mycophenolic-acid and Lymphoma--B-Cell

Topics: Clone Cells; Diagnosis, Differential; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immune Tolerance; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Lymphoma, B-Cell; Male; Middle Aged; Mycophenolic Acid; Skin Ulcer

Topics: Adult; Brain Neoplasms; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Lymphoma, B-Cell; Mycophenolic Acid

Mycophenolic acid (MPA)/mycophenolate mofetil (MMF), a powerful immunosuppressive agent was tested on human B-lymphoma cells (Epstein-Barr virus +/-) in vitro and in SCID mouse xenograft model. Proliferation, apoptotic activity and tumor volume were evaluated. MPA inhibited lymphoma cell proliferation and induced apoptosis (50-60% at 72 h). In vivo, oral administration significantly inhibited subcutaneous tumor growth. Immunohistochemistry showed significantly decreased proliferation rate and higher apoptotic activity in tumors treated with MMF. Xenografted lymphoma cells remained sensitive to MPA. Our results suggest that MPA may be recommended as an additional component of lymphoma chemotherapeutical regimens, with special considerations to post-transplant lymphomas.

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Flow Cytometry; Herpesvirus 4, Human; Humans; Immunoenzyme Techniques; Lymphoma, B-Cell; Mice; Mice, SCID; Mycophenolic Acid; Neovascularization, Pathologic; Xenograft Model Antitumor Assays

Mycophenolate mofetil (MM), an immunosuppressant used after organ transplantation, is also used for treatment of autoimmune myasthenia gravis (MG). A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment. Primary CNS lymphoma regressed on withdrawal of MM. Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

Topics: Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Brain Neoplasms; Cell Transformation, Neoplastic; Drug Therapy, Combination; Female; Frontal Lobe; Humans; Immunity, Cellular; Immunosuppressive Agents; Lymphoma, B-Cell; Magnetic Resonance Imaging; Myasthenia Gravis; Mycophenolic Acid; Parietal Lobe; Prednisone; Pyridostigmine Bromide; Rituximab; T-Lymphocytes; Treatment Outcome

Lymphomas, both within and outside the central nervous system, are uncommon among patients with systemic lupus erythematosus (SLE). We describe a 58-year old Korean woman with SLE who presented with acute headache and confusion in the setting of prednisone and mycophenolate mofetil (MMF) therapy used to treat focal proliferative and membranous lupus nephritis. Three-dimensional brain magnetic resonance imaging (MRI) showed two peripherally ('ring') enhancing lesions within the basal ganglia, bilaterally, with associated mass effect and subfalcine herniation. A brain biopsy revealed an Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma. This is the first description of CNS lymphoma in a patient treated with MMF for lupus nephritis. While intracerebral lymphoma in the immunocompromised patient with lupus is rare, this disorder should be considered in the differential diagnosis of new-onset neurological symptoms among such patients.

Topics: Brain Neoplasms; Female; Humans; Immunosuppressive Agents; Lupus Nephritis; Lymphoma, B-Cell; Middle Aged; Mycophenolic Acid

A case of gross skeletal muscle uptake of 18F-FDG during PET is described. The clinical context of immunosuppression after heart and lung transplantation and the absence of any other known association make the former a likely etiologic factor.

Topics: Adult; Diagnosis, Differential; Drug Interactions; Female; Fever; Fluorodeoxyglucose F18; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Lymphoma, B-Cell; Muscle, Skeletal; Mycophenolic Acid; Positron-Emission Tomography; Radiography, Thoracic; Radiopharmaceuticals; Tacrolimus; Tomography, X-Ray Computed

Topics: Aniline Compounds; Animals; Antigens, Heterophile; B-Lymphocytes; Biphenyl Compounds; Cell Division; Crotonates; Cyclosporine; Drug Resistance; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphoma, B-Cell; Mycophenolic Acid; Nitriles; Primates; Pyrazoles; Swine; T-Lymphocytes; Toluidines; Transplantation, Heterologous; Tumor Cells, Cultured