n(1)-methylnicotinamide has been researched along with Disease Models, Animal in 8 studies
N(1)-methylnicotinamide: RN given refers to parent cpd
1-methylnicotinamide : A pyridinium ion comprising nicotinamide having a methyl group at the 1-position. It is a metabolite of nicotinamide which was initially considered to be biologically inactive but has emerged as an anti-thrombotic and anti-inflammatory agent.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we demonstrated that IL-10-producing macrophages contribute to immune tolerance in the inflamed liver under intestinal barrier disruption in a murine tandem model of dextran sulfate sodium (DSS) colitis and concanavalin A (Con A) hepatitis." | 3.88 | Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages. ( Amiya, T; Chu, PS; Ebinuma, H; Fukuda, S; Kanai, T; Katayama, T; Mikami, Y; Miyake, R; Nakamoto, N; Shiba, S; Suzuki, T; Taniki, N; Teratani, T; Tsukimi, T; Yamaguchi, A, 2018) |
| "We previously showed that 1-methylnicotinamide (1-MNA) and its analog 1,4-dimethylpyridine (1,4-DMP) could inhibit the formation of lung metastases and enhance the efficacy of cyclophosphamide-based chemotherapy in the model of spontaneously metastasizing 4T1 mouse mammary gland tumors." | 3.85 | The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice. ( Chlopicki, S; Denslow, A; Gebicki, J; Maciejewska, M; Marcinek, A; Nowak, M; Switalska, M; Wietrzyk, J, 2017) |
| "Depression is one of the most common psychiatric disorders, and there is strong demand for developing novel antidepressants with better efficacy and less adverse effects." | 1.62 | Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. ( Gu, JH; Ji, CH; Jiang, B; Liu, Y; Tang, WQ; Zhang, Y; Zhao, J, 2021) |
| "Progression of pulmonary hypertension is associated with the activation of the NNMT-MNA pathway in rats and humans." | 1.43 | Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension. ( Chlopicki, S; Fedorowicz, A; Jakubowski, A; Kopec, G; Kutryb-Zając, B; Mateuszuk, Ł; Skórka, T; Słomińska, E; Walczak, M; Zakrzewska, A; Łomnicka, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 1 |
| Zhang, Y | 1 |
| Liu, Y | 1 |
| Tang, WQ | 1 |
| Ji, CH | 1 |
| Gu, JH | 1 |
| Jiang, B | 1 |
| Taniki, N | 1 |
| Nakamoto, N | 1 |
| Chu, PS | 1 |
| Mikami, Y | 1 |
| Amiya, T | 1 |
| Teratani, T | 1 |
| Suzuki, T | 1 |
| Tsukimi, T | 1 |
| Fukuda, S | 1 |
| Yamaguchi, A | 1 |
| Shiba, S | 1 |
| Miyake, R | 1 |
| Katayama, T | 1 |
| Ebinuma, H | 1 |
| Kanai, T | 1 |
| Takeuchi, K | 1 |
| Yokouchi, C | 1 |
| Goto, H | 1 |
| Umehara, K | 1 |
| Yamada, H | 1 |
| Ishii, Y | 1 |
| Tanaka, Y | 1 |
| Kume, S | 1 |
| Araki, H | 1 |
| Nakazawa, J | 1 |
| Chin-Kanasaki, M | 1 |
| Araki, S | 1 |
| Nakagawa, F | 1 |
| Koya, D | 1 |
| Haneda, M | 1 |
| Maegawa, H | 1 |
| Uzu, T | 1 |
| Fedorowicz, A | 1 |
| Mateuszuk, Ł | 1 |
| Kopec, G | 1 |
| Skórka, T | 1 |
| Kutryb-Zając, B | 1 |
| Zakrzewska, A | 1 |
| Walczak, M | 1 |
| Jakubowski, A | 2 |
| Łomnicka, M | 1 |
| Słomińska, E | 1 |
| Chlopicki, S | 3 |
| Denslow, A | 1 |
| Switalska, M | 1 |
| Nowak, M | 1 |
| Maciejewska, M | 1 |
| Marcinek, A | 1 |
| Gebicki, J | 1 |
| Wietrzyk, J | 1 |
| Bryniarski, K | 1 |
| Biedron, R | 1 |
| Marcinkiewicz, J | 1 |
| Fukushima, T | 1 |
1 review available for n(1)-methylnicotinamide and Disease Models, Animal
| Article | Year |
|---|---|
[Elucidation of paraquat poisoning mechanism and development of the neuronal death model].
Topics: Animals; Chaperonin 60; Disease Models, Animal; Electron Transport Complex I; Herbicides; Humans; Li | 2002 |
7 other studies available for n(1)-methylnicotinamide and Disease Models, Animal
| Article | Year |
|---|---|
Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Disease; Depression; Dise | 2021 |
Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.
Topics: Animals; Chemical and Drug Induced Liver Injury; Colitis; Concanavalin A; Dextran Sulfate; Disease M | 2018 |
Alleviation of fatty liver in a rat model by enhancing N
Topics: Aldehyde Oxidase; Animals; Biological Availability; Cytosol; Disease Models, Animal; Enzyme Inhibito | 2018 |
1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.
Topics: Albumins; Animals; Blotting, Western; Disease Models, Animal; Fatty Acids, Nonesterified; Immunohist | 2015 |
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Case-Control Studies; Disease Models, Animal; Disease | 2016 |
The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease Models, Animal; D | 2017 |
Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin.
Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents; Benzofurans; CD4-Positive T-Lymphocytes; CD8-P | 2008 |