n(1), n(12)-diethylspermine has been researched along with Lung Neoplasms in 7 studies
N(1), N(12)-diethylspermine: structure in first source
N(1),N(12)-diethylspermine : A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 7.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 3.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casero, RA | 7 |
| Gabrielson, EW | 1 |
| Pegg, AE | 2 |
| Xiao, L | 3 |
| Barr, LF | 1 |
| Campbell, SE | 1 |
| Tamez, P | 1 |
| Mank-Seymour, AR | 1 |
| Murray, TR | 1 |
| Berkey, KA | 1 |
| Kern, S | 1 |
| Mank, AR | 1 |
| Smith, J | 1 |
| Bergeron, RJ | 2 |
| Celano, P | 3 |
| Ervin, SJ | 2 |
| Wiest, L | 1 |
| Baylin, SB | 1 |
7 other studies available for n(1), n(12)-diethylspermine and Lung Neoplasms
| Article | Year |
|---|---|
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Topics: Acetyltransferases; Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Drug Screening Assay | 1994 |
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.
Topics: Acetyltransferases; Base Sequence; Carcinoma, Small Cell; Cloning, Molecular; Deoxyribonuclease I; H | 1996 |
The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Genes, myc; Genes, | 1998 |
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Topics: Acetyltransferases; Alleles; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Cell Surviva | 1998 |
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Ce | 1992 |
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
Topics: Acetyltransferases; Amino Acid Sequence; Amino Acids; Blotting, Western; Carcinoma; Enzyme Induction | 1990 |
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Topics: Adenosylmethionine Decarboxylase; Carcinoma; Carcinoma, Small Cell; Cells, Cultured; Humans; Lung Ne | 1989 |