myelin-basic-protein and Genital-Neoplasms--Female

Topics: Adult; Aged; Antigens, Neoplasm; Cell Migration Inhibition; Female; Genital Neoplasms, Female; Humans; Leukocytes; Middle Aged; Myelin Basic Protein; Ovarian Neoplasms

Lymphocytes from 278 gynaecological patients (100 controls and 178 patients with a malignant condition) have been investigated for their response to encephalitogenic factor, cancer basic protein, and KCl extract of adenocarcinoma of the body of the uterus as "antigens", using tanned sheep erythrocytes ETS as indicator particles in the electrophoretic mobility test (EMT). Electrophoretic mobility was measured with a Zeiss cytopherometer. The study was split into three test series producing in the cancer group 66% correct positive test results (34% false negatives) and in the control group 83% correct negative results (17% false positives). Consequently, with the instrumentation used, EMT is, at least in our hands, not sufficiently reliable for the diagnosis of cancer.

Topics: Adenocarcinoma; Adult; Aged; Antigens, Neoplasm; Electrophoresis; Female; Genital Neoplasms, Female; Humans; Lymphocytes; Middle Aged; Myelin Basic Protein; Neoplasm Proteins; Uterine Neoplasms

We applied the electrophoretic mobility test (EMT) to 117 patients. 49 patients suffered from gynecological malignant tumors of different types and eleven had a carcinoma in situ. 57 patients served as a control group, 26 of whom were clinically healthy volunteers and 31 had benign gynecological diseases. In the EMT all malignant cases had inhibition values of at least-5% or even more. All other tested persons, the so-called non-malignant or healthy cases, had an inhibition of less than -5% or even an acceleration of the tanned sheep erythrocytes stabilized with sulfosalicylic acid (ETS).

Topics: Antigens; Carcinoma in Situ; Cell Migration Inhibition; Electrophoresis; Erythrocytes; Female; Genital Neoplasms, Female; Humans; Lymphocytes; Myelin Basic Protein