myelin-basic-protein and Intracranial-Aneurysm

Increased plasma copeptin concentrations are related to poor prognosis after aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to assess prognostic significance of plasma copeptin detection compared with glial fibrillary astrocyte protein, myelin basic protein, S100B, phosphorylated axonal neurofilament subunit H, neuron-specific enolase, tau and ubiquitin carboxyl-terminal hydrolase L1 in aSAH.. We detected plasma concentrations of the aforementioned biomarkers in 105 healthy controls using ELISA. Their predictive ability for symptomatic cerebral vasospasm and 6-month poor outcome (Glasgow Outcome Scale score of 1-3) were compared.. Plasma concentrations of the preceding biomarkers were highly correlated with World Federation of Neurological Surgeons subarachnoid hemorrhage scale (WFNS) scores as well as were significantly higher in patients with symptomatic cerebral vasospasm than in those without symptomatic cerebral vasospasm and in patients with poor outcome than in those with good outcome. In terms of area under receiver operating characteristic curve, their predictive value for symptomatic cerebral vasospasm and 6-month poor outcome was in the range of WFNS scores. Plasma copeptin concentration, but not plasma concentrations of other biomarkers, statistically significantly improved the predictive performance of WFNS scores.. Copeptin in plasma might have the potential to be a useful prognostic biomarker for aSAH.

Topics: Adult; Aged; Biomarkers; Case-Control Studies; Female; Gene Expression; Glial Fibrillary Acidic Protein; Glycopeptides; Humans; Intracranial Aneurysm; Male; Middle Aged; Myelin Basic Protein; Neurofilament Proteins; Phosphopyruvate Hydratase; Predictive Value of Tests; Prognosis; Prospective Studies; S100 Calcium Binding Protein beta Subunit; Subarachnoid Hemorrhage; tau Proteins; Ubiquitin Thiolesterase; Vasospasm, Intracranial