mycophenolic-acid and Systemic-Inflammatory-Response-Syndrome

Mycophenolate mofetil is a commonly used immunosuppressive medication in the postliver transplant setting where gastrointestinal side effects tend to predominate. However, in more recent times, emerging and rare side effects are being reported in the literature. We present a case of a patient who had a significant inflammatory response and associated marked weight loss with the uptitration in dose of mycophenolate mofetil. Extensive investigations were performed to exclude other infective, inflammatory or malignant aetiologies for these symptoms, however no other cause was identified. The patient had the medication ceased and subsequently had a dramatic improvement in his inflammatory markers and regained the weight lost while on the medication.

Topics: Aged; C-Reactive Protein; Diagnosis, Differential; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Mycophenolic Acid; Systemic Inflammatory Response Syndrome; Weight Loss