mycophenolic-acid and Tuberculosis--Meningeal

We report a case of central nervous system coinfection with 2 types of opportunistic organisms-Aspergillus and Mycobacterium tuberculosis-in a 33-year-old woman who underwent a renal transplant.. She developed a high-grade fever and right-sided weakness 1 month after the transplant while on mycophenolate mofetil, prednisolone, and cyclosporine.. Brain magnetic resonance imaging revealed multiple mass lesions with peripheral ring enhancement. Colony-stimulating factor polymerase chain reaction was positive for Aspergillus and Mycobacterium tuberculosis.. Broad-spectrum antibiotics, antituberculous agents, and amphotericin were started. Unfortunately, the woman's condition deteriorated, and she died 2 weeks after admission to the hospital.

Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Antitubercular Agents; Aspergillus; Bacteriological Techniques; Cyclosporine; DNA, Bacterial; DNA, Fungal; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Magnetic Resonance Imaging; Meningoencephalitis; Mycobacterium tuberculosis; Mycophenolic Acid; Polymerase Chain Reaction; Prednisolone; Treatment Failure; Tuberculosis, Meningeal