myxococcus-xanthus-antibiotic-ta and Escherichia-coli-Infections

Catheter-associated urinary tract infection is the most common nosocomial infection, and contributes to patient morbidity and mortality. We investigated the effect that the TA adhesive antibiotic had on adhesion and initial growth in urine of Escherichia coli on silicone rubber. The TA antibiotic had reduced adhesion, and inhibited initial growth of the bacteria on the surface. Since adhesion and initial growth on the surface are an essential part of biofilm formation and subsequent infection, we speculate that the TA antibiotic coating might decrease the infection rate associated with indwelling urinary catheter.

Topics: Anti-Bacterial Agents; Bacterial Adhesion; Escherichia coli; Escherichia coli Infections; Humans; Macrolides; Silicone Elastomers; Urinary Tract Infections; Urine