myelin-basic-protein and Child-Development-Disorders--Pervasive

Leukocyte elastase (LE) activity, functional activity of alpha1-proteinase inhibitor, C-reactive protein, autoantibodies to nerve growth factor and to basic myelin protein have been studied in the blood serum of children with psychotic forms of autistic disorders - children psychosis (F84.02) and atypical children psychosis (F84.11). The activation of innate immunity (the increase in LE activity and acute phase proteins) was seen in children psychosis. The more severe mental disturbances, that are characteristic of endogenous atypical children psychosis, were accompanied by the activation of both innate and adaptive immunity ( the increase of the level of autoantibodies to neuroantigenes in the peripheral blood). Correlations between immunological and clinical parameters suggest the involvement of innate and adaptive immunity in the formation of autistic and cognitive disorders in children.

Topics: Adaptive Immunity; alpha 1-Antitrypsin; Autoantibodies; C-Reactive Protein; Child; Child Development Disorders, Pervasive; Child, Preschool; Female; Humans; Immunity, Innate; Leukocyte Elastase; Male; Myelin Basic Protein; Nerve Growth Factor; Psychotic Disorders