myelin-basic-protein and Sepsis

Infection and sepsis are associated with brain white matter injury in preterm infants and the subsequent development of cerebral palsy.. In the present study, we used a neonatal mouse sepsis-induced white matter injury model to determine the contribution of different T cell subsets (αβT cells and γδT cells) to white matter injury and consequent behavioral changes. C57BL/6J wild-type (WT), T cell receptor (TCR) δ-deficient (Tcrd. White matter development was normal in Tcrd. Our results suggest that γδT cells but not αβT cells contribute to sepsis-induced white matter injury and subsequent motor function abnormalities in early life. Modulating the activity of γδT cells in the early stages of preterm white matter injury might represent a novel therapeutic strategy for the treatment of perinatal brain injury.

Topics: Animals; Animals, Newborn; Anxiety; Brain; Cytokines; Disease Models, Animal; Gait; Gene Expression Regulation, Developmental; Leukoencephalopathies; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Movement Disorders; Myelin Basic Protein; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Sepsis; Spleen; T-Lymphocyte Subsets