ED | 1 |
| Obakan-Yerlikaya, P | 1 |
| Palavan-Ünsal, N | 1 |
| Holst, CM | 3 |
| Staaf, J | 3 |
| Jönsson, G | 3 |
| Hegardt, C | 3 |
| Oredsson, SM | 6 |
| Johansson, VM | 2 |
| Miniotis, MF | 1 |
| Berntsson, PS | 1 |
| Alm, K | 4 |
| Myhre, L | 2 |
| Johansson, M | 1 |
| Pledgie-Tracy, A | 1 |
| Billam, M | 1 |
| Hacker, A | 3 |
| Sobolewski, MD | 1 |
| Zhang, Z | 2 |
| Davidson, NE | 5 |
| Cervelli, M | 1 |
| Bellavia, G | 1 |
| Fratini, E | 1 |
| Amendola, R | 1 |
| Polticelli, F | 1 |
| Barba, M | 1 |
| Federico, R | 1 |
| Signore, F | 1 |
| Gucciardo, G | 1 |
| Grillo, R | 1 |
| Mariottini, P | 1 |
| Wolff, AC | 1 |
| Armstrong, DK | 1 |
| Fetting, JH | 1 |
| Carducci, MK | 1 |
| Riley, CD | 1 |
| Bender, JF | 1 |
| Gabrielson, E | 1 |
| Tully, E | 1 |
| Pegg, AE | 1 |
| Balabhadrapathruni, S | 1 |
| Santhakumaran, LM | 1 |
| Thomas, TJ | 2 |
| Shirahata, A | 2 |
| Gallo, MA | 2 |
| Thomas, T | 2 |
| Pledgie, A | 1 |
| Huang, Y | 1 |
| Nair, SK | 1 |
| Verma, A | 1 |
| Chou, TC | 1 |
| Larsson, S | 1 |
| Hahm, HA | 1 |
| McCloskey, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma[NCT04530006] | 20 participants (Anticipated) | Interventional | 2020-12-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for n(1),n(11)-diethylnorspermine and Breast Neoplasms
| Article | Year |
|---|---|
Recent advances in the development of polyamine analogues as antitumor agents.
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Breast Neoplasms; DNA; Drug Discovery; Eflornit | 2009 |
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
Topics: Acetyltransferases; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Divisio | 1999 |
1 trial available for n(1),n(11)-diethylnorspermine and Breast Neoplasms
| Article | Year |
|---|---|
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Drug Administration Sched | 2003 |
13 other studies available for n(1),n(11)-diethylnorspermine and Breast Neoplasms
| Article | Year |
|---|---|
DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Surviv | 2016 |
Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cytochromes c; Huma | 2008 |
Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor; | 2008 |
Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line | 2009 |
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 2010 |
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Breast Neoplasms; Female; Gene Expression P | 2010 |
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Enzyme Induction; Female; Humans; Immun | 2004 |
Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Caspase 8; Caspases; Ce | 2005 |
Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; | 2005 |
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; C | 2005 |
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.
Topics: 2-Methoxyestradiol; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; C | 2007 |
Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death.
Topics: Acetyltransferases; Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Assoc | 2008 |
Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line | 2008 |