mycophenolic-acid has been researched along with Orthomyxoviridae-Infections* in 1 studies
1 other study(ies) available for mycophenolic-acid and Orthomyxoviridae-Infections
| Article | Year |
|---|---|
Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection.
Infection with the highly pathogenic avian influenza H5N1 virus results in a high incidence of mortality in humans. Severe complications from infection are often associated with hypercytokinemia. However, current neuraminidase inhibitors (NAIs) have several limitations including the appearance of oseltamivir-resistant H5N1 virus and the inability to completely ameliorate hyper-immune responses. To overcome these limitations, we evaluated the anti-viral activity of mycophenolic mofetil (MMF) against A/Vietnam/1194/2004 (H5N1) virus infection using MDCK cells and mice. The IC Topics: Animals; Antiviral Agents; Chemokine CXCL10; Chick Embryo; Dogs; Female; Gene Expression Regulation; Host-Pathogen Interactions; Immunologic Factors; IMP Dehydrogenase; Influenza A Virus, H5N1 Subtype; Interferon-beta; Interleukin-1beta; Interleukin-6; Lung; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Orthomyxoviridae Infections; Oseltamivir; RNA, Viral; Survival Analysis; Virus Replication; Zanamivir | 2017 |