mycophenolic-acid and Pulmonary-Aspergillosis

The role of CD19+CD24. From Jan 2009 to Dec 2014, 117 lung Tx recipients were submitted to an immunological follow up I-FU(median: 108.7 months (6.7-310.5)). Immunological follow up consisted of a complete blood peripheral immuno-phenotype, inclusive of CD19+CD24. Among all variables analyzed at multivariate analysis: chronic rejection (OR - 0.19, p = .039), use of Mycophenolate (OR - 0.38, p < .001) and the presence of a concomitant pulmonary infection of S. aureus (OR 0.66, p = .002) and A. fumigatus (OR 0.50, p = .009) were significantly associated to B-reg cell. No significant correlation between CD19+CD24. Our present data highlight, for the first time, that this cell subset might participate in long-term lung graft acceptance mechanisms.

Topics: ADP-ribosyl Cyclase 1; Adult; Aspergillus fumigatus; B-Lymphocytes, Regulatory; Blood Circulation; CD24 Antigen; Chronic Disease; Cohort Studies; Female; Graft Rejection; Humans; Immunophenotyping; Interleukin-10; Italy; Lung Transplantation; Male; Middle Aged; Mycophenolic Acid; Neprilysin; Pulmonary Aspergillosis; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus aureus; T-Lymphocytes, Regulatory