n(1), n(12)-diethylspermine has been researched along with Breast Cancer in 3 studies
N(1), N(12)-diethylspermine: structure in first source
N(1),N(12)-diethylspermine : A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the breast cancer cell line L56Br-C1, treatment with 10 microm DENSPM induced SSAT activity 60 and 240-fold at 24 and 48 h after seeding, respectively, which resulted in polyamine depletion." | 5.31 | Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine. ( Hegardt, C; Johannsson, OT; Oredsson, SM, 2002) |
| " Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition." | 5.29 | Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993) |
| "In the breast cancer cell line L56Br-C1, treatment with 10 microm DENSPM induced SSAT activity 60 and 240-fold at 24 and 48 h after seeding, respectively, which resulted in polyamine depletion." | 1.31 | Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine. ( Hegardt, C; Johannsson, OT; Oredsson, SM, 2002) |
| " Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition." | 1.29 | Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casero, RA | 2 |
| Woster, PM | 1 |
| Davidson, NE | 1 |
| Mank, AR | 1 |
| Prestigiacomo, LJ | 1 |
| Bergeron, RJ | 1 |
| Hegardt, C | 1 |
| Johannsson, OT | 1 |
| Oredsson, SM | 1 |
1 review available for n(1), n(12)-diethylspermine and Breast Cancer
| Article | Year |
|---|---|
Recent advances in the development of polyamine analogues as antitumor agents.
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Breast Neoplasms; DNA; Drug Discovery; Eflornit | 2009 |
2 other studies available for n(1), n(12)-diethylspermine and Breast Cancer
| Article | Year |
|---|---|
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
Topics: Acetyltransferases; Breast Neoplasms; Carcinoma; Cell Division; Drug Resistance; Enzyme Induction; F | 1993 |
Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine.
Topics: Antineoplastic Agents; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell | 2002 |