myelin-basic-protein and Immunologic-Deficiency-Syndromes

myelin-basic-protein has been researched along with Immunologic-Deficiency-Syndromes* in 2 studies

Other Studies

2 other study(ies) available for myelin-basic-protein and Immunologic-Deficiency-Syndromes

Article	Year
The nature of the defect in experimental allergic encephalomyelitis (EAE)-resistant Lewis (Le-R) rats. Journal of immunology (Baltimore, Md. : 1950), 1985, Volume: 134, Issue:3 Recently, a colony of Lewis rats has been described which is resistant to experimental allergic encephalomyelitis (EAE). These rats, termed Le-R, are still histocompatible with other Lewis rats. The genetic defect which results in EAE-resistance was shown not to be linked to the RT1.B (Ir) region of the MHC. Myelin basic protein (BP)-sensitization of Le-R rats induces cells capable of mounting a proliferative response to BP in culture but incapable of transferring EAE after culture with BP. The present study demonstrates that the latter deficiency can be overcome either by incorporating lipopolysaccharide (LPS) in the BP-culture medium or by simultaneous transfer of LPS-activated antigen-nonspecific spleen cells with the BP-sensitized cells. The BP-sensitized Le-R cells fail to transfer EAE due to their inability to initiate lesions in the CNS. LPS, working through an antigen-nonspecific cell or cell products, can correct the defect in the Le-R cells such that the antigen-specific cells become capable of initiating CNS lesions which lead to development of clinical EAE. Topics: Animals; Concanavalin A; Encephalomyelitis, Autoimmune, Experimental; Epitopes; Guinea Pigs; Immunity, Innate; Immunization, Passive; Immunologic Deficiency Syndromes; Lymphocyte Activation; Myelin Basic Protein; Rats; Rats, Inbred Lew; Rats, Inbred Strains	1985
[Use of a thymus polypeptide preparation to diagnose and correct immune deficiency states in multiple sclerosis]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1984, Volume: 84, Issue:2 Thymus-dependent immunity as well as thymic factor and corticosteroid influence upon it were studied in 36 patients with disseminated sclerosis. The illness was diagnosed according to the Poser system with the help of the spontaneous erythrocyte rosette test. The sensitivity of T lymphocytes to thymaline, to basic myelin protein and to prednisolone was analyzed. The Soviet drug thymaline, obtained from calf thymus, was first used for the treatment of disseminated sclerosis. Clinical and immunological results turned out positive. The possibility of differential immunomodulating therapy of disseminated sclerosis is shown. Topics: Adjuvants, Immunologic; Adult; Humans; Immunologic Deficiency Syndromes; Leukocyte Count; Middle Aged; Multiple Sclerosis; Myelin Basic Protein; Prednisolone; Rosette Formation; T-Lymphocytes; Thymus Hormones	1984

Article

Year

The nature of the defect in experimental allergic encephalomyelitis (EAE)-resistant Lewis (Le-R) rats.

Journal of immunology (Baltimore, Md. : 1950), 1985, Volume: 134, Issue:3

Recently, a colony of Lewis rats has been described which is resistant to experimental allergic encephalomyelitis (EAE). These rats, termed Le-R, are still histocompatible with other Lewis rats. The genetic defect which results in EAE-resistance was shown not to be linked to the RT1.B (Ir) region of the MHC. Myelin basic protein (BP)-sensitization of Le-R rats induces cells capable of mounting a proliferative response to BP in culture but incapable of transferring EAE after culture with BP. The present study demonstrates that the latter deficiency can be overcome either by incorporating lipopolysaccharide (LPS) in the BP-culture medium or by simultaneous transfer of LPS-activated antigen-nonspecific spleen cells with the BP-sensitized cells. The BP-sensitized Le-R cells fail to transfer EAE due to their inability to initiate lesions in the CNS. LPS, working through an antigen-nonspecific cell or cell products, can correct the defect in the Le-R cells such that the antigen-specific cells become capable of initiating CNS lesions which lead to development of clinical EAE.

Topics: Animals; Concanavalin A; Encephalomyelitis, Autoimmune, Experimental; Epitopes; Guinea Pigs; Immunity, Innate; Immunization, Passive; Immunologic Deficiency Syndromes; Lymphocyte Activation; Myelin Basic Protein; Rats; Rats, Inbred Lew; Rats, Inbred Strains

1985

[Use of a thymus polypeptide preparation to diagnose and correct immune deficiency states in multiple sclerosis].

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1984, Volume: 84, Issue:2

Thymus-dependent immunity as well as thymic factor and corticosteroid influence upon it were studied in 36 patients with disseminated sclerosis. The illness was diagnosed according to the Poser system with the help of the spontaneous erythrocyte rosette test. The sensitivity of T lymphocytes to thymaline, to basic myelin protein and to prednisolone was analyzed. The Soviet drug thymaline, obtained from calf thymus, was first used for the treatment of disseminated sclerosis. Clinical and immunological results turned out positive. The possibility of differential immunomodulating therapy of disseminated sclerosis is shown.

Topics: Adjuvants, Immunologic; Adult; Humans; Immunologic Deficiency Syndromes; Leukocyte Count; Middle Aged; Multiple Sclerosis; Myelin Basic Protein; Prednisolone; Rosette Formation; T-Lymphocytes; Thymus Hormones

1984