mycophenolic-acid and Iritis

To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life.. This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point.. A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber.. Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.

Topics: Adult; Age Distribution; Age of Onset; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biological Factors; Birdshot Chorioretinopathy; Chorioretinitis; Cyclosporine; Early Diagnosis; Female; Humans; Immunosuppressive Agents; Infliximab; Iritis; Male; Middle Aged; Mycophenolic Acid; Retrospective Studies; Risk Factors; Visual Acuity; Young Adult