mycophenolic-acid and Laryngeal-Neoplasms

Mycophenolic acid is an antimetabolite used experimentally for the treatment of psoriasis. Thirty-eight patients were treated with mycophenolic acid. A double-blind, placebo-controlled study demonstrated the efficacy of mycophenolic acid (P less than .01). A long-term safety study showed the occurrence of hematologic abnormalities, viral infections, and carcinoma. The position of mycophenolic acid in the therapeutic treatment of psoriasis must await the results of a multicenter cooperative study.

Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Squamous Cell; Clinical Trials as Topic; Double-Blind Method; Epiglottis; Female; Humans; Laryngeal Neoplasms; Male; Middle Aged; Mycophenolic Acid; Psoriasis; Virus Diseases