myxothiazol and Leukemia--T-Cell

Myxothiazol, a potent inhibitor of the cytochrome bc1 oxidoreductase, was shown by the use of flow cytometry to block reversibly the late G1/S phase of the cell cycle of human lymphoblastic T-cell line Jurkat (clone 886) at concentrations of 0.5 microgram/ml. These observations are compared to those of other drugs, such as antimycin, which effect the respiratory chain, and with O2-deficiency.

Topics: Acridine Orange; Antifungal Agents; Cell Cycle; Flow Cytometry; Humans; Interphase; Leukemia, T-Cell; Methacrylates; Thiazoles; Tumor Cells, Cultured