mycophenolic-acid and Ophthalmia--Sympathetic

Topics: Capillary Permeability; Drug Therapy, Combination; Fluorescein Angiography; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Mycophenolic Acid; Ophthalmia, Sympathetic; Prednisone; Retinal Detachment; Subretinal Fluid; Young Adult

Topics: Administration, Oral; Blindness; Cyclophosphamide; Drug Therapy, Combination; Eye Enucleation; Eye Pain; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Middle Aged; Mycophenolic Acid; Ophthalmia, Sympathetic; Retinal Diseases; Visual Acuity

To report a case of sympathetic ophthalmia occurring after nonpenetrating ocular trauma.. Interventional case report.. An 18-year-old white male presented with sympathetic ophthalmia four weeks after a hyphema from a nonpenetrating bungee cord injury. Vision was 20/20; there were keratic precipitates, anterior chamber cells, vitritis, and discrete yellow deep choroidal lesions consistent with Dalen-Fuch's nodules OU. The uveitis was treated with topical, oral, and periocular corticosteroids and the oral immunosuppressives cyclosporine and mycophenolate mofetil. Vision remained 20/20 OU for the first year of follow-up; vision OD then deteriorated to 20/50 over the next year with the formation of a posterior subcapsular cataract OD.. Sympathetic ophthalmia may result from nonpenetrating ocular trauma. Ophthalmologists should be aware of this as prompt intervention is warranted.

Topics: Adolescent; Cyclosporine; Drug Therapy, Combination; Eye Injuries; Glucocorticoids; Humans; Hyphema; Immunosuppressive Agents; Male; Mycophenolic Acid; Ophthalmia, Sympathetic; Wounds, Nonpenetrating