myelin-basic-protein and Hypothermia

Multiple randomized controlled trials have shown that hypothermia is a safe and effective treatment for neonatal moderate or severe hypoxic-ischemic encephalopathy (HIE). The neuroprotective mechanisms of hypothermia need further study. The aim of this study was to investigate the effect of hypothermia on the serum levels of myelin basic protein (MBP) and tumor necrosis factor-α (TNF-α) as well as neurodevelopmental outcomes in neonatal HIE.. Eighty-five neonates with moderate-to-severe HIE were divided into a hypothermia group (. After 3 days of treatment, serum levels of MBP and TNF-α in the control group were not significantly different from levels before treatment (. Hypothermia can reduce serum levels of MBP and TNF-α in neonates with HIE. Inhibiting the release of TNF-α may be one of the mechanisms by which hypothermia protects the myelin sheath.. · Hypothermia can reduce serum levels of MBP and TNF-α in neonatal HIE.. · Hypothermia improves neurodevelopmental outcomes and reduces the rate of neurodevelopmental impairment.. · Hypothermia is a feasible and effective treatment for neonates with moderate or severe HIE..

Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Myelin Basic Protein; Tumor Necrosis Factor-alpha