mycophenolic-acid and Staphylococcal-Skin-Infections

Bullous pemphigoid (BP) is a common autoimmune blistering disease in the adult population, but extremely rare in the pediatric population. Childhood BP usually has a favorable prognosis and responds well to topical and oral steroids. However, for patients that do not respond to corticosteroids, therapeutic alternatives are scarce. We report a case of a toddler with recalcitrant BP who was successfully treated with mycophenolate mofetil (MMF).

Topics: Anti-Bacterial Agents; Clindamycin; Dapsone; Diagnosis, Differential; Drug Resistance; Humans; Immunosuppressive Agents; Infant; Lymphocyte Subsets; Male; Mycophenolic Acid; Pemphigoid, Bullous; Prednisone; Pruritus; Remission Induction; Skin Diseases, Vesiculobullous; Staphylococcal Skin Infections; Superinfection; Urticaria

Tufted hair folliculitis (THF) is a rare disease which is characterized by the emergence of multiple hairs from widely dilated follicular orifices surrounded by an inflammatory infiltrate resulting in scarring alopecia. The pathogenesis is not yet fully understood. Although colonization with Staphylococcus aureus could not always be detected and systemic treatment with antibiotics alone is not sufficient, this microorganism is considered to play an important role. Around 30 patients with THF have been reported since the first publication. We present a patient with pemphigus vulgaris who developed THF. To our knowledge, this is the fourth case with an association of these two entities. Amongst other causing mechanisms, the autoimmune reaction may play an important role for the development of THF.

Topics: Administration, Topical; Alopecia; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Dermatologic Agents; Drug Therapy, Combination; Folliculitis; Glucocorticoids; Humans; Male; Methylprednisolone; Middle Aged; Mycophenolic Acid; Pemphigus; Povidone-Iodine; Staphylococcal Skin Infections; Staphylococcus aureus