mycophenolic-acid and Rhinitis--Atrophic

Pasteurella multocida (Pm) is the causative agent of atrophic rhinitis in swine. This study aimed to discover biofilm inhibitors against swine Pm to counteract antibiotic resistance and decrease virulence. The virulence factor outer membrane protein A (OmpA) was targeted. A library of drugs approved by the Food and Drug Administration (FDA) was used to perform virtual screening against PmOmpA. The top-scoring compounds had no effect on the growth of Pm serotype A or D. Mycophenolate mofetil showed the highest efficacy in inhibiting biofilm formation by Pm serotype A, with an IC

Topics: Amino Acid Sequence; Animals; Bacterial Outer Membrane Proteins; Biofilms; Indocyanine Green; Models, Biological; Models, Molecular; Mycophenolic Acid; Pasteurella Infections; Pasteurella multocida; Protein Binding; Rhinitis, Atrophic; Swine; Virulence; Virulence Factors