mycophenolic-acid has been researched along with Nail-Diseases* in 3 studies
3 other study(ies) available for mycophenolic-acid and Nail-Diseases
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Bullous pemphigoid in a patient with suspected non-Herlitz junctional epidermolysis bullosa.
A 56-year-old man with lifelong trauma-induced blisters, nail dystrophy and dental enamel hypoplasia presented with a new spontaneous blistering eruption. Clinicopathologically, he had evidence of both an inherited and an acquired blistering disorder: non-Herlitz junctional epidermolysis bullosa (nHJEB) and bullous pemphigoid (BP). HIstological examination of a skin biopsy found reduced (but not absent) collagen XVII in nonlesional skin, in vivo bound anticollagen XVII antibodies in perilesional skin, and prominent eosinophils in perilesional and lesional skin, with subepidermal blistering. Circulating anticollagen XVII antibodies were also present. Treatment with oral corticosteroids and mycophenolate mofetil led to clinical control of the BP but had no effect on the mechanobullous blistering. Our patient is unusual in that his skin retains some labelling for collagen XVII rather than having the complete absence of immunoreactivity expected in patients with generalized nHJEB. Moreover, we were unable to identify any pathogenic mutations in the COL17A1 gene encoding collagen XVII (or in other EB-associated basement membrane genes). It is plausible that the long-term consequences of basement membrane disruption in our patient, perhaps associated with atypical inherited COL17A1 pathology, might result in a conformationally altered and more immunogenic protein with the subsequent development of anticollagen XVII antibodies and BP as a secondary pathology. Topics: Autoantigens; Blister; Brain Neoplasms; Collagen Type XVII; Dental Enamel Hypoplasia; Eosinophils; Epidermolysis Bullosa, Junctional; Fatal Outcome; Glucocorticoids; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Middle Aged; Mycophenolic Acid; Nail Diseases; Non-Fibrillar Collagens; Pemphigoid, Bullous; Prednisolone | 2010 |
Pemphigus vulgaris with nail involvement presenting with vegetating and verrucous lesions.
We report the case of a 68-year-old female with longstanding insulin-treated diabetes mellitus, observed for the first time in our department in August 1999 with multiple painful erosive lesions of the oral cavity and many bullous or erosive lesions on the abdominal wall, back, and thigh. She also had vegetating and verrucous lesions, similar to common warts, involving the hands and feet, mainly on the palms, palmar surface of the fingers, and nail folds. Her lesions were present for 1 year. Skin and mucous biopsies showed the characteristic histopathologic findings of pemphigus vulgaris, with an epidermal intercellular IgG deposition on direct immunofluorescence. Histology of a warty lesion of the finger also showed suprabasal acantholysis. After partial improvement with low doses of oral steroids and azathioprine, her disease progressed to involve the oral cavity, trunk, hands, feet, and scalp. Control of her disease required successive treatments of mycophenolate mofetil and cyclophosphamide, as well as corticosteroids. A partial response was obtained with all these treatments. After being controlled by cyclophosphamide that was slowly tapered, she is now well controlled with azathioprine and oral steroids, showing only discrete lesions of the oral mucosa after 1 year of followup. We report this case of pemphigus vulgaris with unusual clinical aspects, namely vegetating and verrucous lesions as well as nail involvement, rarely described in this disease. Topics: Aged; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Diabetes Mellitus, Type 1; Disease Progression; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Insulin; Methylprednisolone; Mycophenolic Acid; Nail Diseases; Pemphigus; Skin | 2003 |
Mycophenolate-associated onycholysis.
Topics: Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Nail Diseases | 2000 |